{"id":"https://openalex.org/W2612113311","doi":"https://doi.org/10.1145/3092819.3092830","title":"Overcoming the lack of kinetic information in biochemical reactions networks","display_name":"Overcoming the lack of kinetic information in biochemical reactions networks","publication_year":2017,"publication_date":"2017-05-10","ids":{"openalex":"https://openalex.org/W2612113311","doi":"https://doi.org/10.1145/3092819.3092830","mag":"2612113311"},"language":"en","primary_location":{"id":"doi:10.1145/3092819.3092830","is_oa":false,"landing_page_url":"https://doi.org/10.1145/3092819.3092830","pdf_url":null,"source":{"id":"https://openalex.org/S4210187660","display_name":"ACM SIGMETRICS Performance Evaluation Review","issn_l":"0163-5999","issn":["0163-5999","1557-9484"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319798","host_organization_name":"Association for Computing Machinery","host_organization_lineage":["https://openalex.org/P4310319798"],"host_organization_lineage_names":["Association for Computing Machinery"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACM SIGMETRICS Performance Evaluation Review","raw_type":"journal-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021852862","display_name":"Niccol\u00f2 Totis","orcid":"https://orcid.org/0000-0002-4138-582X"},"institutions":[{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Niccol\u00f3 Totis","raw_affiliation_strings":["University of Turin, Turin, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Turin, Turin, Italy","institution_ids":["https://openalex.org/I55143463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023290184","display_name":"Laura Follia","orcid":"https://orcid.org/0000-0003-1580-0505"},"institutions":[{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Laura Follia","raw_affiliation_strings":["University of Turin, Turin, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Turin, Turin, Italy","institution_ids":["https://openalex.org/I55143463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006463761","display_name":"Chiara Riganti","orcid":"https://orcid.org/0000-0001-9787-4836"},"institutions":[{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Chiara Riganti","raw_affiliation_strings":["University of Turin, Turin, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Turin, Turin, Italy","institution_ids":["https://openalex.org/I55143463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040743234","display_name":"Francesco Novelli","orcid":"https://orcid.org/0000-0002-6259-5666"},"institutions":[{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Francesco Novelli","raw_affiliation_strings":["University of Turin, Turin, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Turin, Turin, Italy","institution_ids":["https://openalex.org/I55143463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064773200","display_name":"Francesca Cordero","orcid":"https://orcid.org/0000-0002-3143-3330"},"institutions":[{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Francesca Cordero","raw_affiliation_strings":["University of Turin, Turin, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Turin, Turin, Italy","institution_ids":["https://openalex.org/I55143463"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5002392135","display_name":"Marco Beccuti","orcid":"https://orcid.org/0000-0001-6125-9460"},"institutions":[{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Marco Beccuti","raw_affiliation_strings":["University of Turin, Turin, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Turin, Turin, Italy","institution_ids":["https://openalex.org/I55143463"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I55143463"],"apc_list":null,"apc_paid":null,"fwci":0.3279,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.58534441,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"44","issue":"4","first_page":"91","last_page":"102"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10791","display_name":"Advanced Control Systems Optimization","score":0.9865000247955322,"subfield":{"id":"https://openalex.org/subfields/2207","display_name":"Control and Systems Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ode","display_name":"Ode","score":0.9094561338424683},{"id":"https://openalex.org/keywords/ordinary-differential-equation","display_name":"Ordinary differential equation","score":0.7615412473678589},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6407842636108398},{"id":"https://openalex.org/keywords/petri-net","display_name":"Petri net","score":0.5071456432342529},{"id":"https://openalex.org/keywords/mathematical-optimization","display_name":"Mathematical optimization","score":0.4750390350818634},{"id":"https://openalex.org/keywords/function","display_name":"Function (biology)","score":0.4462757706642151},{"id":"https://openalex.org/keywords/formalism","display_name":"Formalism (music)","score":0.4168437123298645},{"id":"https://openalex.org/keywords/set","display_name":"Set (abstract data type)","score":0.41539207100868225},{"id":"https://openalex.org/keywords/differential-equation","display_name":"Differential equation","score":0.36327576637268066},{"id":"https://openalex.org/keywords/applied-mathematics","display_name":"Applied mathematics","score":0.36187267303466797},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.26099693775177},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.241151362657547}],"concepts":[{"id":"https://openalex.org/C34862557","wikidata":"https://www.wikidata.org/wiki/Q178985","display_name":"Ode","level":2,"score":0.9094561338424683},{"id":"https://openalex.org/C51544822","wikidata":"https://www.wikidata.org/wiki/Q465274","display_name":"Ordinary differential equation","level":3,"score":0.7615412473678589},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6407842636108398},{"id":"https://openalex.org/C38677869","wikidata":"https://www.wikidata.org/wiki/Q724168","display_name":"Petri net","level":2,"score":0.5071456432342529},{"id":"https://openalex.org/C126255220","wikidata":"https://www.wikidata.org/wiki/Q141495","display_name":"Mathematical optimization","level":1,"score":0.4750390350818634},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.4462757706642151},{"id":"https://openalex.org/C73301696","wikidata":"https://www.wikidata.org/wiki/Q5469984","display_name":"Formalism (music)","level":3,"score":0.4168437123298645},{"id":"https://openalex.org/C177264268","wikidata":"https://www.wikidata.org/wiki/Q1514741","display_name":"Set (abstract data type)","level":2,"score":0.41539207100868225},{"id":"https://openalex.org/C78045399","wikidata":"https://www.wikidata.org/wiki/Q11214","display_name":"Differential equation","level":2,"score":0.36327576637268066},{"id":"https://openalex.org/C28826006","wikidata":"https://www.wikidata.org/wiki/Q33521","display_name":"Applied mathematics","level":1,"score":0.36187267303466797},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.26099693775177},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.241151362657547},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.0},{"id":"https://openalex.org/C558565934","wikidata":"https://www.wikidata.org/wiki/Q2743","display_name":"Musical","level":2,"score":0.0},{"id":"https://openalex.org/C153349607","wikidata":"https://www.wikidata.org/wiki/Q36649","display_name":"Visual arts","level":1,"score":0.0},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C142362112","wikidata":"https://www.wikidata.org/wiki/Q735","display_name":"Art","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1145/3092819.3092830","is_oa":false,"landing_page_url":"https://doi.org/10.1145/3092819.3092830","pdf_url":null,"source":{"id":"https://openalex.org/S4210187660","display_name":"ACM SIGMETRICS Performance Evaluation Review","issn_l":"0163-5999","issn":["0163-5999","1557-9484"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319798","host_organization_name":"Association for Computing Machinery","host_organization_lineage":["https://openalex.org/P4310319798"],"host_organization_lineage_names":["Association for Computing Machinery"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACM SIGMETRICS Performance Evaluation Review","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W1510585142","https://openalex.org/W1547663768","https://openalex.org/W1995024177","https://openalex.org/W2004235182","https://openalex.org/W2017060799","https://openalex.org/W2028908433","https://openalex.org/W2033666853","https://openalex.org/W2038778951","https://openalex.org/W2048596643","https://openalex.org/W2078355959","https://openalex.org/W2085061065","https://openalex.org/W2125739093","https://openalex.org/W2128292224","https://openalex.org/W2131719921","https://openalex.org/W2162297633","https://openalex.org/W2165603655","https://openalex.org/W2292006910","https://openalex.org/W2345381093","https://openalex.org/W2405417647","https://openalex.org/W2610325863","https://openalex.org/W3016146927","https://openalex.org/W4248081355","https://openalex.org/W4248974836","https://openalex.org/W6736949180"],"related_works":["https://openalex.org/W3082668976","https://openalex.org/W2517973022","https://openalex.org/W1543121148","https://openalex.org/W1580703421","https://openalex.org/W2996841952","https://openalex.org/W2618518959","https://openalex.org/W1816071588","https://openalex.org/W2231364979","https://openalex.org/W4295745414","https://openalex.org/W4288093367"],"abstract_inverted_index":{"A":[0],"main":[1],"aspect":[2],"in":[3,52],"computational":[4],"modelling":[5,145],"of":[6,12,26,62,108,118],"biological":[7,100],"systems":[8],"is":[9,95,113,125,170],"the":[10,33,53,133,144,162,168],"determination":[11],"model":[13,16,78],"structure":[14],"and":[15,21,45,102,165],"parameters.":[17],"Due":[18],"to":[19,91,142,160],"economical":[20],"technical":[22],"reasons,":[23],"only":[24],"part":[25],"these":[27,56],"details":[28],"are":[29,35],"well":[30],"characterized,":[31],"while":[32],"rest":[34],"unknown.":[36],"To":[37],"deal":[38],"with":[39,85],"this":[40,69],"difficulty,":[41],"many":[42],"reverse":[43],"engineering":[44],"parameter":[46],"estimation":[47],"methods":[48,57],"have":[49],"been":[50],"proposed":[51],"literature,":[54],"however":[55],"often":[58],"need":[59],"an":[60,73,81,86,98],"amount":[61],"experimental":[63],"data":[64],"not":[65,104],"always":[66],"available.":[67],"In":[68],"paper":[70],"we":[71,147],"propose":[72],"alternative":[74],"approach,":[75],"which":[76,156],"overcomes":[77],"indetermination":[79,124],"solving":[80],"Optimization":[82],"Problem":[83],"(OP)":[84],"objective":[87,134],"function":[88,135],"that,":[89],"similarly":[90],"Flux":[92],"Balance":[93],"Analysis,":[94],"derived":[96],"from":[97],"empirical":[99],"knowledge":[101],"does":[103],"require":[105],"large":[106],"amounts":[107],"data.":[109],"The":[110],"system":[111],"behaviour":[112],"described":[114],"by":[115],"a":[116,149,173],"set":[117],"Ordinary":[119],"Differential":[120],"Equations":[121],"(ODE).":[122],"Model":[123],"resolved":[126],"selecting":[127],"time-varying":[128],"coefficients":[129],"that":[130],"maximize/":[131],"minimize":[132],"at":[136],"each":[137],"ODE":[138],"integration":[139],"step.":[140],"Moreover,":[141],"facilitate":[143],"phase":[146],"provide":[148],"graphical":[150],"formalism,":[151],"based":[152],"on":[153,172,177],"Petri":[154],"Nets,":[155],"can":[157],"be":[158],"used":[159],"derive":[161],"corresponding":[163],"ODEs":[164],"OP.":[166],"Finally,":[167],"approach":[169],"illustrated":[171],"case":[174],"study":[175],"focused":[176],"cancer":[178],"metabolism.":[179]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2}],"updated_date":"2026-05-21T06:26:12.895304","created_date":"2025-10-10T00:00:00"}