{"id":"https://openalex.org/W2804405002","doi":"https://doi.org/10.1145/3200921.3200926","title":"Hybrid Simulation of Dynamic Reaction Networks in Multi-Level Models","display_name":"Hybrid Simulation of Dynamic Reaction Networks in Multi-Level Models","publication_year":2018,"publication_date":"2018-05-14","ids":{"openalex":"https://openalex.org/W2804405002","doi":"https://doi.org/10.1145/3200921.3200926","mag":"2804405002"},"language":"en","primary_location":{"id":"doi:10.1145/3200921.3200926","is_oa":false,"landing_page_url":"https://doi.org/10.1145/3200921.3200926","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 2018 ACM SIGSIM Conference on Principles of Advanced Discrete Simulation","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109384221","display_name":"Tobias Helms","orcid":null},"institutions":[{"id":"https://openalex.org/I4665924","display_name":"University of Rostock","ror":"https://ror.org/03zdwsf69","country_code":"DE","type":"education","lineage":["https://openalex.org/I4665924"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Tobias Helms","raw_affiliation_strings":["University of Rostock, Rostock, Germany"],"affiliations":[{"raw_affiliation_string":"University of Rostock, Rostock, Germany","institution_ids":["https://openalex.org/I4665924"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021312368","display_name":"Pia Wilsdorf","orcid":"https://orcid.org/0000-0001-7447-6667"},"institutions":[{"id":"https://openalex.org/I4665924","display_name":"University of Rostock","ror":"https://ror.org/03zdwsf69","country_code":"DE","type":"education","lineage":["https://openalex.org/I4665924"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Pia Wilsdorf","raw_affiliation_strings":["University of Rostock, Rostock, Germany"],"affiliations":[{"raw_affiliation_string":"University of Rostock, Rostock, Germany","institution_ids":["https://openalex.org/I4665924"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5063515034","display_name":"Adelinde M. Uhrmacher","orcid":"https://orcid.org/0000-0001-5256-4682"},"institutions":[{"id":"https://openalex.org/I4665924","display_name":"University of Rostock","ror":"https://ror.org/03zdwsf69","country_code":"DE","type":"education","lineage":["https://openalex.org/I4665924"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Adelinde M. Uhrmacher","raw_affiliation_strings":["University of Rostock, Rostock, Germany"],"affiliations":[{"raw_affiliation_string":"University of Rostock, Rostock, Germany","institution_ids":["https://openalex.org/I4665924"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5109384221"],"corresponding_institution_ids":["https://openalex.org/I4665924"],"apc_list":null,"apc_paid":null,"fwci":0.1838,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.51978385,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":96},"biblio":{"volume":null,"issue":null,"first_page":"133","last_page":"144"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11195","display_name":"Simulation Techniques and Applications","score":0.9975000023841858,"subfield":{"id":"https://openalex.org/subfields/1803","display_name":"Management Science and Operations Research"},"field":{"id":"https://openalex.org/fields/18","display_name":"Decision Sciences"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T11986","display_name":"Scientific Computing and Data Management","score":0.9714999794960022,"subfield":{"id":"https://openalex.org/subfields/1802","display_name":"Information Systems and Management"},"field":{"id":"https://openalex.org/fields/18","display_name":"Decision Sciences"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6453849077224731}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6453849077224731}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1145/3200921.3200926","is_oa":false,"landing_page_url":"https://doi.org/10.1145/3200921.3200926","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 2018 ACM SIGSIM Conference on Principles of Advanced Discrete Simulation","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":1,"referenced_works":["https://openalex.org/W2163493106"],"related_works":["https://openalex.org/W2748952813","https://openalex.org/W2390279801","https://openalex.org/W2358668433","https://openalex.org/W2376932109","https://openalex.org/W2001405890","https://openalex.org/W2382290278","https://openalex.org/W2478288626","https://openalex.org/W4391913857","https://openalex.org/W2350741829","https://openalex.org/W2530322880"],"abstract_inverted_index":{"Methods":[0],"combining":[1,100],"deterministic":[2,101],"and":[3,35,102,152],"stochastic":[4,13,73,103,129],"concepts":[5,104],"present":[6,114],"an":[7,109,115,122],"efficient":[8],"alternative":[9],"to":[10,48,105],"a":[11,96,161],"purely":[12],"treatment":[14],"of":[15,28,38,67,70,84,117,163],"biochemical":[16,22],"models.":[17],"Traditionally,":[18],"those":[19,46],"methods":[20,47],"split":[21],"reaction":[23,58],"networks":[24,59],"into":[25],"one":[26,36,133],"set":[27,37],"slow":[29],"reactions":[30,40,83],"that":[31,41],"is":[32,42,154],"computed":[33,43],"stochastically":[34],"fast":[39],"deterministically.":[44],"Applying":[45],"multi-level":[49,106,144],"models":[50,107],"with":[51,56,160],"dynamic":[52,57],"nestings":[53],"requires":[54],"coping":[55],"changing":[60],"over":[61],"time.":[62],"In":[63,91],"addition,":[64],"in":[65,132,141],"case":[66],"large":[68],"populations":[69],"nested":[71,86],"entities,":[72],"events":[74,130],"can":[75],"still":[76],"decrease":[77],"the":[78,142],"runtime":[79],"performance":[80],"significantly,":[81],"as":[82],"dynamically":[85],"entities":[87],"are":[88],"inherently":[89],"stochastic.":[90],"this":[92,118],"paper,":[93],"we":[94,113],"apply":[95],"hybrid":[97],"simulation":[98,119,134],"algorithm":[99,120,137],"including":[108],"approximation":[110,124],"control.":[111],"Further,":[112],"extension":[116],"applying":[121],"additional":[123],"by":[125],"executing":[126],"multiple":[127],"independent":[128],"simultaneously":[131],"step.":[135],"The":[136],"has":[138],"been":[139],"implemented":[140],"rule-based":[143],"modeling":[145],"language":[146],"ML-Rules.":[147],"Its":[148],"impact":[149],"on":[150,157],"speed":[151],"accuracy":[153],"evaluated":[155],"based":[156],"simulations":[158],"performed":[159],"model":[162],"Dictyostelium":[164],"discoideum":[165],"amoebas.":[166]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}
