{"id":"https://openalex.org/W2559259166","doi":"https://doi.org/10.1145/2975167.2975196","title":"Robust Kernel Canonical Correlation Analysis to Detect Gene-Gene Interaction for Imaging Genetics Data","display_name":"Robust Kernel Canonical Correlation Analysis to Detect Gene-Gene Interaction for Imaging Genetics Data","publication_year":2016,"publication_date":"2016-10-02","ids":{"openalex":"https://openalex.org/W2559259166","doi":"https://doi.org/10.1145/2975167.2975196","mag":"2559259166"},"language":"en","primary_location":{"id":"doi:10.1145/2975167.2975196","is_oa":true,"landing_page_url":"https://doi.org/10.1145/2975167.2975196","pdf_url":"http://dl.acm.org/ft_gateway.cfm?id=2975196&type=pdf","source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 7th ACM International Conference on Bioinformatics, Computational Biology, and Health Informatics","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://dl.acm.org/ft_gateway.cfm?id=2975196&type=pdf","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049423717","display_name":"Md Ashad Alam","orcid":"https://orcid.org/0000-0002-7622-0216"},"institutions":[{"id":"https://openalex.org/I114832834","display_name":"Tulane University","ror":"https://ror.org/04vmvtb21","country_code":"US","type":"education","lineage":["https://openalex.org/I114832834"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Md. Ashad Alam","raw_affiliation_strings":["Department of Biomedical Engineering, Tulane University, New Orleans, LA, USA"],"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Tulane University, New Orleans, LA, USA","institution_ids":["https://openalex.org/I114832834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065624271","display_name":"Osamu Komori","orcid":"https://orcid.org/0000-0003-2174-1812"},"institutions":[{"id":"https://openalex.org/I111966504","display_name":"University of Fukui","ror":"https://ror.org/00msqp585","country_code":"JP","type":"education","lineage":["https://openalex.org/I111966504"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Osamu Komori","raw_affiliation_strings":["Department of Electrical and Electronics Engineering, University of Fukui, Fukui-shi, Fukui, Japan"],"affiliations":[{"raw_affiliation_string":"Department of Electrical and Electronics Engineering, University of Fukui, Fukui-shi, Fukui, Japan","institution_ids":["https://openalex.org/I111966504"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032850756","display_name":"Vince D. Calhoun","orcid":"https://orcid.org/0000-0001-9058-0747"},"institutions":[{"id":"https://openalex.org/I169521973","display_name":"University of New Mexico","ror":"https://ror.org/05fs6jp91","country_code":"US","type":"education","lineage":["https://openalex.org/I169521973"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vince Calhoun","raw_affiliation_strings":["Department of Electrical and Computer Engineering, The University of New Mexico, Albuquerque, NM, USA"],"affiliations":[{"raw_affiliation_string":"Department of Electrical and Computer Engineering, The University of New Mexico, Albuquerque, NM, USA","institution_ids":["https://openalex.org/I169521973"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100339108","display_name":"Yu-Ping Wang","orcid":"https://orcid.org/0000-0002-2822-5813"},"institutions":[{"id":"https://openalex.org/I114832834","display_name":"Tulane University","ror":"https://ror.org/04vmvtb21","country_code":"US","type":"education","lineage":["https://openalex.org/I114832834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yu-Ping Wang","raw_affiliation_strings":["Department of Biomedical Engineering, Tulane University, New Orleans, LA, USA"],"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Tulane University, New Orleans, LA, USA","institution_ids":["https://openalex.org/I114832834"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5049423717"],"corresponding_institution_ids":["https://openalex.org/I114832834"],"apc_list":null,"apc_paid":null,"fwci":0.8716,"has_fulltext":true,"cited_by_count":5,"citation_normalized_percentile":{"value":0.77432433,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":96},"biblio":{"volume":null,"issue":null,"first_page":"279","last_page":"288"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9950000047683716,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9950000047683716,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11468","display_name":"Genetic Mapping and Diversity in Plants and Animals","score":0.9921000003814697,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9919999837875366,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/kernel","display_name":"Kernel (algebra)","score":0.7078961133956909},{"id":"https://openalex.org/keywords/covariance","display_name":"Covariance","score":0.478878915309906},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4475404620170593},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.4441143274307251},{"id":"https://openalex.org/keywords/kernel-method","display_name":"Kernel method","score":0.4267512857913971},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.4172241687774658},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.3747004270553589},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.34481996297836304},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.2860087752342224},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.26208826899528503},{"id":"https://openalex.org/keywords/support-vector-machine","display_name":"Support vector machine","score":0.1577753722667694}],"concepts":[{"id":"https://openalex.org/C74193536","wikidata":"https://www.wikidata.org/wiki/Q574844","display_name":"Kernel (algebra)","level":2,"score":0.7078961133956909},{"id":"https://openalex.org/C178650346","wikidata":"https://www.wikidata.org/wiki/Q201984","display_name":"Covariance","level":2,"score":0.478878915309906},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4475404620170593},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.4441143274307251},{"id":"https://openalex.org/C122280245","wikidata":"https://www.wikidata.org/wiki/Q620622","display_name":"Kernel method","level":3,"score":0.4267512857913971},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.4172241687774658},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.3747004270553589},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.34481996297836304},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2860087752342224},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.26208826899528503},{"id":"https://openalex.org/C12267149","wikidata":"https://www.wikidata.org/wiki/Q282453","display_name":"Support vector machine","level":2,"score":0.1577753722667694},{"id":"https://openalex.org/C114614502","wikidata":"https://www.wikidata.org/wiki/Q76592","display_name":"Combinatorics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1145/2975167.2975196","is_oa":true,"landing_page_url":"https://doi.org/10.1145/2975167.2975196","pdf_url":"http://dl.acm.org/ft_gateway.cfm?id=2975196&type=pdf","source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 7th ACM International Conference on Bioinformatics, Computational Biology, and Health Informatics","raw_type":"proceedings-article"}],"best_oa_location":{"id":"doi:10.1145/2975167.2975196","is_oa":true,"landing_page_url":"https://doi.org/10.1145/2975167.2975196","pdf_url":"http://dl.acm.org/ft_gateway.cfm?id=2975196&type=pdf","source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 7th ACM International Conference on Bioinformatics, Computational Biology, and Health Informatics","raw_type":"proceedings-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1578671231","display_name":null,"funder_award_id":"RO1 GM1099068","funder_id":"https://openalex.org/F4320319990","funder_display_name":"National Institute for Health and Care Research"},{"id":"https://openalex.org/G1742386403","display_name":null,"funder_award_id":"MH104680","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G2418860820","display_name":null,"funder_award_id":"1539067","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3815360550","display_name":null,"funder_award_id":"153906","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G4407193152","display_name":null,"funder_award_id":"1539067","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G4691463003","display_name":null,"funder_award_id":"R01 GM109068","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G4744289370","display_name":null,"funder_award_id":"539067","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G6429669059","display_name":null,"funder_award_id":"109068","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6990212532","display_name":null,"funder_award_id":"R01 GM109068","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7579577999","display_name":null,"funder_award_id":"R01 GM109068, R01 MH104680","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7683153553","display_name":null,"funder_award_id":"R01 MH104680","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G8469263691","display_name":null,"funder_award_id":"R01 MH104680","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320319990","display_name":"National Institute for Health and Care Research","ror":"https://ror.org/0187kwz08"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2559259166.pdf","grobid_xml":"https://content.openalex.org/works/W2559259166.grobid-xml"},"referenced_works_count":50,"referenced_works":["https://openalex.org/W35014902","https://openalex.org/W139501938","https://openalex.org/W813296025","https://openalex.org/W1497960466","https://openalex.org/W1532551225","https://openalex.org/W1822695366","https://openalex.org/W1967827763","https://openalex.org/W1968617782","https://openalex.org/W1972598934","https://openalex.org/W1991863700","https://openalex.org/W2001059210","https://openalex.org/W2002070806","https://openalex.org/W2005051528","https://openalex.org/W2012712694","https://openalex.org/W2026069168","https://openalex.org/W2035163205","https://openalex.org/W2041170649","https://openalex.org/W2043565980","https://openalex.org/W2065371646","https://openalex.org/W2072986941","https://openalex.org/W2076495671","https://openalex.org/W2083095455","https://openalex.org/W2089870445","https://openalex.org/W2100235303","https://openalex.org/W2112552549","https://openalex.org/W2120572720","https://openalex.org/W2122617678","https://openalex.org/W2128207034","https://openalex.org/W2130055251","https://openalex.org/W2130789388","https://openalex.org/W2145544165","https://openalex.org/W2147184730","https://openalex.org/W2156204103","https://openalex.org/W2158217645","https://openalex.org/W2161633633","https://openalex.org/W2171418097","https://openalex.org/W2188217758","https://openalex.org/W2280148061","https://openalex.org/W2316032241","https://openalex.org/W2506890028","https://openalex.org/W2547788783","https://openalex.org/W2557615715","https://openalex.org/W2998520482","https://openalex.org/W3015387428","https://openalex.org/W3099761860","https://openalex.org/W3105132240","https://openalex.org/W4205806204","https://openalex.org/W4252112654","https://openalex.org/W6676726796","https://openalex.org/W6677945236"],"related_works":["https://openalex.org/W2089892314","https://openalex.org/W1603091392","https://openalex.org/W4386075310","https://openalex.org/W2095626363","https://openalex.org/W2169565408","https://openalex.org/W2127229869","https://openalex.org/W3123056048","https://openalex.org/W4248019443","https://openalex.org/W2150638158","https://openalex.org/W2121506664"],"abstract_inverted_index":{"In":[0,82],"genome-wide":[1],"interaction":[2],"studies,":[3],"to":[4,58,90,117,146,158],"detect":[5,59],"gene-gene":[6],"interactions,":[7],"most":[8],"methods":[9,25,35,76,157],"are":[10,30,78],"divided":[11],"into":[12],"two":[13],"folds:":[14],"single":[15,39],"nucleotide":[16],"polymorphisms":[17],"(SNP)":[18],"based":[19,26,36,51,75,113,132],"and":[20,105,143,161,170,175],"gene-based":[21],"methods.":[22,191],"Basically,":[23],"the":[24,28,34,43,60,67,101,119,122,155,173,180,185,189],"on":[27,37,114,133,167],"gene":[29,168],"more":[31],"effective":[32],"than":[33,148],"a":[38,111,127],"SNP.":[40],"Recent":[41],"years,":[42],"kernel":[44,49,85,98,103,135,150],"canonical":[45],"correlation":[46],"analysis":[47,177],"(Classical":[48],"CCA)":[50],"U":[52],"statistic":[53],"(KCCU)":[54],"has":[55],"been":[56],"proposed":[57,156,181],"nonlinear":[61],"relationship":[62],"between":[63],"genes.":[64],"To":[65],"estimate":[66,118],"variance":[68,120],"in":[69],"KCCU,":[70],"they":[71],"have":[72],"used":[73],"resampling":[74],"which":[77,137],"highly":[79],"computationally":[80],"intensive.":[81],"addition,":[83],"classical":[84,149],"CCA":[86],"is":[87,138],"not":[88],"robust":[89,97,102,129,134,182],"contaminated":[91,141],"data.":[92],"We,":[93],"therefore,":[94],"first":[95],"discuss":[96],"mean":[99],"element,":[100],"covariance,":[104],"cross-covariance":[106],"operators.":[107],"Second,":[108],"we":[109,125,153],"propose":[110,126],"method":[112,131,183],"influence":[115],"function":[116],"of":[121,188],"KCCU.":[123],"Third,":[124],"nonparametric":[128],"KCCU":[130],"CCA,":[136],"designed":[139],"for":[140],"data":[142,160,164],"less":[144],"sensitive":[145],"noise":[147],"CCA.":[151],"Finally,":[152],"investigate":[154],"synthesized":[159,174],"imaging":[162],"genetic":[163],"set.":[165],"Based":[166],"ontology":[169],"pathway":[171],"analysis,":[172],"genetics":[176],"demonstrate":[178],"that":[179],"shows":[184],"superior":[186],"performance":[187],"state-of-the-art":[190]},"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-04-10T15:06:20.359241","created_date":"2025-10-10T00:00:00"}