{"id":"https://openalex.org/W2735155250","doi":"https://doi.org/10.1145/3067695.3082491","title":"Efficient, effective, and insightful tackling of the high-dose-rate brachytherapy treatment planning problem for prostate cancer using evolutionary multi-objective optimization algorithms","display_name":"Efficient, effective, and insightful tackling of the high-dose-rate brachytherapy treatment planning problem for prostate cancer using evolutionary multi-objective optimization algorithms","publication_year":2017,"publication_date":"2017-07-11","ids":{"openalex":"https://openalex.org/W2735155250","doi":"https://doi.org/10.1145/3067695.3082491","mag":"2735155250"},"language":"en","primary_location":{"id":"doi:10.1145/3067695.3082491","is_oa":false,"landing_page_url":"https://doi.org/10.1145/3067695.3082491","pdf_url":null,"source":{"id":"https://openalex.org/S4363608771","display_name":"Proceedings of the Genetic and Evolutionary Computation Conference Companion","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the Genetic and Evolutionary Computation Conference Companion","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://ir.cwi.nl/pub/26544/GECC1114.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081219326","display_name":"Ngoc Hoang Luong","orcid":"https://orcid.org/0000-0002-6768-1950"},"institutions":[{"id":"https://openalex.org/I1341640284","display_name":"Centrum Wiskunde & Informatica","ror":"https://ror.org/00x7ekv49","country_code":"NL","type":"facility","lineage":["https://openalex.org/I1341640284","https://openalex.org/I2800991832","https://openalex.org/I4405262988"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Ngoc Hoang Luong","raw_affiliation_strings":["Centrum Wiskunde & Informatica, Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centrum Wiskunde & Informatica, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I1341640284"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068027604","display_name":"Anton Bouter","orcid":"https://orcid.org/0000-0003-4599-0733"},"institutions":[{"id":"https://openalex.org/I1341640284","display_name":"Centrum Wiskunde & Informatica","ror":"https://ror.org/00x7ekv49","country_code":"NL","type":"facility","lineage":["https://openalex.org/I1341640284","https://openalex.org/I2800991832","https://openalex.org/I4405262988"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Anton Bouter","raw_affiliation_strings":["Centrum Wiskunde & Informatica, Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centrum Wiskunde & Informatica, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I1341640284"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053141528","display_name":"Marjolein C. van der Meer","orcid":null},"institutions":[{"id":"https://openalex.org/I2802928900","display_name":"Amsterdam UMC Location University of Amsterdam","ror":"https://ror.org/03t4gr691","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2802928900","https://openalex.org/I4210151833"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Marjolein C. van der Meer","raw_affiliation_strings":["Academic Medical Center, Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Academic Medical Center, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I2802928900"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022272327","display_name":"Yury Niatsetski","orcid":"https://orcid.org/0000-0002-2756-2834"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yury Niatsetski","raw_affiliation_strings":["Elekta, Veenendaal, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Elekta, Veenendaal, The Netherlands","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087895051","display_name":"Cees Witteveen","orcid":"https://orcid.org/0000-0002-7717-1209"},"institutions":[{"id":"https://openalex.org/I98358874","display_name":"Delft University of Technology","ror":"https://ror.org/02e2c7k09","country_code":"NL","type":"education","lineage":["https://openalex.org/I98358874"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Cees Witteveen","raw_affiliation_strings":["Delft University of Technology, Delft, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Delft University of Technology, Delft, The Netherlands","institution_ids":["https://openalex.org/I98358874"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060970719","display_name":"Arjan Bel","orcid":"https://orcid.org/0000-0003-1576-6220"},"institutions":[{"id":"https://openalex.org/I2802928900","display_name":"Amsterdam UMC Location University of Amsterdam","ror":"https://ror.org/03t4gr691","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2802928900","https://openalex.org/I4210151833"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Arjan Bel","raw_affiliation_strings":["Academic Medical Center, Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Academic Medical Center, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I2802928900"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025122230","display_name":"Tanja Alderliesten","orcid":"https://orcid.org/0000-0003-4261-7511"},"institutions":[{"id":"https://openalex.org/I2802928900","display_name":"Amsterdam UMC Location University of Amsterdam","ror":"https://ror.org/03t4gr691","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2802928900","https://openalex.org/I4210151833"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Tanja Alderliesten","raw_affiliation_strings":["Academic Medical Center, Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Academic Medical Center, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I2802928900"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5031539135","display_name":"Peter A. N. Bosman","orcid":"https://orcid.org/0000-0002-4186-6666"},"institutions":[{"id":"https://openalex.org/I1341640284","display_name":"Centrum Wiskunde & Informatica","ror":"https://ror.org/00x7ekv49","country_code":"NL","type":"facility","lineage":["https://openalex.org/I1341640284","https://openalex.org/I2800991832","https://openalex.org/I4405262988"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Peter A. N. Bosman","raw_affiliation_strings":["Centrum Wiskunde & Informatica, Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centrum Wiskunde & Informatica, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I1341640284"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":8,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.064,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.73293173,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":97},"biblio":{"volume":null,"issue":null,"first_page":"1372","last_page":"1379"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10848","display_name":"Advanced Multi-Objective Optimization Algorithms","score":0.9973000288009644,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10848","display_name":"Advanced Multi-Objective Optimization Algorithms","score":0.9973000288009644,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10124","display_name":"Prostate Cancer Diagnosis and Treatment","score":0.9934999942779541,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11489","display_name":"Air Traffic Management and Optimization","score":0.9789000153541565,"subfield":{"id":"https://openalex.org/subfields/2202","display_name":"Aerospace Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/radiation-treatment-planning","display_name":"Radiation treatment planning","score":0.7194277048110962},{"id":"https://openalex.org/keywords/brachytherapy","display_name":"Brachytherapy","score":0.7067477107048035},{"id":"https://openalex.org/keywords/evolutionary-algorithm","display_name":"Evolutionary algorithm","score":0.5881473422050476},{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"Prostate cancer","score":0.5592592358589172},{"id":"https://openalex.org/keywords/optimization-problem","display_name":"Optimization problem","score":0.5432535409927368},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.532538115978241},{"id":"https://openalex.org/keywords/mathematical-optimization","display_name":"Mathematical optimization","score":0.5009558200836182},{"id":"https://openalex.org/keywords/prostate-brachytherapy","display_name":"Prostate brachytherapy","score":0.4978196620941162},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.40978139638900757},{"id":"https://openalex.org/keywords/radiation-therapy","display_name":"Radiation therapy","score":0.3602404296398163},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.26586970686912537},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.25178641080856323},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.23470130562782288},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.12344327569007874},{"id":"https://openalex.org/keywords/surgery","display_name":"Surgery","score":0.11849424242973328}],"concepts":[{"id":"https://openalex.org/C201645570","wikidata":"https://www.wikidata.org/wiki/Q830637","display_name":"Radiation treatment planning","level":3,"score":0.7194277048110962},{"id":"https://openalex.org/C2777416452","wikidata":"https://www.wikidata.org/wiki/Q896687","display_name":"Brachytherapy","level":3,"score":0.7067477107048035},{"id":"https://openalex.org/C159149176","wikidata":"https://www.wikidata.org/wiki/Q14489129","display_name":"Evolutionary algorithm","level":2,"score":0.5881473422050476},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.5592592358589172},{"id":"https://openalex.org/C137836250","wikidata":"https://www.wikidata.org/wiki/Q984063","display_name":"Optimization problem","level":2,"score":0.5432535409927368},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.532538115978241},{"id":"https://openalex.org/C126255220","wikidata":"https://www.wikidata.org/wiki/Q141495","display_name":"Mathematical optimization","level":1,"score":0.5009558200836182},{"id":"https://openalex.org/C2778648096","wikidata":"https://www.wikidata.org/wiki/Q17009878","display_name":"Prostate brachytherapy","level":4,"score":0.4978196620941162},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.40978139638900757},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.3602404296398163},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.26586970686912537},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.25178641080856323},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.23470130562782288},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.12344327569007874},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.11849424242973328},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1145/3067695.3082491","is_oa":false,"landing_page_url":"https://doi.org/10.1145/3067695.3082491","pdf_url":null,"source":{"id":"https://openalex.org/S4363608771","display_name":"Proceedings of the Genetic and Evolutionary Computation Conference Companion","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the Genetic and Evolutionary Computation Conference Companion","raw_type":"proceedings-article"},{"id":"pmh:oai:pure.amsterdamumc.nl:openaire_cris_publications/2ada28a8-b5ac-4499-bdd3-dddd8e72f355","is_oa":false,"landing_page_url":"https://pure.amsterdamumc.nl/en/publications/2ada28a8-b5ac-4499-bdd3-dddd8e72f355","pdf_url":null,"source":{"id":"https://openalex.org/S7407055222","display_name":"Pure Amsterdam UMC","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Luong, N H, Bouter, A, van der Meer, M C, Niatsetski, Y, Witteveen, C, Bel, A, Alderliesten, T & Bosman, P A N 2017, Efficient, effective, and insightful tackling of the high-dose-rate brachytherapy treatment planning problem for prostate cancer using evolutionary multi-objective optimization algorithms. in GECCO '17 Companion: Proceedings of the Genetic and Evolutionary Computation Conference Companion. ACM, New York, pp. 1372-1379. https://doi.org/10.1145/3067695.3082491","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"pmh:cwi:oai:cwi.nl:26544","is_oa":true,"landing_page_url":"https://ir.cwi.nl/pub/26544","pdf_url":"https://ir.cwi.nl/pub/26544/GECC1114.pdf","source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/conferencepaper"},{"id":"pmh:amcpub:oai:pure.amc.nl:publications/cb29ee4f-cb87-48fb-9a88-1857ffa03979","is_oa":false,"landing_page_url":"https://pure.amc.nl/en/publications/efficient-effective-and-insightful-tackling-of-the-highdoserate-brachytherapy-treatment-planning-problem-for-prostate-cancer-using-evolutionary-multiobjective-optimization-algorithms(cb29ee4f-cb87-48fb-9a88-1857ffa03979).html","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"GECCO '17 Companion: Proceedings of the Genetic and Evolutionary Computation Conference Companion, 1372 - 1379","raw_type":"info:eu-repo/semantics/conferencepaper"}],"best_oa_location":{"id":"pmh:cwi:oai:cwi.nl:26544","is_oa":true,"landing_page_url":"https://ir.cwi.nl/pub/26544","pdf_url":"https://ir.cwi.nl/pub/26544/GECC1114.pdf","source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/conferencepaper"},"sustainable_development_goals":[{"score":0.5699999928474426,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"awards":[{"id":"https://openalex.org/G119055134","display_name":null,"funder_award_id":"628.006.003","funder_id":"https://openalex.org/F4320321800","funder_display_name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek"}],"funders":[{"id":"https://openalex.org/F4320321800","display_name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek","ror":"https://ror.org/04jsz6e67"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2735155250.pdf","grobid_xml":"https://content.openalex.org/works/W2735155250.grobid-xml"},"referenced_works_count":16,"referenced_works":["https://openalex.org/W1558919105","https://openalex.org/W1595498733","https://openalex.org/W2011198825","https://openalex.org/W2033907961","https://openalex.org/W2047608066","https://openalex.org/W2061715500","https://openalex.org/W2064057265","https://openalex.org/W2092939357","https://openalex.org/W2116926066","https://openalex.org/W2125843529","https://openalex.org/W2126105956","https://openalex.org/W2128483828","https://openalex.org/W2169042387","https://openalex.org/W2733459154","https://openalex.org/W2953215605","https://openalex.org/W4240115424"],"related_works":["https://openalex.org/W2415632822","https://openalex.org/W1968581313","https://openalex.org/W2086196749","https://openalex.org/W2807885017","https://openalex.org/W2810663015","https://openalex.org/W328240141","https://openalex.org/W2106662487","https://openalex.org/W2102373670","https://openalex.org/W2460936463","https://openalex.org/W2809967836"],"abstract_inverted_index":{"We":[0,132],"address":[1],"the":[2,21,34,38,42,48,58,86,107,137,167,173,194],"problem":[3,13,74,108,116,135,160,180],"of":[4,20],"high-dose-rate":[5],"brachytherapy":[6],"treatment":[7,17,90,96],"planning":[8,87],"for":[9,81,89],"prostate":[10,39],"cancer.":[11],"The":[12,73],"involves":[14],"determining":[15],"a":[16,26,94,113,149],"plan":[18,97],"consisting":[19],"so-called":[22],"dwell":[23],"times":[24],"that":[25,37,106,117,152],"radiation":[27,50,82],"source":[28],"resides":[29],"at":[30,60],"different":[31],"positions":[32],"inside":[33],"patient":[35],"such":[36],"volume":[40],"and":[41,65,127,203],"seminal":[43],"vesicles":[44],"are":[45,67],"covered":[46],"by":[47],"prescribed":[49],"dose":[51,83],"level":[52],"as":[53,55,69,71,112],"much":[54],"possible":[56],"while":[57,85],"organs":[59,128],"risk,":[61],"e.g.,":[62],"bladder,":[63],"rectum,":[64],"urethra,":[66],"irradiated":[68],"little":[70],"possible.":[72],"is":[75,98,148,153],"highly":[76],"constrained,":[77],"following":[78],"clinical":[79],"requirements":[80],"distribution":[84],"process":[88],"planners":[91],"to":[92,124,129,155,162,175,188],"design":[93],"clinically-acceptable":[95],"strictly":[99],"time-limited.":[100],"In":[101],"this":[102,134],"paper,":[103],"we":[104],"propose":[105],"can":[109],"be":[110,125,130,189],"formulated":[111],"bi-objective":[114],"optimization":[115,196],"intuitively":[118],"describes":[119],"trade-offs":[120],"between":[121,159],"target":[122],"volumes":[123],"radiated":[126],"spared.":[131],"solve":[133],"with":[136,205],"recently-introduced":[138],"Multi-Objective":[139],"Real-Valued":[140],"Gene-pool":[141],"Optimal":[142],"Mixing":[143],"Evolutionary":[144],"Algorithm":[145],"(MO-RV-GOMEA),":[146],"which":[147],"promising":[150],"MOEA":[151],"able":[154],"effectively":[156],"exploit":[157],"dependencies":[158],"variables":[161],"tackle":[163],"complicated":[164],"problems":[165],"in":[166,185],"continuous":[168],"domain.":[169],"MO-RV-GOMEA":[170],"also":[171],"has":[172],"capability":[174],"perform":[176],"partial":[177],"evaluations":[178],"if":[179],"structures":[181],"allow":[182],"local":[183],"variations":[184],"existing":[186],"solutions":[187],"efficiently":[190],"computed,":[191],"substantially":[192],"accelerating":[193],"overall":[195],"performance.":[197],"Experiments":[198],"on":[199],"real":[200],"medical":[201],"data":[202],"comparison":[204],"state-of-the-art":[206],"MOEAs":[207],"confirm":[208],"our":[209],"claims.":[210]},"counts_by_year":[{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2017,"cited_by_count":1}],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}