{"id":"https://openalex.org/W2888432474","doi":"https://doi.org/10.1145/3233547.3233580","title":"TFmeta","display_name":"TFmeta","publication_year":2018,"publication_date":"2018-08-15","ids":{"openalex":"https://openalex.org/W2888432474","doi":"https://doi.org/10.1145/3233547.3233580","mag":"2888432474"},"language":"en","primary_location":{"id":"doi:10.1145/3233547.3233580","is_oa":false,"landing_page_url":"https://doi.org/10.1145/3233547.3233580","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 2018 ACM International Conference on Bioinformatics, Computational Biology, and Health Informatics","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100388016","display_name":"Yi Zhang","orcid":"https://orcid.org/0000-0001-5065-2339"},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yi Zhang","raw_affiliation_strings":["University of Kentucky, Lexington, KY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Kentucky, Lexington, KY, USA","institution_ids":["https://openalex.org/I143302722"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100447051","display_name":"Xiaofei Zhang","orcid":"https://orcid.org/0000-0002-9934-5417"},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaofei Zhang","raw_affiliation_strings":["University of Kentucky, Lexington, KY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Kentucky, Lexington, KY, USA","institution_ids":["https://openalex.org/I143302722"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029157205","display_name":"Andrew N. Lane","orcid":"https://orcid.org/0000-0003-1121-5106"},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew N. Lane","raw_affiliation_strings":["University of Kentucky, Lexington, KY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Kentucky, Lexington, KY, USA","institution_ids":["https://openalex.org/I143302722"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058623652","display_name":"Teresa W.\u2010M. Fan","orcid":"https://orcid.org/0000-0002-7292-8938"},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Teresa W-M. Fan","raw_affiliation_strings":["University of Kentucky, Lexington, KY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Kentucky, Lexington, KY, USA","institution_ids":["https://openalex.org/I143302722"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102842945","display_name":"Jinze Liu","orcid":"https://orcid.org/0000-0003-0555-9412"},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jinze Liu","raw_affiliation_strings":["University of Kentucky, Lexington, KY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Kentucky, Lexington, KY, USA","institution_ids":["https://openalex.org/I143302722"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.16,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.48261338,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":96},"biblio":{"volume":null,"issue":null,"first_page":"351","last_page":"359"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.9976999759674072,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.9976999759674072,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11482","display_name":"RNA modifications and cancer","score":0.996999979019165,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/reprogramming","display_name":"Reprogramming","score":0.7588953971862793},{"id":"https://openalex.org/keywords/transcription-factor","display_name":"Transcription factor","score":0.7053713798522949},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.6095026135444641},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5651827454566956},{"id":"https://openalex.org/keywords/cancer-cell","display_name":"Cancer cell","score":0.5481966137886047},{"id":"https://openalex.org/keywords/metabolic-pathway","display_name":"Metabolic pathway","score":0.5113639235496521},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.508391797542572},{"id":"https://openalex.org/keywords/phenotype","display_name":"Phenotype","score":0.508171558380127},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.4779148995876312},{"id":"https://openalex.org/keywords/glycolysis","display_name":"Glycolysis","score":0.4475831389427185},{"id":"https://openalex.org/keywords/lung-cancer","display_name":"Lung cancer","score":0.4247419238090515},{"id":"https://openalex.org/keywords/enzyme","display_name":"Enzyme","score":0.38773584365844727},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.3301880955696106},{"id":"https://openalex.org/keywords/cancer-research","display_name":"Cancer research","score":0.32730433344841003},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.22125455737113953},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.18554043769836426},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.10763117671012878},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.06139105558395386}],"concepts":[{"id":"https://openalex.org/C77255625","wikidata":"https://www.wikidata.org/wiki/Q402093","display_name":"Reprogramming","level":3,"score":0.7588953971862793},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.7053713798522949},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6095026135444641},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5651827454566956},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.5481966137886047},{"id":"https://openalex.org/C192989942","wikidata":"https://www.wikidata.org/wiki/Q68685","display_name":"Metabolic pathway","level":3,"score":0.5113639235496521},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.508391797542572},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.508171558380127},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4779148995876312},{"id":"https://openalex.org/C20251656","wikidata":"https://www.wikidata.org/wiki/Q162643","display_name":"Glycolysis","level":3,"score":0.4475831389427185},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.4247419238090515},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.38773584365844727},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3301880955696106},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.32730433344841003},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.22125455737113953},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.18554043769836426},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.10763117671012878},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.06139105558395386}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1145/3233547.3233580","is_oa":false,"landing_page_url":"https://doi.org/10.1145/3233547.3233580","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 2018 ACM International Conference on Bioinformatics, Computational Biology, and Health Informatics","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.550000011920929}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W1490655572","https://openalex.org/W1678356000","https://openalex.org/W1900337607","https://openalex.org/W1968468939","https://openalex.org/W1999574084","https://openalex.org/W2008634667","https://openalex.org/W2014233861","https://openalex.org/W2033250049","https://openalex.org/W2036659083","https://openalex.org/W2041596211","https://openalex.org/W2042981247","https://openalex.org/W2044525257","https://openalex.org/W2055255976","https://openalex.org/W2074873270","https://openalex.org/W2076513103","https://openalex.org/W2083992760","https://openalex.org/W2086144884","https://openalex.org/W2096252634","https://openalex.org/W2097259163","https://openalex.org/W2098023402","https://openalex.org/W2101234009","https://openalex.org/W2109384743","https://openalex.org/W2110328538","https://openalex.org/W2111840226","https://openalex.org/W2126925799","https://openalex.org/W2129265801","https://openalex.org/W2135030836","https://openalex.org/W2135259589","https://openalex.org/W2154787822","https://openalex.org/W2157230165","https://openalex.org/W2159482845","https://openalex.org/W2247766769","https://openalex.org/W2295598076","https://openalex.org/W2412359813","https://openalex.org/W2600290945","https://openalex.org/W2622514592","https://openalex.org/W2770660823","https://openalex.org/W2785792383","https://openalex.org/W2997591727","https://openalex.org/W3102476541","https://openalex.org/W4294216483"],"related_works":["https://openalex.org/W1631979401","https://openalex.org/W2395945797","https://openalex.org/W2129470469","https://openalex.org/W2368295610","https://openalex.org/W1543102035","https://openalex.org/W2035612098","https://openalex.org/W4388492048","https://openalex.org/W2791478098","https://openalex.org/W3153882382","https://openalex.org/W2162091548"],"abstract_inverted_index":{"Metabolic":[0],"reprogramming":[1,15,51,75],"is":[2],"a":[3,66],"hallmark":[4],"of":[5,24,76,134,139,142,153],"cancer.":[6],"In":[7,60],"cancer":[8,29,58,77,158],"cells,":[9],"transcription":[10,22],"factors":[11],"(TFs)":[12],"govern":[13,49,74],"metabolic":[14,25,39,50,140,145],"through":[16],"abnormally":[17],"increasing":[18],"or":[19],"decreasing":[20],"the":[21,37,131,135,143,151],"rate":[23],"enzymes,":[26],"which":[27,148],"provides":[28],"cells":[30],"growth":[31],"advantages":[32],"and":[33,89,107,116],"concurrently":[34],"leads":[35],"to":[36,70],"altered":[38],"phenotypes":[40],"observed":[41],"in":[42,84,155],"many":[43],"cancers.":[44],"Consequently,":[45],"targeting":[46],"TFs":[47,72,88,127],"that":[48,73,128],"can":[52],"be":[53,130],"highly":[54],"effective":[55],"for":[56],"novel":[57],"therapeutics.":[59],"this":[61],"work,":[62],"we":[63],"present":[64],"TFmeta,":[65],"machine":[67],"learning":[68],"approach":[69,80,123],"uncover":[71],"metabolism.":[78],"Our":[79],"achieves":[81],"state-of-the-art":[82],"performance":[83],"reconstructing":[85],"interactions":[86],"between":[87],"their":[90],"target":[91],"genes":[92],"on":[93],"public":[94],"benchmark":[95],"data":[96],"sets.":[97],"Leveraging":[98],"TF":[99],"binding":[100],"profiles":[101],"inferred":[102],"from":[103,111],"genome-wide":[104],"ChIP-Seq":[105],"experiments":[106],"150":[108],"RNA-Seq":[109],"samples":[110],"75":[112],"paired":[113],"cancerous":[114],"(CA)":[115],"non-cancerous":[117],"(NC)":[118],"human":[119],"lung":[120,157],"tissues,":[121],"our":[122],"predicted":[124],"19":[125],"key":[126],"may":[129,149],"major":[132],"regulators":[133],"gene":[136],"expression":[137],"changes":[138],"enzymes":[141],"central":[144],"pathway":[146],"glycolysis,":[147],"underlie":[150],"dysregulation":[152],"glycolysis":[154],"non-small-cell":[156],"patients.":[159]},"counts_by_year":[{"year":2019,"cited_by_count":2}],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2018-08-31T00:00:00"}
