{"id":"https://openalex.org/W2483293055","doi":"https://doi.org/10.1145/2908961.2931718","title":"Path-based Guidance of an Evolutionary Algorithm in Mapping a Fitness Landscape and its Connectivity","display_name":"Path-based Guidance of an Evolutionary Algorithm in Mapping a Fitness Landscape and its Connectivity","publication_year":2016,"publication_date":"2016-07-20","ids":{"openalex":"https://openalex.org/W2483293055","doi":"https://doi.org/10.1145/2908961.2931718","mag":"2483293055"},"language":"en","primary_location":{"id":"doi:10.1145/2908961.2931718","is_oa":false,"landing_page_url":"https://doi.org/10.1145/2908961.2931718","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 2016 on Genetic and Evolutionary Computation Conference Companion","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5105350545","display_name":"Emmanuel Sapin","orcid":"https://orcid.org/0000-0002-7188-3715"},"institutions":[{"id":"https://openalex.org/I162714631","display_name":"George Mason University","ror":"https://ror.org/02jqj7156","country_code":"US","type":"education","lineage":["https://openalex.org/I162714631"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Emmanuel Sapin","raw_affiliation_strings":["George Mason University, Fairfax,, VA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"George Mason University, Fairfax,, VA, USA","institution_ids":["https://openalex.org/I162714631"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111782149","display_name":"Kenneth De Jong","orcid":"https://orcid.org/0000-0002-2799-280X"},"institutions":[{"id":"https://openalex.org/I162714631","display_name":"George Mason University","ror":"https://ror.org/02jqj7156","country_code":"US","type":"education","lineage":["https://openalex.org/I162714631"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kenneth De Jong","raw_affiliation_strings":["George Mason University, Fairfax, , VA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"George Mason University, Fairfax, , VA, USA","institution_ids":["https://openalex.org/I162714631"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044722808","display_name":"Amarda Shehu","orcid":"https://orcid.org/0000-0001-5230-4610"},"institutions":[{"id":"https://openalex.org/I162714631","display_name":"George Mason University","ror":"https://ror.org/02jqj7156","country_code":"US","type":"education","lineage":["https://openalex.org/I162714631"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amarda Shehu","raw_affiliation_strings":["George Mason University, Fairfax,, VA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"George Mason University, Fairfax,, VA, USA","institution_ids":["https://openalex.org/I162714631"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I162714631"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.08897708,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"1293","last_page":"1298"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9972000122070312,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9972000122070312,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9853000044822693,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10540","display_name":"Advanced Fluorescence Microscopy Techniques","score":0.9836000204086304,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/path","display_name":"Path (computing)","score":0.747672975063324},{"id":"https://openalex.org/keywords/energy-landscape","display_name":"Energy landscape","score":0.6435419321060181},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6188423037528992},{"id":"https://openalex.org/keywords/fitness-landscape","display_name":"Fitness landscape","score":0.5751727819442749},{"id":"https://openalex.org/keywords/sequence","display_name":"Sequence (biology)","score":0.4619027078151703},{"id":"https://openalex.org/keywords/evolutionary-algorithm","display_name":"Evolutionary algorithm","score":0.4483262598514557},{"id":"https://openalex.org/keywords/state","display_name":"State (computer science)","score":0.44130265712738037},{"id":"https://openalex.org/keywords/structural-basin","display_name":"Structural basin","score":0.4370197057723999},{"id":"https://openalex.org/keywords/function","display_name":"Function (biology)","score":0.4321907162666321},{"id":"https://openalex.org/keywords/key","display_name":"Key (lock)","score":0.4231027662754059},{"id":"https://openalex.org/keywords/fitness-function","display_name":"Fitness function","score":0.42277389764785767},{"id":"https://openalex.org/keywords/energy","display_name":"Energy (signal processing)","score":0.4132674038410187},{"id":"https://openalex.org/keywords/theoretical-computer-science","display_name":"Theoretical computer science","score":0.39455974102020264},{"id":"https://openalex.org/keywords/distributed-computing","display_name":"Distributed computing","score":0.33306944370269775},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.293720543384552},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.27457183599472046},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.20960330963134766},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.18880099058151245},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.1547437310218811},{"id":"https://openalex.org/keywords/evolutionary-biology","display_name":"Evolutionary biology","score":0.15276795625686646},{"id":"https://openalex.org/keywords/computer-network","display_name":"Computer network","score":0.1170879602432251},{"id":"https://openalex.org/keywords/genetic-algorithm","display_name":"Genetic algorithm","score":0.09698072075843811},{"id":"https://openalex.org/keywords/population","display_name":"Population","score":0.08841714262962341}],"concepts":[{"id":"https://openalex.org/C2777735758","wikidata":"https://www.wikidata.org/wiki/Q817765","display_name":"Path (computing)","level":2,"score":0.747672975063324},{"id":"https://openalex.org/C119621388","wikidata":"https://www.wikidata.org/wiki/Q5377166","display_name":"Energy landscape","level":2,"score":0.6435419321060181},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6188423037528992},{"id":"https://openalex.org/C91852762","wikidata":"https://www.wikidata.org/wiki/Q3307742","display_name":"Fitness landscape","level":3,"score":0.5751727819442749},{"id":"https://openalex.org/C2778112365","wikidata":"https://www.wikidata.org/wiki/Q3511065","display_name":"Sequence (biology)","level":2,"score":0.4619027078151703},{"id":"https://openalex.org/C159149176","wikidata":"https://www.wikidata.org/wiki/Q14489129","display_name":"Evolutionary algorithm","level":2,"score":0.4483262598514557},{"id":"https://openalex.org/C48103436","wikidata":"https://www.wikidata.org/wiki/Q599031","display_name":"State (computer science)","level":2,"score":0.44130265712738037},{"id":"https://openalex.org/C109007969","wikidata":"https://www.wikidata.org/wiki/Q749565","display_name":"Structural basin","level":2,"score":0.4370197057723999},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.4321907162666321},{"id":"https://openalex.org/C26517878","wikidata":"https://www.wikidata.org/wiki/Q228039","display_name":"Key (lock)","level":2,"score":0.4231027662754059},{"id":"https://openalex.org/C176066374","wikidata":"https://www.wikidata.org/wiki/Q629118","display_name":"Fitness function","level":3,"score":0.42277389764785767},{"id":"https://openalex.org/C186370098","wikidata":"https://www.wikidata.org/wiki/Q442787","display_name":"Energy (signal processing)","level":2,"score":0.4132674038410187},{"id":"https://openalex.org/C80444323","wikidata":"https://www.wikidata.org/wiki/Q2878974","display_name":"Theoretical computer science","level":1,"score":0.39455974102020264},{"id":"https://openalex.org/C120314980","wikidata":"https://www.wikidata.org/wiki/Q180634","display_name":"Distributed computing","level":1,"score":0.33306944370269775},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.293720543384552},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.27457183599472046},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.20960330963134766},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.18880099058151245},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1547437310218811},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.15276795625686646},{"id":"https://openalex.org/C31258907","wikidata":"https://www.wikidata.org/wiki/Q1301371","display_name":"Computer network","level":1,"score":0.1170879602432251},{"id":"https://openalex.org/C8880873","wikidata":"https://www.wikidata.org/wiki/Q187787","display_name":"Genetic algorithm","level":2,"score":0.09698072075843811},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.08841714262962341},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.0},{"id":"https://openalex.org/C38652104","wikidata":"https://www.wikidata.org/wiki/Q3510521","display_name":"Computer security","level":1,"score":0.0},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1145/2908961.2931718","is_oa":false,"landing_page_url":"https://doi.org/10.1145/2908961.2931718","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 2016 on Genetic and Evolutionary Computation Conference Companion","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.6800000071525574,"id":"https://metadata.un.org/sdg/7","display_name":"Affordable and clean energy"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":11,"referenced_works":["https://openalex.org/W1566214213","https://openalex.org/W1798761798","https://openalex.org/W2033650210","https://openalex.org/W2073853984","https://openalex.org/W2077743314","https://openalex.org/W2103237643","https://openalex.org/W2114479908","https://openalex.org/W2207060474","https://openalex.org/W2326545242","https://openalex.org/W2343931134","https://openalex.org/W2509964510"],"related_works":["https://openalex.org/W2036107212","https://openalex.org/W2044498124","https://openalex.org/W2164084664","https://openalex.org/W1634842376","https://openalex.org/W4250294025","https://openalex.org/W1970185413","https://openalex.org/W2159937791","https://openalex.org/W2138958036","https://openalex.org/W192154461","https://openalex.org/W1966735857"],"abstract_inverted_index":{"Understanding":[0],"function":[1],"regulation":[2],"in":[3,35],"proteins":[4,129],"that":[5,18,40,56,96,142],"switch":[6],"between":[7],"different":[8],"structural":[9],"states":[10,22],"at":[11],"equilibrium":[12],"requires":[13],"both":[14],"finding":[15,85],"the":[16,25,32,57,79,98,113,118],"basins":[17],"correspond":[19],"to":[20,46,67,103,132,146],"such":[21],"and":[23,83,135,155],"computing":[24],"sequence":[26],"of":[27,81,100,130],"intermediate":[28],"structures":[29],"employed":[30],"(i.e.,":[31],"path":[33,84],"taken)":[34],"basin-to-basin":[36],"switching.":[37],"Recent":[38],"worksuggests":[39],"evolutionary":[41],"strategies":[42],"can":[43,60],"be":[44,61],"used":[45],"map":[47,111],"protein":[48],"energy":[49],"landscapes":[50],"effectively.":[51],"Further":[52],"work":[53],"has":[54],"shown":[55],"constructed":[58],"maps":[59],"additionally":[62],"equipped":[63],"with":[64,117,150],"connectivity":[65],"information":[66,152],"help":[68],"identify":[69],"basin-switching":[70],"paths.":[71],"Here":[72],"we":[73],"highlight":[74],"a":[75,91],"potential":[76],"issue":[77],"when":[78,112],"problems":[80],"mapping":[82],"are":[86,153],"considered":[87],"separately.":[88],"We":[89],"conduct":[90],"simple,":[92],"proof-of":[93],"principle":[94],"study":[95,122],"demonstrates":[97],"ability":[99],"an":[101,109,148],"EA":[102,114,149],"allow":[104],"extracting":[105],"better":[106],"paths":[107],"from":[108],"EA-built":[110],"is":[115,123],"supplied":[116],"right":[119],"information.":[120],"The":[121,137],"conducted":[124],"on":[125],"two":[126],"key,":[127],"multi-state":[128],"importance":[131],"human":[133],"biology":[134],"disease.":[136],"results":[138],"presented":[139],"here":[140],"suggest":[141],"further":[143],"research":[144],"efforts":[145],"guide":[147],"path-based":[151],"warranted":[154],"feasible.":[156]},"counts_by_year":[],"updated_date":"2026-07-29T14:22:42.915294","created_date":"2025-10-10T00:00:00"}