{"id":"https://openalex.org/W2027670229","doi":"https://doi.org/10.1145/2808719.2808721","title":"High-speed westfall-young permutation procedure for genome-wide association studies","display_name":"High-speed westfall-young permutation procedure for genome-wide association studies","publication_year":2015,"publication_date":"2015-09-09","ids":{"openalex":"https://openalex.org/W2027670229","doi":"https://doi.org/10.1145/2808719.2808721","mag":"2027670229"},"language":"en","primary_location":{"id":"doi:10.1145/2808719.2808721","is_oa":true,"landing_page_url":"https://doi.org/10.1145/2808719.2808721","pdf_url":"http://dl.acm.org/ft_gateway.cfm?id=2808721&type=pdf","source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 6th ACM Conference on Bioinformatics, Computational Biology and Health Informatics","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://dl.acm.org/ft_gateway.cfm?id=2808721&type=pdf","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019829876","display_name":"Aika Terada","orcid":null},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Aika Terada","raw_affiliation_strings":["The Univ. of Tokyo, BRD, AIST"],"affiliations":[{"raw_affiliation_string":"The Univ. of Tokyo, BRD, AIST","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017961802","display_name":"Hanyoung Kim","orcid":"https://orcid.org/0000-0001-5721-4104"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hanyoung Kim","raw_affiliation_strings":["Tokyo Inst. of Technol"],"affiliations":[{"raw_affiliation_string":"Tokyo Inst. of Technol","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5022912020","display_name":"Jun Sese","orcid":"https://orcid.org/0000-0003-3495-4382"},"institutions":[{"id":"https://openalex.org/I73613424","display_name":"National Institute of Advanced Industrial Science and Technology","ror":"https://ror.org/01703db54","country_code":"JP","type":"government","lineage":["https://openalex.org/I73613424"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Jun Sese","raw_affiliation_strings":["BRD, AIST","BRD, AIST#TAB#"],"affiliations":[{"raw_affiliation_string":"BRD, AIST","institution_ids":[]},{"raw_affiliation_string":"BRD, AIST#TAB#","institution_ids":["https://openalex.org/I73613424"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5019829876"],"corresponding_institution_ids":["https://openalex.org/I74801974"],"apc_list":null,"apc_paid":null,"fwci":0.9888,"has_fulltext":true,"cited_by_count":11,"citation_normalized_percentile":{"value":0.7997162,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":null,"issue":null,"first_page":"17","last_page":"26"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11213","display_name":"Genomic variations and chromosomal abnormalities","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11772","display_name":"Genetics and Neurodevelopmental Disorders","score":0.9699000120162964,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/genome-wide-association-study","display_name":"Genome-wide association study","score":0.8321860432624817},{"id":"https://openalex.org/keywords/permutation","display_name":"Permutation (music)","score":0.652105987071991},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6503770351409912},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphism","display_name":"Single-nucleotide polymorphism","score":0.6428337097167969},{"id":"https://openalex.org/keywords/bonferroni-correction","display_name":"Bonferroni correction","score":0.6107917428016663},{"id":"https://openalex.org/keywords/genetic-association","display_name":"Genetic association","score":0.5198507905006409},{"id":"https://openalex.org/keywords/snp","display_name":"SNP","score":0.44669389724731445},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.3290737271308899},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.2971123456954956},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.20613515377044678},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.19784387946128845},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.17342635989189148},{"id":"https://openalex.org/keywords/genotype","display_name":"Genotype","score":0.08513405919075012}],"concepts":[{"id":"https://openalex.org/C106208931","wikidata":"https://www.wikidata.org/wiki/Q1098876","display_name":"Genome-wide association study","level":5,"score":0.8321860432624817},{"id":"https://openalex.org/C21308566","wikidata":"https://www.wikidata.org/wiki/Q7169365","display_name":"Permutation (music)","level":2,"score":0.652105987071991},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6503770351409912},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.6428337097167969},{"id":"https://openalex.org/C127808970","wikidata":"https://www.wikidata.org/wiki/Q385989","display_name":"Bonferroni correction","level":2,"score":0.6107917428016663},{"id":"https://openalex.org/C186413461","wikidata":"https://www.wikidata.org/wiki/Q744727","display_name":"Genetic association","level":5,"score":0.5198507905006409},{"id":"https://openalex.org/C139275648","wikidata":"https://www.wikidata.org/wiki/Q17134011","display_name":"SNP","level":5,"score":0.44669389724731445},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3290737271308899},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.2971123456954956},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.20613515377044678},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.19784387946128845},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.17342635989189148},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.08513405919075012},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C24890656","wikidata":"https://www.wikidata.org/wiki/Q82811","display_name":"Acoustics","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1145/2808719.2808721","is_oa":true,"landing_page_url":"https://doi.org/10.1145/2808719.2808721","pdf_url":"http://dl.acm.org/ft_gateway.cfm?id=2808721&type=pdf","source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 6th ACM Conference on Bioinformatics, Computational Biology and Health Informatics","raw_type":"proceedings-article"}],"best_oa_location":{"id":"doi:10.1145/2808719.2808721","is_oa":true,"landing_page_url":"https://doi.org/10.1145/2808719.2808721","pdf_url":"http://dl.acm.org/ft_gateway.cfm?id=2808721&type=pdf","source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 6th ACM Conference on Bioinformatics, Computational Biology and Health Informatics","raw_type":"proceedings-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1523731414","display_name":null,"funder_award_id":"Research Fellowships for Young Scientists","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G2692133907","display_name":null,"funder_award_id":"15H01717","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G3459562248","display_name":null,"funder_award_id":"Grant","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G4588193779","display_name":null,"funder_award_id":"24240044","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G4636223006","display_name":null,"funder_award_id":"JSPS KAK","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G5640883929","display_name":null,"funder_award_id":"Research Fellow","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G8004478673","display_name":null,"funder_award_id":"JSPS Research Fellowship","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G8470055433","display_name":null,"funder_award_id":"Research Fellowship","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G8485472354","display_name":null,"funder_award_id":"JSPS Research Fellow","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G942918087","display_name":null,"funder_award_id":"JSPS Research Fellowships for Young Scientists","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2027670229.pdf","grobid_xml":"https://content.openalex.org/works/W2027670229.grobid-xml"},"referenced_works_count":26,"referenced_works":["https://openalex.org/W1596515083","https://openalex.org/W1970956636","https://openalex.org/W1976842852","https://openalex.org/W2037586880","https://openalex.org/W2039542300","https://openalex.org/W2041467022","https://openalex.org/W2060181803","https://openalex.org/W2061324458","https://openalex.org/W2064340631","https://openalex.org/W2101759642","https://openalex.org/W2101889545","https://openalex.org/W2104579579","https://openalex.org/W2110065044","https://openalex.org/W2113381189","https://openalex.org/W2116868464","https://openalex.org/W2117446594","https://openalex.org/W2121044470","https://openalex.org/W2137797806","https://openalex.org/W2142966772","https://openalex.org/W2161633633","https://openalex.org/W2217809488","https://openalex.org/W2796349379","https://openalex.org/W2796856748","https://openalex.org/W3047398590","https://openalex.org/W3103280585","https://openalex.org/W4230727657"],"related_works":["https://openalex.org/W2798513666","https://openalex.org/W3009106047","https://openalex.org/W2594299395","https://openalex.org/W2066467839","https://openalex.org/W2111842731","https://openalex.org/W2170506381","https://openalex.org/W2765794416","https://openalex.org/W2039666944","https://openalex.org/W1531630856","https://openalex.org/W1486217206"],"abstract_inverted_index":{"Genome-wide":[0],"association":[1],"studies":[2],"(GWASs)":[3],"are":[4,45,124,141],"widely":[5,162],"used":[6,133,163],"to":[7,19,88,94,107,134],"investigate":[8],"statistically":[9],"significant":[10],"associations":[11,44],"between":[12],"diseases":[13],"and":[14,153,166,174],"single":[15],"nucleotide":[16],"polymorphisms":[17],"(SNPs)":[18],"identify":[20],"causal":[21],"factors":[22],"of":[23,29,48,51,86,130,183],"diseases.":[24],"In":[25],"GWAS,":[26],"statistical":[27],"significance":[28,122],"more":[30,61,72,154],"than":[31,151,155,159],"one":[32,171,175],"million":[33,172],"SNPs":[34,73,116,173],"have":[35],"been":[36],"recently":[37],"assessed,":[38],"but":[39],"in":[40,178],"many":[41],"case,":[42],"no":[43],"found":[46],"because":[47],"the":[49,84,120],"application":[50,85],"conservative":[52],"multiple":[53],"testing":[54],"corrections,":[55],"such":[56,64],"as":[57,65],"Bonferroni":[58],"correction.":[59],"While":[60],"sensitive":[62],"methods,":[63],"Westfall-Young":[66,99],"permutation":[67,100],"procedure":[68,101],"(WY),":[69],"would":[70],"relate":[71],"with":[74,187],"diseases,":[75],"its":[76],"extremely":[77],"long":[78],"computational":[79],"time":[80],"has":[81],"prohibited":[82],"from":[83],"WY":[87,109,152],"GWAS.":[89],"We":[90],"introduce":[91],"an":[92],"algorithm":[93],"accelerate":[95],"WY,":[96],"named":[97],"High-speed":[98],"(HWY).":[102],"HWY":[103,146,188],"utilizes":[104],"three":[105],"techniques":[106],"make":[108],"computationally":[110],"practical.":[111],"First,":[112],"P-value":[113],"calculations":[114],"for":[115],"that":[117],"cannot":[118],"affect":[119],"adjusted":[121],"level":[123],"pruned.":[125],"Second,":[126],"a":[127,144,161,168],"lookup":[128],"table":[129],"P-values":[131],"is":[132],"avoid":[135],"frequent":[136],"duplicate":[137],"calculations.":[138],"Finally,":[139],"computations":[140],"parallelized":[142],"using":[143],"GPGPU.":[145],"was":[147],"619":[148],"times":[149,157],"faster":[150,158],"122":[156],"PLINK,":[160],"GWAS":[164,185],"software,":[165],"analyzed":[167],"dataset":[169],"contained":[170],"thousand":[176],"individuals":[177],"approximately":[179],"two":[180],"hours.":[181],"Re-analysis":[182],"existing":[184],"datasets":[186],"may":[189],"uncover":[190],"additional":[191],"hidden":[192],"SNP-trait":[193],"associations.":[194]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1}],"updated_date":"2026-04-15T08:11:43.952461","created_date":"2025-10-10T00:00:00"}