{"id":"https://openalex.org/W2804382710","doi":"https://doi.org/10.1145/3196494.3196541","title":"Large-Scale Privacy-Preserving Statistical Computations for Distributed Genome-Wide Association Studies","display_name":"Large-Scale Privacy-Preserving Statistical Computations for Distributed Genome-Wide Association Studies","publication_year":2018,"publication_date":"2018-05-29","ids":{"openalex":"https://openalex.org/W2804382710","doi":"https://doi.org/10.1145/3196494.3196541","mag":"2804382710"},"language":"en","primary_location":{"id":"doi:10.1145/3196494.3196541","is_oa":true,"landing_page_url":"https://doi.org/10.1145/3196494.3196541","pdf_url":"https://dl.acm.org/doi/pdf/10.1145/3196494.3196541","source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 2018 on Asia Conference on Computer and Communications Security","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://dl.acm.org/doi/pdf/10.1145/3196494.3196541","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076958709","display_name":"Oleksandr Tkachenko","orcid":"https://orcid.org/0000-0001-9232-6902"},"institutions":[{"id":"https://openalex.org/I31512782","display_name":"Technical University of Darmstadt","ror":"https://ror.org/05n911h24","country_code":"DE","type":"education","lineage":["https://openalex.org/I31512782"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Oleksandr Tkachenko","raw_affiliation_strings":["TU Darmstadt, Darmstadt, Germany"],"affiliations":[{"raw_affiliation_string":"TU Darmstadt, Darmstadt, Germany","institution_ids":["https://openalex.org/I31512782"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014368618","display_name":"Christian Weinert","orcid":"https://orcid.org/0000-0003-4906-6871"},"institutions":[{"id":"https://openalex.org/I31512782","display_name":"Technical University of Darmstadt","ror":"https://ror.org/05n911h24","country_code":"DE","type":"education","lineage":["https://openalex.org/I31512782"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Christian Weinert","raw_affiliation_strings":["TU Darmstadt, Darmstadt, Germany"],"affiliations":[{"raw_affiliation_string":"TU Darmstadt, Darmstadt, Germany","institution_ids":["https://openalex.org/I31512782"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100724917","display_name":"Thomas Schneider","orcid":"https://orcid.org/0000-0001-8090-1316"},"institutions":[{"id":"https://openalex.org/I31512782","display_name":"Technical University of Darmstadt","ror":"https://ror.org/05n911h24","country_code":"DE","type":"education","lineage":["https://openalex.org/I31512782"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Thomas Schneider","raw_affiliation_strings":["TU Darmstadt, Darmstadt, Germany"],"affiliations":[{"raw_affiliation_string":"TU Darmstadt, Darmstadt, Germany","institution_ids":["https://openalex.org/I31512782"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5063890041","display_name":"Kay Hamacher","orcid":"https://orcid.org/0000-0002-6921-8345"},"institutions":[{"id":"https://openalex.org/I31512782","display_name":"Technical University of Darmstadt","ror":"https://ror.org/05n911h24","country_code":"DE","type":"education","lineage":["https://openalex.org/I31512782"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Kay Hamacher","raw_affiliation_strings":["TU Darmstadt, Darmstadt, Germany"],"affiliations":[{"raw_affiliation_string":"TU Darmstadt, Darmstadt, Germany","institution_ids":["https://openalex.org/I31512782"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5076958709"],"corresponding_institution_ids":["https://openalex.org/I31512782"],"apc_list":null,"apc_paid":null,"fwci":3.0463,"has_fulltext":true,"cited_by_count":29,"citation_normalized_percentile":{"value":0.93148994,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":null,"issue":null,"first_page":"221","last_page":"235"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10764","display_name":"Privacy-Preserving Technologies in Data","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10764","display_name":"Privacy-Preserving Technologies in Data","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10237","display_name":"Cryptography and Data Security","score":0.9966999888420105,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10720","display_name":"Complexity and Algorithms in Graphs","score":0.9824000000953674,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.7478044629096985},{"id":"https://openalex.org/keywords/integer","display_name":"Integer (computer science)","score":0.48698219656944275},{"id":"https://openalex.org/keywords/protocol","display_name":"Protocol (science)","score":0.4493723511695862},{"id":"https://openalex.org/keywords/information-privacy","display_name":"Information privacy","score":0.4424690008163452},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.40611881017684937},{"id":"https://openalex.org/keywords/theoretical-computer-science","display_name":"Theoretical computer science","score":0.33795422315597534},{"id":"https://openalex.org/keywords/computer-security","display_name":"Computer security","score":0.17998066544532776}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.7478044629096985},{"id":"https://openalex.org/C97137487","wikidata":"https://www.wikidata.org/wiki/Q729138","display_name":"Integer (computer science)","level":2,"score":0.48698219656944275},{"id":"https://openalex.org/C2780385302","wikidata":"https://www.wikidata.org/wiki/Q367158","display_name":"Protocol (science)","level":3,"score":0.4493723511695862},{"id":"https://openalex.org/C123201435","wikidata":"https://www.wikidata.org/wiki/Q456632","display_name":"Information privacy","level":2,"score":0.4424690008163452},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.40611881017684937},{"id":"https://openalex.org/C80444323","wikidata":"https://www.wikidata.org/wiki/Q2878974","display_name":"Theoretical computer science","level":1,"score":0.33795422315597534},{"id":"https://openalex.org/C38652104","wikidata":"https://www.wikidata.org/wiki/Q3510521","display_name":"Computer security","level":1,"score":0.17998066544532776},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1145/3196494.3196541","is_oa":true,"landing_page_url":"https://doi.org/10.1145/3196494.3196541","pdf_url":"https://dl.acm.org/doi/pdf/10.1145/3196494.3196541","source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 2018 on Asia Conference on Computer and Communications Security","raw_type":"proceedings-article"},{"id":"pmh:oai:tubiblio.ulb.tu-darmstadt.de:101504","is_oa":false,"landing_page_url":"http://tubiblio.ulb.tu-darmstadt.de/101504/","pdf_url":null,"source":{"id":"https://openalex.org/S4377196390","display_name":"TUbilio (Technical University of Darmstadt)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I31512782","host_organization_name":"Technische Universit\u00e4t Darmstadt","host_organization_lineage":["https://openalex.org/I31512782"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Konferenzver\u00f6ffentlichung"},{"id":"pmh:oai:tubiblio.ulb.tu-darmstadt.de:106369","is_oa":false,"landing_page_url":"http://tubiblio.ulb.tu-darmstadt.de/106369/","pdf_url":null,"source":{"id":"https://openalex.org/S4377196390","display_name":"TUbilio (Technical University of Darmstadt)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I31512782","host_organization_name":"Technische Universit\u00e4t Darmstadt","host_organization_lineage":["https://openalex.org/I31512782"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Masterarbeit"}],"best_oa_location":{"id":"doi:10.1145/3196494.3196541","is_oa":true,"landing_page_url":"https://doi.org/10.1145/3196494.3196541","pdf_url":"https://dl.acm.org/doi/pdf/10.1145/3196494.3196541","source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 2018 on Asia Conference on Computer and Communications Security","raw_type":"proceedings-article"},"sustainable_development_goals":[{"score":0.6399999856948853,"id":"https://metadata.un.org/sdg/16","display_name":"Peace, Justice and strong institutions"}],"awards":[{"id":"https://openalex.org/G352791218","display_name":null,"funder_award_id":"(BMBF)","funder_id":"https://openalex.org/F4320321114","funder_display_name":"Bundesministerium f\u00fcr Bildung und Forschung"},{"id":"https://openalex.org/G4956763309","display_name":null,"funder_award_id":"CRISP","funder_id":"https://openalex.org/F4320321114","funder_display_name":"Bundesministerium f\u00fcr Bildung und Forschung"},{"id":"https://openalex.org/G6450601438","display_name":null,"funder_award_id":"project E4","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G8482022808","display_name":null,"funder_award_id":"CRC 1119","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"}],"funders":[{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"},{"id":"https://openalex.org/F4320321114","display_name":"Bundesministerium f\u00fcr Bildung und Forschung","ror":"https://ror.org/04pz7b180"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2804382710.pdf","grobid_xml":"https://content.openalex.org/works/W2804382710.grobid-xml"},"referenced_works_count":68,"referenced_works":["https://openalex.org/W112435724","https://openalex.org/W121345474","https://openalex.org/W173953576","https://openalex.org/W287743910","https://openalex.org/W1485800369","https://openalex.org/W1533179050","https://openalex.org/W1554946929","https://openalex.org/W1565207014","https://openalex.org/W1733404337","https://openalex.org/W1795113477","https://openalex.org/W1826277484","https://openalex.org/W1873763122","https://openalex.org/W1969009977","https://openalex.org/W1978124765","https://openalex.org/W1992735538","https://openalex.org/W1996068512","https://openalex.org/W1997708663","https://openalex.org/W2001084165","https://openalex.org/W2007233204","https://openalex.org/W2019891719","https://openalex.org/W2027471022","https://openalex.org/W2034165041","https://openalex.org/W2040228409","https://openalex.org/W2040807773","https://openalex.org/W2056489112","https://openalex.org/W2058636961","https://openalex.org/W2060302414","https://openalex.org/W2063724771","https://openalex.org/W2076000582","https://openalex.org/W2079854622","https://openalex.org/W2081256122","https://openalex.org/W2087249453","https://openalex.org/W2088492763","https://openalex.org/W2101659679","https://openalex.org/W2119422255","https://openalex.org/W2124940696","https://openalex.org/W2127555295","https://openalex.org/W2130671266","https://openalex.org/W2134167315","https://openalex.org/W2135297873","https://openalex.org/W2141481372","https://openalex.org/W2156400232","https://openalex.org/W2159024459","https://openalex.org/W2166106997","https://openalex.org/W2198130350","https://openalex.org/W2201294065","https://openalex.org/W2211774783","https://openalex.org/W2218239923","https://openalex.org/W2218329981","https://openalex.org/W2227148039","https://openalex.org/W2247376876","https://openalex.org/W2256458751","https://openalex.org/W2258795902","https://openalex.org/W2304501949","https://openalex.org/W2398448180","https://openalex.org/W2461759357","https://openalex.org/W2515815450","https://openalex.org/W2539273492","https://openalex.org/W2543549542","https://openalex.org/W2577421826","https://openalex.org/W2605105376","https://openalex.org/W2621320758","https://openalex.org/W2680102885","https://openalex.org/W2768204244","https://openalex.org/W2794686063","https://openalex.org/W2990399857","https://openalex.org/W3028867652","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W1901944325","https://openalex.org/W2052299349","https://openalex.org/W4297728441","https://openalex.org/W2187824534","https://openalex.org/W2148720069","https://openalex.org/W2794524342","https://openalex.org/W2443844466","https://openalex.org/W2999797892","https://openalex.org/W2387965307","https://openalex.org/W2766088533"],"abstract_inverted_index":{"We":[0,229],"present":[1],"privacy-preserving":[2],"solutions":[3,38],"for":[4,27,39,61,156,168,174],"Genome-Wide":[5],"Association":[6],"Studies":[7],"(GWAS)":[8],"based":[9],"on":[10,30],"Secure":[11],"Multi-Party":[12],"Computation":[13],"(SMPC).":[14],"Using":[15],"SMPC,":[16],"we":[17,55,100,121,151,179],"protect":[18],"the":[19,62,69,104,123,132,157,203,221],"privacy":[20],"of":[21,50,103,126,139,147,166,206,220,237,241],"patients":[22],"when":[23],"medical":[24],"institutes":[25],"collaborate":[26],"computing":[28],"statistics":[29],"genomic":[31],"data":[32,193],"in":[33,68,79,97,112,233],"a":[34,80],"distributed":[35,81],"fashion.":[36],"Previous":[37],"this":[40],"task":[41],"lack":[42],"efficiency":[43,219],"and/or":[44],"use":[45,102,162],"inadequate":[46],"algorithms":[47,60],"that":[48,93,161],"are":[49],"limited":[51],"practical":[52],"value.":[53],"Concretely,":[54],"optimize":[56],"and":[57,66,76,130,159,213,239],"implement":[58],"multiple":[59,195],"\u03c7^2":[63,222],"$-,":[64],"G-,":[65],"P-test":[67],"ABY":[70,113,127],"framework":[71],"(Demmler":[72,114],"et":[73,115,141,208],"al.,":[74,116],"NDSS\u00bb15)":[75],"evaluate":[77],"them":[78],"GWAS":[82],"scenario.":[83],"Statistical":[84],"tests":[85],"generally":[86],"require":[87],"advanced":[88],"mathematical":[89],"operations.":[90],"For":[91],"operations":[92],"cannot":[94],"be":[95,146],"calculated":[96],"integer":[98,133],"arithmetic,":[99],"make":[101],"existing":[105],"IEEE":[106],"754":[107],"floating":[108,135],"point":[109,136],"arithmetic":[110],"implementation":[111],"CCS\u00bb15).":[117],"To":[118],"improve":[119],"performance,":[120],"extend":[122],"mixed-protocol":[124],"capabilities":[125],"by":[128,224],"optimizing":[129],"implementing":[131],"to":[134,202,226],"conversion":[137],"protocols":[138],"Aliasgari":[140],"al.\\":[142,209],"(NDSS\u00bb13),":[143],"which":[144],"may":[145],"independent":[148],"interest.":[149],"Furthermore,":[150],"consider":[152,180],"extended":[153],"contingency":[154],"tables":[155],"\u03c7^2$-":[158],"G-test":[160],"codeword":[163],"counts":[164,167],"instead":[165],"only":[169],"two":[170,185],"alleles,":[171],"thereby":[172],"allowing":[173],"advanced,":[175],"realistic":[176],"analyses.":[177],"Finally,":[178],"an":[181,216],"outsourcing":[182],"scenario":[183],"where":[184],"non-colluding":[186],"semi-trusted":[187],"third":[188],"parties":[189],"process":[190],"secret-shared":[191],"input":[192],"from":[194],"institutes.":[196,243],"Our":[197],"extensive":[198],"evaluation":[199],"shows,":[200],"compared":[201],"prior":[204],"art":[205],"Constable":[207],"(BMC":[210],"Medical":[211],"Informatics":[212],"Decision":[214],"Making\u00bb15),":[215],"improved":[217],"run-time":[218],"$-test":[223],"up":[225],"factor":[227],"37x.":[228],"additionally":[230],"demonstrate":[231],"practicality":[232],"scenarios":[234],"with":[235],"millions":[236],"participants":[238],"hundreds":[240],"collaborating":[242]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":1}],"updated_date":"2026-04-10T15:06:20.359241","created_date":"2025-10-10T00:00:00"}