{"id":"https://openalex.org/W2749419202","doi":"https://doi.org/10.1145/3107411.3108206","title":"Notch Signaling Plays an Important Role in mTEC Specification during Fetal Thymus Development","display_name":"Notch Signaling Plays an Important Role in mTEC Specification during Fetal Thymus Development","publication_year":2017,"publication_date":"2017-08-20","ids":{"openalex":"https://openalex.org/W2749419202","doi":"https://doi.org/10.1145/3107411.3108206","mag":"2749419202"},"language":"en","primary_location":{"id":"doi:10.1145/3107411.3108206","is_oa":false,"landing_page_url":"https://doi.org/10.1145/3107411.3108206","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 8th ACM International Conference on Bioinformatics, Computational Biology,and Health Informatics","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100407515","display_name":"Dong Liu","orcid":"https://orcid.org/0000-0003-2043-5346"},"institutions":[{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Dong Liu","raw_affiliation_strings":["University of Edinburgh, Edinburgh, United Kingdom"],"affiliations":[{"raw_affiliation_string":"University of Edinburgh, Edinburgh, United Kingdom","institution_ids":["https://openalex.org/I98677209"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046020733","display_name":"Anastasia I. Kousa","orcid":"https://orcid.org/0000-0002-4550-0389"},"institutions":[{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Anastasia I. Kousa","raw_affiliation_strings":["University of Edinburgh, Edinburgh, United Kingdom"],"affiliations":[{"raw_affiliation_string":"University of Edinburgh, Edinburgh, United Kingdom","institution_ids":["https://openalex.org/I98677209"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028138093","display_name":"Simon R. Tomlinson","orcid":"https://orcid.org/0000-0003-3465-9156"},"institutions":[{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Simon R. Tomlinson","raw_affiliation_strings":["University of Edinburgh, Edinburgh, United Kingdom"],"affiliations":[{"raw_affiliation_string":"University of Edinburgh, Edinburgh, United Kingdom","institution_ids":["https://openalex.org/I98677209"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5011641448","display_name":"Clare Blackburn","orcid":"https://orcid.org/0000-0002-6326-640X"},"institutions":[{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"C. Clare Blackburn","raw_affiliation_strings":["University of Edinburgh, Edinburgh, United Kingdom"],"affiliations":[{"raw_affiliation_string":"University of Edinburgh, Edinburgh, United Kingdom","institution_ids":["https://openalex.org/I98677209"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5100407515"],"corresponding_institution_ids":["https://openalex.org/I98677209"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.09192398,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"598","last_page":"598"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12140","display_name":"Renal and related cancers","score":0.7358999848365784,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12140","display_name":"Renal and related cancers","score":0.7358999848365784,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10731","display_name":"Educational Games and Gamification","score":0.6758999824523926,"subfield":{"id":"https://openalex.org/subfields/3204","display_name":"Developmental and Educational Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T11141","display_name":"Childhood Cancer Survivors' Quality of Life","score":0.6565999984741211,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/notch-signaling-pathway","display_name":"Notch signaling pathway","score":0.7228223085403442},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.6760115623474121},{"id":"https://openalex.org/keywords/transcription-factor","display_name":"Transcription factor","score":0.616823136806488},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.6160814762115479},{"id":"https://openalex.org/keywords/tec","display_name":"TEC","score":0.5813372135162354},{"id":"https://openalex.org/keywords/progenitor","display_name":"Progenitor","score":0.5242208242416382},{"id":"https://openalex.org/keywords/progenitor-cell","display_name":"Progenitor cell","score":0.5128198266029358},{"id":"https://openalex.org/keywords/immune-system","display_name":"Immune system","score":0.4601353704929352},{"id":"https://openalex.org/keywords/cellular-differentiation","display_name":"Cellular differentiation","score":0.42402973771095276},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"Signal transduction","score":0.4014572501182556},{"id":"https://openalex.org/keywords/immunology","display_name":"Immunology","score":0.36863118410110474},{"id":"https://openalex.org/keywords/stem-cell","display_name":"Stem cell","score":0.3373056650161743},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.16542017459869385},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.1521771252155304}],"concepts":[{"id":"https://openalex.org/C161879069","wikidata":"https://www.wikidata.org/wiki/Q904082","display_name":"Notch signaling pathway","level":3,"score":0.7228223085403442},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6760115623474121},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.616823136806488},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6160814762115479},{"id":"https://openalex.org/C176379880","wikidata":"https://www.wikidata.org/wiki/Q18031939","display_name":"TEC","level":3,"score":0.5813372135162354},{"id":"https://openalex.org/C15729860","wikidata":"https://www.wikidata.org/wiki/Q2329919","display_name":"Progenitor","level":4,"score":0.5242208242416382},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.5128198266029358},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4601353704929352},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.42402973771095276},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4014572501182556},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.36863118410110474},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.3373056650161743},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.16542017459869385},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1521771252155304},{"id":"https://openalex.org/C1276947","wikidata":"https://www.wikidata.org/wiki/Q333","display_name":"Astronomy","level":1,"score":0.0},{"id":"https://openalex.org/C116403925","wikidata":"https://www.wikidata.org/wiki/Q162219","display_name":"Ionosphere","level":2,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1145/3107411.3108206","is_oa":false,"landing_page_url":"https://doi.org/10.1145/3107411.3108206","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 8th ACM International Conference on Bioinformatics, Computational Biology,and Health Informatics","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4393375503","https://openalex.org/W2084533426","https://openalex.org/W2043337239","https://openalex.org/W2019260118","https://openalex.org/W2026748421","https://openalex.org/W2578732716","https://openalex.org/W2057870358","https://openalex.org/W2889893284","https://openalex.org/W4392186812","https://openalex.org/W2762443209"],"abstract_inverted_index":{"Thymic":[0],"epithelial":[1,40],"cells":[2],"(TECs)":[3],"are":[4,21,32],"a":[5,27,37],"vital":[6],"element":[7],"of":[8,26,75,101,107],"the":[9,47,62,67,76,98,102,108],"thymic":[10,39,109],"microenvironments":[11],"that":[12,44],"direct":[13],"T":[14],"cell":[15,42],"differentiation":[16,58],"and":[17,20,52,73,78,105],"repertoire":[18],"selection,":[19],"thus":[22],"indispensable":[23],"for":[24,117],"development":[25,104],"functional":[28],"immune":[29],"system.":[30],"TECs":[31],"thought":[33],"to":[34,96],"derive":[35],"from":[36],"bipotent":[38],"progenitor":[41],"(TEPC)":[43],"differentiates":[45],"into":[46],"functionally":[48],"distinct":[49],"cortical":[50],"(c)":[51],"medullary":[53],"(m)":[54],"TEC":[55,57,71],"sub-lineages.":[56],"is":[59,81],"orchestrated":[60],"by":[61],"transcription":[63],"factor":[64],"FOXN1.":[65],"However,":[66],"precise":[68],"mechanisms":[69],"regulating":[70],"differentiation,":[72],"divergence":[74],"cTEC":[77],"mTEC":[79,122],"sub-lineages":[80],"not":[82],"yet":[83],"understood.":[84],"Here,":[85],"we":[86],"have":[87],"used":[88],"bioinformatics":[89],"analysis":[90],"in":[91,121],"conjunction":[92],"with":[93],"experimental":[94],"validation":[95],"investigate":[97],"molecular":[99],"regulation":[100],"early":[103],"specification":[106,123],"epithelium.":[110],"Our":[111],"data":[112],"demonstrate":[113],"an":[114],"important":[115],"role":[116],"Notch":[118],"signaling":[119],"pathway":[120],"during":[124],"fetal":[125],"thymus":[126],"development.":[127]},"counts_by_year":[],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}
