{"id":"https://openalex.org/W2890505987","doi":"https://doi.org/10.1145/3239438.3239458","title":"Numerical Simulation Study on Flow Field Microenvironment of Chondrocytes in Articular Cartilage Defect Repair Area","display_name":"Numerical Simulation Study on Flow Field Microenvironment of Chondrocytes in Articular Cartilage Defect Repair Area","publication_year":2018,"publication_date":"2018-06-08","ids":{"openalex":"https://openalex.org/W2890505987","doi":"https://doi.org/10.1145/3239438.3239458","mag":"2890505987"},"language":"en","primary_location":{"id":"doi:10.1145/3239438.3239458","is_oa":false,"landing_page_url":"https://doi.org/10.1145/3239438.3239458","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 2nd International Conference on Medical and Health Informatics","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062815270","display_name":"Xige Ma","orcid":null},"institutions":[{"id":"https://openalex.org/I136765683","display_name":"Tianjin University of Technology","ror":"https://ror.org/00zbe0w13","country_code":"CN","type":"education","lineage":["https://openalex.org/I136765683"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xige Ma","raw_affiliation_strings":["National Demonstration Center for Experimental Mechanical and Electrical Engineering Education, Tianjin University of Technology, Tianjin, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Demonstration Center for Experimental Mechanical and Electrical Engineering Education, Tianjin University of Technology, Tianjin, China","institution_ids":["https://openalex.org/I136765683"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083193824","display_name":"Haiying Liu","orcid":"https://orcid.org/0000-0002-9063-8096"},"institutions":[{"id":"https://openalex.org/I136765683","display_name":"Tianjin University of Technology","ror":"https://ror.org/00zbe0w13","country_code":"CN","type":"education","lineage":["https://openalex.org/I136765683"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Haiying Liu","raw_affiliation_strings":["National Demonstration Center for Experimental Mechanical and Electrical Engineering Education, Tianjin University of Technology, Tianjin, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Demonstration Center for Experimental Mechanical and Electrical Engineering Education, Tianjin University of Technology, Tianjin, China","institution_ids":["https://openalex.org/I136765683"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101041324","display_name":"Sen Zhao","orcid":null},"institutions":[{"id":"https://openalex.org/I136765683","display_name":"Tianjin University of Technology","ror":"https://ror.org/00zbe0w13","country_code":"CN","type":"education","lineage":["https://openalex.org/I136765683"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhao Sen","raw_affiliation_strings":["National Demonstration Center for Experimental Mechanical and Electrical Engineering Education, Tianjin University of Technology, Tianjin, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Demonstration Center for Experimental Mechanical and Electrical Engineering Education, Tianjin University of Technology, Tianjin, China","institution_ids":["https://openalex.org/I136765683"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101752207","display_name":"Chunqiu Zhang","orcid":"https://orcid.org/0000-0002-4788-104X"},"institutions":[{"id":"https://openalex.org/I136765683","display_name":"Tianjin University of Technology","ror":"https://ror.org/00zbe0w13","country_code":"CN","type":"education","lineage":["https://openalex.org/I136765683"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chunqiu Zhang","raw_affiliation_strings":["National Demonstration Center for Experimental Mechanical and Electrical Engineering Education, Tianjin University of Technology, Tianjin, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Demonstration Center for Experimental Mechanical and Electrical Engineering Education, Tianjin University of Technology, Tianjin, China","institution_ids":["https://openalex.org/I136765683"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.14652544,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"206","last_page":"211"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.9988999962806702,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.9988999962806702,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11570","display_name":"Periodontal Regeneration and Treatments","score":0.9793999791145325,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11131","display_name":"Proteoglycans and glycosaminoglycans research","score":0.9765999913215637,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cartilage","display_name":"Cartilage","score":0.7604799270629883},{"id":"https://openalex.org/keywords/extracellular-matrix","display_name":"Extracellular matrix","score":0.6891924738883972},{"id":"https://openalex.org/keywords/finite-element-method","display_name":"Finite element method","score":0.6180267333984375},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.5789394378662109},{"id":"https://openalex.org/keywords/chondrocyte","display_name":"Chondrocyte","score":0.5772147178649902},{"id":"https://openalex.org/keywords/biomedical-engineering","display_name":"Biomedical engineering","score":0.5484996438026428},{"id":"https://openalex.org/keywords/matrix","display_name":"Matrix (chemical analysis)","score":0.4811074137687683},{"id":"https://openalex.org/keywords/coupling","display_name":"Coupling (piping)","score":0.46639320254325867},{"id":"https://openalex.org/keywords/flow","display_name":"Flow (mathematics)","score":0.4179912209510803},{"id":"https://openalex.org/keywords/mechanics","display_name":"Mechanics","score":0.34282052516937256},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.31480276584625244},{"id":"https://openalex.org/keywords/anatomy","display_name":"Anatomy","score":0.26561790704727173},{"id":"https://openalex.org/keywords/composite-material","display_name":"Composite material","score":0.2007349729537964},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.1282573640346527},{"id":"https://openalex.org/keywords/structural-engineering","display_name":"Structural engineering","score":0.12696465849876404},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.1033254861831665},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.08869379758834839}],"concepts":[{"id":"https://openalex.org/C2780550940","wikidata":"https://www.wikidata.org/wiki/Q502730","display_name":"Cartilage","level":2,"score":0.7604799270629883},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.6891924738883972},{"id":"https://openalex.org/C135628077","wikidata":"https://www.wikidata.org/wiki/Q220184","display_name":"Finite element method","level":2,"score":0.6180267333984375},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.5789394378662109},{"id":"https://openalex.org/C2781403057","wikidata":"https://www.wikidata.org/wiki/Q775480","display_name":"Chondrocyte","level":3,"score":0.5772147178649902},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.5484996438026428},{"id":"https://openalex.org/C106487976","wikidata":"https://www.wikidata.org/wiki/Q685816","display_name":"Matrix (chemical analysis)","level":2,"score":0.4811074137687683},{"id":"https://openalex.org/C131584629","wikidata":"https://www.wikidata.org/wiki/Q4308705","display_name":"Coupling (piping)","level":2,"score":0.46639320254325867},{"id":"https://openalex.org/C38349280","wikidata":"https://www.wikidata.org/wiki/Q1434290","display_name":"Flow (mathematics)","level":2,"score":0.4179912209510803},{"id":"https://openalex.org/C57879066","wikidata":"https://www.wikidata.org/wiki/Q41217","display_name":"Mechanics","level":1,"score":0.34282052516937256},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.31480276584625244},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.26561790704727173},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.2007349729537964},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1282573640346527},{"id":"https://openalex.org/C66938386","wikidata":"https://www.wikidata.org/wiki/Q633538","display_name":"Structural engineering","level":1,"score":0.12696465849876404},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.1033254861831665},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.08869379758834839},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1145/3239438.3239458","is_oa":false,"landing_page_url":"https://doi.org/10.1145/3239438.3239458","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 2nd International Conference on Medical and Health Informatics","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":9,"referenced_works":["https://openalex.org/W1171201438","https://openalex.org/W1991626074","https://openalex.org/W2008973916","https://openalex.org/W2030001335","https://openalex.org/W2039691161","https://openalex.org/W2066420478","https://openalex.org/W2087418982","https://openalex.org/W2349500431","https://openalex.org/W3024990854"],"related_works":["https://openalex.org/W3113789775","https://openalex.org/W4232436370","https://openalex.org/W2490525963","https://openalex.org/W2168602801","https://openalex.org/W1480797633","https://openalex.org/W4313424032","https://openalex.org/W2039195542","https://openalex.org/W3214112236","https://openalex.org/W2897130206","https://openalex.org/W1965971430"],"abstract_inverted_index":{"Multi-scale":[0],"numerical":[1],"simulation":[2],"was":[3,79,121,128],"used":[4],"to":[5,41,130,148],"study":[6,165],"the":[7,59,68,83,101,116,124,131,141,144,150,164,167,170,178],"change":[8],"of":[9,13,17,62,85,91,104,119,143,154,166,169,172,182],"flow":[10,60,89,102,125],"field":[11,61,126],"microenvironment":[12,127],"chondrocytes":[14,155,176],"after":[15],"repair":[16],"cartilage":[18,29,50,183],"defects.":[19],"A":[20],"solid-liquid":[21],"coupling":[22,39],"biphasic":[23],"finite":[24,31,135],"element":[25,32,136],"model":[26],"for":[27,34,49,54,140,163],"articular":[28],"and":[30,51,64,77,93,100,106,177,180],"micro-model":[33],"chondrocyte":[35],"were":[36],"established,":[37],"using":[38],"variables":[40],"establish":[42],"consistent":[43],"boundary":[44],"conditions":[45],"between":[46],"macroscopic":[47],"models":[48,53],"microscopic":[52,151],"chondrocytes.":[55],"After":[56],"defect":[57],"repair,":[58],"chondron":[63,92,105],"extracellular":[65,94,107],"matrix":[66,95,108],"in":[67,96,109,156],"middle":[69,97],"layer":[70,98,111],"changed":[71,113],"significantly":[72],"under":[73],"cyclic":[74],"compression":[75],"loading,":[76],"it":[78],"also":[80],"influenced":[81],"by":[82],"properties":[84],"tissue-engineered":[86],"cartilage.":[87,133],"The":[88,134],"velocity":[90,103],"increased,":[99],"deep":[110],"increased":[112],"little.":[114],"When":[115],"elastic":[117],"modulus":[118],"TEC":[120],"0.3":[122],"MPa,":[123],"closer":[129],"intact":[132],"method":[137],"make":[138],"up":[139],"lack":[142],"current":[145],"technical":[146],"means":[147],"measure":[149],"mechanical":[152],"environment":[153],"vivo.":[157],"It":[158],"has":[159],"some":[160],"guiding":[161],"significance":[162],"mechanism":[168],"effect":[171],"biomechanical":[173],"factors":[174],"on":[175],"prevention":[179],"treatment":[181],"diseases.":[184]},"counts_by_year":[],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}