{"id":"https://openalex.org/W2048351355","doi":"https://doi.org/10.1145/2649387.2660790","title":"An analysis of conformational changes upon RNA-protein binding","display_name":"An analysis of conformational changes upon RNA-protein binding","publication_year":2014,"publication_date":"2014-09-20","ids":{"openalex":"https://openalex.org/W2048351355","doi":"https://doi.org/10.1145/2649387.2660790","mag":"2048351355"},"language":"en","primary_location":{"id":"doi:10.1145/2649387.2660790","is_oa":false,"landing_page_url":"https://doi.org/10.1145/2649387.2660790","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 5th ACM Conference on Bioinformatics, Computational Biology, and Health Informatics","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002542664","display_name":"Kannan Sankar","orcid":"https://orcid.org/0000-0002-8917-9718"},"institutions":[{"id":"https://openalex.org/I173911158","display_name":"Iowa State University","ror":"https://ror.org/04rswrd78","country_code":"US","type":"education","lineage":["https://openalex.org/I173911158"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kannan Sankar","raw_affiliation_strings":["Iowa State University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Iowa State University","institution_ids":["https://openalex.org/I173911158"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036878383","display_name":"Rasna R. Walia","orcid":"https://orcid.org/0000-0001-7088-5535"},"institutions":[{"id":"https://openalex.org/I173911158","display_name":"Iowa State University","ror":"https://ror.org/04rswrd78","country_code":"US","type":"education","lineage":["https://openalex.org/I173911158"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rasna R. Walia","raw_affiliation_strings":["Iowa State University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Iowa State University","institution_ids":["https://openalex.org/I173911158"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009184116","display_name":"Carla M. Mann","orcid":"https://orcid.org/0000-0001-5930-4111"},"institutions":[{"id":"https://openalex.org/I173911158","display_name":"Iowa State University","ror":"https://ror.org/04rswrd78","country_code":"US","type":"education","lineage":["https://openalex.org/I173911158"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carla M. Mann","raw_affiliation_strings":["Iowa State University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Iowa State University","institution_ids":["https://openalex.org/I173911158"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023494109","display_name":"Robert L. Jernigan","orcid":"https://orcid.org/0000-0003-0996-8360"},"institutions":[{"id":"https://openalex.org/I173911158","display_name":"Iowa State University","ror":"https://ror.org/04rswrd78","country_code":"US","type":"education","lineage":["https://openalex.org/I173911158"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert L. Jernigan","raw_affiliation_strings":["Iowa State University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Iowa State University","institution_ids":["https://openalex.org/I173911158"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004737962","display_name":"Vasant Honavar","orcid":"https://orcid.org/0000-0001-5399-3489"},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vasant G. Honavar","raw_affiliation_strings":["Pennsylvania State University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pennsylvania State University","institution_ids":["https://openalex.org/I130769515"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5074103258","display_name":"Drena Dobbs","orcid":"https://orcid.org/0000-0003-4404-9554"},"institutions":[{"id":"https://openalex.org/I173911158","display_name":"Iowa State University","ror":"https://ror.org/04rswrd78","country_code":"US","type":"education","lineage":["https://openalex.org/I173911158"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Drena Dobbs","raw_affiliation_strings":["Iowa State University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Iowa State University","institution_ids":["https://openalex.org/I173911158"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1423,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.54175039,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":null,"issue":null,"first_page":"592","last_page":"593"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11482","display_name":"RNA modifications and cancer","score":0.9969000220298767,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rna","display_name":"RNA","score":0.7755829095840454},{"id":"https://openalex.org/keywords/conformational-change","display_name":"Conformational change","score":0.6616374850273132},{"id":"https://openalex.org/keywords/rna-binding-protein","display_name":"RNA-binding protein","score":0.611046552658081},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.4805627167224884},{"id":"https://openalex.org/keywords/transcription","display_name":"Transcription (linguistics)","score":0.47736120223999023},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.4551238715648651},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.4259069561958313},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.4147145748138428},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.36977434158325195},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3279944658279419},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.24637839198112488}],"concepts":[{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.7755829095840454},{"id":"https://openalex.org/C2777339483","wikidata":"https://www.wikidata.org/wiki/Q647203","display_name":"Conformational change","level":2,"score":0.6616374850273132},{"id":"https://openalex.org/C41282012","wikidata":"https://www.wikidata.org/wiki/Q3928341","display_name":"RNA-binding protein","level":4,"score":0.611046552658081},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4805627167224884},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.47736120223999023},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4551238715648651},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4259069561958313},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4147145748138428},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.36977434158325195},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3279944658279419},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.24637839198112488},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1145/2649387.2660790","is_oa":false,"landing_page_url":"https://doi.org/10.1145/2649387.2660790","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 5th ACM Conference on Bioinformatics, Computational Biology, and Health Informatics","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":5,"referenced_works":["https://openalex.org/W1980017556","https://openalex.org/W1994183585","https://openalex.org/W2016489736","https://openalex.org/W2124432783","https://openalex.org/W2156650169"],"related_works":["https://openalex.org/W2147993839","https://openalex.org/W1840103016","https://openalex.org/W54859794","https://openalex.org/W2064941026","https://openalex.org/W2359508303","https://openalex.org/W1983151649","https://openalex.org/W2057323302","https://openalex.org/W1966225171","https://openalex.org/W2025859988","https://openalex.org/W2611346549"],"abstract_inverted_index":{"RNA-binding":[0,81,123],"proteins":[1,82,100,139],"(RBPs)":[2],"have":[3,42,47,60],"myriad":[4],"functions":[5],"in":[6,16,22,50,66,118,138],"transcription,":[7],"translation,":[8],"and":[9,25,77,98,133,156,162],"post-transcriptional":[10],"gene":[11],"regulation,":[12],"with":[13],"central":[14],"roles":[15],"normal":[17],"development":[18],"as":[19,21],"well":[20],"both":[23],"genetic":[24],"infectious":[26],"diseases.":[27],"When":[28],"a":[29,33,90],"protein":[30],"binds":[31],"RNA,":[32,54],"conformational":[34,45,58,104,114,136],"change":[35],"often":[36],"occurs.":[37],"For":[38],"RNA-protein":[39,148,153],"complexes":[40,79],"that":[41,106],"been":[43,48,62],"characterized,":[44,64],"changes":[46,59,105,115,137],"observed":[49,117],"the":[51,53,70,103,113,122,128,145],"protein,":[52],"or":[55],"both.":[56],"These":[57],"not":[61],"sufficiently":[63],"however,":[65],"part":[67],"due":[68],"to":[69,101],"small":[71],"number":[72],"of":[73,75,80,93,96,112,121,127,130,147],"structures":[74],"bound":[76,97],"unbound":[78,99],"available":[83],"until":[84],"recently.":[85],"Here":[86],"we":[87],"systematically":[88],"analyze":[89],"new":[91],"dataset":[92],"90":[94],"pairs":[95],"evaluate":[102],"occur":[107],"upon":[108],"RNA":[109,131],"binding.":[110],"Most":[111],"were":[116],"non-interfacial":[119],"regions":[120],"proteins.":[124],"Detailed":[125],"analyses":[126],"modes":[129],"binding":[132],"any":[134],"associated":[135],"are":[140],"critical":[141],"for":[142,150,158,163],"fully":[143],"understanding":[144],"mechanisms":[146],"recognition,":[149],"developing":[151],"better":[152],"docking":[154],"methods":[155,157],"predicting":[159],"interfacial":[160],"residues,":[161],"RNA-based":[164],"drug":[165],"design.":[166]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}
