{"id":"https://openalex.org/W2022756003","doi":"https://doi.org/10.1145/2769458.2769477","title":"Exploring the Relationship between Adherence to Treatment and Viral Load through a New Discrete Simulation Model of HIV Infectivity","display_name":"Exploring the Relationship between Adherence to Treatment and Viral Load through a New Discrete Simulation Model of HIV Infectivity","publication_year":2015,"publication_date":"2015-06-10","ids":{"openalex":"https://openalex.org/W2022756003","doi":"https://doi.org/10.1145/2769458.2769477","mag":"2022756003"},"language":"en","primary_location":{"id":"doi:10.1145/2769458.2769477","is_oa":false,"landing_page_url":"https://doi.org/10.1145/2769458.2769477","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 3rd ACM SIGSIM Conference on Principles of Advanced Discrete Simulation","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055552491","display_name":"Ela Rana","orcid":null},"institutions":[{"id":"https://openalex.org/I149292303","display_name":"Troy University","ror":"https://ror.org/029jj9438","country_code":"US","type":"education","lineage":["https://openalex.org/I149292303"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ela Rana","raw_affiliation_strings":["Troy University, Troy, AL, USA"],"affiliations":[{"raw_affiliation_string":"Troy University, Troy, AL, USA","institution_ids":["https://openalex.org/I149292303"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023496425","display_name":"Philippe J. Giabbanelli","orcid":"https://orcid.org/0000-0001-6816-355X"},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Philippe J. Giabbanelli","raw_affiliation_strings":["University of Cambridge, Cambridge, United Kingdom"],"affiliations":[{"raw_affiliation_string":"University of Cambridge, Cambridge, United Kingdom","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078470592","display_name":"Naga Harish Balabhadrapathruni","orcid":null},"institutions":[{"id":"https://openalex.org/I149292303","display_name":"Troy University","ror":"https://ror.org/029jj9438","country_code":"US","type":"education","lineage":["https://openalex.org/I149292303"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Naga H. Balabhadrapathruni","raw_affiliation_strings":["Troy University, Troy, AL, USA"],"affiliations":[{"raw_affiliation_string":"Troy University, Troy, AL, USA","institution_ids":["https://openalex.org/I149292303"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101581477","display_name":"Xiaoyu Li","orcid":"https://orcid.org/0000-0003-0778-092X"},"institutions":[{"id":"https://openalex.org/I149292303","display_name":"Troy University","ror":"https://ror.org/029jj9438","country_code":"US","type":"education","lineage":["https://openalex.org/I149292303"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaoyu Li","raw_affiliation_strings":["Troy University, Troy, AL, USA"],"affiliations":[{"raw_affiliation_string":"Troy University, Troy, AL, USA","institution_ids":["https://openalex.org/I149292303"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026089310","display_name":"Vijay Mago","orcid":"https://orcid.org/0000-0002-9741-3463"},"institutions":[{"id":"https://openalex.org/I149292303","display_name":"Troy University","ror":"https://ror.org/029jj9438","country_code":"US","type":"education","lineage":["https://openalex.org/I149292303"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vijay K. Mago","raw_affiliation_strings":["Troy University, Troy, AL, USA"],"affiliations":[{"raw_affiliation_string":"Troy University, Troy, AL, USA","institution_ids":["https://openalex.org/I149292303"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5055552491"],"corresponding_institution_ids":["https://openalex.org/I149292303"],"apc_list":null,"apc_paid":null,"fwci":0.3782,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.61534916,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":97},"biblio":{"volume":null,"issue":null,"first_page":"145","last_page":"156"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10082","display_name":"HIV/AIDS Research and Interventions","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10082","display_name":"HIV/AIDS Research and Interventions","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9977999925613403,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10327","display_name":"Adolescent Sexual and Reproductive Health","score":0.9679999947547913,"subfield":{"id":"https://openalex.org/subfields/3600","display_name":"General Health Professions"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/human-immunodeficiency-virus","display_name":"Human immunodeficiency virus (HIV)","score":0.6696116924285889},{"id":"https://openalex.org/keywords/infectivity","display_name":"Infectivity","score":0.6062344312667847},{"id":"https://openalex.org/keywords/viral-load","display_name":"Viral load","score":0.5135191082954407},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.5060972571372986},{"id":"https://openalex.org/keywords/schedule","display_name":"Schedule","score":0.49639374017715454},{"id":"https://openalex.org/keywords/congruence","display_name":"Congruence (geometry)","score":0.43820568919181824},{"id":"https://openalex.org/keywords/medication-adherence","display_name":"Medication adherence","score":0.4331355094909668},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4170586168766022},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.40981438755989075},{"id":"https://openalex.org/keywords/intensive-care-medicine","display_name":"Intensive care medicine","score":0.3636775612831116},{"id":"https://openalex.org/keywords/virology","display_name":"Virology","score":0.34199488162994385},{"id":"https://openalex.org/keywords/immunology","display_name":"Immunology","score":0.333139568567276},{"id":"https://openalex.org/keywords/virus","display_name":"Virus","score":0.2826983332633972},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.22792986035346985},{"id":"https://openalex.org/keywords/social-psychology","display_name":"Social psychology","score":0.12005382776260376},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.07798352837562561}],"concepts":[{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.6696116924285889},{"id":"https://openalex.org/C106358424","wikidata":"https://www.wikidata.org/wiki/Q1662346","display_name":"Infectivity","level":3,"score":0.6062344312667847},{"id":"https://openalex.org/C142462285","wikidata":"https://www.wikidata.org/wiki/Q2528140","display_name":"Viral load","level":3,"score":0.5135191082954407},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5060972571372986},{"id":"https://openalex.org/C68387754","wikidata":"https://www.wikidata.org/wiki/Q7271585","display_name":"Schedule","level":2,"score":0.49639374017715454},{"id":"https://openalex.org/C132074034","wikidata":"https://www.wikidata.org/wiki/Q154210","display_name":"Congruence (geometry)","level":2,"score":0.43820568919181824},{"id":"https://openalex.org/C3018553135","wikidata":"https://www.wikidata.org/wiki/Q67004728","display_name":"Medication adherence","level":2,"score":0.4331355094909668},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4170586168766022},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.40981438755989075},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.3636775612831116},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.34199488162994385},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.333139568567276},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.2826983332633972},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.22792986035346985},{"id":"https://openalex.org/C77805123","wikidata":"https://www.wikidata.org/wiki/Q161272","display_name":"Social psychology","level":1,"score":0.12005382776260376},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.07798352837562561},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1145/2769458.2769477","is_oa":false,"landing_page_url":"https://doi.org/10.1145/2769458.2769477","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 3rd ACM SIGSIM Conference on Principles of Advanced Discrete Simulation","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8199999928474426}],"awards":[],"funders":[{"id":"https://openalex.org/F4320312775","display_name":"United Kingdom Clinical Research Collaboration","ror":"https://ror.org/025ecp212"},{"id":"https://openalex.org/F4320319992","display_name":"British Heart Foundation","ror":"https://ror.org/02wdwnk04"},{"id":"https://openalex.org/F4320322551","display_name":"Simon Fraser University","ror":"https://ror.org/0213rcc28"},{"id":"https://openalex.org/F4320326774","display_name":"Centre for Diet and Activity Research","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W1524659766","https://openalex.org/W1958445774","https://openalex.org/W1970854150","https://openalex.org/W1987136336","https://openalex.org/W2001917666","https://openalex.org/W2004249311","https://openalex.org/W2006435453","https://openalex.org/W2012961958","https://openalex.org/W2015100089","https://openalex.org/W2017639551","https://openalex.org/W2018665836","https://openalex.org/W2023734936","https://openalex.org/W2025582221","https://openalex.org/W2035755044","https://openalex.org/W2044403736","https://openalex.org/W2047173345","https://openalex.org/W2053391460","https://openalex.org/W2056915105","https://openalex.org/W2057975334","https://openalex.org/W2058120380","https://openalex.org/W2061763109","https://openalex.org/W2063486020","https://openalex.org/W2089151634","https://openalex.org/W2096686116","https://openalex.org/W2114487034","https://openalex.org/W2116560165","https://openalex.org/W2118036437","https://openalex.org/W2127832030","https://openalex.org/W2136647574","https://openalex.org/W2140789060","https://openalex.org/W2142793137","https://openalex.org/W2143265231","https://openalex.org/W2144854003","https://openalex.org/W2167641210","https://openalex.org/W2183940924","https://openalex.org/W2317463284","https://openalex.org/W2337766402","https://openalex.org/W2339006876","https://openalex.org/W2738563190","https://openalex.org/W4388364567"],"related_works":["https://openalex.org/W2008875895","https://openalex.org/W1970932468","https://openalex.org/W1932710078","https://openalex.org/W1995328853","https://openalex.org/W1983916957","https://openalex.org/W2510793503","https://openalex.org/W1976788601","https://openalex.org/W2330877710","https://openalex.org/W2151894560","https://openalex.org/W2053780334"],"abstract_inverted_index":{"Human":[0],"immunodeficiency":[1],"virus":[2],"(HIV)":[3],"has":[4],"been":[5],"a":[6,18,30,57,81,88],"major":[7],"health":[8,102],"problem":[9],"throughout":[10],"the":[11,24,53,69,135],"world":[12],"for":[13,23,43,74,112,141],"decades.":[14],"This":[15],"paper":[16],"introduces":[17],"new":[19],"discrete":[20,139],"simulation":[21],"model":[22,34,54],"growth":[25],"of":[26,48,60,71,76,84,137],"HIV":[27,142],"infection":[28,94],"within":[29],"host":[31],"body.":[32],"The":[33],"is":[35,116,131],"developed":[36],"incrementally,":[37],"and":[38,65,119],"compared":[39],"at":[40],"each":[41],"stage":[42],"congruence":[44],"with":[45],"real-world":[46],"observations":[47],"disease":[49],"dynamics.":[50,143],"We":[51,78],"used":[52],"to":[55,67,148,153],"get":[56],"better":[58],"understanding":[59],"how":[61],"HIV-infected":[62],"cells":[63],"behave,":[64],"particularly":[66],"assess":[68],"importance":[70],"medication":[72,160,166],"adherence":[73,85,106,115,123,156],"effectiveness":[75],"treatment.":[77],"found":[79],"that":[80],"small":[82,120],"lack":[83],"could":[86],"have":[87],"proportionally":[89],"much":[90,145],"larger":[91],"impact":[92],"on":[93,101],"as":[95,97,157,159],"well":[96,158],"trigger":[98],"negative":[99],"effects":[100],"sooner.":[103],"Consequently,":[104],"improving":[105],"can":[107],"be":[108,125,149],"very":[109],"beneficial":[110],"(particularly":[111],"those":[113],"whose":[114],"already":[117],"high),":[118],"issues":[121],"in":[122,134,151],"should":[124],"addressed":[126],"early":[127],"on.":[128],"Our":[129],"work":[130,146],"one":[132],"step":[133],"development":[136],"detailed":[138],"simulations":[140],"However,":[144],"remains":[147],"done":[150],"order":[152],"accurately":[154],"capture":[155],"schedule,":[161],"viral":[162],"resistance,":[163],"or":[164],"multiple":[165],"types.":[167]},"counts_by_year":[{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2016,"cited_by_count":2}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}
