{"id":"https://openalex.org/W2557794580","doi":"https://doi.org/10.1145/2975167.2985686","title":"Explorations in Very Early Prognosis of the Human Immune Response to Influenza","display_name":"Explorations in Very Early Prognosis of the Human Immune Response to Influenza","publication_year":2016,"publication_date":"2016-10-02","ids":{"openalex":"https://openalex.org/W2557794580","doi":"https://doi.org/10.1145/2975167.2985686","mag":"2557794580"},"language":"en","primary_location":{"id":"doi:10.1145/2975167.2985686","is_oa":true,"landing_page_url":"https://doi.org/10.1145/2975167.2985686","pdf_url":"http://dl.acm.org/ft_gateway.cfm?id=2985686&type=pdf","source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 7th ACM International Conference on Bioinformatics, Computational Biology, and Health Informatics","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://dl.acm.org/ft_gateway.cfm?id=2985686&type=pdf","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043692141","display_name":"Mmanu Chaturvedi","orcid":null},"institutions":[{"id":"https://openalex.org/I92446798","display_name":"Colorado State University","ror":"https://ror.org/03k1gpj17","country_code":"US","type":"education","lineage":["https://openalex.org/I92446798"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Mmanu Chaturvedi","raw_affiliation_strings":["Department of Computer Science, Colorado State University, Fort Collins, Colorado"],"affiliations":[{"raw_affiliation_string":"Department of Computer Science, Colorado State University, Fort Collins, Colorado","institution_ids":["https://openalex.org/I92446798"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063172366","display_name":"Tomojit Ghosh","orcid":"https://orcid.org/0000-0001-6875-3840"},"institutions":[{"id":"https://openalex.org/I92446798","display_name":"Colorado State University","ror":"https://ror.org/03k1gpj17","country_code":"US","type":"education","lineage":["https://openalex.org/I92446798"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tomojit Ghosh","raw_affiliation_strings":["Department of Computer Science, Colorado State University, Fort Collins, Colorado"],"affiliations":[{"raw_affiliation_string":"Department of Computer Science, Colorado State University, Fort Collins, Colorado","institution_ids":["https://openalex.org/I92446798"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061567476","display_name":"Michael Kirby","orcid":"https://orcid.org/0000-0001-9802-9263"},"institutions":[{"id":"https://openalex.org/I92446798","display_name":"Colorado State University","ror":"https://ror.org/03k1gpj17","country_code":"US","type":"education","lineage":["https://openalex.org/I92446798"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Kirby","raw_affiliation_strings":["Department of Mathematics, Colorado State University, Fort Collins, Colorado"],"affiliations":[{"raw_affiliation_string":"Department of Mathematics, Colorado State University, Fort Collins, Colorado","institution_ids":["https://openalex.org/I92446798"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100455516","display_name":"Xiaoyu Liu","orcid":"https://orcid.org/0000-0003-0078-2199"},"institutions":[{"id":"https://openalex.org/I92446798","display_name":"Colorado State University","ror":"https://ror.org/03k1gpj17","country_code":"US","type":"education","lineage":["https://openalex.org/I92446798"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaoyu Liu","raw_affiliation_strings":["Department of Mathematics, Colorado State University, Fort Collins, Colorado"],"affiliations":[{"raw_affiliation_string":"Department of Mathematics, Colorado State University, Fort Collins, Colorado","institution_ids":["https://openalex.org/I92446798"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100606130","display_name":"Xiaofeng Ma","orcid":"https://orcid.org/0000-0002-3967-5975"},"institutions":[{"id":"https://openalex.org/I92446798","display_name":"Colorado State University","ror":"https://ror.org/03k1gpj17","country_code":"US","type":"education","lineage":["https://openalex.org/I92446798"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaofeng Ma","raw_affiliation_strings":["Department of Mathematics, Colorado State University, Fort Collins, Colorado"],"affiliations":[{"raw_affiliation_string":"Department of Mathematics, Colorado State University, Fort Collins, Colorado","institution_ids":["https://openalex.org/I92446798"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5058045880","display_name":"Shannon Stiverson","orcid":null},"institutions":[{"id":"https://openalex.org/I92446798","display_name":"Colorado State University","ror":"https://ror.org/03k1gpj17","country_code":"US","type":"education","lineage":["https://openalex.org/I92446798"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shannon Stiverson","raw_affiliation_strings":["Department of Mathematics, Colorado State University, Fort Collins, Colorado"],"affiliations":[{"raw_affiliation_string":"Department of Mathematics, Colorado State University, Fort Collins, Colorado","institution_ids":["https://openalex.org/I92446798"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5043692141"],"corresponding_institution_ids":["https://openalex.org/I92446798"],"apc_list":null,"apc_paid":null,"fwci":0.1557,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.59905877,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":96},"biblio":{"volume":null,"issue":null,"first_page":"562","last_page":"570"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.9973999857902527,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.9973999857902527,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.9944000244140625,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9884999990463257,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/immune-system","display_name":"Immune system","score":0.6468622088432312},{"id":"https://openalex.org/keywords/support-vector-machine","display_name":"Support vector machine","score":0.5991388559341431},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5507460832595825},{"id":"https://openalex.org/keywords/suite","display_name":"Suite","score":0.5456106066703796},{"id":"https://openalex.org/keywords/set","display_name":"Set (abstract data type)","score":0.5415101647377014},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.5237733721733093},{"id":"https://openalex.org/keywords/artificial-neural-network","display_name":"Artificial neural network","score":0.4890936017036438},{"id":"https://openalex.org/keywords/human-influenza","display_name":"Human influenza","score":0.45653635263442993},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.4512743353843689},{"id":"https://openalex.org/keywords/nonlinear-system","display_name":"Nonlinear system","score":0.43364930152893066},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.3572819232940674},{"id":"https://openalex.org/keywords/immunology","display_name":"Immunology","score":0.2979409098625183},{"id":"https://openalex.org/keywords/coronavirus-disease-2019","display_name":"Coronavirus disease 2019 (COVID-19)","score":0.27643734216690063},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.26848942041397095},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.2009153962135315},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.14741221070289612}],"concepts":[{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6468622088432312},{"id":"https://openalex.org/C12267149","wikidata":"https://www.wikidata.org/wiki/Q282453","display_name":"Support vector machine","level":2,"score":0.5991388559341431},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5507460832595825},{"id":"https://openalex.org/C79581498","wikidata":"https://www.wikidata.org/wiki/Q1367530","display_name":"Suite","level":2,"score":0.5456106066703796},{"id":"https://openalex.org/C177264268","wikidata":"https://www.wikidata.org/wiki/Q1514741","display_name":"Set (abstract data type)","level":2,"score":0.5415101647377014},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.5237733721733093},{"id":"https://openalex.org/C50644808","wikidata":"https://www.wikidata.org/wiki/Q192776","display_name":"Artificial neural network","level":2,"score":0.4890936017036438},{"id":"https://openalex.org/C3020180211","wikidata":"https://www.wikidata.org/wiki/Q2840","display_name":"Human influenza","level":5,"score":0.45653635263442993},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.4512743353843689},{"id":"https://openalex.org/C158622935","wikidata":"https://www.wikidata.org/wiki/Q660848","display_name":"Nonlinear system","level":2,"score":0.43364930152893066},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3572819232940674},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2979409098625183},{"id":"https://openalex.org/C3008058167","wikidata":"https://www.wikidata.org/wiki/Q84263196","display_name":"Coronavirus disease 2019 (COVID-19)","level":4,"score":0.27643734216690063},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.26848942041397095},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2009153962135315},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.14741221070289612},{"id":"https://openalex.org/C166957645","wikidata":"https://www.wikidata.org/wiki/Q23498","display_name":"Archaeology","level":1,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C95457728","wikidata":"https://www.wikidata.org/wiki/Q309","display_name":"History","level":0,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C524204448","wikidata":"https://www.wikidata.org/wiki/Q788926","display_name":"Infectious disease (medical specialty)","level":3,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1145/2975167.2985686","is_oa":true,"landing_page_url":"https://doi.org/10.1145/2975167.2985686","pdf_url":"http://dl.acm.org/ft_gateway.cfm?id=2985686&type=pdf","source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 7th ACM International Conference on Bioinformatics, Computational Biology, and Health Informatics","raw_type":"proceedings-article"}],"best_oa_location":{"id":"doi:10.1145/2975167.2985686","is_oa":true,"landing_page_url":"https://doi.org/10.1145/2975167.2985686","pdf_url":"http://dl.acm.org/ft_gateway.cfm?id=2985686&type=pdf","source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 7th ACM International Conference on Bioinformatics, Computational Biology, and Health Informatics","raw_type":"proceedings-article"},"sustainable_development_goals":[{"score":0.7400000095367432,"display_name":"Reduced inequalities","id":"https://metadata.un.org/sdg/10"}],"awards":[{"id":"https://openalex.org/G7452504376","display_name":null,"funder_award_id":"1322508","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G848032724","display_name":null,"funder_award_id":"Science","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G870643760","display_name":"RAPID: Early Warning Algorithms for Predicting Ebola Infection Outcomes","funder_award_id":"1513633","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2557794580.pdf","grobid_xml":"https://content.openalex.org/works/W2557794580.grobid-xml"},"referenced_works_count":51,"referenced_works":["https://openalex.org/W184020152","https://openalex.org/W1523709528","https://openalex.org/W1545878925","https://openalex.org/W1602128406","https://openalex.org/W1630179759","https://openalex.org/W1849221894","https://openalex.org/W1971524600","https://openalex.org/W1991499125","https://openalex.org/W1993570538","https://openalex.org/W2001187841","https://openalex.org/W2004077922","https://openalex.org/W2006626130","https://openalex.org/W2029949252","https://openalex.org/W2030728462","https://openalex.org/W2031735032","https://openalex.org/W2036161092","https://openalex.org/W2048987737","https://openalex.org/W2051812123","https://openalex.org/W2061868430","https://openalex.org/W2064266162","https://openalex.org/W2069869279","https://openalex.org/W2073429525","https://openalex.org/W2073747823","https://openalex.org/W2083947243","https://openalex.org/W2092942228","https://openalex.org/W2097936772","https://openalex.org/W2108728387","https://openalex.org/W2108857546","https://openalex.org/W2109885856","https://openalex.org/W2114391324","https://openalex.org/W2123106337","https://openalex.org/W2124488712","https://openalex.org/W2130410032","https://openalex.org/W2135141639","https://openalex.org/W2143426320","https://openalex.org/W2145686583","https://openalex.org/W2148226248","https://openalex.org/W2154349465","https://openalex.org/W2155920295","https://openalex.org/W2155929186","https://openalex.org/W2167481521","https://openalex.org/W2256139303","https://openalex.org/W2257440619","https://openalex.org/W2279836332","https://openalex.org/W2346579683","https://openalex.org/W2474761760","https://openalex.org/W2511304340","https://openalex.org/W3099577482","https://openalex.org/W3207021134","https://openalex.org/W3207342693","https://openalex.org/W4253020087"],"related_works":["https://openalex.org/W4231704780","https://openalex.org/W2083794993","https://openalex.org/W352609212","https://openalex.org/W1511772879","https://openalex.org/W4379115841","https://openalex.org/W4200340037","https://openalex.org/W608917066","https://openalex.org/W4283652261","https://openalex.org/W585424826","https://openalex.org/W564602992"],"abstract_inverted_index":{"We":[0,19,74],"conduct":[1],"machine":[2,80],"learning":[3,81],"experiments":[4],"on":[5,29,64,106],"time-dependent":[6],"gene":[7],"expression":[8],"measurements":[9],"associated":[10],"with":[11],"the":[12,24,50,65,114,125],"immune":[13],"response":[14],"to":[15,83,120],"influenza":[16],"in":[17,124],"humans.":[18],"employ":[20],"three":[21],"partitions":[22,85],"of":[23,43,55,61,78],"two":[25],"data":[26],"sets":[27],"focusing":[28,63],"H1N1":[30,35],"only,":[31],"H3N2":[32,37],"only":[33],"and":[34,36,89,104,113,117],"combined.":[38],"From":[39],"a":[40,57,76],"total":[41],"set":[42],"1439":[44],"known":[45],"biological":[46],"pathways,":[47],"we":[48,96],"identify":[49],"most":[51],"discriminatory,":[52],"potentially":[53],"capable":[54],"providing":[56],"very":[58,126],"early":[59,127],"prognosis":[60,128],"infection,":[62],"time":[66],"period":[67],"t":[68],"\u2264":[69],"29":[70],"hours":[71],"post":[72],"infection.":[73],"apply":[75],"suite":[77],"different":[79],"algorithms":[82],"these":[84],"including":[86],"linear,":[87],"nonlinear,":[88],"sparse":[90],"support":[91],"vector":[92],"machines.":[93],"In":[94],"addition,":[95],"use":[97],"artificial":[98],"neural":[99],"networks":[100],"(ANN),":[101],"k-nearest":[102],"neighbors":[103],"classification":[105],"Grassmann":[107],"manifolds.":[108],"The":[109],"cAMP":[110],"Signaling":[111],"pathway":[112],"genes":[115],"PAPSS1":[116],"PAPSS2":[118],"appeared":[119],"play":[121],"central":[122],"role":[123],"problem.":[129]},"counts_by_year":[{"year":2022,"cited_by_count":2},{"year":2017,"cited_by_count":1}],"updated_date":"2026-04-10T15:06:20.359241","created_date":"2025-10-10T00:00:00"}
