{"id":"https://openalex.org/W2548714032","doi":"https://doi.org/10.1145/2980258.2982038","title":"A Comparative Study and Analysis of DNA Sequence Classifiers for Predicting Human Diseases","display_name":"A Comparative Study and Analysis of DNA Sequence Classifiers for Predicting Human Diseases","publication_year":2016,"publication_date":"2016-08-25","ids":{"openalex":"https://openalex.org/W2548714032","doi":"https://doi.org/10.1145/2980258.2982038","mag":"2548714032"},"language":"en","primary_location":{"id":"doi:10.1145/2980258.2982038","is_oa":false,"landing_page_url":"https://doi.org/10.1145/2980258.2982038","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the International Conference on Informatics and Analytics","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016978236","display_name":"N. K. Sakthivel","orcid":null},"institutions":[{"id":"https://openalex.org/I860813019","display_name":"Bharath University","ror":"https://ror.org/04yazpn06","country_code":"IN","type":"education","lineage":["https://openalex.org/I860813019"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"N. K. Sakthivel","raw_affiliation_strings":["IEEE, Bharath University"],"affiliations":[{"raw_affiliation_string":"IEEE, Bharath University","institution_ids":["https://openalex.org/I860813019"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054507472","display_name":"N. P. Gopalan","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N. P. Gopalan","raw_affiliation_strings":["Department of Computer Applications, National Institute of Technology"],"affiliations":[{"raw_affiliation_string":"Department of Computer Applications, National Institute of Technology","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5018246389","display_name":"S. Subasree","orcid":null},"institutions":[{"id":"https://openalex.org/I36253440","display_name":"IEEE Computer Society","ror":"https://ror.org/05nxk6n24","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I36253440"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. Subasree","raw_affiliation_strings":["IEEE, CSE, Nehru College Engineering and Research Centre"],"affiliations":[{"raw_affiliation_string":"IEEE, CSE, Nehru College Engineering and Research Centre","institution_ids":["https://openalex.org/I36253440"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5016978236"],"corresponding_institution_ids":["https://openalex.org/I860813019"],"apc_list":null,"apc_paid":null,"fwci":0.1667,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.64135609,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":96},"biblio":{"volume":null,"issue":null,"first_page":"1","last_page":"5"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.9962999820709229,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9955000281333923,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cluster-analysis","display_name":"Cluster analysis","score":0.6206290125846863},{"id":"https://openalex.org/keywords/random-forest","display_name":"Random forest","score":0.6161606907844543},{"id":"https://openalex.org/keywords/genome","display_name":"Genome","score":0.6137042045593262},{"id":"https://openalex.org/keywords/human-genome","display_name":"Human genome","score":0.5915213823318481},{"id":"https://openalex.org/keywords/classifier","display_name":"Classifier (UML)","score":0.5695634484291077},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5442578792572021},{"id":"https://openalex.org/keywords/hierarchical-clustering","display_name":"Hierarchical clustering","score":0.5023946762084961},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.47653087973594666},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.46226561069488525},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4209452271461487},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.3479558825492859},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.3402145504951477},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3168467581272125},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.27815914154052734},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.22146594524383545}],"concepts":[{"id":"https://openalex.org/C73555534","wikidata":"https://www.wikidata.org/wiki/Q622825","display_name":"Cluster analysis","level":2,"score":0.6206290125846863},{"id":"https://openalex.org/C169258074","wikidata":"https://www.wikidata.org/wiki/Q245748","display_name":"Random forest","level":2,"score":0.6161606907844543},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.6137042045593262},{"id":"https://openalex.org/C197077220","wikidata":"https://www.wikidata.org/wiki/Q720988","display_name":"Human genome","level":4,"score":0.5915213823318481},{"id":"https://openalex.org/C95623464","wikidata":"https://www.wikidata.org/wiki/Q1096149","display_name":"Classifier (UML)","level":2,"score":0.5695634484291077},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5442578792572021},{"id":"https://openalex.org/C92835128","wikidata":"https://www.wikidata.org/wiki/Q1277447","display_name":"Hierarchical clustering","level":3,"score":0.5023946762084961},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.47653087973594666},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.46226561069488525},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4209452271461487},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.3479558825492859},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.3402145504951477},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3168467581272125},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.27815914154052734},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.22146594524383545}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1145/2980258.2982038","is_oa":false,"landing_page_url":"https://doi.org/10.1145/2980258.2982038","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the International Conference on Informatics and Analytics","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W7419881","https://openalex.org/W1595456161","https://openalex.org/W1611185808","https://openalex.org/W1929627202","https://openalex.org/W1973001880","https://openalex.org/W2004403098","https://openalex.org/W2051121270","https://openalex.org/W2058967034","https://openalex.org/W2068537457","https://openalex.org/W2068996502","https://openalex.org/W2080240378","https://openalex.org/W2090247362","https://openalex.org/W2096525273","https://openalex.org/W2103017472","https://openalex.org/W2105813018","https://openalex.org/W2123060905","https://openalex.org/W2134974358","https://openalex.org/W2136410628","https://openalex.org/W2154654747","https://openalex.org/W2644341057","https://openalex.org/W3164135786","https://openalex.org/W4238718120","https://openalex.org/W6836725202"],"related_works":["https://openalex.org/W3193043704","https://openalex.org/W4386259002","https://openalex.org/W1546989560","https://openalex.org/W3171520305","https://openalex.org/W3135126032","https://openalex.org/W1924178503","https://openalex.org/W4308716060","https://openalex.org/W4280648719","https://openalex.org/W2889302474","https://openalex.org/W3200375535"],"abstract_inverted_index":{"Understanding":[0],"and":[1,28,51,63,72,108,118,130,135,153,167,232,246,265,286,310,333,345],"predicting":[2,255,301,327],"Human":[3,49,256,278],"Genome":[4,22,95],"Patterns":[5,258],"are":[6,185,205],"one":[7],"of":[8,21,59,123,139,181,191,201],"the":[9,30,74,137,179,189,199,214,240,269,290,319,329],"challenging":[10],"issues":[11],"regarding":[12],"human":[13,84,150,224],"health.":[14],"To":[15],"achieve":[16],"this,":[17],"a":[18,41,148,154,222,276],"large":[19],"amount":[20],"Data":[23],"Sets":[24],"need":[25,69],"to":[26,70,78,238,317,348],"analysis":[27],"predict":[29,81,239,318,349],"diseases":[31,53,156,225],"patterns":[32,152,157,190,242,303],"with":[33,308,337,353],"highest":[34],"Classification":[35],"Accuracy.":[36],"It":[37],"is":[38,44,68,89,176,194,211,220,254,294,300,315,326,341],"noted":[39,177,212],"that":[40,178,213,296],"single":[42],"Gene":[43],"not":[45],"responsible":[46],"for":[47,195],"many":[48],"Diseases":[50,257,279],"instead,":[52],"occur":[54],"by":[55],"different":[56,196],"or":[57,80],"group":[58],"genomes":[60],"interacting":[61],"together":[62],"causes":[64],"diseases.":[65,85],"Hence":[66],"it":[67,175,210,236,293,314],"analyse":[71],"associate":[73],"complete":[75],"genome":[76,142,151,197,203,302],"sequences":[77],"understand":[79],"various":[82],"possible":[83],"This":[86],"research":[87,145],"work":[88,146],"identified":[90],"three":[91,141,183],"recently":[92],"proposed":[93],"popular":[94],"Cluster":[96],"Classifiers":[97,115],"namely":[98,158],"Hierarchical-Random":[99,215],"Forest":[100,216],"based":[101,217],"Clustering":[102,218],"(HRF-Cluster),":[103],"Genetic":[104],"Algorithm-Gene":[105],"Association":[106,252,298],"Classifier":[107,112,253,273,299],"Weighted":[109,270],"Common":[110,271],"Neighbor":[111,272],"(wCN).":[113],"These":[114],"were":[116],"implemented":[117],"studied":[119],"thoroughly":[120],"in":[121],"terms":[122],"Prediction":[124],"Accuracy,":[125],"Memory":[126,128],"Utilization,":[127],"Usage":[129],"Processing":[131],"Time.":[132],"For":[133],"training":[134],"analysing":[136],"performances":[138,180,200],"these":[140,182,202],"classifiers,":[143],"this":[144],"considered":[147],"few":[149,155,223,277],"Cerebral":[159,227,281,320,330],"Vascular":[160,228,282,321,331],"Disease":[161,169,229,248,263,322],"Pattern,":[162,164,166],"Sugar":[163,233,266,287,334],"Cardiomyopathy":[165,244,260],"Pericardial":[168,247,262],"Pattern.":[170,249,323],"From":[171,207,289],"our":[172,208],"experimental":[173],"results,":[174],"classifiers":[184,204],"purely":[186],"depend":[187],"on":[188],"genomes.":[192],"That":[193],"patterns,":[198],"different.":[206],"Results,":[209],"(HRF-Cluster)":[219],"predicted":[221],"like":[226,243,259,280],"Pattern":[230],"(11%)":[231],"(12%),":[234],"but":[235,312],"fails":[237],"existing":[241],"pattern":[245,350],"The":[250,324],"GA-Gene":[251,297],"(29%),":[261],"(3%)":[264],"(16%).":[267],"Similarly,":[268],"(wCN)":[274],"predicts":[275],"disease":[283,332],"(13":[284],"%)":[285],"(20%).":[288],"results":[291],"obtained,":[292],"established":[295],"very":[304],"well":[305],"as":[306,335,351],"compared":[307,336,352],"HRF-Cluster":[309],"wCN":[311,325,340],"however":[313],"unable":[316],"better":[328],"HRF-Cluster.":[338,354],"But":[339],"consuming":[342],"more":[343],"memory":[344],"Execution":[346],"time":[347]},"counts_by_year":[{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}