{"id":"https://openalex.org/W3011277118","doi":"https://doi.org/10.1145/3368555.3384466","title":"Multiple instance learning for predicting necrotizing enterocolitis in premature infants using microbiome data","display_name":"Multiple instance learning for predicting necrotizing enterocolitis in premature infants using microbiome data","publication_year":2020,"publication_date":"2020-03-20","ids":{"openalex":"https://openalex.org/W3011277118","doi":"https://doi.org/10.1145/3368555.3384466","mag":"3011277118","pmid":"https://pubmed.ncbi.nlm.nih.gov/34318306"},"language":"en","primary_location":{"id":"doi:10.1145/3368555.3384466","is_oa":false,"landing_page_url":"https://doi.org/10.1145/3368555.3384466","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the ACM Conference on Health, Inference, and Learning","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8313028","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009126155","display_name":"Thomas A. Hooven","orcid":"https://orcid.org/0000-0003-1959-186X"},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Thomas Hooven","raw_affiliation_strings":["University of Pittsburgh"],"affiliations":[{"raw_affiliation_string":"University of Pittsburgh","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072482796","display_name":"Yun Chao Lin","orcid":"https://orcid.org/0000-0002-7475-0694"},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yun Chao Lin","raw_affiliation_strings":["Columbia University"],"affiliations":[{"raw_affiliation_string":"Columbia University","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012289548","display_name":"Ansaf Salleb-Aouissi","orcid":"https://orcid.org/0000-0001-9858-905X"},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ansaf Salleb-Aouissi","raw_affiliation_strings":["Columbia University"],"affiliations":[{"raw_affiliation_string":"Columbia University","institution_ids":["https://openalex.org/I78577930"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5009126155"],"corresponding_institution_ids":["https://openalex.org/I170201317"],"apc_list":null,"apc_paid":null,"fwci":1.3318,"has_fulltext":false,"cited_by_count":16,"citation_normalized_percentile":{"value":0.78215989,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"2020","issue":null,"first_page":"99","last_page":"109"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11294","display_name":"Infant Nutrition and Health","score":0.9983999729156494,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11294","display_name":"Infant Nutrition and Health","score":0.9983999729156494,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.9955000281333923,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13289","display_name":"Infant Health and Development","score":0.9760000109672546,"subfield":{"id":"https://openalex.org/subfields/3611","display_name":"Pharmacy"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/necrotizing-enterocolitis","display_name":"Necrotizing enterocolitis","score":0.820206880569458},{"id":"https://openalex.org/keywords/microbiome","display_name":"Microbiome","score":0.7659156322479248},{"id":"https://openalex.org/keywords/receiver-operating-characteristic","display_name":"Receiver operating characteristic","score":0.6004583835601807},{"id":"https://openalex.org/keywords/enterocolitis","display_name":"Enterocolitis","score":0.5407618880271912},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.5016138553619385},{"id":"https://openalex.org/keywords/warning-system","display_name":"Warning system","score":0.4263600707054138},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.41067758202552795},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.3743143677711487},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.36334967613220215},{"id":"https://openalex.org/keywords/pediatrics","display_name":"Pediatrics","score":0.3437047600746155},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.24792340397834778},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.18201252818107605},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.17722663283348083}],"concepts":[{"id":"https://openalex.org/C2779303187","wikidata":"https://www.wikidata.org/wiki/Q10859678","display_name":"Necrotizing enterocolitis","level":2,"score":0.820206880569458},{"id":"https://openalex.org/C143121216","wikidata":"https://www.wikidata.org/wiki/Q1330402","display_name":"Microbiome","level":2,"score":0.7659156322479248},{"id":"https://openalex.org/C58471807","wikidata":"https://www.wikidata.org/wiki/Q327120","display_name":"Receiver operating characteristic","level":2,"score":0.6004583835601807},{"id":"https://openalex.org/C2776258884","wikidata":"https://www.wikidata.org/wiki/Q3055368","display_name":"Enterocolitis","level":2,"score":0.5407618880271912},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5016138553619385},{"id":"https://openalex.org/C29825287","wikidata":"https://www.wikidata.org/wiki/Q1427940","display_name":"Warning system","level":2,"score":0.4263600707054138},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.41067758202552795},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3743143677711487},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.36334967613220215},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.3437047600746155},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.24792340397834778},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.18201252818107605},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.17722663283348083},{"id":"https://openalex.org/C76155785","wikidata":"https://www.wikidata.org/wiki/Q418","display_name":"Telecommunications","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1145/3368555.3384466","is_oa":false,"landing_page_url":"https://doi.org/10.1145/3368555.3384466","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the ACM Conference on Health, Inference, and Learning","raw_type":"proceedings-article"},{"id":"pmid:34318306","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34318306","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the ACM Conference on Health, Inference, and Learning","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:8313028","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8313028","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Proc ACM Conf Health Inference Learn (2020)","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:8313028","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8313028","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Proc ACM Conf Health Inference Learn (2020)","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8399999737739563,"display_name":"Good health and well-being"}],"awards":[{"id":"https://openalex.org/G8749315754","display_name":null,"funder_award_id":"K08AI132555","funder_id":"https://openalex.org/F4320337373","funder_display_name":"Center for Information Technology"}],"funders":[{"id":"https://openalex.org/F4320337373","display_name":"Center for Information Technology","ror":"https://ror.org/03jh5a977"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":42,"referenced_works":["https://openalex.org/W58918046","https://openalex.org/W229800277","https://openalex.org/W1971224803","https://openalex.org/W1996796871","https://openalex.org/W2050451609","https://openalex.org/W2108122869","https://openalex.org/W2108745803","https://openalex.org/W2110119381","https://openalex.org/W2133546413","https://openalex.org/W2138358572","https://openalex.org/W2157049614","https://openalex.org/W2166325326","https://openalex.org/W2295620997","https://openalex.org/W2326641739","https://openalex.org/W2334099820","https://openalex.org/W2567070169","https://openalex.org/W2592244930","https://openalex.org/W2592537218","https://openalex.org/W2592895748","https://openalex.org/W2767844672","https://openalex.org/W2769542288","https://openalex.org/W2770324303","https://openalex.org/W2784094750","https://openalex.org/W2785934082","https://openalex.org/W2808466192","https://openalex.org/W2889553927","https://openalex.org/W2905322719","https://openalex.org/W2909145450","https://openalex.org/W2915529376","https://openalex.org/W2962019792","https://openalex.org/W2985559811","https://openalex.org/W2990138404","https://openalex.org/W2990618091","https://openalex.org/W2995792428","https://openalex.org/W2999905431","https://openalex.org/W3092618863","https://openalex.org/W3138102151","https://openalex.org/W4248468736","https://openalex.org/W4252160351","https://openalex.org/W6684369376","https://openalex.org/W6730673340","https://openalex.org/W6747701563"],"related_works":["https://openalex.org/W3015717938","https://openalex.org/W2300046951","https://openalex.org/W2082136782","https://openalex.org/W2325845343","https://openalex.org/W1509450179","https://openalex.org/W2054756716","https://openalex.org/W2077704628","https://openalex.org/W2139847602","https://openalex.org/W2940540567","https://openalex.org/W2793730533"],"abstract_inverted_index":{"Necrotizing":[0],"enterocolitis":[1],"(NEC)":[2],"is":[3,38],"a":[4,76,128,169,177],"life-threatening":[5],"intestinal":[6],"disease":[7,37,159],"that":[8,53,83],"primarily":[9],"affects":[10],"preterm":[11,134],"infants":[12,28,66,151],"during":[13],"their":[14],"first":[15],"weeks":[16],"after":[17],"birth.":[18],"Mortality":[19],"rates":[20],"associated":[21],"with":[22,41,59,143,187],"NEC":[23,92,175],"are":[24,29,47],"15-30%,":[25],"and":[26,61,105,124,183],"surviving":[27],"susceptible":[30],"to":[31,64,87,101,158],"multiple":[32,77],"serious,":[33],"long-term":[34],"complications.":[35],"The":[36,97],"sporadic":[39],"and,":[40],"currently":[42],"available":[43],"tools,":[44],"unpredictable.":[45],"We":[46,136],"creating":[48],"an":[49],"early":[50,171],"warning":[51,172],"system":[52,82,173],"uses":[54,75],"stool":[55,111,188],"microbiome":[56,112,125,189],"features,":[57],"combined":[58,186],"clinical":[60,123,182],"demographic":[62,184],"information,":[63],"identify":[65],"at":[67,153],"high":[68],"risk":[69],"of":[70,110,119,132,145,168,180],"developing":[71],"NEC.":[72],"Our":[73,161],"approach":[74,98],"instance":[78],"learning,":[79],"neural":[80],"network-based":[81],"could":[84],"be":[85],"used":[86],"generate":[88],"daily":[89],"or":[90],"weekly":[91],"predictions":[93],"for":[94,149,166,174],"premature":[95],"infants.":[96,135],"was":[99],"selected":[100],"effectively":[102],"utilize":[103],"sparse":[104],"weakly":[106],"annotated":[107],"datasets":[108],"characteristic":[109],"analysis.":[113],"Here":[114],"we":[115],"describe":[116],"initial":[117],"validation":[118],"our":[120],"system,":[121],"using":[122,176],"data":[126],"from":[127],"nested":[129],"case-control":[130],"study":[131],"161":[133],"show":[137],"receiver-operator":[138],"curve":[139],"areas":[140],"above":[141],"0.9,":[142],"75%":[144],"dominant":[146],"predictive":[147],"samples":[148],"NEC-affected":[150],"identified":[152],"least":[154],"24":[155],"hours":[156],"prior":[157],"onset.":[160],"results":[162],"pave":[163],"the":[164],"way":[165],"development":[167],"real-time":[170],"limited":[178],"set":[179],"basic":[181],"details":[185],"data.":[190]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":1}],"updated_date":"2026-04-21T08:09:41.155169","created_date":"2025-10-10T00:00:00"}