{"id":"https://openalex.org/W2548613950","doi":"https://doi.org/10.1145/2908446.2908461","title":"A System Dynamics Model for Chemotherapy","display_name":"A System Dynamics Model for Chemotherapy","publication_year":2016,"publication_date":"2016-05-09","ids":{"openalex":"https://openalex.org/W2548613950","doi":"https://doi.org/10.1145/2908446.2908461","mag":"2548613950"},"language":"en","primary_location":{"id":"doi:10.1145/2908446.2908461","is_oa":false,"landing_page_url":"https://doi.org/10.1145/2908446.2908461","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 10th International Conference on Informatics and Systems","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036012094","display_name":"Mahmoud Heshmat","orcid":"https://orcid.org/0000-0003-1492-4223"},"institutions":[{"id":"https://openalex.org/I32619867","display_name":"Egypt-Japan University of Science and Technology","ror":"https://ror.org/02x66tk73","country_code":"EG","type":"education","lineage":["https://openalex.org/I32619867"]}],"countries":["EG"],"is_corresponding":true,"raw_author_name":"M. Heshmat","raw_affiliation_strings":["Department of Industrial Engineering and Systems Management, Egypt-Japan University of Science and Technology (E-JUST), Alexandria, Egypt"],"affiliations":[{"raw_affiliation_string":"Department of Industrial Engineering and Systems Management, Egypt-Japan University of Science and Technology (E-JUST), Alexandria, Egypt","institution_ids":["https://openalex.org/I32619867"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5014763439","display_name":"Amr Eltawil","orcid":"https://orcid.org/0000-0001-6073-8240"},"institutions":[{"id":"https://openalex.org/I32619867","display_name":"Egypt-Japan University of Science and Technology","ror":"https://ror.org/02x66tk73","country_code":"EG","type":"education","lineage":["https://openalex.org/I32619867"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"A. Eltawil","raw_affiliation_strings":["Department of Industrial Engineering and Systems Management, Egypt-Japan University of Science and Technology (E-JUST), Alexandria, Egypt"],"affiliations":[{"raw_affiliation_string":"Department of Industrial Engineering and Systems Management, Egypt-Japan University of Science and Technology (E-JUST), Alexandria, Egypt","institution_ids":["https://openalex.org/I32619867"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5036012094"],"corresponding_institution_ids":["https://openalex.org/I32619867"],"apc_list":null,"apc_paid":null,"fwci":0.4522,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.68459734,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":null,"issue":null,"first_page":"7","last_page":"13"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11829","display_name":"Mathematical Biology Tumor Growth","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11829","display_name":"Mathematical Biology Tumor Growth","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9782999753952026,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12850","display_name":"Field-Flow Fractionation Techniques","score":0.9555000066757202,"subfield":{"id":"https://openalex.org/subfields/2206","display_name":"Computational Mechanics"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chemotherapy","display_name":"Chemotherapy","score":0.74974125623703},{"id":"https://openalex.org/keywords/toxicity","display_name":"Toxicity","score":0.7037192583084106},{"id":"https://openalex.org/keywords/drug","display_name":"Drug","score":0.4744742214679718},{"id":"https://openalex.org/keywords/cancer-chemotherapy","display_name":"Cancer chemotherapy","score":0.4547639489173889},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.44738203287124634},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4195120930671692},{"id":"https://openalex.org/keywords/drug-toxicity","display_name":"Drug toxicity","score":0.4142577052116394},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.3918185830116272},{"id":"https://openalex.org/keywords/oncology","display_name":"Oncology","score":0.32303234934806824},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.2516026496887207}],"concepts":[{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.74974125623703},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.7037192583084106},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.4744742214679718},{"id":"https://openalex.org/C2983288658","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Cancer chemotherapy","level":3,"score":0.4547639489173889},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.44738203287124634},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4195120930671692},{"id":"https://openalex.org/C2992092908","wikidata":"https://www.wikidata.org/wiki/Q45959","display_name":"Drug toxicity","level":3,"score":0.4142577052116394},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3918185830116272},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.32303234934806824},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2516026496887207}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1145/2908446.2908461","is_oa":false,"landing_page_url":"https://doi.org/10.1145/2908446.2908461","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 10th International Conference on Informatics and Systems","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8399999737739563,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":6,"referenced_works":["https://openalex.org/W2037548799","https://openalex.org/W2060085351","https://openalex.org/W2087600569","https://openalex.org/W2134805717","https://openalex.org/W2247019932","https://openalex.org/W4238689661"],"related_works":["https://openalex.org/W141149922","https://openalex.org/W2351699909","https://openalex.org/W3179572886","https://openalex.org/W4387799353","https://openalex.org/W331635108","https://openalex.org/W2181629603","https://openalex.org/W2413405428","https://openalex.org/W47781288","https://openalex.org/W2170381017","https://openalex.org/W3157427301"],"abstract_inverted_index":{"Chemotherapy":[0],"is":[1,15,86,106,139,160,172],"one":[2],"of":[3,36,74,92,115,118,145],"the":[4,22,26,30,43,51,64,68,90,93,116,128,131,143,151,158,176],"most":[5],"common":[6],"approaches":[7],"in":[8,42,50],"cancer":[9],"treatment.":[10],"The":[11,108,154],"problem":[12],"with":[13,39,96,121,125,134],"chemotherapy":[14,37,123],"that":[16,157],"it":[17],"does":[18],"not":[19],"only":[20],"kill":[21],"cancerous":[23,75,119],"cells,":[24,76],"but":[25],"therapy":[27],"affects":[28],"badly":[29],"healthy":[31],"cells":[32,120],"as":[33,72],"well.":[34],"Accumulation":[35],"drugs":[38],"repeated":[40,122],"doses":[41,124,146,164,167,171,180],"patient's":[44,177],"body":[45],"leads":[46],"to":[47,88,141,163],"increasing":[48],"toxicity":[49,132],"whole":[52],"body.":[53],"This":[54],"paper":[55],"develops":[56],"a":[57,112],"general":[58],"system":[59,94],"dynamics":[60],"model":[61,101,159],"which":[62],"clarifies":[63],"different":[65],"factors":[66],"affecting":[67],"treatment":[69,152],"plans":[70],"such":[71],"number":[73,117],"drug":[77],"accumulation,":[78],"and":[79,83,148],"toxicity.":[80],"A":[81,99],"stock":[82],"flow":[84],"diagram":[85],"constructed":[87],"show":[89,111,142,156],"interaction":[91],"variables":[95],"each":[97],"other.":[98],"simulation":[100,109],"using":[102],"iT":[103],"hink":[104],"software":[105],"used.":[107],"results":[110,155],"decreasing":[113],"trend":[114],"time.":[126,135],"On":[127],"other":[129],"hand,":[130],"increases":[133],"Finally,":[136],"sensitivity":[137],"analysis":[138],"conducted":[140],"effect":[144],"cancellation":[147,165],"delay":[149],"on":[150,175],"efficacy.":[153],"more":[161,173],"sensitive":[162],"than":[166,179],"delay,":[168],"thus":[169],"cancelling":[170],"critical":[174],"health":[178],"delaying.":[181]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2017,"cited_by_count":2}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}