{"id":"https://openalex.org/W2748673233","doi":"https://doi.org/10.1145/3107411.3108205","title":"Streptomyces Clavuligerus Constraint-Based Modeling and Gene Expression Analysis for Clavulanic Acid Production","display_name":"Streptomyces Clavuligerus Constraint-Based Modeling and Gene Expression Analysis for Clavulanic Acid Production","publication_year":2017,"publication_date":"2017-08-20","ids":{"openalex":"https://openalex.org/W2748673233","doi":"https://doi.org/10.1145/3107411.3108205","mag":"2748673233"},"language":"en","primary_location":{"id":"doi:10.1145/3107411.3108205","is_oa":false,"landing_page_url":"https://doi.org/10.1145/3107411.3108205","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 8th ACM International Conference on Bioinformatics, Computational Biology,and Health Informatics","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001909546","display_name":"Le\u00f3n F. Toro","orcid":"https://orcid.org/0000-0002-3074-396X"},"institutions":[{"id":"https://openalex.org/I35961687","display_name":"Universidad de Antioquia","ror":"https://ror.org/03bp5hc83","country_code":"CO","type":"education","lineage":["https://openalex.org/I35961687"]}],"countries":["CO"],"is_corresponding":true,"raw_author_name":"Le\u00f3n F. Toro","raw_affiliation_strings":["Universidad de Antioquia, Medell\u00edn, Colombia"],"affiliations":[{"raw_affiliation_string":"Universidad de Antioquia, Medell\u00edn, Colombia","institution_ids":["https://openalex.org/I35961687"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021551091","display_name":"Laura Pinilla-Mendoza","orcid":null},"institutions":[{"id":"https://openalex.org/I35961687","display_name":"Universidad de Antioquia","ror":"https://ror.org/03bp5hc83","country_code":"CO","type":"education","lineage":["https://openalex.org/I35961687"]}],"countries":["CO"],"is_corresponding":false,"raw_author_name":"Laura Pinilla-Mendoza","raw_affiliation_strings":["Universidad de Antioquia, Medell\u00edn, Colombia"],"affiliations":[{"raw_affiliation_string":"Universidad de Antioquia, Medell\u00edn, Colombia","institution_ids":["https://openalex.org/I35961687"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021491364","display_name":"Rigoberto R\u00edos\u2010Estepa","orcid":"https://orcid.org/0000-0002-3287-7056"},"institutions":[{"id":"https://openalex.org/I35961687","display_name":"Universidad de Antioquia","ror":"https://ror.org/03bp5hc83","country_code":"CO","type":"education","lineage":["https://openalex.org/I35961687"]}],"countries":["CO"],"is_corresponding":false,"raw_author_name":"Rigoberto R\u00edos-Estepa","raw_affiliation_strings":["Universidad de Antioquia, Medell\u00edn, Colombia"],"affiliations":[{"raw_affiliation_string":"Universidad de Antioquia, Medell\u00edn, Colombia","institution_ids":["https://openalex.org/I35961687"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5001909546"],"corresponding_institution_ids":["https://openalex.org/I35961687"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.09086345,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"198","issue":null,"first_page":"597","last_page":"597"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10171","display_name":"Biofuel production and bioconversion","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/streptomyces-clavuligerus","display_name":"Streptomyces clavuligerus","score":0.9880998730659485},{"id":"https://openalex.org/keywords/clavulanic-acid","display_name":"Clavulanic acid","score":0.684245228767395},{"id":"https://openalex.org/keywords/secondary-metabolism","display_name":"Secondary metabolism","score":0.625757098197937},{"id":"https://openalex.org/keywords/transcriptome","display_name":"Transcriptome","score":0.5437094569206238},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5339231491088867},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.5148014426231384},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.4969387352466583},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.48281630873680115},{"id":"https://openalex.org/keywords/streptomyces","display_name":"Streptomyces","score":0.46270090341567993},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.4582061767578125},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"Gene expression profiling","score":0.4199508726596832},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.34039801359176636},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.29631507396698},{"id":"https://openalex.org/keywords/bacteria","display_name":"Bacteria","score":0.22370263934135437},{"id":"https://openalex.org/keywords/biosynthesis","display_name":"Biosynthesis","score":0.20350807905197144}],"concepts":[{"id":"https://openalex.org/C2777211131","wikidata":"https://www.wikidata.org/wiki/Q7623381","display_name":"Streptomyces clavuligerus","level":5,"score":0.9880998730659485},{"id":"https://openalex.org/C2779454058","wikidata":"https://www.wikidata.org/wiki/Q415709","display_name":"Clavulanic acid","level":4,"score":0.684245228767395},{"id":"https://openalex.org/C2777157883","wikidata":"https://www.wikidata.org/wiki/Q3360529","display_name":"Secondary metabolism","level":4,"score":0.625757098197937},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.5437094569206238},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5339231491088867},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5148014426231384},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4969387352466583},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.48281630873680115},{"id":"https://openalex.org/C2779920670","wikidata":"https://www.wikidata.org/wiki/Q1144013","display_name":"Streptomyces","level":3,"score":0.46270090341567993},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4582061767578125},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.4199508726596832},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.34039801359176636},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.29631507396698},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.22370263934135437},{"id":"https://openalex.org/C553450214","wikidata":"https://www.wikidata.org/wiki/Q851162","display_name":"Biosynthesis","level":3,"score":0.20350807905197144},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.0},{"id":"https://openalex.org/C2779708577","wikidata":"https://www.wikidata.org/wiki/Q201928","display_name":"Amoxicillin","level":3,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1145/3107411.3108205","is_oa":false,"landing_page_url":"https://doi.org/10.1145/3107411.3108205","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 8th ACM International Conference on Bioinformatics, Computational Biology,and Health Informatics","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":2,"referenced_works":["https://openalex.org/W2047029681","https://openalex.org/W2065104071"],"related_works":["https://openalex.org/W2380098081","https://openalex.org/W2058560071","https://openalex.org/W2338595164","https://openalex.org/W2040417624","https://openalex.org/W1966376096","https://openalex.org/W2921456107","https://openalex.org/W2123815603","https://openalex.org/W2277643962","https://openalex.org/W2181955749","https://openalex.org/W2127752772"],"abstract_inverted_index":{"In":[0,75],"this":[1],"work,":[2],"we":[3],"use":[4],"a":[5,13,64],"high-resolution":[6],"transcriptome":[7],"of":[8],"S.":[9],"clavuligerus":[10],"cultured":[11],"on":[12,43],"chemically":[14],"defined":[15],"medium":[16],"and":[17,73],"the":[18,34,57,77],"corresponding":[19,58],"measured":[20],"metabolic":[21,32,36],"fluxes":[22,50,82],"as":[23,90],"experimental":[24],"constraints":[25],"to":[26,39,52,68],"identify":[27],"through":[28],"an":[29],"expanded":[30],"genome-scale":[31],"model":[33],"different":[35],"process":[37],"associated":[38,62],"primary/secondary":[40],"metabolism":[41,95],"based":[42],"available":[44],"omics":[45],"integration":[46],"algorithms.":[47],"The":[48],"predicted":[49],"showed":[51],"be":[53],"in":[54,80,99],"agreement":[55],"with":[56,84],"gene":[59],"expression":[60],"data":[61],"providing":[63],"detailed":[65],"interpretation":[66],"compared":[67],"traditional":[69],"constrained-based":[70],"methods":[71],"(FBA":[72],"pFBA).":[74],"general,":[76],"observed":[78],"patterns":[79],"intracellular":[81],"coincided":[83],"reactions":[85],"that":[86],"have":[87],"been":[88],"identified":[89],"important":[91],"precursors":[92],"for":[93],"secondary":[94],"mainly":[96],"those":[97],"involved":[98],"clavulanic":[100],"acid":[101],"synthesis.":[102]},"counts_by_year":[],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}
