{"id":"https://openalex.org/W2954376225","doi":"https://doi.org/10.1145/3326172.3326176","title":"Electrochemical DNA Sensor Based On Graphene/Zirconia Nanocomposite for Label-Free Detection of Exon-19 Mutations in Lung Cancer","display_name":"Electrochemical DNA Sensor Based On Graphene/Zirconia Nanocomposite for Label-Free Detection of Exon-19 Mutations in Lung Cancer","publication_year":2019,"publication_date":"2019-03-28","ids":{"openalex":"https://openalex.org/W2954376225","doi":"https://doi.org/10.1145/3326172.3326176","mag":"2954376225"},"language":"en","primary_location":{"id":"doi:10.1145/3326172.3326176","is_oa":false,"landing_page_url":"https://doi.org/10.1145/3326172.3326176","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 2019 9th International Conference on Biomedical Engineering and Technology","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024420049","display_name":"Lih Poh Lin","orcid":"https://orcid.org/0000-0001-6812-6118"},"institutions":[{"id":"https://openalex.org/I927443849","display_name":"Tunku Abdul Rahman University of Management and Technology","ror":"https://ror.org/03b3zvp63","country_code":"MY","type":"education","lineage":["https://openalex.org/I927443849"]}],"countries":["MY"],"is_corresponding":true,"raw_author_name":"Lih Poh Lin","raw_affiliation_strings":["Department of Electrical and Electronic Engineering, Tunku Abdul Rahman University College, Jalan Genting Kelang, Kuala Lumpur, Malaysia"],"affiliations":[{"raw_affiliation_string":"Department of Electrical and Electronic Engineering, Tunku Abdul Rahman University College, Jalan Genting Kelang, Kuala Lumpur, Malaysia","institution_ids":["https://openalex.org/I927443849"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044840893","display_name":"Michelle T.T. Tan","orcid":"https://orcid.org/0000-0002-0109-3961"},"institutions":[{"id":"https://openalex.org/I155043079","display_name":"University of Nottingham Malaysia Campus","ror":"https://ror.org/04mz9mt17","country_code":"MY","type":"education","lineage":["https://openalex.org/I142263535","https://openalex.org/I155043079"]}],"countries":["MY"],"is_corresponding":false,"raw_author_name":"Michelle Tien Tien Tan","raw_affiliation_strings":["Department of Electrical and Electronic Engineering, University of Nottingham, Jalan Broga, Semenyih, Malaysia"],"affiliations":[{"raw_affiliation_string":"Department of Electrical and Electronic Engineering, University of Nottingham, Jalan Broga, Semenyih, Malaysia","institution_ids":["https://openalex.org/I155043079"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034563250","display_name":"Hwei\u2010San Loh","orcid":"https://orcid.org/0000-0002-6173-6367"},"institutions":[{"id":"https://openalex.org/I155043079","display_name":"University of Nottingham Malaysia Campus","ror":"https://ror.org/04mz9mt17","country_code":"MY","type":"education","lineage":["https://openalex.org/I142263535","https://openalex.org/I155043079"]}],"countries":["MY"],"is_corresponding":false,"raw_author_name":"Hwei San Loh","raw_affiliation_strings":["School of Biosciences, University of Nottingham, Jalan Broga, Semenyih, Malaysia"],"affiliations":[{"raw_affiliation_string":"School of Biosciences, University of Nottingham, Jalan Broga, Semenyih, Malaysia","institution_ids":["https://openalex.org/I155043079"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5024420049"],"corresponding_institution_ids":["https://openalex.org/I927443849"],"apc_list":null,"apc_paid":null,"fwci":0.1705,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.51661738,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":95},"biblio":{"volume":null,"issue":null,"first_page":"223","last_page":"228"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14285","display_name":"Biopolymer Synthesis and Applications","score":0.9824000000953674,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.9684000015258789,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dielectric-spectroscopy","display_name":"Dielectric spectroscopy","score":0.7558771371841431},{"id":"https://openalex.org/keywords/nanocomposite","display_name":"Nanocomposite","score":0.683233916759491},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.6303722858428955},{"id":"https://openalex.org/keywords/graphene","display_name":"Graphene","score":0.5735200047492981},{"id":"https://openalex.org/keywords/cyclic-voltammetry","display_name":"Cyclic voltammetry","score":0.5573651194572449},{"id":"https://openalex.org/keywords/electrode","display_name":"Electrode","score":0.4663132131099701},{"id":"https://openalex.org/keywords/biosensor","display_name":"Biosensor","score":0.4481668174266815},{"id":"https://openalex.org/keywords/scanning-electron-microscope","display_name":"Scanning electron microscope","score":0.41686272621154785},{"id":"https://openalex.org/keywords/electrochemistry","display_name":"Electrochemistry","score":0.32912677526474},{"id":"https://openalex.org/keywords/nanotechnology","display_name":"Nanotechnology","score":0.3175027370452881},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.26343321800231934},{"id":"https://openalex.org/keywords/composite-material","display_name":"Composite material","score":0.060611456632614136}],"concepts":[{"id":"https://openalex.org/C7040849","wikidata":"https://www.wikidata.org/wiki/Q899580","display_name":"Dielectric spectroscopy","level":4,"score":0.7558771371841431},{"id":"https://openalex.org/C92880739","wikidata":"https://www.wikidata.org/wiki/Q2639556","display_name":"Nanocomposite","level":2,"score":0.683233916759491},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.6303722858428955},{"id":"https://openalex.org/C30080830","wikidata":"https://www.wikidata.org/wiki/Q169917","display_name":"Graphene","level":2,"score":0.5735200047492981},{"id":"https://openalex.org/C2777869211","wikidata":"https://www.wikidata.org/wiki/Q1147647","display_name":"Cyclic voltammetry","level":4,"score":0.5573651194572449},{"id":"https://openalex.org/C17525397","wikidata":"https://www.wikidata.org/wiki/Q176140","display_name":"Electrode","level":2,"score":0.4663132131099701},{"id":"https://openalex.org/C160756335","wikidata":"https://www.wikidata.org/wiki/Q669391","display_name":"Biosensor","level":2,"score":0.4481668174266815},{"id":"https://openalex.org/C26771246","wikidata":"https://www.wikidata.org/wiki/Q321095","display_name":"Scanning electron microscope","level":2,"score":0.41686272621154785},{"id":"https://openalex.org/C52859227","wikidata":"https://www.wikidata.org/wiki/Q7877","display_name":"Electrochemistry","level":3,"score":0.32912677526474},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.3175027370452881},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.26343321800231934},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.060611456632614136},{"id":"https://openalex.org/C147789679","wikidata":"https://www.wikidata.org/wiki/Q11372","display_name":"Physical chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1145/3326172.3326176","is_oa":false,"landing_page_url":"https://doi.org/10.1145/3326172.3326176","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 2019 9th International Conference on Biomedical Engineering and Technology","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Peace, Justice and strong institutions","id":"https://metadata.un.org/sdg/16","score":0.6100000143051147}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W1672385484","https://openalex.org/W1967064805","https://openalex.org/W1976072030","https://openalex.org/W2005764143","https://openalex.org/W2014355212","https://openalex.org/W2032994792","https://openalex.org/W2035737754","https://openalex.org/W2041738076","https://openalex.org/W2046584142","https://openalex.org/W2063021873","https://openalex.org/W2144932503","https://openalex.org/W2160457870","https://openalex.org/W2165187741","https://openalex.org/W2168841302","https://openalex.org/W2182634182","https://openalex.org/W2258190155","https://openalex.org/W2570618306","https://openalex.org/W2587243552","https://openalex.org/W2626588037","https://openalex.org/W2751456910","https://openalex.org/W2887224709","https://openalex.org/W4292542249"],"related_works":["https://openalex.org/W2506226718","https://openalex.org/W2092816171","https://openalex.org/W2380339328","https://openalex.org/W1976861527","https://openalex.org/W2509298593","https://openalex.org/W4381060394","https://openalex.org/W1996763009","https://openalex.org/W2008912847","https://openalex.org/W4362667714","https://openalex.org/W2252828978"],"abstract_inverted_index":{"In":[0],"this":[1],"study,":[2],"a":[3,18,49],"specific":[4],"impedimetric":[5],"DNA":[6,115,146,203,218,228],"sensor":[7],"based":[8],"on":[9,97,147],"graphene/zirconia":[10,44,141],"nanocomposite":[11,45,60,85],"has":[12],"been":[13],"developed":[14,207,246],"to":[15,32,77,102,112,219,224,236],"serve":[16],"as":[17,163,165,198],"simple":[19],"and":[20,71,82,94,134,142,184,191,250,265],"rapid":[21],"method":[22,51],"for":[23,201,215],"epidermal":[24],"growth":[25],"factor":[26],"receptor":[27],"(EGFR)":[28],"mutations":[29],"testing,":[30],"necessary":[31],"guide":[33],"the":[34,53,124,148,153,166,185,199,213],"treatment":[35],"regime":[36],"of":[37,55,119,123,139,144,155,168,227,254,263],"tyrosine":[38],"kinase":[39],"inhibitors":[40],"(TKIs)":[41],"therapy.":[42],"The":[43,58,84,175,206,230,245],"was":[46,61,86,196],"synthesized":[47],"via":[48],"green":[50],"without":[52],"use":[54],"harsh":[56],"chemicals.":[57],"as-synthesized":[59],"characterized":[62,128],"with":[63,88,106,180,239],"scanning":[64],"electron":[65,156],"microscopy":[66],"(SEM),":[67],"X-ray":[68,74],"diffractometry":[69],"(XRD)":[70],"energy":[72],"dispersive":[73],"spectroscopy":[75,132],"(EDX)":[76],"evaluate":[78],"its":[79],"morphology,":[80],"crystallinity":[81],"composition.":[83],"functionalized":[87],"1-pyrenebutyric":[89],"acid":[90],"N-hydroxysuccinimide":[91],"ester":[92],"(PSE)":[93],"dropped":[95],"casted":[96],"screen":[98],"printed":[99],"electrode":[100,149],"(SPCE)":[101],"provide":[103],"amide":[104],"bonding":[105],"single-stranded":[107,145],"probe-DNA":[108],"that":[109],"is":[110,248],"complementary":[111],"exon-19":[113,216,220,237],"wild-type":[114,217],"sequence.":[116],"Electrochemical":[117],"responses":[118],"each":[120],"assembly":[121],"step":[122],"sensing":[125],"platform":[126],"were":[127,150,178],"by":[129,152],"electrochemical":[130,188],"impedance":[131,189],"(EIS)":[133],"cyclic":[135],"voltammetry":[136],"(CV).":[137],"Deposition":[138],"PSE-functionalized":[140],"immobilization":[143],"reflected":[151],"increment":[154],"transfer":[157],"resistance":[158],"(Rct)":[159],"in":[160,172,187,261],"EIS":[161],"analysis":[162],"well":[164],"reduction":[167],"peak":[169],"current":[170],"(ip)":[171],"CV":[173],"analysis.":[174],"modified":[176],"electrodes":[177],"hybridized":[179],"different":[181],"target":[182],"DNAs":[183],"difference":[186],"before":[190],"after":[192],"hybridization":[193,204],"(normalized":[194],"value)":[195],"adopted":[197],"measurement":[200],"label-free":[202],"detection.":[205],"genosensor":[208],"demonstrated":[209],"strong":[210],"distinction":[211],"between":[212],"Rct":[214],"mutated":[221],"DNA,":[222],"leading":[223],"promising":[225],"quantitation":[226],"mutations.":[229],"biosensor":[231,247],"also":[232],"exhibited":[233],"high":[234],"specificity":[235],"sequence":[238],"clear":[240],"discrimination":[241],"against":[242],"non-complementary":[243],"target.":[244],"disposable":[249],"requires":[251],"no":[252],"labelling":[253],"probe":[255],"or":[256],"target,":[257],"making":[258],"it":[259],"beneficial":[260],"terms":[262],"simplicity":[264],"efficiency.":[266]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}
