{"id":"https://openalex.org/W2972874842","doi":"https://doi.org/10.1145/3340286","title":"DNA Sequencing Technologies","display_name":"DNA Sequencing Technologies","publication_year":2019,"publication_date":"2019-09-13","ids":{"openalex":"https://openalex.org/W2972874842","doi":"https://doi.org/10.1145/3340286","mag":"2972874842"},"language":"en","primary_location":{"id":"doi:10.1145/3340286","is_oa":false,"landing_page_url":"https://doi.org/10.1145/3340286","pdf_url":null,"source":{"id":"https://openalex.org/S157921468","display_name":"ACM Computing Surveys","issn_l":"0360-0300","issn":["0360-0300","1557-7341"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319798","host_organization_name":"Association for Computing Machinery","host_organization_lineage":["https://openalex.org/P4310319798"],"host_organization_lineage_names":["Association for Computing Machinery"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACM Computing Surveys","raw_type":"journal-article"},"type":"review","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030015771","display_name":"Ka\u2010Chun Wong","orcid":"https://orcid.org/0000-0001-6062-733X"},"institutions":[{"id":"https://openalex.org/I168719708","display_name":"City University of Hong Kong","ror":"https://ror.org/03q8dnn23","country_code":"HK","type":"education","lineage":["https://openalex.org/I168719708"]}],"countries":["HK"],"is_corresponding":true,"raw_author_name":"Ka-Chun Wong","raw_affiliation_strings":["City University of Hong Kong, Hong Kong SAR"],"affiliations":[{"raw_affiliation_string":"City University of Hong Kong, Hong Kong SAR","institution_ids":["https://openalex.org/I168719708"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100669872","display_name":"Jiao Zhang","orcid":"https://orcid.org/0000-0003-0343-5563"},"institutions":[{"id":"https://openalex.org/I168719708","display_name":"City University of Hong Kong","ror":"https://ror.org/03q8dnn23","country_code":"HK","type":"education","lineage":["https://openalex.org/I168719708"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Jiao Zhang","raw_affiliation_strings":["City University of Hong Kong, Hong Kong SAR"],"affiliations":[{"raw_affiliation_string":"City University of Hong Kong, Hong Kong SAR","institution_ids":["https://openalex.org/I168719708"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016741865","display_name":"Shankai Yan","orcid":"https://orcid.org/0000-0003-0369-4979"},"institutions":[{"id":"https://openalex.org/I168719708","display_name":"City University of Hong Kong","ror":"https://ror.org/03q8dnn23","country_code":"HK","type":"education","lineage":["https://openalex.org/I168719708"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Shankai Yan","raw_affiliation_strings":["City University of Hong Kong, Hong Kong SAR"],"affiliations":[{"raw_affiliation_string":"City University of Hong Kong, Hong Kong SAR","institution_ids":["https://openalex.org/I168719708"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002127716","display_name":"Xiangtao Li","orcid":"https://orcid.org/0000-0001-9089-1799"},"institutions":[{"id":"https://openalex.org/I184983240","display_name":"Northeast Normal University","ror":"https://ror.org/02rkvz144","country_code":"CN","type":"education","lineage":["https://openalex.org/I184983240"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiangtao Li","raw_affiliation_strings":["Northeast Normal University, Changchun, China"],"affiliations":[{"raw_affiliation_string":"Northeast Normal University, Changchun, China","institution_ids":["https://openalex.org/I184983240"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066935890","display_name":"Qiuzhen Lin","orcid":"https://orcid.org/0000-0003-2415-0401"},"institutions":[{"id":"https://openalex.org/I180726961","display_name":"Shenzhen University","ror":"https://ror.org/01vy4gh70","country_code":"CN","type":"education","lineage":["https://openalex.org/I180726961"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qiuzhen Lin","raw_affiliation_strings":["Shenzhen University, Shenzhen, China"],"affiliations":[{"raw_affiliation_string":"Shenzhen University, Shenzhen, China","institution_ids":["https://openalex.org/I180726961"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008386708","display_name":"Sam Kwong","orcid":"https://orcid.org/0000-0001-7484-7261"},"institutions":[{"id":"https://openalex.org/I168719708","display_name":"City University of Hong Kong","ror":"https://ror.org/03q8dnn23","country_code":"HK","type":"education","lineage":["https://openalex.org/I168719708"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Sam Kwong","raw_affiliation_strings":["City University of Hong Kong, Hong Kong SAR"],"affiliations":[{"raw_affiliation_string":"City University of Hong Kong, Hong Kong SAR","institution_ids":["https://openalex.org/I168719708"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101756728","display_name":"Cheng Liang","orcid":"https://orcid.org/0000-0003-3832-0969"},"institutions":[{"id":"https://openalex.org/I28006308","display_name":"Shandong Normal University","ror":"https://ror.org/01wy3h363","country_code":"CN","type":"education","lineage":["https://openalex.org/I28006308"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Cheng Liang","raw_affiliation_strings":["Shandong Normal University, Shandong, China"],"affiliations":[{"raw_affiliation_string":"Shandong Normal University, Shandong, China","institution_ids":["https://openalex.org/I28006308"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5030015771"],"corresponding_institution_ids":["https://openalex.org/I168719708"],"apc_list":null,"apc_paid":null,"fwci":2.4841,"has_fulltext":false,"cited_by_count":48,"citation_normalized_percentile":{"value":0.90143683,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"52","issue":"5","first_page":"1","last_page":"30"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9955000281333923,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.9922999739646912,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dna-sequencing","display_name":"DNA sequencing","score":0.7514458894729614},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6308110952377319},{"id":"https://openalex.org/keywords/indel","display_name":"Indel","score":0.5562136173248291},{"id":"https://openalex.org/keywords/hybrid-genome-assembly","display_name":"Hybrid genome assembly","score":0.5226868391036987},{"id":"https://openalex.org/keywords/deep-sequencing","display_name":"Deep sequencing","score":0.4789626896381378},{"id":"https://openalex.org/keywords/genomics","display_name":"Genomics","score":0.4602339267730713},{"id":"https://openalex.org/keywords/data-science","display_name":"Data science","score":0.4535742998123169},{"id":"https://openalex.org/keywords/massive-parallel-sequencing","display_name":"Massive parallel sequencing","score":0.4331570565700531},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.42978435754776},{"id":"https://openalex.org/keywords/snapshot","display_name":"Snapshot (computer storage)","score":0.4176388680934906},{"id":"https://openalex.org/keywords/genome","display_name":"Genome","score":0.3702009320259094},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.3464052677154541},{"id":"https://openalex.org/keywords/reference-genome","display_name":"Reference genome","score":0.30949410796165466},{"id":"https://openalex.org/keywords/dna","display_name":"DNA","score":0.24861720204353333},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.24720054864883423},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.17033728957176208},{"id":"https://openalex.org/keywords/database","display_name":"Database","score":0.1497814655303955},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphism","display_name":"Single-nucleotide polymorphism","score":0.11351555585861206},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.08613824844360352}],"concepts":[{"id":"https://openalex.org/C51679486","wikidata":"https://www.wikidata.org/wiki/Q380546","display_name":"DNA sequencing","level":3,"score":0.7514458894729614},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6308110952377319},{"id":"https://openalex.org/C119054055","wikidata":"https://www.wikidata.org/wiki/Q1576681","display_name":"Indel","level":5,"score":0.5562136173248291},{"id":"https://openalex.org/C113425843","wikidata":"https://www.wikidata.org/wiki/Q5953213","display_name":"Hybrid genome assembly","level":5,"score":0.5226868391036987},{"id":"https://openalex.org/C132917006","wikidata":"https://www.wikidata.org/wiki/Q5250436","display_name":"Deep sequencing","level":4,"score":0.4789626896381378},{"id":"https://openalex.org/C189206191","wikidata":"https://www.wikidata.org/wiki/Q222046","display_name":"Genomics","level":4,"score":0.4602339267730713},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.4535742998123169},{"id":"https://openalex.org/C192800701","wikidata":"https://www.wikidata.org/wiki/Q6784807","display_name":"Massive parallel sequencing","level":4,"score":0.4331570565700531},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.42978435754776},{"id":"https://openalex.org/C55282118","wikidata":"https://www.wikidata.org/wiki/Q252683","display_name":"Snapshot (computer storage)","level":2,"score":0.4176388680934906},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.3702009320259094},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.3464052677154541},{"id":"https://openalex.org/C192953774","wikidata":"https://www.wikidata.org/wiki/Q7307127","display_name":"Reference genome","level":4,"score":0.30949410796165466},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.24861720204353333},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.24720054864883423},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.17033728957176208},{"id":"https://openalex.org/C77088390","wikidata":"https://www.wikidata.org/wiki/Q8513","display_name":"Database","level":1,"score":0.1497814655303955},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.11351555585861206},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08613824844360352},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1145/3340286","is_oa":false,"landing_page_url":"https://doi.org/10.1145/3340286","pdf_url":null,"source":{"id":"https://openalex.org/S157921468","display_name":"ACM Computing Surveys","issn_l":"0360-0300","issn":["0360-0300","1557-7341"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319798","host_organization_name":"Association for Computing Machinery","host_organization_lineage":["https://openalex.org/P4310319798"],"host_organization_lineage_names":["Association for Computing Machinery"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACM Computing Surveys","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/9","score":0.5,"display_name":"Industry, innovation and infrastructure"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":153,"referenced_works":["https://openalex.org/W18557924","https://openalex.org/W57849914","https://openalex.org/W1567333450","https://openalex.org/W1590169480","https://openalex.org/W1965175512","https://openalex.org/W1968458420","https://openalex.org/W1970110423","https://openalex.org/W1971531553","https://openalex.org/W1971584645","https://openalex.org/W1972924519","https://openalex.org/W1973067702","https://openalex.org/W1974646727","https://openalex.org/W1980184764","https://openalex.org/W1980355960","https://openalex.org/W1982088757","https://openalex.org/W1982538875","https://openalex.org/W1992595091","https://openalex.org/W2005129098","https://openalex.org/W2005271647","https://openalex.org/W2007772656","https://openalex.org/W2009720434","https://openalex.org/W2009886994","https://openalex.org/W2010361633","https://openalex.org/W2013469333","https://openalex.org/W2015292449","https://openalex.org/W2017952818","https://openalex.org/W2022986961","https://openalex.org/W2024528333","https://openalex.org/W2035593347","https://openalex.org/W2052754611","https://openalex.org/W2055043387","https://openalex.org/W2055666215","https://openalex.org/W2057791956","https://openalex.org/W2058087601","https://openalex.org/W2059198040","https://openalex.org/W2059300459","https://openalex.org/W2059670608","https://openalex.org/W2061680337","https://openalex.org/W2065213545","https://openalex.org/W2065310919","https://openalex.org/W2065817684","https://openalex.org/W2067062665","https://openalex.org/W2069066547","https://openalex.org/W2074275641","https://openalex.org/W2075560011","https://openalex.org/W2076151007","https://openalex.org/W2076357933","https://openalex.org/W2082447166","https://openalex.org/W2084821192","https://openalex.org/W2086399100","https://openalex.org/W2088612061","https://openalex.org/W2089216231","https://openalex.org/W2090705041","https://openalex.org/W2095898308","https://openalex.org/W2097804771","https://openalex.org/W2099589970","https://openalex.org/W2099698839","https://openalex.org/W2103011829","https://openalex.org/W2103441770","https://openalex.org/W2103811075","https://openalex.org/W2104846587","https://openalex.org/W2108058966","https://openalex.org/W2108166985","https://openalex.org/W2108234281","https://openalex.org/W2111584304","https://openalex.org/W2112113834","https://openalex.org/W2113649367","https://openalex.org/W2116041602","https://openalex.org/W2116120463","https://openalex.org/W2117131162","https://openalex.org/W2117608012","https://openalex.org/W2119180969","https://openalex.org/W2119868628","https://openalex.org/W2119923823","https://openalex.org/W2120048439","https://openalex.org/W2120457919","https://openalex.org/W2121016876","https://openalex.org/W2121762798","https://openalex.org/W2123340910","https://openalex.org/W2124960286","https://openalex.org/W2124985265","https://openalex.org/W2126298009","https://openalex.org/W2127407003","https://openalex.org/W2128114769","https://openalex.org/W2128945836","https://openalex.org/W2129148650","https://openalex.org/W2130804286","https://openalex.org/W2131675589","https://openalex.org/W2132341951","https://openalex.org/W2132378736","https://openalex.org/W2133212095","https://openalex.org/W2134471382","https://openalex.org/W2134800079","https://openalex.org/W2135216100","https://openalex.org/W2135253885","https://openalex.org/W2136145671","https://openalex.org/W2137779717","https://openalex.org/W2138270253","https://openalex.org/W2138601221","https://openalex.org/W2138618895","https://openalex.org/W2139306346","https://openalex.org/W2139747296","https://openalex.org/W2141040548","https://openalex.org/W2141978199","https://openalex.org/W2142518990","https://openalex.org/W2142898494","https://openalex.org/W2143196035","https://openalex.org/W2144610372","https://openalex.org/W2146290346","https://openalex.org/W2148875515","https://openalex.org/W2149771342","https://openalex.org/W2149992227","https://openalex.org/W2150131459","https://openalex.org/W2150506261","https://openalex.org/W2151794156","https://openalex.org/W2153027378","https://openalex.org/W2154397429","https://openalex.org/W2155707112","https://openalex.org/W2157888653","https://openalex.org/W2159946869","https://openalex.org/W2160969485","https://openalex.org/W2161546116","https://openalex.org/W2162010421","https://openalex.org/W2164631357","https://openalex.org/W2166022874","https://openalex.org/W2166117893","https://openalex.org/W2168133698","https://openalex.org/W2168440186","https://openalex.org/W2169035256","https://openalex.org/W2169131332","https://openalex.org/W2169508919","https://openalex.org/W2173033037","https://openalex.org/W2195724570","https://openalex.org/W2210296741","https://openalex.org/W2223549218","https://openalex.org/W2233603983","https://openalex.org/W2247766769","https://openalex.org/W2259815689","https://openalex.org/W2321507159","https://openalex.org/W2334656801","https://openalex.org/W2396849069","https://openalex.org/W2409457507","https://openalex.org/W2415697913","https://openalex.org/W2471122080","https://openalex.org/W2514454343","https://openalex.org/W2529555647","https://openalex.org/W2550586733","https://openalex.org/W2583735774","https://openalex.org/W2616754551","https://openalex.org/W2951951814","https://openalex.org/W4233928114","https://openalex.org/W4238719510","https://openalex.org/W4243977291"],"related_works":["https://openalex.org/W2160981405","https://openalex.org/W2553356891","https://openalex.org/W2952824393","https://openalex.org/W2754643976","https://openalex.org/W2934828429","https://openalex.org/W2951648583","https://openalex.org/W2767263086","https://openalex.org/W1820394219","https://openalex.org/W4323313960","https://openalex.org/W1966822396"],"abstract_inverted_index":{"The":[0,82],"recent":[1],"advances":[2],"in":[3,48,92,123,146],"DNA":[4,34,70,86,178],"sequencing":[5,9,13,35,38,61,71,87,98,144,151,179],"technology,":[6],"from":[7,142],"first-generation":[8],"(FGS)":[10],"to":[11,117,136],"third-generation":[12],"(TGS),":[14],"have":[15],"constantly":[16],"transformed":[17],"the":[18,49,97,124,140,168,171,176],"genome":[19],"research":[20],"landscape.":[21],"Its":[22],"data":[23,39,54,78,99,102,110,145],"throughput":[24],"is":[25,72,88],"unprecedented":[26],"and":[27,44,56,80,90,106,115,164,184],"severalfold":[28],"as":[29,150],"compared":[30],"with":[31,74],"past":[32],"technologies.":[33],"technologies":[36,180],"generate":[37],"that":[40],"are":[41,104,113,133],"big,":[42],"sparse,":[43],"heterogeneous.":[45],"This":[46],"results":[47],"rapid":[50],"development":[51],"of":[52,69,85,130,170],"various":[53],"protocols":[55,103],"bioinformatics":[57,131],"tools":[58,132],"for":[59,181],"handling":[60],"data.":[62],"In":[63,108],"this":[64],"review,":[65],"a":[66,120],"historical":[67],"snapshot":[68],"taken":[73],"an":[75],"emphasis":[76],"on":[77],"manipulation":[79],"tools.":[81],"technological":[83],"history":[84],"described":[89],"reviewed":[91,135],"thorough":[93],"detail.":[94],"To":[95],"manipulate":[96],"generated,":[100],"different":[101,147],"introduced":[105],"reviewed.":[107],"particular,":[109],"compression":[111],"methods":[112],"highlighted":[114],"discussed":[116],"provide":[118],"readers":[119,138],"practical":[121],"perspective":[122],"real-world":[125],"setting.":[126],"A":[127],"large":[128],"variety":[129],"also":[134],"help":[137],"extract":[139],"most":[141],"their":[143,182],"aspects,":[148],"such":[149],"quality":[152],"control,":[153],"genomic":[154],"visualization,":[155],"single-nucleotide":[156],"variant":[157],"calling,":[158,160,163],"INDEL":[159],"structural":[161],"variation":[162],"integrative":[165],"analysis.":[166],"Toward":[167],"end":[169],"article,":[172],"we":[173],"critically":[174],"discuss":[175],"existing":[177],"pitfalls":[183],"potential":[185],"solutions.":[186]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":3},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":9},{"year":2017,"cited_by_count":1}],"updated_date":"2026-03-27T05:58:40.876381","created_date":"2025-10-10T00:00:00"}
