{"id":"https://openalex.org/W2787402052","doi":"https://doi.org/10.1145/3175587.3175595","title":"An Exploration of Epitope-Based Vaccine Design with Broad Protection Against Influenza A (H3) Viral Strains Using Computational Biology","display_name":"An Exploration of Epitope-Based Vaccine Design with Broad Protection Against Influenza A (H3) Viral Strains Using Computational Biology","publication_year":2017,"publication_date":"2017-12-08","ids":{"openalex":"https://openalex.org/W2787402052","doi":"https://doi.org/10.1145/3175587.3175595","mag":"2787402052"},"language":"en","primary_location":{"id":"doi:10.1145/3175587.3175595","is_oa":false,"landing_page_url":"https://doi.org/10.1145/3175587.3175595","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the International Conference on Bioinformatics Research and Applications 2017","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074216071","display_name":"Yijun Zou","orcid":null},"institutions":[{"id":"https://openalex.org/I191208505","display_name":"Xiamen University","ror":"https://ror.org/00mcjh785","country_code":"CN","type":"education","lineage":["https://openalex.org/I191208505"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yijun Zou","raw_affiliation_strings":["National Institute of Diagnostics and Vaccine Development in Infectious Diseases, Xiamen University, Xiamen, Fujian, China"],"affiliations":[{"raw_affiliation_string":"National Institute of Diagnostics and Vaccine Development in Infectious Diseases, Xiamen University, Xiamen, Fujian, China","institution_ids":["https://openalex.org/I191208505"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5074216071"],"corresponding_institution_ids":["https://openalex.org/I191208505"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.24608962,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"66","last_page":"70"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10167","display_name":"Influenza Virus Research Studies","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10167","display_name":"Influenza Virus Research Studies","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.9987999796867371,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/epitope","display_name":"Epitope","score":0.9184348583221436},{"id":"https://openalex.org/keywords/virology","display_name":"Virology","score":0.7763507962226868},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5303659439086914},{"id":"https://openalex.org/keywords/antibody","display_name":"Antibody","score":0.4757351875305176},{"id":"https://openalex.org/keywords/linear-epitope","display_name":"Linear epitope","score":0.46048080921173096},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.43103495240211487},{"id":"https://openalex.org/keywords/antigen","display_name":"Antigen","score":0.42053523659706116},{"id":"https://openalex.org/keywords/epitope-mapping","display_name":"Epitope mapping","score":0.41802671551704407},{"id":"https://openalex.org/keywords/immunology","display_name":"Immunology","score":0.21148458123207092}],"concepts":[{"id":"https://openalex.org/C195616568","wikidata":"https://www.wikidata.org/wiki/Q128711","display_name":"Epitope","level":3,"score":0.9184348583221436},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.7763507962226868},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5303659439086914},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.4757351875305176},{"id":"https://openalex.org/C78598654","wikidata":"https://www.wikidata.org/wiki/Q17140316","display_name":"Linear epitope","level":4,"score":0.46048080921173096},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.43103495240211487},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.42053523659706116},{"id":"https://openalex.org/C2781241564","wikidata":"https://www.wikidata.org/wiki/Q1347450","display_name":"Epitope mapping","level":4,"score":0.41802671551704407},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.21148458123207092}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1145/3175587.3175595","is_oa":false,"landing_page_url":"https://doi.org/10.1145/3175587.3175595","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the International Conference on Bioinformatics Research and Applications 2017","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.7300000190734863,"id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":8,"referenced_works":["https://openalex.org/W1981214256","https://openalex.org/W2020398539","https://openalex.org/W2034694458","https://openalex.org/W2106088492","https://openalex.org/W2112297490","https://openalex.org/W2119131075","https://openalex.org/W2163413324","https://openalex.org/W4211121147"],"related_works":["https://openalex.org/W3189724180","https://openalex.org/W2062700146","https://openalex.org/W4241031629","https://openalex.org/W4214932605","https://openalex.org/W2471846512","https://openalex.org/W2019166448","https://openalex.org/W2896840187","https://openalex.org/W1988043950","https://openalex.org/W2003373552","https://openalex.org/W2031358662"],"abstract_inverted_index":{"Influenza":[0],"is":[1,133],"a":[2],"highly":[3],"contagious":[4],"disease":[5],"due":[6],"to":[7],"its":[8],"frequently":[9],"mutating":[10],"viral":[11],"Hemaglutinin":[12],"(HA)":[13],"and":[14,95,107],"Neuraminidase":[15],"(NA)":[16],"proteins.[1]":[17],"WHO":[18],"reports":[19],"that":[20,66],"250,000-500,000":[21],"people":[22],"worldwide":[23],"die":[24],"of":[25,46,120],"seasonal":[26],"influenza":[27,39,49],"every":[28],"year.[2]This":[29],"necessitates":[30],"the":[31,44,59,117,136],"search":[32],"for":[33],"universal":[34],"vaccines,":[35],"or":[36],"broadly":[37,62],"protective":[38],"vaccines.":[40],"This":[41],"research":[42],"explored":[43],"feasibility":[45],"epitope-based":[47,121],"broad-spectrum":[48,122],"H3":[50,69],"vaccine":[51,123],"design":[52,124],"based":[53],"on":[54],"common":[55],"linear":[56],"epitopes.":[57],"Given":[58],"previously":[60],"prepared":[61],"neutralizing":[63],"antibody":[64],"4E3":[65],"recognizes":[67],"multiple":[68],"strains":[70],"by":[71],"NIDVD,":[72],"three":[73,83],"epitope":[74],"candidates":[75],"were":[76,85],"selected":[77],"using":[78,90,109,125,130],"computer-simulated":[79],"antigen-antibody":[80],"docking.":[81],"The":[82,112],"epitopes":[84],"then":[86],"evaluated":[87,108],"in":[88],"vitro":[89],"molecular":[91],"cloning,":[92],"protein":[93],"expression":[94],"immunoassay":[96],"technologies.":[97],"EPI-3":[98],"(amino":[99],"acid":[100],"sequence:":[101],"WGVHHPVTDNDQIFLYAQA)":[102],"was":[103],"successfully":[104],"cloned,":[105],"expressed,":[106],"Western":[110],"Blot.":[111],"positive":[113],"WB":[114],"result":[115],"proved":[116],"methodological":[118],"validity":[119],"computational":[126],"biology.":[127],"Further":[128],"work":[129],"this":[131],"method":[132],"expected":[134],"from":[135],"scientific":[137],"community.":[138]},"counts_by_year":[],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}
