{"id":"https://openalex.org/W2749578772","doi":"https://doi.org/10.1145/3107411.3107472","title":"Predictive and Comparative Network Analysis of the Gut Microbiota in Type 2 Diabetes","display_name":"Predictive and Comparative Network Analysis of the Gut Microbiota in Type 2 Diabetes","publication_year":2017,"publication_date":"2017-08-20","ids":{"openalex":"https://openalex.org/W2749578772","doi":"https://doi.org/10.1145/3107411.3107472","mag":"2749578772"},"language":"en","primary_location":{"id":"doi:10.1145/3107411.3107472","is_oa":false,"landing_page_url":"https://doi.org/10.1145/3107411.3107472","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 8th ACM International Conference on Bioinformatics, Computational Biology,and Health Informatics","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052114281","display_name":"Mostafa Abbas","orcid":"https://orcid.org/0000-0001-6781-5384"},"institutions":[{"id":"https://openalex.org/I4210138380","display_name":"Qatar Cardiovascular Research Center","ror":"https://ror.org/038vyt185","country_code":"QA","type":"healthcare","lineage":["https://openalex.org/I4210138380"]}],"countries":["QA"],"is_corresponding":true,"raw_author_name":"Mostafa Abbas","raw_affiliation_strings":["Qatar Computing Research Institute (QCRI), Doha, Qatar"],"affiliations":[{"raw_affiliation_string":"Qatar Computing Research Institute (QCRI), Doha, Qatar","institution_ids":["https://openalex.org/I4210138380"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5079233454","display_name":"Yasser EL\u2010Manzalawy","orcid":"https://orcid.org/0000-0002-4681-7994"},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yasser EL-Manzalawy","raw_affiliation_strings":["Pennsylvania State University, University Park, PA, USA"],"affiliations":[{"raw_affiliation_string":"Pennsylvania State University, University Park, PA, USA","institution_ids":["https://openalex.org/I130769515"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5052114281"],"corresponding_institution_ids":["https://openalex.org/I4210138380"],"apc_list":null,"apc_paid":null,"fwci":0.2127,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.5408666,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":96},"biblio":{"volume":null,"issue":null,"first_page":"313","last_page":"320"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.998199999332428,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.9878000020980835,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/metagenomics","display_name":"Metagenomics","score":0.9051271677017212},{"id":"https://openalex.org/keywords/profiling","display_name":"Profiling (computer programming)","score":0.6930022239685059},{"id":"https://openalex.org/keywords/microbiome","display_name":"Microbiome","score":0.6031265258789062},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5818185210227966},{"id":"https://openalex.org/keywords/human-microbiome-project","display_name":"Human Microbiome Project","score":0.5602366924285889},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5039610266685486},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4886613190174103},{"id":"https://openalex.org/keywords/network-analysis","display_name":"Network analysis","score":0.48415929079055786},{"id":"https://openalex.org/keywords/taxonomy","display_name":"Taxonomy (biology)","score":0.423062264919281},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.3332541882991791},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.32257747650146484},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.32072699069976807},{"id":"https://openalex.org/keywords/human-microbiome","display_name":"Human microbiome","score":0.2711073160171509},{"id":"https://openalex.org/keywords/ecology","display_name":"Ecology","score":0.20327937602996826},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.10721215605735779},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.09910422563552856},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.09727305173873901}],"concepts":[{"id":"https://openalex.org/C15151743","wikidata":"https://www.wikidata.org/wiki/Q903778","display_name":"Metagenomics","level":3,"score":0.9051271677017212},{"id":"https://openalex.org/C187191949","wikidata":"https://www.wikidata.org/wiki/Q1138496","display_name":"Profiling (computer programming)","level":2,"score":0.6930022239685059},{"id":"https://openalex.org/C143121216","wikidata":"https://www.wikidata.org/wiki/Q1330402","display_name":"Microbiome","level":2,"score":0.6031265258789062},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5818185210227966},{"id":"https://openalex.org/C190944805","wikidata":"https://www.wikidata.org/wiki/Q3922751","display_name":"Human Microbiome Project","level":4,"score":0.5602366924285889},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5039610266685486},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4886613190174103},{"id":"https://openalex.org/C32946077","wikidata":"https://www.wikidata.org/wiki/Q618079","display_name":"Network analysis","level":2,"score":0.48415929079055786},{"id":"https://openalex.org/C58642233","wikidata":"https://www.wikidata.org/wiki/Q8269924","display_name":"Taxonomy (biology)","level":2,"score":0.423062264919281},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.3332541882991791},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.32257747650146484},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.32072699069976807},{"id":"https://openalex.org/C91478284","wikidata":"https://www.wikidata.org/wiki/Q6623796","display_name":"Human microbiome","level":3,"score":0.2711073160171509},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.20327937602996826},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10721215605735779},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.09910422563552856},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.09727305173873901},{"id":"https://openalex.org/C119599485","wikidata":"https://www.wikidata.org/wiki/Q43035","display_name":"Electrical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1145/3107411.3107472","is_oa":false,"landing_page_url":"https://doi.org/10.1145/3107411.3107472","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 8th ACM International Conference on Bioinformatics, Computational Biology,and Health Informatics","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":52,"referenced_works":["https://openalex.org/W1596324102","https://openalex.org/W1703384511","https://openalex.org/W1852605861","https://openalex.org/W1910481555","https://openalex.org/W1971061059","https://openalex.org/W1981599889","https://openalex.org/W1988925586","https://openalex.org/W1995962575","https://openalex.org/W2033829415","https://openalex.org/W2035837169","https://openalex.org/W2036509718","https://openalex.org/W2071841602","https://openalex.org/W2072970694","https://openalex.org/W2073332363","https://openalex.org/W2100647041","https://openalex.org/W2106393550","https://openalex.org/W2107432340","https://openalex.org/W2116846792","https://openalex.org/W2120358246","https://openalex.org/W2123830992","https://openalex.org/W2124351063","https://openalex.org/W2127048411","https://openalex.org/W2133290123","https://openalex.org/W2135989088","https://openalex.org/W2136482257","https://openalex.org/W2136850043","https://openalex.org/W2138857742","https://openalex.org/W2143104527","https://openalex.org/W2145853890","https://openalex.org/W2150187510","https://openalex.org/W2152246397","https://openalex.org/W2156909104","https://openalex.org/W2159675211","https://openalex.org/W2159954944","https://openalex.org/W2165698076","https://openalex.org/W2167637859","https://openalex.org/W2219959112","https://openalex.org/W2257287664","https://openalex.org/W2283175985","https://openalex.org/W2295598076","https://openalex.org/W2330978860","https://openalex.org/W2345658906","https://openalex.org/W2473355215","https://openalex.org/W2538669636","https://openalex.org/W2606321545","https://openalex.org/W2768375068","https://openalex.org/W2911964244","https://openalex.org/W2938977831","https://openalex.org/W2997183031","https://openalex.org/W3102476541","https://openalex.org/W3102641634","https://openalex.org/W6677946334"],"related_works":["https://openalex.org/W2391004329","https://openalex.org/W1968369492","https://openalex.org/W2043102924","https://openalex.org/W2995607319","https://openalex.org/W1222064643","https://openalex.org/W2761818597","https://openalex.org/W2624135745","https://openalex.org/W1543301402","https://openalex.org/W2315403509","https://openalex.org/W3139084279"],"abstract_inverted_index":{"Metagenome-wide":[0],"analysis":[1,60,77,105,155],"studies":[2],"provide":[3],"a":[4],"unique":[5],"set":[6],"of":[7,13,24,32,49,75,103,131,143],"microbial":[8,25,150],"features":[9,132],"for":[10,19],"biomarker":[11],"discovery":[12],"associated":[14,177],"disease":[15],"as":[16,18],"well":[17],"studying":[20],"diversity":[21],"and":[22,42,64,92,96,110,163],"dynamics":[23],"communities":[26],"under":[27],"different":[28,67],"conditions.":[29],"Taxonomic":[30],"classification":[31,147],"microbes":[33,39],"in":[34,43,58,149,173],"metagenomic":[35],"samples":[36],"quantifies":[37],"what":[38,44],"are":[40,157],"present":[41],"proportion.":[45],"Despite":[46],"the":[47,73,76,101,123,141,160,174],"availably":[48],"several":[50],"computational":[51],"taxonomy":[52,68,87],"profiling":[53,69,88],"methods,":[54],"this":[55,82],"crucial":[56],"step":[57],"metagenome-wide":[59,104],"remains":[61],"very":[62],"challenging":[63],"how":[65],"using":[66,128],"methods":[70,89,148],"might":[71],"influence":[72],"outcome":[74,102],"is":[78],"not":[79],"well-studied.":[80],"In":[81,135],"work,":[83],"we":[84],"consider":[85],"three":[86],"(MetaPhlAn2,":[90],"Kraken,":[91],"EBI":[93],"metagenomics":[94],"pipeline)":[95],"examine":[97],"their":[98],"effect":[99],"on":[100,107],"based":[106],"machine":[108],"learning":[109],"comparative":[111],"network":[112,151],"approaches.":[113],"Our":[114],"results":[115,139,156],"suggest":[116],"that":[117],"Kraken":[118],"OTU-based":[119],"data":[120],"representation":[121],"yields":[122],"best":[124],"performing":[125],"classifiers":[126],"even":[127],"less":[129],"number":[130],"(e.g.,":[133],"OTUs).":[134],"addition,":[136],"our":[137,154],"preliminary":[138],"underscore":[140],"viability":[142],"leveraging":[144],"multiple":[145],"taxonomic":[146],"analysis.":[152],"Finally,":[153],"consistent":[158],"with":[159,178],"current":[161],"knowledge":[162],"reveal":[164],"novel":[165],"insights":[166],"into":[167],"interaction":[168],"relationships":[169],"between":[170],"potential":[171],"biomarkers":[172],"gut":[175],"microbiome":[176],"T2D.":[179]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2019,"cited_by_count":2}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}
