{"id":"https://openalex.org/W1981480991","doi":"https://doi.org/10.1145/2742060.2742115","title":"A SystemC Platform for Signal Transduction Modelling and Simulation in Systems Biology","display_name":"A SystemC Platform for Signal Transduction Modelling and Simulation in Systems Biology","publication_year":2015,"publication_date":"2015-05-19","ids":{"openalex":"https://openalex.org/W1981480991","doi":"https://doi.org/10.1145/2742060.2742115","mag":"1981480991"},"language":"en","primary_location":{"id":"doi:10.1145/2742060.2742115","is_oa":false,"landing_page_url":"https://doi.org/10.1145/2742060.2742115","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 25th edition on Great Lakes Symposium on VLSI","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031773625","display_name":"Rosario Distefano","orcid":"https://orcid.org/0000-0001-7241-7751"},"institutions":[{"id":"https://openalex.org/I119439378","display_name":"University of Verona","ror":"https://ror.org/039bp8j42","country_code":"IT","type":"education","lineage":["https://openalex.org/I119439378"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Rosario Distefano","raw_affiliation_strings":["University of Verona, Verona, Italy","University of Verona, VERONA, Italy#TAB#"],"affiliations":[{"raw_affiliation_string":"University of Verona, Verona, Italy","institution_ids":["https://openalex.org/I119439378"]},{"raw_affiliation_string":"University of Verona, VERONA, Italy#TAB#","institution_ids":["https://openalex.org/I119439378"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040302302","display_name":"Franco Fummi","orcid":"https://orcid.org/0000-0002-4404-5791"},"institutions":[{"id":"https://openalex.org/I119439378","display_name":"University of Verona","ror":"https://ror.org/039bp8j42","country_code":"IT","type":"education","lineage":["https://openalex.org/I119439378"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Franco Fummi","raw_affiliation_strings":["University of Verona, Verona, Italy","University of Verona, VERONA, Italy#TAB#"],"affiliations":[{"raw_affiliation_string":"University of Verona, Verona, Italy","institution_ids":["https://openalex.org/I119439378"]},{"raw_affiliation_string":"University of Verona, VERONA, Italy#TAB#","institution_ids":["https://openalex.org/I119439378"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073711928","display_name":"Carlo Laudanna","orcid":"https://orcid.org/0000-0003-4050-1056"},"institutions":[{"id":"https://openalex.org/I119439378","display_name":"University of Verona","ror":"https://ror.org/039bp8j42","country_code":"IT","type":"education","lineage":["https://openalex.org/I119439378"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Carlo Laudanna","raw_affiliation_strings":["University of Verona, Verona, Italy","University of Verona, VERONA, Italy#TAB#"],"affiliations":[{"raw_affiliation_string":"University of Verona, Verona, Italy","institution_ids":["https://openalex.org/I119439378"]},{"raw_affiliation_string":"University of Verona, VERONA, Italy#TAB#","institution_ids":["https://openalex.org/I119439378"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088231786","display_name":"Nicola Bombieri","orcid":"https://orcid.org/0000-0003-3256-5885"},"institutions":[{"id":"https://openalex.org/I119439378","display_name":"University of Verona","ror":"https://ror.org/039bp8j42","country_code":"IT","type":"education","lineage":["https://openalex.org/I119439378"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Nicola Bombieri","raw_affiliation_strings":["University of Verona, Verona, Italy","University of Verona, VERONA, Italy#TAB#"],"affiliations":[{"raw_affiliation_string":"University of Verona, Verona, Italy","institution_ids":["https://openalex.org/I119439378"]},{"raw_affiliation_string":"University of Verona, VERONA, Italy#TAB#","institution_ids":["https://openalex.org/I119439378"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5002057785","display_name":"Rosalba Giugno","orcid":"https://orcid.org/0000-0001-9843-7638"},"institutions":[{"id":"https://openalex.org/I39063666","display_name":"University of Catania","ror":"https://ror.org/03a64bh57","country_code":"IT","type":"education","lineage":["https://openalex.org/I39063666"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Rosalba Giugno","raw_affiliation_strings":["University of Catania, Catania, Italy","University of Catania , Catania, Italy"],"affiliations":[{"raw_affiliation_string":"University of Catania, Catania, Italy","institution_ids":["https://openalex.org/I39063666"]},{"raw_affiliation_string":"University of Catania , Catania, Italy","institution_ids":["https://openalex.org/I39063666"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5031773625"],"corresponding_institution_ids":["https://openalex.org/I119439378"],"apc_list":null,"apc_paid":null,"fwci":0.2917,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.60275447,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":96},"biblio":{"volume":null,"issue":null,"first_page":"233","last_page":"236"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10904","display_name":"Embedded Systems Design Techniques","score":0.9864000082015991,"subfield":{"id":"https://openalex.org/subfields/1708","display_name":"Hardware and Architecture"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9807999730110168,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/systemc","display_name":"SystemC","score":0.8988687992095947},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.658245861530304},{"id":"https://openalex.org/keywords/abstraction","display_name":"Abstraction","score":0.6416909694671631},{"id":"https://openalex.org/keywords/systems-biology","display_name":"Systems biology","score":0.6109697222709656},{"id":"https://openalex.org/keywords/granularity","display_name":"Granularity","score":0.5210687518119812},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"Signal transduction","score":0.506726086139679},{"id":"https://openalex.org/keywords/discrete-event-simulation","display_name":"Discrete event simulation","score":0.5038072466850281},{"id":"https://openalex.org/keywords/crosstalk","display_name":"Crosstalk","score":0.4322354197502136},{"id":"https://openalex.org/keywords/transduction","display_name":"Transduction (biophysics)","score":0.42791447043418884},{"id":"https://openalex.org/keywords/signal","display_name":"SIGNAL (programming language)","score":0.4137859344482422},{"id":"https://openalex.org/keywords/distributed-computing","display_name":"Distributed computing","score":0.3694608211517334},{"id":"https://openalex.org/keywords/computer-architecture","display_name":"Computer architecture","score":0.3499656617641449},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.24108803272247314},{"id":"https://openalex.org/keywords/simulation","display_name":"Simulation","score":0.20794197916984558},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.19578832387924194},{"id":"https://openalex.org/keywords/programming-language","display_name":"Programming language","score":0.14543458819389343},{"id":"https://openalex.org/keywords/electronic-engineering","display_name":"Electronic engineering","score":0.14247429370880127},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.13667577505111694},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.10941094160079956}],"concepts":[{"id":"https://openalex.org/C2776928060","wikidata":"https://www.wikidata.org/wiki/Q1753563","display_name":"SystemC","level":2,"score":0.8988687992095947},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.658245861530304},{"id":"https://openalex.org/C124304363","wikidata":"https://www.wikidata.org/wiki/Q673661","display_name":"Abstraction","level":2,"score":0.6416909694671631},{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.6109697222709656},{"id":"https://openalex.org/C177774035","wikidata":"https://www.wikidata.org/wiki/Q1246948","display_name":"Granularity","level":2,"score":0.5210687518119812},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.506726086139679},{"id":"https://openalex.org/C147203929","wikidata":"https://www.wikidata.org/wiki/Q574814","display_name":"Discrete event simulation","level":2,"score":0.5038072466850281},{"id":"https://openalex.org/C169822122","wikidata":"https://www.wikidata.org/wiki/Q230187","display_name":"Crosstalk","level":2,"score":0.4322354197502136},{"id":"https://openalex.org/C15152581","wikidata":"https://www.wikidata.org/wiki/Q7833966","display_name":"Transduction (biophysics)","level":2,"score":0.42791447043418884},{"id":"https://openalex.org/C2779843651","wikidata":"https://www.wikidata.org/wiki/Q7390335","display_name":"SIGNAL (programming language)","level":2,"score":0.4137859344482422},{"id":"https://openalex.org/C120314980","wikidata":"https://www.wikidata.org/wiki/Q180634","display_name":"Distributed computing","level":1,"score":0.3694608211517334},{"id":"https://openalex.org/C118524514","wikidata":"https://www.wikidata.org/wiki/Q173212","display_name":"Computer architecture","level":1,"score":0.3499656617641449},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.24108803272247314},{"id":"https://openalex.org/C44154836","wikidata":"https://www.wikidata.org/wiki/Q45045","display_name":"Simulation","level":1,"score":0.20794197916984558},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19578832387924194},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.14543458819389343},{"id":"https://openalex.org/C24326235","wikidata":"https://www.wikidata.org/wiki/Q126095","display_name":"Electronic engineering","level":1,"score":0.14247429370880127},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.13667577505111694},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.10941094160079956},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1145/2742060.2742115","is_oa":false,"landing_page_url":"https://doi.org/10.1145/2742060.2742115","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 25th edition on Great Lakes Symposium on VLSI","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":13,"referenced_works":["https://openalex.org/W22950313","https://openalex.org/W1543750907","https://openalex.org/W1986397618","https://openalex.org/W2000233729","https://openalex.org/W2011835017","https://openalex.org/W2024060242","https://openalex.org/W2025037494","https://openalex.org/W2107697435","https://openalex.org/W2111682035","https://openalex.org/W2119510512","https://openalex.org/W2135648313","https://openalex.org/W2284263109","https://openalex.org/W2484971506"],"related_works":["https://openalex.org/W2301151507","https://openalex.org/W2170936907","https://openalex.org/W2380800843","https://openalex.org/W2140328095","https://openalex.org/W77471018","https://openalex.org/W3150987667","https://openalex.org/W1852321729","https://openalex.org/W1963774445","https://openalex.org/W2063411778","https://openalex.org/W2096955763"],"abstract_inverted_index":{"Signal":[0],"transduction":[1,28,63],"is":[2],"a":[3,61],"class":[4],"of":[5,26,36,51],"cell's":[6],"biological":[7],"processes,":[8],"which":[9],"are":[10],"commonly":[11],"represented":[12],"as":[13],"highly":[14],"concurrent":[15],"reactive":[16],"systems.":[17],"In":[18],"the":[19,74,78,91,96,100,111,114],"Systems":[20],"Biology":[21],"community,":[22],"modelling":[23,64,82],"and":[24,45,56,65,71],"simulation":[25,66],"signal":[27,62],"require":[29],"overcoming":[30],"issues":[31],"like":[32],"discrete":[33],"event-based":[34],"execution":[35],"complex":[37],"systems,":[38],"description":[39,47],"from":[40,110],"building":[41],"blocks":[42],"through":[43],"composition":[44],"encapsulation,":[46],"at":[48,84],"different":[49,85],"levels":[50],"granularity,":[52],"methods":[53],"for":[54],"abstraction":[55,86],"refinement.":[57],"This":[58],"paper":[59,89],"presents":[60],"platform":[67,75,97],"based":[68],"on":[69],"SystemC,":[70],"shows":[72],"how":[73],"allows":[76],"handling":[77],"system":[79],"complexity":[80],"by":[81,94],"it":[83],"levels.":[87],"The":[88],"reports":[90],"results":[92],"obtained":[93],"applying":[95],"to":[98],"model":[99],"intracellular":[101],"signalling":[102],"network":[103],"controlling":[104],"integrin":[105],"activation":[106],"mediating":[107],"leukocyte":[108],"recruitment":[109],"blood":[112],"into":[113],"tissues.":[115]},"counts_by_year":[{"year":2016,"cited_by_count":2}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}
