{"id":"https://openalex.org/W3101099287","doi":"https://doi.org/10.1145/3388440.3414923","title":"Beyond B-Cell Epitopes","display_name":"Beyond B-Cell Epitopes","publication_year":2020,"publication_date":"2020-09-21","ids":{"openalex":"https://openalex.org/W3101099287","doi":"https://doi.org/10.1145/3388440.3414923","mag":"3101099287"},"language":"en","primary_location":{"id":"doi:10.1145/3388440.3414923","is_oa":false,"landing_page_url":"https://doi.org/10.1145/3388440.3414923","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 11th ACM International Conference on Bioinformatics, Computational Biology and Health Informatics","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040586900","display_name":"Salvador Eugenio C. Caoili","orcid":"https://orcid.org/0000-0002-3210-3763"},"institutions":[{"id":"https://openalex.org/I5791819","display_name":"University of the Philippines Manila","ror":"https://ror.org/01rrczv41","country_code":"PH","type":"education","lineage":["https://openalex.org/I103911934","https://openalex.org/I5791819"]}],"countries":["PH"],"is_corresponding":true,"raw_author_name":"Salvador Eugenio C. Caoili","raw_affiliation_strings":["Biomedical Innovations Research for Translational Health Science (BIRTHS) Laboratory Department of Biochemistry and Molecular Biology, College of Medicine, University of the Philippines Manila"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Innovations Research for Translational Health Science (BIRTHS) Laboratory Department of Biochemistry and Molecular Biology, College of Medicine, University of the Philippines Manila","institution_ids":["https://openalex.org/I5791819"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5040586900"],"corresponding_institution_ids":["https://openalex.org/I5791819"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.10844457,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"1","last_page":"1"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12505","display_name":"Peptidase Inhibition and Analysis","score":0.9909999966621399,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/epitope","display_name":"Epitope","score":0.9670073986053467},{"id":"https://openalex.org/keywords/paratope","display_name":"Paratope","score":0.9556085467338562},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5526852011680603},{"id":"https://openalex.org/keywords/antibody","display_name":"Antibody","score":0.44741126894950867},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.43072882294654846},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.3214745819568634},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.1622464656829834}],"concepts":[{"id":"https://openalex.org/C195616568","wikidata":"https://www.wikidata.org/wiki/Q128711","display_name":"Epitope","level":3,"score":0.9670073986053467},{"id":"https://openalex.org/C9086966","wikidata":"https://www.wikidata.org/wiki/Q489135","display_name":"Paratope","level":4,"score":0.9556085467338562},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5526852011680603},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.44741126894950867},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.43072882294654846},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3214745819568634},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1622464656829834}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1145/3388440.3414923","is_oa":false,"landing_page_url":"https://doi.org/10.1145/3388440.3414923","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 11th ACM International Conference on Bioinformatics, Computational Biology and Health Informatics","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.6899999976158142,"id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2972990938","https://openalex.org/W2100617793","https://openalex.org/W2037745559","https://openalex.org/W4210635245","https://openalex.org/W2103053267","https://openalex.org/W2205639271","https://openalex.org/W2521166570","https://openalex.org/W4250653039","https://openalex.org/W4283010788","https://openalex.org/W4241393631"],"abstract_inverted_index":{"B-cell":[0,64,93,129,141],"epitope":[1,72],"prediction":[2],"was":[3],"first":[4],"developed":[5],"to":[6,44,102,123,171,188],"help":[7],"design":[8],"peptide-based":[9],"vaccines":[10],"for":[11,41],"protective":[12],"antibody-mediated":[13],"immunity":[14],"exemplified":[15],"by":[16,182],"neutralization":[17,178],"of":[18,46,70,78,134,149,162,179],"biological":[19,147,180],"activity":[20,148,181],"(e.g.,":[21,152],"pathogen":[22],"infectivity).":[23],"Requisite":[24],"computational":[25],"tools":[26],"are":[27,51],"benchmarked":[28],"using":[29],"experimentally":[30],"obtained":[31],"paratope-epitope":[32,173],"binding":[33,174],"data,":[34],"which":[35],"also":[36],"serve":[37],"as":[38],"training":[39],"data":[40,50,104,124,175],"machine-learning":[42],"approaches":[43],"development":[45],"said":[47],"tools.":[48],"Such":[49],"curated":[52],"in":[53,81,100,159,196],"the":[54,68,75,82,88,112,146,160,197],"Immune":[55],"Epitope":[56],"Database":[57],"(IEDB).":[58],"However,":[59],"IEDB":[60,92,107],"curation":[61],"guidelines":[62],"define":[63],"epitopes":[65,142],"primarily":[66],"on":[67,125,177],"basis":[69],"paratope-bound":[71],"structures,":[73],"obscuring":[74],"crucial":[76],"role":[77],"conformational":[79,126,194],"disorder":[80,127,195],"underlying":[83],"immune":[84],"recognition":[85],"process.":[86],"For":[87],"present":[89],"work,":[90],"pertinent":[91],"assay":[94],"records":[95],"were":[96],"retrieved":[97],"and":[98,108,117,143,154,192],"analyzed":[99],"relation":[101],"other":[103],"from":[105],"both":[106],"external":[109],"sources":[110],"including":[111],"Protein":[113],"Data":[114],"Bank":[115],"(PDB)":[116],"published":[118],"literature,":[119],"with":[120,156,186],"special":[121],"attention":[122],"among":[128],"epitopes.":[130,164],"This":[131],"revealed":[132],"examples":[133],"antipeptide":[135,184],"antibodies":[136],"that":[137],"recognize":[138],"conformationally":[139],"disordered":[140],"thereby":[144],"neutralize":[145],"cognate":[150],"targets":[151],"proteins":[153],"pathogens),":[155],"inconsistency":[157],"noted":[158],"definition":[161],"some":[163],"These":[165],"results":[166],"suggest":[167],"an":[168],"alternative":[169],"approach":[170],"curating":[172],"based":[176],"polyclonal":[183],"antibodies,":[185],"reference":[187],"immunogenic":[189],"peptide":[190],"sequences":[191],"their":[193],"unbound":[198],"state.":[199]},"counts_by_year":[],"updated_date":"2026-04-30T09:15:22.047038","created_date":"2025-10-10T00:00:00"}