{"id":"https://openalex.org/W2978489789","doi":"https://doi.org/10.1145/3340037.3340049","title":"Aberrant Functional Connectivity Dynamics of Superior Temporal Sulcus and Its Associations with GABA Genes Expression in Autism","display_name":"Aberrant Functional Connectivity Dynamics of Superior Temporal Sulcus and Its Associations with GABA Genes Expression in Autism","publication_year":2019,"publication_date":"2019-01-01","ids":{"openalex":"https://openalex.org/W2978489789","doi":"https://doi.org/10.1145/3340037.3340049","mag":"2978489789"},"language":"en","primary_location":{"id":"doi:10.1145/3340037.3340049","is_oa":false,"landing_page_url":"https://doi.org/10.1145/3340037.3340049","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the third International Conference on Medical and Health Informatics 2019  - ICMHI 2019","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008845556","display_name":"Xiaonan Guo","orcid":"https://orcid.org/0000-0003-1400-4478"},"institutions":[{"id":"https://openalex.org/I150229711","display_name":"University of Electronic Science and Technology of China","ror":"https://ror.org/04qr3zq92","country_code":"CN","type":"education","lineage":["https://openalex.org/I150229711"]},{"id":"https://openalex.org/I4210118299","display_name":"Institute for Biomedicine","ror":"https://ror.org/02hsggv49","country_code":"IT","type":"facility","lineage":["https://openalex.org/I1319360392","https://openalex.org/I4210118299"]}],"countries":["CN","IT"],"is_corresponding":true,"raw_author_name":"Xiaonan Guo","raw_affiliation_strings":["School of Life Science and Technology, Center for Information in BioMedicine; The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, University of Electronic Science and Technology of China, Chengdu, China","School of Life Science and Technology, Center for Information in BioMedicine"],"affiliations":[{"raw_affiliation_string":"School of Life Science and Technology, Center for Information in BioMedicine; The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, University of Electronic Science and Technology of China, Chengdu, China","institution_ids":["https://openalex.org/I150229711"]},{"raw_affiliation_string":"School of Life Science and Technology, Center for Information in BioMedicine","institution_ids":["https://openalex.org/I4210118299"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011344649","display_name":"Changchun He","orcid":null},"institutions":[{"id":"https://openalex.org/I4210118299","display_name":"Institute for Biomedicine","ror":"https://ror.org/02hsggv49","country_code":"IT","type":"facility","lineage":["https://openalex.org/I1319360392","https://openalex.org/I4210118299"]},{"id":"https://openalex.org/I150229711","display_name":"University of Electronic Science and Technology of China","ror":"https://ror.org/04qr3zq92","country_code":"CN","type":"education","lineage":["https://openalex.org/I150229711"]}],"countries":["CN","IT"],"is_corresponding":false,"raw_author_name":"Changchun He","raw_affiliation_strings":["School of Life Science and Technology, Center for Information in BioMedicine; The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, University of Electronic Science and Technology of China, Chengdu, China","School of Life Science and Technology, Center for Information in BioMedicine"],"affiliations":[{"raw_affiliation_string":"School of Life Science and Technology, Center for Information in BioMedicine; The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, University of Electronic Science and Technology of China, Chengdu, China","institution_ids":["https://openalex.org/I150229711"]},{"raw_affiliation_string":"School of Life Science and Technology, Center for Information in BioMedicine","institution_ids":["https://openalex.org/I4210118299"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033505193","display_name":"Xujun Duan","orcid":"https://orcid.org/0000-0001-8543-2117"},"institutions":[{"id":"https://openalex.org/I4210118299","display_name":"Institute for Biomedicine","ror":"https://ror.org/02hsggv49","country_code":"IT","type":"facility","lineage":["https://openalex.org/I1319360392","https://openalex.org/I4210118299"]},{"id":"https://openalex.org/I150229711","display_name":"University of Electronic Science and Technology of China","ror":"https://ror.org/04qr3zq92","country_code":"CN","type":"education","lineage":["https://openalex.org/I150229711"]}],"countries":["CN","IT"],"is_corresponding":false,"raw_author_name":"Xujun Duan","raw_affiliation_strings":["School of Life Science and Technology, Center for Information in BioMedicine; The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, University of Electronic Science and Technology of China, Chengdu, China","School of Life Science and Technology, Center for Information in BioMedicine"],"affiliations":[{"raw_affiliation_string":"School of Life Science and Technology, Center for Information in BioMedicine; The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, University of Electronic Science and Technology of China, Chengdu, China","institution_ids":["https://openalex.org/I150229711"]},{"raw_affiliation_string":"School of Life Science and Technology, Center for Information in BioMedicine","institution_ids":["https://openalex.org/I4210118299"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077133951","display_name":"Shaoqiang Han","orcid":"https://orcid.org/0000-0001-7331-0315"},"institutions":[{"id":"https://openalex.org/I4210118299","display_name":"Institute for Biomedicine","ror":"https://ror.org/02hsggv49","country_code":"IT","type":"facility","lineage":["https://openalex.org/I1319360392","https://openalex.org/I4210118299"]},{"id":"https://openalex.org/I150229711","display_name":"University of Electronic Science and Technology of China","ror":"https://ror.org/04qr3zq92","country_code":"CN","type":"education","lineage":["https://openalex.org/I150229711"]}],"countries":["CN","IT"],"is_corresponding":false,"raw_author_name":"Shaoqiang Han","raw_affiliation_strings":["School of Life Science and Technology, Center for Information in BioMedicine; The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, University of Electronic Science and Technology of China, Chengdu, China","School of Life Science and Technology, Center for Information in BioMedicine"],"affiliations":[{"raw_affiliation_string":"School of Life Science and Technology, Center for Information in BioMedicine; The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, University of Electronic Science and Technology of China, Chengdu, China","institution_ids":["https://openalex.org/I150229711"]},{"raw_affiliation_string":"School of Life Science and Technology, Center for Information in BioMedicine","institution_ids":["https://openalex.org/I4210118299"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088047720","display_name":"Jinming Xiao","orcid":"https://orcid.org/0000-0002-8012-6070"},"institutions":[{"id":"https://openalex.org/I150229711","display_name":"University of Electronic Science and Technology of China","ror":"https://ror.org/04qr3zq92","country_code":"CN","type":"education","lineage":["https://openalex.org/I150229711"]},{"id":"https://openalex.org/I4210118299","display_name":"Institute for Biomedicine","ror":"https://ror.org/02hsggv49","country_code":"IT","type":"facility","lineage":["https://openalex.org/I1319360392","https://openalex.org/I4210118299"]}],"countries":["CN","IT"],"is_corresponding":false,"raw_author_name":"Jinming Xiao","raw_affiliation_strings":["School of Life Science and Technology, Center for Information in BioMedicine; The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, University of Electronic Science and Technology of China, Chengdu, China","School of Life Science and Technology, Center for Information in BioMedicine"],"affiliations":[{"raw_affiliation_string":"School of Life Science and Technology, Center for Information in BioMedicine; The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, University of Electronic Science and Technology of China, Chengdu, China","institution_ids":["https://openalex.org/I150229711"]},{"raw_affiliation_string":"School of Life Science and Technology, Center for Information in BioMedicine","institution_ids":["https://openalex.org/I4210118299"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100786255","display_name":"Huafu Chen","orcid":"https://orcid.org/0000-0002-4062-4753"},"institutions":[{"id":"https://openalex.org/I150229711","display_name":"University of Electronic Science and Technology of China","ror":"https://ror.org/04qr3zq92","country_code":"CN","type":"education","lineage":["https://openalex.org/I150229711"]},{"id":"https://openalex.org/I4210118299","display_name":"Institute for Biomedicine","ror":"https://ror.org/02hsggv49","country_code":"IT","type":"facility","lineage":["https://openalex.org/I1319360392","https://openalex.org/I4210118299"]}],"countries":["CN","IT"],"is_corresponding":false,"raw_author_name":"Huafu Chen","raw_affiliation_strings":["School of Life Science and Technology, Center for Information in BioMedicine; The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, University of Electronic Science and Technology of China, Chengdu, China","School of Life Science and Technology, Center for Information in BioMedicine"],"affiliations":[{"raw_affiliation_string":"School of Life Science and Technology, Center for Information in BioMedicine; The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, University of Electronic Science and Technology of China, Chengdu, China","institution_ids":["https://openalex.org/I150229711"]},{"raw_affiliation_string":"School of Life Science and Technology, Center for Information in BioMedicine","institution_ids":["https://openalex.org/I4210118299"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5008845556"],"corresponding_institution_ids":["https://openalex.org/I150229711","https://openalex.org/I4210118299"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.12809737,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":96},"biblio":{"volume":null,"issue":null,"first_page":"21","last_page":"25"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10241","display_name":"Functional Brain Connectivity Studies","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10241","display_name":"Functional Brain Connectivity Studies","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10106","display_name":"Autism Spectrum Disorder Research","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/superior-temporal-sulcus","display_name":"Superior temporal sulcus","score":0.7215117812156677},{"id":"https://openalex.org/keywords/autism","display_name":"Autism","score":0.6520224809646606},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.5680652856826782},{"id":"https://openalex.org/keywords/autism-spectrum-disorder","display_name":"Autism spectrum disorder","score":0.5677538514137268},{"id":"https://openalex.org/keywords/functional-magnetic-resonance-imaging","display_name":"Functional magnetic resonance imaging","score":0.5226733088493347},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.4600401520729065},{"id":"https://openalex.org/keywords/superior-temporal-gyrus","display_name":"Superior temporal gyrus","score":0.436245322227478},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.37372851371765137},{"id":"https://openalex.org/keywords/developmental-psychology","display_name":"Developmental psychology","score":0.1430235207080841}],"concepts":[{"id":"https://openalex.org/C2778355574","wikidata":"https://www.wikidata.org/wiki/Q732362","display_name":"Superior temporal sulcus","level":3,"score":0.7215117812156677},{"id":"https://openalex.org/C205778803","wikidata":"https://www.wikidata.org/wiki/Q38404","display_name":"Autism","level":2,"score":0.6520224809646606},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5680652856826782},{"id":"https://openalex.org/C2778538070","wikidata":"https://www.wikidata.org/wiki/Q1436063","display_name":"Autism spectrum disorder","level":3,"score":0.5677538514137268},{"id":"https://openalex.org/C2779226451","wikidata":"https://www.wikidata.org/wiki/Q903809","display_name":"Functional magnetic resonance imaging","level":2,"score":0.5226733088493347},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.4600401520729065},{"id":"https://openalex.org/C2777497123","wikidata":"https://www.wikidata.org/wiki/Q3064601","display_name":"Superior temporal gyrus","level":3,"score":0.436245322227478},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.37372851371765137},{"id":"https://openalex.org/C138496976","wikidata":"https://www.wikidata.org/wiki/Q175002","display_name":"Developmental psychology","level":1,"score":0.1430235207080841}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1145/3340037.3340049","is_oa":false,"landing_page_url":"https://doi.org/10.1145/3340037.3340049","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the third International Conference on Medical and Health Informatics 2019  - ICMHI 2019","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G3517326054","display_name":null,"funder_award_id":"61533006?61673089, 81771919","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W1541267199","https://openalex.org/W1965183327","https://openalex.org/W1976623182","https://openalex.org/W2004734596","https://openalex.org/W2057550180","https://openalex.org/W2072529925","https://openalex.org/W2076276327","https://openalex.org/W2079554826","https://openalex.org/W2082284485","https://openalex.org/W2108573091","https://openalex.org/W2127590260","https://openalex.org/W2167868121","https://openalex.org/W2198253440","https://openalex.org/W2206163921","https://openalex.org/W2291733379","https://openalex.org/W2474678163","https://openalex.org/W2534059206","https://openalex.org/W2614349964","https://openalex.org/W2744921996","https://openalex.org/W2895742324","https://openalex.org/W2898580606","https://openalex.org/W4247665917"],"related_works":["https://openalex.org/W1232981735","https://openalex.org/W2997338437","https://openalex.org/W2128476537","https://openalex.org/W2154369653","https://openalex.org/W2110333289","https://openalex.org/W2100509922","https://openalex.org/W2022677779","https://openalex.org/W3087756695","https://openalex.org/W2486058157","https://openalex.org/W2555801784"],"abstract_inverted_index":{"Autism":[0,81],"spectrum":[1],"disorder":[2],"(ASD)":[3],"is":[4],"associated":[5],"with":[6,67,92,149,158,162],"functional":[7,35,55,73],"coordination":[8],"disturbances":[9],"among":[10],"brain":[11],"regions.":[12],"Genetic":[13],"studies":[14],"implicated":[15],"that":[16,207],"dysfunctional":[17],"gamma-aminobutyric":[18],"acid":[19],"(GABA)":[20],"system":[21],"may":[22],"play":[23],"an":[24],"important":[25],"role":[26],"in":[27,45,62,89,200,232],"autism":[28],"etiology.":[29],"Based":[30],"on":[31],"previous":[32],"reported":[33],"static":[34],"connectivity":[36,56,241],"abnormalities":[37,148,242],"of":[38,59,104,118,152,212,229],"the":[39,47,53,60,80,105,116,119,131,145,153,169,177,192,213,230,236],"posterior":[40,197],"superior":[41],"temporal":[42,132,174,179],"sulcus":[43],"(pSTS)":[44],"ASD,":[46],"current":[48],"study":[49],"aimed":[50],"to":[51,129,143,218],"explore":[52],"dynamic":[54],"(dFC)":[57],"variability":[58,147,167,188,210,228],"pSTS":[61,107,171,194,215,231],"ASD":[63,93,163,233],"and":[64,94,115,172,181,195,234,243],"its":[65],"associations":[66],"GABA":[68,154,219,244],"receptor":[69,155,220],"genes":[70,221,245],"expression.":[71,222,246],"Resting-state":[72],"magnetic":[74],"resonance":[75],"imaging":[76],"data":[77,151],"obtained":[78],"from":[79],"Brain":[82],"Imaging":[83],"Data":[84],"Exchange":[85],"repository":[86],"were":[87,108,216],"analyzed":[88],"209":[90],"males":[91],"298":[95],"demographically-matched":[96],"control":[97],"males.":[98],"For":[99],"each":[100,124],"subject,":[101],"dFC":[102,120,146,166,187,209,227],"maps":[103],"bilateral":[106,196,214],"constructed":[109],"through":[110],"Flexible":[111],"Least":[112],"Squares":[113],"strategy,":[114],"variance":[117],"time":[121],"series":[122],"at":[123],"voxel":[125],"was":[126,139,189],"further":[127],"calculated":[128],"quantify":[130],"variability.":[133],"Finally,":[134],"gene":[135],"expression":[136,150,203],"decoding":[137,204],"analysis":[138],"performed":[140],"using":[141],"NeuroVault":[142],"associate":[144],"genes.":[156],"Compared":[157],"typical":[159],"controls,":[160],"individuals":[161],"showed":[164,206],"increased":[165],"between":[168,191,239],"left":[170],"right":[173,193],"regions,":[175],"including":[176],"middle":[178],"gyrus":[180],"fusiform":[182],"gyrus.":[183],"In":[184],"addition,":[185],"decreased":[186],"found":[190],"cingulate":[198],"cortex":[199],"ASD.":[201],"Gene":[202],"result":[205],"aberrant":[208],"patterns":[211],"related":[217],"These":[223],"findings":[224],"suggest":[225],"abnormal":[226],"implicate":[235],"potential":[237],"links":[238],"these":[240]},"counts_by_year":[{"year":2023,"cited_by_count":2}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}