{"id":"https://openalex.org/W2886214138","doi":"https://doi.org/10.1145/3205455.3205505","title":"Better and faster catheter position optimization in HDR brachytherapy for prostate cancer using multi-objective real-valued GOMEA","display_name":"Better and faster catheter position optimization in HDR brachytherapy for prostate cancer using multi-objective real-valued GOMEA","publication_year":2018,"publication_date":"2018-07-02","ids":{"openalex":"https://openalex.org/W2886214138","doi":"https://doi.org/10.1145/3205455.3205505","mag":"2886214138"},"language":"en","primary_location":{"id":"doi:10.1145/3205455.3205505","is_oa":false,"landing_page_url":"https://doi.org/10.1145/3205455.3205505","pdf_url":null,"source":{"id":"https://openalex.org/S4363608932","display_name":"Proceedings of the Genetic and Evolutionary Computation Conference","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the Genetic and Evolutionary Computation Conference","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://ir.cwi.nl/pub/27886/27886.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053141528","display_name":"Marjolein C. van der Meer","orcid":null},"institutions":[{"id":"https://openalex.org/I2802928900","display_name":"Amsterdam UMC Location University of Amsterdam","ror":"https://ror.org/03t4gr691","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2802928900","https://openalex.org/I4210151833"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Marjolein C. van der Meer","raw_affiliation_strings":["Academic Medical Center, Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Academic Medical Center, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I2802928900"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015936442","display_name":"Bradley R. Pieters","orcid":"https://orcid.org/0000-0002-7427-8836"},"institutions":[{"id":"https://openalex.org/I2802928900","display_name":"Amsterdam UMC Location University of Amsterdam","ror":"https://ror.org/03t4gr691","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2802928900","https://openalex.org/I4210151833"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Bradley R. Pieters","raw_affiliation_strings":["Academic Medical Center, Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Academic Medical Center, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I2802928900"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022272327","display_name":"Yury Niatsetski","orcid":"https://orcid.org/0000-0002-2756-2834"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yury Niatsetski","raw_affiliation_strings":["Elekta, Veenendaal, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Elekta, Veenendaal, The Netherlands","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025122230","display_name":"Tanja Alderliesten","orcid":"https://orcid.org/0000-0003-4261-7511"},"institutions":[{"id":"https://openalex.org/I2802928900","display_name":"Amsterdam UMC Location University of Amsterdam","ror":"https://ror.org/03t4gr691","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2802928900","https://openalex.org/I4210151833"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Tanja Alderliesten","raw_affiliation_strings":["Academic Medical Center, Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Academic Medical Center, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I2802928900"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060970719","display_name":"Arjan Bel","orcid":"https://orcid.org/0000-0003-1576-6220"},"institutions":[{"id":"https://openalex.org/I2802928900","display_name":"Amsterdam UMC Location University of Amsterdam","ror":"https://ror.org/03t4gr691","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2802928900","https://openalex.org/I4210151833"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Arjan Bel","raw_affiliation_strings":["Academic Medical Center, Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Academic Medical Center, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I2802928900"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5031539135","display_name":"Peter A. N. Bosman","orcid":"https://orcid.org/0000-0002-4186-6666"},"institutions":[{"id":"https://openalex.org/I1341640284","display_name":"Centrum Wiskunde & Informatica","ror":"https://ror.org/00x7ekv49","country_code":"NL","type":"facility","lineage":["https://openalex.org/I1341640284","https://openalex.org/I2800991832","https://openalex.org/I4405262988"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Peter A. N. Bosman","raw_affiliation_strings":["Centrum Wiskunde & Informatica, Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centrum Wiskunde & Informatica, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I1341640284"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":18.7953,"has_fulltext":true,"cited_by_count":13,"citation_normalized_percentile":{"value":1.0,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":98},"biblio":{"volume":null,"issue":null,"first_page":"1387","last_page":"1394"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10124","display_name":"Prostate Cancer Diagnosis and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10124","display_name":"Prostate Cancer Diagnosis and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.9840999841690063,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10358","display_name":"Advanced Radiotherapy Techniques","score":0.9642000198364258,"subfield":{"id":"https://openalex.org/subfields/3108","display_name":"Radiation"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/brachytherapy","display_name":"Brachytherapy","score":0.7537949085235596},{"id":"https://openalex.org/keywords/benchmark","display_name":"Benchmark (surveying)","score":0.7434552907943726},{"id":"https://openalex.org/keywords/prostate-brachytherapy","display_name":"Prostate brachytherapy","score":0.5980582237243652},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.583869218826294},{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"Prostate cancer","score":0.4938269555568695},{"id":"https://openalex.org/keywords/radiation-treatment-planning","display_name":"Radiation treatment planning","score":0.4474155008792877},{"id":"https://openalex.org/keywords/medical-physics","display_name":"Medical physics","score":0.3337287902832031},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.2489437460899353},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.19035133719444275},{"id":"https://openalex.org/keywords/radiology","display_name":"Radiology","score":0.16603195667266846},{"id":"https://openalex.org/keywords/radiation-therapy","display_name":"Radiation therapy","score":0.09933590888977051}],"concepts":[{"id":"https://openalex.org/C2777416452","wikidata":"https://www.wikidata.org/wiki/Q896687","display_name":"Brachytherapy","level":3,"score":0.7537949085235596},{"id":"https://openalex.org/C185798385","wikidata":"https://www.wikidata.org/wiki/Q1161707","display_name":"Benchmark (surveying)","level":2,"score":0.7434552907943726},{"id":"https://openalex.org/C2778648096","wikidata":"https://www.wikidata.org/wiki/Q17009878","display_name":"Prostate brachytherapy","level":4,"score":0.5980582237243652},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.583869218826294},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.4938269555568695},{"id":"https://openalex.org/C201645570","wikidata":"https://www.wikidata.org/wiki/Q830637","display_name":"Radiation treatment planning","level":3,"score":0.4474155008792877},{"id":"https://openalex.org/C19527891","wikidata":"https://www.wikidata.org/wiki/Q1120908","display_name":"Medical physics","level":1,"score":0.3337287902832031},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2489437460899353},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.19035133719444275},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.16603195667266846},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.09933590888977051},{"id":"https://openalex.org/C13280743","wikidata":"https://www.wikidata.org/wiki/Q131089","display_name":"Geodesy","level":1,"score":0.0},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.0},{"id":"https://openalex.org/C205649164","wikidata":"https://www.wikidata.org/wiki/Q1071","display_name":"Geography","level":0,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1145/3205455.3205505","is_oa":false,"landing_page_url":"https://doi.org/10.1145/3205455.3205505","pdf_url":null,"source":{"id":"https://openalex.org/S4363608932","display_name":"Proceedings of the Genetic and Evolutionary Computation Conference","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the Genetic and Evolutionary Computation Conference","raw_type":"proceedings-article"},{"id":"pmh:oai:pure.amsterdamumc.nl:publications/5b534dfe-2b0f-41fb-ac6a-a757ee821634","is_oa":false,"landing_page_url":"https://pure.amsterdamumc.nl/en/publications/5b534dfe-2b0f-41fb-ac6a-a757ee821634","pdf_url":null,"source":{"id":"https://openalex.org/S7407055222","display_name":"Pure Amsterdam UMC","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"van der Meer, M C, Alderliesten, T, Pieters, B R, Bel, A, Niatsetski, Y & Bosman, P A N 2018, Better and faster catheter position optimization in HDR brachytherapy for prostate cancer using multi-objective real-valued GOMEA. in GECCO 2018 - Proceedings of the 2018 Genetic and Evolutionary Computation Conference. GECCO 2018 - Proceedings of the 2018 Genetic and Evolutionary Computation Conference, Association for Computing Machinery, Inc, pp. 1387-1394, 2018 Genetic and Evolutionary Computation Conference, GECCO 2018, Kyoto, Japan, 15/07/2018. https://doi.org/10.1145/3205455.3205505","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"pmh:cwi:oai:cwi.nl:27886","is_oa":true,"landing_page_url":"https://ir.cwi.nl/pub/27886","pdf_url":"https://ir.cwi.nl/pub/27886/27886.pdf","source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/conferencepaper"},{"id":"pmh:amcpub:oai:pure.amc.nl:publications/0c72494a-f6ea-47de-9a5d-835a3db14ff9","is_oa":false,"landing_page_url":"https://pure.amc.nl/en/publications/better-and-faster-catheter-position-optimization-in-hdr-brachytherapy-for-prostate-cancer-using-multiobjective-realvalued-gomea(0c72494a-f6ea-47de-9a5d-835a3db14ff9).html","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"GECCO 2018 - Proceedings of the 2018 Genetic and Evolutionary Computation Conference, 1387 - 1394","raw_type":"info:eu-repo/semantics/conferencepaper"}],"best_oa_location":{"id":"pmh:cwi:oai:cwi.nl:27886","is_oa":true,"landing_page_url":"https://ir.cwi.nl/pub/27886","pdf_url":"https://ir.cwi.nl/pub/27886/27886.pdf","source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/conferencepaper"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.6800000071525574}],"awards":[{"id":"https://openalex.org/G119055134","display_name":null,"funder_award_id":"628.006.003","funder_id":"https://openalex.org/F4320321800","funder_display_name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek"},{"id":"https://openalex.org/G8201264057","display_name":null,"funder_award_id":"628006003","funder_id":"https://openalex.org/F4320321800","funder_display_name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek"}],"funders":[{"id":"https://openalex.org/F4320321800","display_name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek","ror":"https://ror.org/04jsz6e67"}],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W2886214138.pdf"},"referenced_works_count":15,"referenced_works":["https://openalex.org/W21929159","https://openalex.org/W1967827409","https://openalex.org/W1980777855","https://openalex.org/W1989242673","https://openalex.org/W2061715500","https://openalex.org/W2116926066","https://openalex.org/W2125843529","https://openalex.org/W2154145393","https://openalex.org/W2169042387","https://openalex.org/W2238493174","https://openalex.org/W2616991245","https://openalex.org/W2731179780","https://openalex.org/W2733459154","https://openalex.org/W2773170687","https://openalex.org/W3102752510"],"related_works":["https://openalex.org/W2415632822","https://openalex.org/W1968581313","https://openalex.org/W2086196749","https://openalex.org/W2807885017","https://openalex.org/W2597882543","https://openalex.org/W328240141","https://openalex.org/W2102373670","https://openalex.org/W2809967836","https://openalex.org/W2460936463","https://openalex.org/W2089776905"],"abstract_inverted_index":{"The":[0,103],"recently-introduced":[1],"Gene-pool":[2],"Optimal":[3],"Mixing":[4],"Evolutionary":[5],"Algorithm":[6],"(GOMEA)":[7],"family":[8],"has":[9,76],"been":[10],"shown":[11],"to":[12,52,73,83,99,116,151,185],"be":[13,95,140,152],"capable":[14],"of":[15,58,88,105,129],"excellent":[16],"performance":[17,104],"on":[18,109,169],"academic":[19],"benchmark":[20],"problems,":[21],"outperforming":[22],"other":[23],"state-of-the-art":[24,119],"EAs,":[25],"especially":[26],"when":[27],"efficient":[28],"partial":[29,92],"evaluations":[30,93],"are":[31,183],"possible.":[32],"This":[33],"holds":[34],"true":[35],"also":[36],"for":[37,65,165,172],"the":[38,41,53,84,89,130],"latest":[39],"extension,":[40],"Multi-Objective":[42],"Real-Valued":[43],"GOMEA":[44],"(MO-RV-GOMEA).":[45],"In":[46],"this":[47,101],"paper,":[48],"we":[49],"apply":[50],"MO-RV-GOMEA":[51,98,106,136],"real-world":[54,78,111,188],"multi-objective":[55],"optimization":[56],"problem":[57,69,181],"catheter":[59,163],"placement":[60,164],"in":[61,154],"High-Dose-Rate":[62],"(HDR)":[63],"brachytherapy":[64,167],"prostate":[66,166],"cancer,":[67],"a":[68,117,126],"that":[70,122,134,179],"is":[71,107,123],"non-trivial":[72],"solve":[74],"and":[75,80,114,157,168],"high":[77],"importance":[79],"relevance.":[81],"Due":[82],"underlying":[85],"geometric":[86],"structure":[87],"real-valued":[90],"variables,":[91],"can":[94,139],"performed,":[96],"allowing":[97],"exploit":[100],"structure.":[102],"tested":[108],"three":[110],"patient":[112],"cases":[113],"compared":[115],"recent":[118],"mixed-integer":[120],"EA":[121],"aimed":[124],"at":[125],"restricted":[127],"version":[128],"problem.":[131],"We":[132],"find":[133],"with":[135],"better":[137,186],"solutions":[138],"found":[141],"much":[142,148],"faster,":[143],"making":[144],"our":[145],"proposed":[146],"approach":[147],"more":[149],"realistic":[150],"used":[153,171],"clinical":[155,189],"practice,":[156],"enabling":[158],"new":[159],"insights":[160],"into":[161],"both":[162],"objectives":[170],"automated":[173],"treatment":[174],"planning.":[175],"First":[176],"results":[177],"indicate":[178],"richer":[180],"models":[182],"needed":[184],"match":[187],"preferences.":[190]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":4}],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2018-08-22T00:00:00"}