{"id":"https://openalex.org/W3157158784","doi":"https://doi.org/10.1145/3412841.3441940","title":"Development of an explainable clinical decision support system for the prediction of patient quality of life in amyotrophic lateral sclerosis","display_name":"Development of an explainable clinical decision support system for the prediction of patient quality of life in amyotrophic lateral sclerosis","publication_year":2021,"publication_date":"2021-03-22","ids":{"openalex":"https://openalex.org/W3157158784","doi":"https://doi.org/10.1145/3412841.3441940","mag":"3157158784"},"language":"en","primary_location":{"id":"doi:10.1145/3412841.3441940","is_oa":true,"landing_page_url":"https://doi.org/10.1145/3412841.3441940","pdf_url":"https://dl.acm.org/doi/pdf/10.1145/3412841.3441940","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 36th Annual ACM Symposium on Applied Computing","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://dl.acm.org/doi/pdf/10.1145/3412841.3441940","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006177257","display_name":"Anna Markella Antoniadi","orcid":"https://orcid.org/0000-0002-8285-1997"},"institutions":[{"id":"https://openalex.org/I100930933","display_name":"University College Dublin","ror":"https://ror.org/05m7pjf47","country_code":"IE","type":"education","lineage":["https://openalex.org/I100930933"]}],"countries":["IE"],"is_corresponding":true,"raw_author_name":"Anna Markella Antoniadi","raw_affiliation_strings":["University College Dublin, Dublin, Ireland"],"affiliations":[{"raw_affiliation_string":"University College Dublin, Dublin, Ireland","institution_ids":["https://openalex.org/I100930933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013567168","display_name":"Miriam Galvin","orcid":"https://orcid.org/0000-0002-8232-8020"},"institutions":[{"id":"https://openalex.org/I205274468","display_name":"Trinity College Dublin","ror":"https://ror.org/02tyrky19","country_code":"IE","type":"education","lineage":["https://openalex.org/I205274468"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Miriam Galvin","raw_affiliation_strings":["Trinity College Dublin, Dublin, Ireland"],"affiliations":[{"raw_affiliation_string":"Trinity College Dublin, Dublin, Ireland","institution_ids":["https://openalex.org/I205274468"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031372738","display_name":"Mark Heverin","orcid":"https://orcid.org/0000-0002-7326-4432"},"institutions":[{"id":"https://openalex.org/I205274468","display_name":"Trinity College Dublin","ror":"https://ror.org/02tyrky19","country_code":"IE","type":"education","lineage":["https://openalex.org/I205274468"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Mark Heverin","raw_affiliation_strings":["Trinity College Dublin, Dublin, Ireland"],"affiliations":[{"raw_affiliation_string":"Trinity College Dublin, Dublin, Ireland","institution_ids":["https://openalex.org/I205274468"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030609927","display_name":"Orla Hardiman","orcid":"https://orcid.org/0000-0003-2610-1291"},"institutions":[{"id":"https://openalex.org/I205274468","display_name":"Trinity College Dublin","ror":"https://ror.org/02tyrky19","country_code":"IE","type":"education","lineage":["https://openalex.org/I205274468"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Orla Hardiman","raw_affiliation_strings":["Trinity College Dublin, Dublin, Ireland"],"affiliations":[{"raw_affiliation_string":"Trinity College Dublin, Dublin, Ireland","institution_ids":["https://openalex.org/I205274468"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5061456583","display_name":"Catherine Mooney","orcid":"https://orcid.org/0000-0002-7696-1364"},"institutions":[{"id":"https://openalex.org/I100930933","display_name":"University College Dublin","ror":"https://ror.org/05m7pjf47","country_code":"IE","type":"education","lineage":["https://openalex.org/I100930933"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Catherine Mooney","raw_affiliation_strings":["University College Dublin, Dublin, Ireland"],"affiliations":[{"raw_affiliation_string":"University College Dublin, Dublin, Ireland","institution_ids":["https://openalex.org/I100930933"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5006177257"],"corresponding_institution_ids":["https://openalex.org/I100930933"],"apc_list":null,"apc_paid":null,"fwci":0.8714,"has_fulltext":true,"cited_by_count":11,"citation_normalized_percentile":{"value":0.7626479,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":null,"issue":null,"first_page":"594","last_page":"602"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10855","display_name":"Amyotrophic Lateral Sclerosis Research","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10855","display_name":"Amyotrophic Lateral Sclerosis Research","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10510","display_name":"Stroke Rehabilitation and Recovery","score":0.9190000295639038,"subfield":{"id":"https://openalex.org/subfields/2742","display_name":"Rehabilitation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/amyotrophic-lateral-sclerosis","display_name":"Amyotrophic lateral sclerosis","score":0.938637375831604},{"id":"https://openalex.org/keywords/quality","display_name":"Quality (philosophy)","score":0.5633371472358704},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5041342973709106},{"id":"https://openalex.org/keywords/quality-of-life","display_name":"Quality of life (healthcare)","score":0.4993422031402588},{"id":"https://openalex.org/keywords/decision-support-system","display_name":"Decision support system","score":0.45827531814575195},{"id":"https://openalex.org/keywords/physical-medicine-and-rehabilitation","display_name":"Physical medicine and rehabilitation","score":0.35887885093688965},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.31730231642723083},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.3094547986984253},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.14539998769760132},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.09440958499908447}],"concepts":[{"id":"https://openalex.org/C2780596555","wikidata":"https://www.wikidata.org/wiki/Q206901","display_name":"Amyotrophic lateral sclerosis","level":3,"score":0.938637375831604},{"id":"https://openalex.org/C2779530757","wikidata":"https://www.wikidata.org/wiki/Q1207505","display_name":"Quality (philosophy)","level":2,"score":0.5633371472358704},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5041342973709106},{"id":"https://openalex.org/C2779951463","wikidata":"https://www.wikidata.org/wiki/Q7268788","display_name":"Quality of life (healthcare)","level":2,"score":0.4993422031402588},{"id":"https://openalex.org/C107327155","wikidata":"https://www.wikidata.org/wiki/Q330268","display_name":"Decision support system","level":2,"score":0.45827531814575195},{"id":"https://openalex.org/C99508421","wikidata":"https://www.wikidata.org/wiki/Q2678675","display_name":"Physical medicine and rehabilitation","level":1,"score":0.35887885093688965},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.31730231642723083},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3094547986984253},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.14539998769760132},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.09440958499908447},{"id":"https://openalex.org/C159110408","wikidata":"https://www.wikidata.org/wiki/Q121176","display_name":"Nursing","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1145/3412841.3441940","is_oa":true,"landing_page_url":"https://doi.org/10.1145/3412841.3441940","pdf_url":"https://dl.acm.org/doi/pdf/10.1145/3412841.3441940","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 36th Annual ACM Symposium on Applied Computing","raw_type":"proceedings-article"},{"id":"pmh:oai:researchrepository.ucd.ie:10197/24388","is_oa":true,"landing_page_url":"http://hdl.handle.net/10197/24388","pdf_url":null,"source":{"id":"https://openalex.org/S4306402280","display_name":"Research Repository UCD (University College Dublin)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I100930933","host_organization_name":"University College Dublin","host_organization_lineage":["https://openalex.org/I100930933"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Conference Publication"}],"best_oa_location":{"id":"doi:10.1145/3412841.3441940","is_oa":true,"landing_page_url":"https://doi.org/10.1145/3412841.3441940","pdf_url":"https://dl.acm.org/doi/pdf/10.1145/3412841.3441940","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 36th Annual ACM Symposium on Applied Computing","raw_type":"proceedings-article"},"sustainable_development_goals":[{"score":0.6200000047683716,"display_name":"Peace, Justice and strong institutions","id":"https://metadata.un.org/sdg/16"}],"awards":[{"id":"https://openalex.org/G1076797115","display_name":null,"funder_award_id":"co-funded","funder_id":"https://openalex.org/F4320335322","funder_display_name":"European Regional Development Fund"},{"id":"https://openalex.org/G559108330","display_name":null,"funder_award_id":"6/RC/3948","funder_id":"https://openalex.org/F4320320847","funder_display_name":"Science Foundation Ireland"},{"id":"https://openalex.org/G6264155063","display_name":null,"funder_award_id":"16/RC/3948","funder_id":"https://openalex.org/F4320320847","funder_display_name":"Science Foundation Ireland"},{"id":"https://openalex.org/G7128578356","display_name":null,"funder_award_id":"16/RC/3948","funder_id":"https://openalex.org/F4320335322","funder_display_name":"European Regional Development Fund"}],"funders":[{"id":"https://openalex.org/F4320314158","display_name":"EU Joint Programme \u2013 Neurodegenerative Disease Research","ror":null},{"id":"https://openalex.org/F4320320847","display_name":"Science Foundation Ireland","ror":"https://ror.org/0271asj38"},{"id":"https://openalex.org/F4320335322","display_name":"European Regional Development Fund","ror":"https://ror.org/00k4n6c32"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3157158784.pdf","grobid_xml":"https://content.openalex.org/works/W3157158784.grobid-xml"},"referenced_works_count":32,"referenced_works":["https://openalex.org/W1964177214","https://openalex.org/W1983207657","https://openalex.org/W1992926914","https://openalex.org/W2064186732","https://openalex.org/W2076142604","https://openalex.org/W2092532270","https://openalex.org/W2097360283","https://openalex.org/W2108381339","https://openalex.org/W2113481412","https://openalex.org/W2127079253","https://openalex.org/W2131107163","https://openalex.org/W2131245560","https://openalex.org/W2135046866","https://openalex.org/W2146694293","https://openalex.org/W2152384075","https://openalex.org/W2152493933","https://openalex.org/W2171534282","https://openalex.org/W2254893639","https://openalex.org/W2295598076","https://openalex.org/W2311912039","https://openalex.org/W2518689955","https://openalex.org/W2558521926","https://openalex.org/W2615182018","https://openalex.org/W2618851150","https://openalex.org/W2945717673","https://openalex.org/W2962862931","https://openalex.org/W2999615587","https://openalex.org/W3007334237","https://openalex.org/W3102476541","https://openalex.org/W3136399630","https://openalex.org/W4256260097","https://openalex.org/W4294541781"],"related_works":["https://openalex.org/W2070831599","https://openalex.org/W4206749202","https://openalex.org/W2048256717","https://openalex.org/W2393752460","https://openalex.org/W4292226083","https://openalex.org/W2938751847","https://openalex.org/W4387118726","https://openalex.org/W2059706093","https://openalex.org/W4213128270","https://openalex.org/W4390108853"],"abstract_inverted_index":{"Amyotrophic":[0],"Lateral":[1],"Sclerosis":[2],"(ALS)":[3],"is":[4,30,48,65],"a":[5,14,22,51,63,70,113,152,166,198,207,213],"rare":[6],"neurodegenerative":[7],"and":[8,20,35,89,95,124,171,212,229,247],"currently":[9],"incurable":[10],"disease.":[11],"It":[12],"causes":[13],"rapid":[15],"decline":[16],"in":[17,57],"motor":[18],"functions":[19],"has":[21],"fatal":[23],"trajectory.":[24],"The":[25,43,79,132,186,232],"aim":[26],"of":[27,40,45,68,81,130,139,210,216,221],"the":[28,37,82,85,92,119,128,137,140,159,175,182,201,219,238,248],"treatment":[29],"mostly":[31],"to":[32,49,59,111,151,168,174,180,205],"alleviate":[33],"symptoms":[34],"improve":[36],"patient's":[38],"quality":[39],"life":[41],"(QoL).":[42],"goal":[44],"this":[46,104],"study":[47],"develop":[50],"Clinical":[52],"Decision":[53],"Support":[54],"System":[55],"(CDSS)":[56],"order":[58],"alert":[60],"clinicians":[61],"when":[62],"patient":[64],"at":[66,100,240],"risk":[67],"experiencing":[69],"low":[71],"QoL,":[72,116],"so":[73],"that":[74],"they":[75],"are":[76],"better":[77],"supported.":[78],"source":[80],"data":[83],"was":[84,143,149,191],"Irish":[86],"ALS":[87],"Registry":[88],"interviews":[90],"with":[91,197],"90":[93],"patients":[94],"their":[96],"primary":[97],"informal":[98],"caregiver":[99],"three":[101,195,233],"time-points.":[102],"In":[103],"dataset,":[105],"there":[106],"were":[107,237],"two":[108,222],"different":[109],"scores":[110],"measure":[112],"person's":[114],"overall":[115],"based":[117],"on":[118,200],"McGill":[120],"QoL":[121],"(MQoL)":[122],"Questionnaire":[123],"we":[125,134],"worked":[126],"towards":[127],"prediction":[129],"both.":[131],"method":[133],"used":[135,158],"for":[136,245],"development":[138],"predictive":[141],"models":[142],"Extreme":[144],"Gradient":[145],"Boosting":[146],"(XGBoost),":[147],"which":[148],"compared":[150],"logistic":[153],"regression":[154],"baseline":[155],"model.":[156],"We":[157],"SHAP":[160],"(SHapley":[161],"Additive":[162],"exPlanations)":[163],"values":[164],"as":[165,177,179],"technique":[167],"provide":[169],"local":[170],"global":[172],"explanations":[173],"outputs":[176],"well":[178],"select":[181],"most":[183,234],"important":[184,235],"features.":[185],"total":[187],"calculated":[188],"MQoL":[189],"score":[190,209,215,244],"predicted":[192],"accurately":[193],"by":[194],"features,":[196],"F1-score":[199],"test":[202],"set":[203],"equal":[204],"0.81,":[206],"recall":[208],"0.78,":[211],"precision":[214],"0.84,":[217],"while,":[218],"addition":[220],"features":[223,236],"produced":[224],"similar":[225],"outcomes":[226],"(0.79,":[227],"0.70":[228],"0.90":[230],"respectively).":[231],"age":[239],"disease":[241],"onset,":[242],"ALSFRS":[243],"orthopnoea":[246],"caregiver's":[249],"status":[250],"pre-caregiving.":[251]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2}],"updated_date":"2026-04-10T15:06:20.359241","created_date":"2025-10-10T00:00:00"}