{"id":"https://openalex.org/W1975282571","doi":"https://doi.org/10.1145/2811163.2811167","title":"Development of a Framework for Constructing a Virtual Physiological Human with the Integration of COntext Specific Directed Associations (CODA)","display_name":"Development of a Framework for Constructing a Virtual Physiological Human with the Integration of COntext Specific Directed Associations (CODA)","publication_year":2015,"publication_date":"2015-10-22","ids":{"openalex":"https://openalex.org/W1975282571","doi":"https://doi.org/10.1145/2811163.2811167","mag":"1975282571"},"language":"en","primary_location":{"id":"doi:10.1145/2811163.2811167","is_oa":false,"landing_page_url":"https://doi.org/10.1145/2811163.2811167","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the ACM Ninth International Workshop on Data and Text Mining in Biomedical Informatics","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002000972","display_name":"Hasun Yu","orcid":null},"institutions":[{"id":"https://openalex.org/I157485424","display_name":"Korea Advanced Institute of Science and Technology","ror":"https://ror.org/05apxxy63","country_code":"KR","type":"education","lineage":["https://openalex.org/I157485424"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Hasun Yu","raw_affiliation_strings":["KAIST & Bio-Synergy Research Center, Daejeon, South Korea"],"affiliations":[{"raw_affiliation_string":"KAIST & Bio-Synergy Research Center, Daejeon, South Korea","institution_ids":["https://openalex.org/I157485424"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103282907","display_name":"Jin\u2010Myung Jung","orcid":"https://orcid.org/0000-0002-4962-8347"},"institutions":[{"id":"https://openalex.org/I157485424","display_name":"Korea Advanced Institute of Science and Technology","ror":"https://ror.org/05apxxy63","country_code":"KR","type":"education","lineage":["https://openalex.org/I157485424"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jinmyung Jung","raw_affiliation_strings":["KAIST & Bio-Synergy Research Center, Daejeon, South Korea"],"affiliations":[{"raw_affiliation_string":"KAIST & Bio-Synergy Research Center, Daejeon, South Korea","institution_ids":["https://openalex.org/I157485424"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047099815","display_name":"Seyeol Yoon","orcid":"https://orcid.org/0000-0003-4665-6331"},"institutions":[{"id":"https://openalex.org/I157485424","display_name":"Korea Advanced Institute of Science and Technology","ror":"https://ror.org/05apxxy63","country_code":"KR","type":"education","lineage":["https://openalex.org/I157485424"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Seyeol Yoon","raw_affiliation_strings":["KAIST & Bio-Synergy Research Center, Daejeon, South Korea"],"affiliations":[{"raw_affiliation_string":"KAIST & Bio-Synergy Research Center, Daejeon, South Korea","institution_ids":["https://openalex.org/I157485424"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103011138","display_name":"Mijin Kwon","orcid":"https://orcid.org/0000-0001-8977-8393"},"institutions":[{"id":"https://openalex.org/I157485424","display_name":"Korea Advanced Institute of Science and Technology","ror":"https://ror.org/05apxxy63","country_code":"KR","type":"education","lineage":["https://openalex.org/I157485424"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Mijin Kwon","raw_affiliation_strings":["KAIST & Bio-Synergy Research Center, Daejeon, South Korea"],"affiliations":[{"raw_affiliation_string":"KAIST & Bio-Synergy Research Center, Daejeon, South Korea","institution_ids":["https://openalex.org/I157485424"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029565879","display_name":"Yeeok Kang","orcid":null},"institutions":[{"id":"https://openalex.org/I157485424","display_name":"Korea Advanced Institute of Science and Technology","ror":"https://ror.org/05apxxy63","country_code":"KR","type":"education","lineage":["https://openalex.org/I157485424"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Yeeok Kang","raw_affiliation_strings":["KAIST & Bio-Synergy Research Center, Daejeon, South Korea"],"affiliations":[{"raw_affiliation_string":"KAIST & Bio-Synergy Research Center, Daejeon, South Korea","institution_ids":["https://openalex.org/I157485424"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049465829","display_name":"Sunghwa Bae","orcid":null},"institutions":[{"id":"https://openalex.org/I157485424","display_name":"Korea Advanced Institute of Science and Technology","ror":"https://ror.org/05apxxy63","country_code":"KR","type":"education","lineage":["https://openalex.org/I157485424"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Sunghwa Bae","raw_affiliation_strings":["KAIST & Bio-Synergy Research Center, Daejeon, South Korea"],"affiliations":[{"raw_affiliation_string":"KAIST & Bio-Synergy Research Center, Daejeon, South Korea","institution_ids":["https://openalex.org/I157485424"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5037879375","display_name":"Doheon Lee","orcid":"https://orcid.org/0000-0001-9070-4316"},"institutions":[{"id":"https://openalex.org/I157485424","display_name":"Korea Advanced Institute of Science and Technology","ror":"https://ror.org/05apxxy63","country_code":"KR","type":"education","lineage":["https://openalex.org/I157485424"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Doheon Lee","raw_affiliation_strings":["KAIST & Bio-Synergy Research Center, Daejeon, South Korea"],"affiliations":[{"raw_affiliation_string":"KAIST & Bio-Synergy Research Center, Daejeon, South Korea","institution_ids":["https://openalex.org/I157485424"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5002000972"],"corresponding_institution_ids":["https://openalex.org/I157485424"],"apc_list":null,"apc_paid":null,"fwci":0.1459,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.54598941,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":null,"issue":null,"first_page":"18","last_page":"18"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9908999800682068,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/context","display_name":"Context (archaeology)","score":0.6946604251861572},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6252709627151489},{"id":"https://openalex.org/keywords/biological-network","display_name":"Biological network","score":0.599532961845398},{"id":"https://openalex.org/keywords/in-silico","display_name":"In silico","score":0.582817554473877},{"id":"https://openalex.org/keywords/process","display_name":"Process (computing)","score":0.5295459032058716},{"id":"https://openalex.org/keywords/relation","display_name":"Relation (database)","score":0.4953855276107788},{"id":"https://openalex.org/keywords/drug-discovery","display_name":"Drug discovery","score":0.49448347091674805},{"id":"https://openalex.org/keywords/virtual-screening","display_name":"Virtual screening","score":0.4524199366569519},{"id":"https://openalex.org/keywords/business-process-discovery","display_name":"Business process discovery","score":0.42548608779907227},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4098307490348816},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.329865038394928},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3051031529903412},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.27873361110687256},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.21630769968032837},{"id":"https://openalex.org/keywords/work-in-process","display_name":"Work in process","score":0.1485365629196167},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.13412082195281982},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.08583462238311768}],"concepts":[{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.6946604251861572},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6252709627151489},{"id":"https://openalex.org/C28225019","wikidata":"https://www.wikidata.org/wiki/Q4915005","display_name":"Biological network","level":2,"score":0.599532961845398},{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.582817554473877},{"id":"https://openalex.org/C98045186","wikidata":"https://www.wikidata.org/wiki/Q205663","display_name":"Process (computing)","level":2,"score":0.5295459032058716},{"id":"https://openalex.org/C25343380","wikidata":"https://www.wikidata.org/wiki/Q277521","display_name":"Relation (database)","level":2,"score":0.4953855276107788},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.49448347091674805},{"id":"https://openalex.org/C103697762","wikidata":"https://www.wikidata.org/wiki/Q4112105","display_name":"Virtual screening","level":3,"score":0.4524199366569519},{"id":"https://openalex.org/C93453677","wikidata":"https://www.wikidata.org/wiki/Q1017580","display_name":"Business process discovery","level":5,"score":0.42548608779907227},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4098307490348816},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.329865038394928},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3051031529903412},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.27873361110687256},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.21630769968032837},{"id":"https://openalex.org/C174998907","wikidata":"https://www.wikidata.org/wiki/Q357662","display_name":"Work in process","level":2,"score":0.1485365629196167},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.13412082195281982},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.08583462238311768},{"id":"https://openalex.org/C21547014","wikidata":"https://www.wikidata.org/wiki/Q1423657","display_name":"Operations management","level":1,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C85345410","wikidata":"https://www.wikidata.org/wiki/Q851587","display_name":"Business process","level":3,"score":0.0},{"id":"https://openalex.org/C207505557","wikidata":"https://www.wikidata.org/wiki/Q4374012","display_name":"Business process modeling","level":4,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1145/2811163.2811167","is_oa":false,"landing_page_url":"https://doi.org/10.1145/2811163.2811167","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the ACM Ninth International Workshop on Data and Text Mining in Biomedical Informatics","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.4699999988079071,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"awards":[{"id":"https://openalex.org/G7650184580","display_name":null,"funder_award_id":"NRF-2012M3A9C4048758","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"}],"funders":[{"id":"https://openalex.org/F4320322120","display_name":"National Research Foundation of Korea","ror":"https://ror.org/013aysd81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":6,"referenced_works":["https://openalex.org/W1980767243","https://openalex.org/W1981409633","https://openalex.org/W2112696414","https://openalex.org/W2159482845","https://openalex.org/W2170974939","https://openalex.org/W4294216483"],"related_works":["https://openalex.org/W3174709249","https://openalex.org/W2017055503","https://openalex.org/W2059230675","https://openalex.org/W2376003823","https://openalex.org/W4402273478","https://openalex.org/W2594726310","https://openalex.org/W2355193834","https://openalex.org/W1597404095","https://openalex.org/W4386306196","https://openalex.org/W2530048721"],"abstract_inverted_index":{"Construction":[0],"of":[1,36,49,67],"a":[2],"virtual":[3],"physiological":[4],"human":[5,28],"system":[6],"by":[7],"reconstructing":[8,53],"biological":[9,25,54,81],"networks":[10,26,55],"is":[11,94,98],"proposed":[12],"as":[13,80],"an":[14],"alternative":[15],"to":[16,101,105],"traditional":[17,37],"drug":[18,38],"development":[19],"process.":[20],"In":[21,85],"silico":[22],"methods":[23],"using":[24],"in":[27,71,91],"have":[29,56],"been":[30],"used":[31],"for":[32,52],"resolving":[33],"current":[34],"issues":[35],"discovery":[39],"like":[40,107],"high":[41],"costs":[42],"and":[43,83,96],"low":[44],"success":[45],"rates.":[46],"However,":[47],"most":[48],"previous":[50,92],"approaches":[51],"considered":[57],"only":[58,70],"one":[59],"relation":[60],"type":[61,108],"although":[62],"there":[63],"are":[64],"various":[65],"types":[66],"relations":[68],"not":[69,99],"molecular":[72],"level":[73],"but":[74],"also":[75],"within":[76],"over-molecule":[77],"levels":[78],"such":[79],"processes":[82],"diseases.":[84],"addition,":[86],"each":[87],"tissue":[88],"specific":[89],"network":[90],"works":[93],"isolated":[95],"it":[97],"appropriate":[100],"analyze":[102],"diseases":[103],"associated":[104],"multi-tissues":[106],"2":[109],"diabetes":[110],"(T2D).":[111]},"counts_by_year":[{"year":2017,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}