{"id":"https://openalex.org/W1974918139","doi":"https://doi.org/10.1145/2742060.2743762","title":"Formal Analysis Provides Parameters for Guiding Hyperoxidation in Bacteria using Phototoxic Proteins","display_name":"Formal Analysis Provides Parameters for Guiding Hyperoxidation in Bacteria using Phototoxic Proteins","publication_year":2015,"publication_date":"2015-05-19","ids":{"openalex":"https://openalex.org/W1974918139","doi":"https://doi.org/10.1145/2742060.2743762","mag":"1974918139"},"language":"en","primary_location":{"id":"doi:10.1145/2742060.2743762","is_oa":false,"landing_page_url":"https://doi.org/10.1145/2742060.2743762","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 25th edition on Great Lakes Symposium on VLSI","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052617216","display_name":"Qinsi Wang","orcid":"https://orcid.org/0000-0002-5868-9686"},"institutions":[{"id":"https://openalex.org/I74973139","display_name":"Carnegie Mellon University","ror":"https://ror.org/05x2bcf33","country_code":"US","type":"education","lineage":["https://openalex.org/I74973139"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Qinsi Wang","raw_affiliation_strings":["Carnegie Mellon University, Pittsburgh, PA, USA","Carnegie-Mellon University, Pittsburgh, Pa., USA#TAB#"],"affiliations":[{"raw_affiliation_string":"Carnegie Mellon University, Pittsburgh, PA, USA","institution_ids":["https://openalex.org/I74973139"]},{"raw_affiliation_string":"Carnegie-Mellon University, Pittsburgh, Pa., USA#TAB#","institution_ids":["https://openalex.org/I74973139"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017141796","display_name":"Nata\u0161a Mi\u0161kov-\u017divanov","orcid":"https://orcid.org/0000-0003-1110-3403"},"institutions":[{"id":"https://openalex.org/I74973139","display_name":"Carnegie Mellon University","ror":"https://ror.org/05x2bcf33","country_code":"US","type":"education","lineage":["https://openalex.org/I74973139"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Natasa Miskov-Zivanov","raw_affiliation_strings":["Carnegie Mellon University, Pittsburgh, PA, USA","Carnegie-Mellon University, Pittsburgh, Pa., USA#TAB#"],"affiliations":[{"raw_affiliation_string":"Carnegie Mellon University, Pittsburgh, PA, USA","institution_ids":["https://openalex.org/I74973139"]},{"raw_affiliation_string":"Carnegie-Mellon University, Pittsburgh, Pa., USA#TAB#","institution_ids":["https://openalex.org/I74973139"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061349447","display_name":"Cheryl A. Telmer","orcid":"https://orcid.org/0000-0002-7649-3134"},"institutions":[{"id":"https://openalex.org/I74973139","display_name":"Carnegie Mellon University","ror":"https://ror.org/05x2bcf33","country_code":"US","type":"education","lineage":["https://openalex.org/I74973139"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cheryl Telmer","raw_affiliation_strings":["Carnegie Mellon University, Pittsburgh, PA, USA","Carnegie-Mellon University, Pittsburgh, Pa., USA#TAB#"],"affiliations":[{"raw_affiliation_string":"Carnegie Mellon University, Pittsburgh, PA, USA","institution_ids":["https://openalex.org/I74973139"]},{"raw_affiliation_string":"Carnegie-Mellon University, Pittsburgh, Pa., USA#TAB#","institution_ids":["https://openalex.org/I74973139"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5105356861","display_name":"Edmund M. Clarke","orcid":null},"institutions":[{"id":"https://openalex.org/I74973139","display_name":"Carnegie Mellon University","ror":"https://ror.org/05x2bcf33","country_code":"US","type":"education","lineage":["https://openalex.org/I74973139"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Edmund M. Clarke","raw_affiliation_strings":["Carnegie Mellon University, Pittsburgh, PA, USA","Carnegie-Mellon University, Pittsburgh, Pa., USA#TAB#"],"affiliations":[{"raw_affiliation_string":"Carnegie Mellon University, Pittsburgh, PA, USA","institution_ids":["https://openalex.org/I74973139"]},{"raw_affiliation_string":"Carnegie-Mellon University, Pittsburgh, Pa., USA#TAB#","institution_ids":["https://openalex.org/I74973139"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5052617216"],"corresponding_institution_ids":["https://openalex.org/I74973139"],"apc_list":null,"apc_paid":null,"fwci":0.5835,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.67637323,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":null,"issue":null,"first_page":"315","last_page":"320"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12561","display_name":"bioluminescence and chemiluminescence research","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12561","display_name":"bioluminescence and chemiluminescence research","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10957","display_name":"Photodynamic Therapy Research Studies","score":0.9941999912261963,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10782","display_name":"Nanoplatforms for cancer theranostics","score":0.9889000058174133,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bacteria","display_name":"Bacteria","score":0.4852316379547119},{"id":"https://openalex.org/keywords/phototoxicity","display_name":"Phototoxicity","score":0.4553118944168091},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.44110703468322754},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.39872992038726807},{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.3948224186897278},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.15233799815177917},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.13883718848228455},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.08397573232650757}],"concepts":[{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.4852316379547119},{"id":"https://openalex.org/C20639190","wikidata":"https://www.wikidata.org/wiki/Q2088972","display_name":"Phototoxicity","level":3,"score":0.4553118944168091},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.44110703468322754},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.39872992038726807},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.3948224186897278},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.15233799815177917},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.13883718848228455},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.08397573232650757},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1145/2742060.2743762","is_oa":false,"landing_page_url":"https://doi.org/10.1145/2742060.2743762","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 25th edition on Great Lakes Symposium on VLSI","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Zero hunger","id":"https://metadata.un.org/sdg/2","score":0.8199999928474426}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":9,"referenced_works":["https://openalex.org/W1532984679","https://openalex.org/W1996609162","https://openalex.org/W2052751103","https://openalex.org/W2106114981","https://openalex.org/W2108930323","https://openalex.org/W2113407647","https://openalex.org/W2138686369","https://openalex.org/W2166280160","https://openalex.org/W2170277763"],"related_works":["https://openalex.org/W4387497383","https://openalex.org/W2948807893","https://openalex.org/W2778153218","https://openalex.org/W2748952813","https://openalex.org/W1531601525","https://openalex.org/W2091803777","https://openalex.org/W2038518000","https://openalex.org/W2078814861","https://openalex.org/W2527526854","https://openalex.org/W1976181487"],"abstract_inverted_index":{"In":[0],"this":[1],"work,":[2],"we":[3,48],"developed":[4],"a":[5,9,57,71,119],"methodology":[6],"to":[7,26,41,54,65,69,89,116],"analyze":[8],"bacteria":[10,18,36,79],"model":[11,61,91],"that":[12,96],"mimics":[13],"the":[14,27,45,93,105],"stages":[15],"through":[16],"which":[17,107],"change":[19],"when":[20],"phage":[21,58],"therapy":[22],"is":[23],"applied.":[24],"Due":[25],"widespread":[28],"misuse":[29],"and":[30,44,76,92],"overuse":[31],"of":[32,83,104],"antibiotics,":[33,56],"drug":[34],"resistant":[35],"now":[37],"pose":[38],"significant":[39],"risks":[40],"health,":[42],"agriculture":[43],"environment.":[46],"Therefore,":[47],"were":[49],"interested":[50],"in":[51,118],"an":[52,66,98],"alternative":[53],"conventional":[55],"therapy.":[59],"Our":[60],"was":[62],"designed":[63],"according":[64],"experimental":[67],"procedure":[68],"engineer":[70],"temperate":[72],"phage,":[73],"Lambda":[74],"(\u03bb),":[75],"then":[77],"kill":[78],"via":[80],"light-activated":[81],"production":[82],"superoxide.":[84],"We":[85],"applied":[86],"formal":[87],"analysis":[88],"our":[90],"results":[94],"show":[95],"such":[97],"approach":[99],"can":[100],"speed":[101],"up":[102],"evaluation":[103],"system,":[106],"would":[108],"be":[109],"impractical":[110],"or":[111],"possibly":[112],"not":[113],"even":[114],"feasible":[115],"study":[117],"wet":[120],"lab.":[121]},"counts_by_year":[{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}