{"id":"https://openalex.org/W3104897066","doi":"https://doi.org/10.1145/3388440.3412457","title":"Translocator","display_name":"Translocator","publication_year":2020,"publication_date":"2020-09-21","ids":{"openalex":"https://openalex.org/W3104897066","doi":"https://doi.org/10.1145/3388440.3412457","mag":"3104897066"},"language":"en","primary_location":{"id":"doi:10.1145/3388440.3412457","is_oa":false,"landing_page_url":"https://doi.org/10.1145/3388440.3412457","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 11th ACM International Conference on Bioinformatics, Computational Biology and Health Informatics","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5107836821","display_name":"Ye Wu","orcid":null},"institutions":[{"id":"https://openalex.org/I889458895","display_name":"University of Hong Kong","ror":"https://ror.org/02zhqgq86","country_code":"HK","type":"education","lineage":["https://openalex.org/I889458895"]}],"countries":["HK"],"is_corresponding":true,"raw_author_name":"Ye Wu","raw_affiliation_strings":["Department of Computer Science, The University of Hong Kong, Hong Kong, China"],"affiliations":[{"raw_affiliation_string":"Department of Computer Science, The University of Hong Kong, Hong Kong, China","institution_ids":["https://openalex.org/I889458895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027440970","display_name":"Ruibang Luo","orcid":"https://orcid.org/0000-0001-9711-6533"},"institutions":[{"id":"https://openalex.org/I889458895","display_name":"University of Hong Kong","ror":"https://ror.org/02zhqgq86","country_code":"HK","type":"education","lineage":["https://openalex.org/I889458895"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Ruibang Luo","raw_affiliation_strings":["Department of Computer Science, The University of Hong Kong, Hong Kong, China"],"affiliations":[{"raw_affiliation_string":"Department of Computer Science, The University of Hong Kong, Hong Kong, China","institution_ids":["https://openalex.org/I889458895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077116003","display_name":"Tak\u2010Wah Lam","orcid":"https://orcid.org/0000-0003-4676-8587"},"institutions":[{"id":"https://openalex.org/I889458895","display_name":"University of Hong Kong","ror":"https://ror.org/02zhqgq86","country_code":"HK","type":"education","lineage":["https://openalex.org/I889458895"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Tak-Wah Lam","raw_affiliation_strings":["Department of Computer Science, The University of Hong Kong, Hong Kong, China"],"affiliations":[{"raw_affiliation_string":"Department of Computer Science, The University of Hong Kong, Hong Kong, China","institution_ids":["https://openalex.org/I889458895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033934413","display_name":"Hing\u2010Fung Ting","orcid":"https://orcid.org/0000-0002-2807-2351"},"institutions":[{"id":"https://openalex.org/I889458895","display_name":"University of Hong Kong","ror":"https://ror.org/02zhqgq86","country_code":"HK","type":"education","lineage":["https://openalex.org/I889458895"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Hing-Fung Ting","raw_affiliation_strings":["Department of Computer Science, The University of Hong Kong, Hong Kong, China"],"affiliations":[{"raw_affiliation_string":"Department of Computer Science, The University of Hong Kong, Hong Kong, China","institution_ids":["https://openalex.org/I889458895"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100704433","display_name":"Junwen Wang","orcid":"https://orcid.org/0000-0002-4432-4707"},"institutions":[{"id":"https://openalex.org/I4210125099","display_name":"Mayo Clinic in Arizona","ror":"https://ror.org/03jp40720","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210125099"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Junwen Wang","raw_affiliation_strings":["Department of Health Sciences Research, Mayo Clinic Arizona, Scottsdale, United States"],"affiliations":[{"raw_affiliation_string":"Department of Health Sciences Research, Mayo Clinic Arizona, Scottsdale, United States","institution_ids":["https://openalex.org/I4210125099"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5107836821"],"corresponding_institution_ids":["https://openalex.org/I889458895"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.11036047,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"1","last_page":"7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10434","display_name":"Chromosomal and Genetic Variations","score":0.9957000017166138,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":0.9919999837875366,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chromosomal-translocation","display_name":"Chromosomal translocation","score":0.6895894408226013},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6402631998062134},{"id":"https://openalex.org/keywords/nanopore-sequencing","display_name":"Nanopore sequencing","score":0.613797128200531},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.40122467279434204},{"id":"https://openalex.org/keywords/genome","display_name":"Genome","score":0.27399742603302},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.25357985496520996},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.16668492555618286},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.1308186650276184}],"concepts":[{"id":"https://openalex.org/C138626823","wikidata":"https://www.wikidata.org/wiki/Q916504","display_name":"Chromosomal translocation","level":3,"score":0.6895894408226013},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6402631998062134},{"id":"https://openalex.org/C126513998","wikidata":"https://www.wikidata.org/wiki/Q8973627","display_name":"Nanopore sequencing","level":4,"score":0.613797128200531},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.40122467279434204},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.27399742603302},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.25357985496520996},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.16668492555618286},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1308186650276184}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1145/3388440.3412457","is_oa":false,"landing_page_url":"https://doi.org/10.1145/3388440.3412457","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 11th ACM International Conference on Bioinformatics, Computational Biology and Health Informatics","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.5199999809265137,"id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W1973067702","https://openalex.org/W2029996495","https://openalex.org/W2036929827","https://openalex.org/W2075996757","https://openalex.org/W2082534286","https://openalex.org/W2083870688","https://openalex.org/W2111350087","https://openalex.org/W2137759177","https://openalex.org/W2141581393","https://openalex.org/W2144958038","https://openalex.org/W2147733682","https://openalex.org/W2162758337","https://openalex.org/W2337261418","https://openalex.org/W2582800429","https://openalex.org/W2607669908","https://openalex.org/W2789843538","https://openalex.org/W2950214184","https://openalex.org/W2951149781","https://openalex.org/W2952870794","https://openalex.org/W2990344913","https://openalex.org/W3098304617"],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W2748952813","https://openalex.org/W3094600310","https://openalex.org/W3145183415","https://openalex.org/W2741734231","https://openalex.org/W2418290521","https://openalex.org/W2086424522","https://openalex.org/W1969012488","https://openalex.org/W2068903944","https://openalex.org/W2902387322"],"abstract_inverted_index":{"Translocation":[0],"is":[1,55,141],"an":[2,30,79],"important":[3],"class":[4],"of":[5,45],"structural":[6],"variants":[7],"known":[8,106],"to":[9,59,83,131,138],"be":[10],"associated":[11],"with":[12,40,103],"cancer":[13],"formation":[14],"and":[15,72,120,133],"treatment.":[16],"The":[17],"recent":[18],"development":[19],"in":[20,32],"single-molecule":[21],"sequencing":[22],"technologies":[23],"that":[24,77,111],"produce":[25],"long":[26,47,94],"reads":[27,95],"has":[28],"promised":[29],"advance":[31],"detecting":[33],"translocations":[34,104],"accurately.":[35],"However,":[36],"existing":[37],"tools":[38],"struggled":[39],"the":[41,46,51,65,85,126,134],"high":[42],"base":[43],"error-rate":[44],"reads.":[48,62],"Figuring":[49],"out":[50],"correct":[52,86],"translocation":[53,74],"breakpoints":[54],"especially":[56],"challenging":[57],"due":[58],"suboptimally":[60],"aligned":[61],"To":[63],"address":[64],"problem,":[66],"we":[67,90],"developed":[68],"Translocator,":[69],"a":[70,97],"robust":[71],"accurate":[73],"detection":[75],"method":[76],"implements":[78],"effective":[80],"realignment":[81],"algorithm":[82],"recover":[84],"alignments.":[87],"For":[88],"benchmarking,":[89],"analyzed":[91],"using":[92],"NA12878":[93],"against":[96],"modified":[98],"GRCh38":[99],"reference":[100],"genome":[101],"embedded":[102],"at":[105,144],"locations.":[107],"Our":[108],"results":[109],"show":[110],"Translocator":[112,140],"significantly":[113],"outperformed":[114],"other":[115],"state-of-the-art":[116],"methods,":[117],"including":[118],"Sniffles":[119],"PBSV.":[121],"On":[122],"Oxford":[123],"Nanopore":[124],"data,":[125],"recall":[127],"improved":[128],"from":[129,136],"48.2%":[130],"87.5%":[132],"precision":[135],"88.7%":[137],"92.7%.":[139],"available":[142],"open-source":[143],"https://github.com/HKU-BAL/Translocator.":[145]},"counts_by_year":[],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2020-11-23T00:00:00"}
