{"id":"https://openalex.org/W1968556589","doi":"https://doi.org/10.1145/2649387.2649419","title":"CNVnet","display_name":"CNVnet","publication_year":2014,"publication_date":"2014-09-20","ids":{"openalex":"https://openalex.org/W1968556589","doi":"https://doi.org/10.1145/2649387.2649419","mag":"1968556589"},"language":"en","primary_location":{"id":"doi:10.1145/2649387.2649419","is_oa":false,"landing_page_url":"https://doi.org/10.1145/2649387.2649419","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 5th ACM Conference on Bioinformatics, Computational Biology, and Health Informatics","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109705656","display_name":"Zhiyong Wang","orcid":"https://orcid.org/0009-0009-2335-4892"},"institutions":[{"id":"https://openalex.org/I160992636","display_name":"Toyota Technological Institute at Chicago","ror":"https://ror.org/02sn5gb64","country_code":"US","type":"education","lineage":["https://openalex.org/I160992636"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Zhiyong Wang","raw_affiliation_strings":["Toyota Technological Institute at Chicago, Chicago, Illinois"],"affiliations":[{"raw_affiliation_string":"Toyota Technological Institute at Chicago, Chicago, Illinois","institution_ids":["https://openalex.org/I160992636"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019398608","display_name":"Jinbo Xu","orcid":"https://orcid.org/0000-0001-7111-4839"},"institutions":[{"id":"https://openalex.org/I160992636","display_name":"Toyota Technological Institute at Chicago","ror":"https://ror.org/02sn5gb64","country_code":"US","type":"education","lineage":["https://openalex.org/I160992636"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jinbo Xu","raw_affiliation_strings":["Toyota Technological Institute at Chicago, Chicago, Illinois"],"affiliations":[{"raw_affiliation_string":"Toyota Technological Institute at Chicago, Chicago, Illinois","institution_ids":["https://openalex.org/I160992636"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103054154","display_name":"Xinghua Shi","orcid":"https://orcid.org/0000-0003-4662-3177"},"institutions":[{"id":"https://openalex.org/I102149020","display_name":"University of North Carolina at Charlotte","ror":"https://ror.org/04dawnj30","country_code":"US","type":"education","lineage":["https://openalex.org/I102149020"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xinghua Shi","raw_affiliation_strings":["University of North Carolina at Charlotte, Charlotte, NC"],"affiliations":[{"raw_affiliation_string":"University of North Carolina at Charlotte, Charlotte, NC","institution_ids":["https://openalex.org/I102149020"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5109705656"],"corresponding_institution_ids":["https://openalex.org/I160992636"],"apc_list":null,"apc_paid":null,"fwci":0.1394,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.51618961,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":null,"issue":null,"first_page":"128","last_page":"137"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9987999796867371,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9987999796867371,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11213","display_name":"Genomic variations and chromosomal abnormalities","score":0.9987000226974487,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.9952999949455261,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/copy-number-variation","display_name":"Copy-number variation","score":0.7670626640319824},{"id":"https://openalex.org/keywords/phenotype","display_name":"Phenotype","score":0.6512818336486816},{"id":"https://openalex.org/keywords/human-genome","display_name":"Human genome","score":0.5922946929931641},{"id":"https://openalex.org/keywords/genome","display_name":"Genome","score":0.5493320226669312},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.518398106098175},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5157113671302795},{"id":"https://openalex.org/keywords/population","display_name":"Population","score":0.4758436679840088},{"id":"https://openalex.org/keywords/affect","display_name":"Affect (linguistics)","score":0.4104149341583252},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.3896007537841797},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.37296342849731445},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.09160977602005005},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.07617712020874023}],"concepts":[{"id":"https://openalex.org/C120821319","wikidata":"https://www.wikidata.org/wiki/Q1501491","display_name":"Copy-number variation","level":4,"score":0.7670626640319824},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.6512818336486816},{"id":"https://openalex.org/C197077220","wikidata":"https://www.wikidata.org/wiki/Q720988","display_name":"Human genome","level":4,"score":0.5922946929931641},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.5493320226669312},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.518398106098175},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5157113671302795},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4758436679840088},{"id":"https://openalex.org/C2776035688","wikidata":"https://www.wikidata.org/wiki/Q1606558","display_name":"Affect (linguistics)","level":2,"score":0.4104149341583252},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3896007537841797},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.37296342849731445},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.09160977602005005},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.07617712020874023},{"id":"https://openalex.org/C46312422","wikidata":"https://www.wikidata.org/wiki/Q11024","display_name":"Communication","level":1,"score":0.0},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1145/2649387.2649419","is_oa":false,"landing_page_url":"https://doi.org/10.1145/2649387.2649419","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 5th ACM Conference on Bioinformatics, Computational Biology, and Health Informatics","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320333028","display_name":"University of North Carolina at Charlotte","ror":"https://ror.org/04dawnj30"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":44,"referenced_works":["https://openalex.org/W3219084","https://openalex.org/W990924570","https://openalex.org/W1946460195","https://openalex.org/W1971538947","https://openalex.org/W1977854072","https://openalex.org/W1989111033","https://openalex.org/W2004915807","https://openalex.org/W2008620264","https://openalex.org/W2009464182","https://openalex.org/W2014606320","https://openalex.org/W2016165461","https://openalex.org/W2027455260","https://openalex.org/W2041170649","https://openalex.org/W2054883878","https://openalex.org/W2065776802","https://openalex.org/W2074693857","https://openalex.org/W2077124055","https://openalex.org/W2084708009","https://openalex.org/W2092748385","https://openalex.org/W2097078077","https://openalex.org/W2100941248","https://openalex.org/W2104261859","https://openalex.org/W2106398669","https://openalex.org/W2116126626","https://openalex.org/W2118622562","https://openalex.org/W2122189635","https://openalex.org/W2132178599","https://openalex.org/W2135046866","https://openalex.org/W2137289649","https://openalex.org/W2140514146","https://openalex.org/W2156200251","https://openalex.org/W2156925439","https://openalex.org/W2163480486","https://openalex.org/W2168755415","https://openalex.org/W2169698020","https://openalex.org/W2171777347","https://openalex.org/W2188493080","https://openalex.org/W2622342421","https://openalex.org/W2885727518","https://openalex.org/W3142239405","https://openalex.org/W3159658498","https://openalex.org/W4229766664","https://openalex.org/W4235019056","https://openalex.org/W4392731388"],"related_works":["https://openalex.org/W2513883126","https://openalex.org/W2560936962","https://openalex.org/W2788727012","https://openalex.org/W2950264897","https://openalex.org/W2365914065","https://openalex.org/W3166677598","https://openalex.org/W1969895229","https://openalex.org/W2026058428","https://openalex.org/W2082414949","https://openalex.org/W2108497208"],"abstract_inverted_index":{"The":[0],"impact":[1],"of":[2,39,101],"individual":[3],"copy":[4],"number":[5,38],"variants":[6,141],"(CNVs)":[7],"on":[8,28],"human":[9,43,102],"traits":[10],"is":[11],"becoming":[12],"increasingly":[13],"clear":[14],"through":[15],"technological":[16],"advances":[17],"in":[18,41,143],"genetic":[19,140],"studies.":[20],"However,":[21],"interactions":[22,51],"between":[23],"CNVs":[24,40,62,88,111],"exerting":[25],"joint":[26,90],"effects":[27],"phenotypes":[29],"has":[30],"not":[31],"been":[32],"well":[33],"characterized":[34],"since":[35],"the":[36,42,98,105,135],"sheer":[37],"genome,":[44],"presents":[45],"a":[46,73,131,147],"computational":[47],"challenge":[48],"for":[49],"evaluating":[50],"among":[52],"multiple":[53,139],"CNVs.":[54],"To":[55],"address":[56],"this":[57],"unmet":[58],"need":[59],"and":[60,82,109,122],"characterize":[61],"that":[63,112],"cooperate":[64],"with":[65,89],"each":[66],"other":[67],"to":[68,85,96,115,133,145],"modulate":[69],"phenotype,":[70],"we":[71],"developed":[72],"novel":[74],"systematic":[75],"approach,":[76],"CNVnet,":[77],"which":[78,138],"combines":[79],"sparse":[80],"learning":[81],"biological":[83],"networks":[84],"identify":[86],"interacting":[87],"phenotypic":[91],"effect.":[92],"We":[93],"applied":[94],"CNVnet":[95],"analyze":[97,134],"CNV":[99],"catalog":[100],"genomes":[103],"from":[104],"1000":[106],"Genomes":[107],"Project":[108],"identified":[110],"collectively":[113],"contribute":[114],"population":[116],"differentiation,":[117],"affect":[118,146],"gene":[119],"expression":[120],"patterns,":[121],"potentially":[123],"have":[124],"downstream":[125],"biomedical":[126],"implications.":[127],"Our":[128],"approach":[129],"establishes":[130],"framework":[132],"manner":[136],"by":[137],"act":[142],"concert":[144],"given":[148],"phenotype.":[149]},"counts_by_year":[{"year":2015,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2016-06-24T00:00:00"}
