{"id":"https://openalex.org/W1998778851","doi":"https://doi.org/10.1145/2506583.2512359","title":"Landscape of neutralizing assessment of monoclonal antibodies against dengue virus","display_name":"Landscape of neutralizing assessment of monoclonal antibodies against dengue virus","publication_year":2013,"publication_date":"2013-09-22","ids":{"openalex":"https://openalex.org/W1998778851","doi":"https://doi.org/10.1145/2506583.2512359","mag":"1998778851"},"language":"en","primary_location":{"id":"doi:10.1145/2506583.2512359","is_oa":false,"landing_page_url":"https://doi.org/10.1145/2506583.2512359","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the International Conference on Bioinformatics, Computational Biology and Biomedical Informatics","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101467488","display_name":"Jing Sun","orcid":"https://orcid.org/0000-0002-4320-1377"},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jing Sun","raw_affiliation_strings":["Cancer Vaccine Center, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA and Department of Medicine, Harvard Medical School, Boston, MA, USA, 678-641-6910"],"affiliations":[{"raw_affiliation_string":"Cancer Vaccine Center, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA and Department of Medicine, Harvard Medical School, Boston, MA, USA, 678-641-6910","institution_ids":["https://openalex.org/I4210117453","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111766989","display_name":"Guang Lan Zhang","orcid":null},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Guang Lan Zhang","raw_affiliation_strings":["Cancer Vaccine Center, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA; Department of Medicine, Harvard Medical School, Boston, MA, USA and Department of Computer Science, Metropolitan College, Boston University, Boston, MA, USA, 617-838-7917","Cancer Vaccine Center, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA"],"affiliations":[{"raw_affiliation_string":"Cancer Vaccine Center, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA; Department of Medicine, Harvard Medical School, Boston, MA, USA and Department of Computer Science, Metropolitan College, Boston University, Boston, MA, USA, 617-838-7917","institution_ids":["https://openalex.org/I4210117453","https://openalex.org/I111088046","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Cancer Vaccine Center, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I4210117453","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071073233","display_name":"Lars R\u00f8nn Olsen","orcid":"https://orcid.org/0000-0002-6725-7850"},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]},{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]}],"countries":["DK","US"],"is_corresponding":false,"raw_author_name":"Lars R\u00f8nn Olsen","raw_affiliation_strings":["Cancer Vaccine Center, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA and Bioinformatics Centre, Department of Biology, University of Copenhagen, Copenhagen, Denmark, +4528734892"],"affiliations":[{"raw_affiliation_string":"Cancer Vaccine Center, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA and Bioinformatics Centre, Department of Biology, University of Copenhagen, Copenhagen, Denmark, +4528734892","institution_ids":["https://openalex.org/I4210117453","https://openalex.org/I124055696","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013709830","display_name":"Ellis L. Reinherz","orcid":"https://orcid.org/0000-0003-1048-5526"},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ellis L. Reinherz","raw_affiliation_strings":["Cancer Vaccine Center, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA; Department of Medicine, Harvard Medical School, Boston, MA, USA and Laboratory of Immunobiology and Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA, 617-632-3412","Cancer Vaccine Center, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA"],"affiliations":[{"raw_affiliation_string":"Cancer Vaccine Center, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA; Department of Medicine, Harvard Medical School, Boston, MA, USA and Laboratory of Immunobiology and Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA, 617-632-3412","institution_ids":["https://openalex.org/I4210117453","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Cancer Vaccine Center, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I4210117453","https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5089063979","display_name":"Vladimir Brusi\u0107","orcid":"https://orcid.org/0000-0003-0523-5266"},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]},{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vladimir Brusic","raw_affiliation_strings":["Cancer Vaccine Center, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA; Department of Medicine, Harvard Medical School, Boston, MA, USA and Department of Computer Science, Metropolitan College, Boston University, Boston, MA, USA, 617-910-8058","Cancer Vaccine Center, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA"],"affiliations":[{"raw_affiliation_string":"Cancer Vaccine Center, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA; Department of Medicine, Harvard Medical School, Boston, MA, USA and Department of Computer Science, Metropolitan College, Boston University, Boston, MA, USA, 617-910-8058","institution_ids":["https://openalex.org/I4210117453","https://openalex.org/I111088046","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Cancer Vaccine Center, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I4210117453","https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5101467488"],"corresponding_institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210117453"],"apc_list":null,"apc_paid":null,"fwci":0.6258,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.74372958,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":null,"issue":null,"first_page":"836","last_page":"842"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10166","display_name":"Mosquito-borne diseases and control","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10166","display_name":"Mosquito-borne diseases and control","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11135","display_name":"Virology and Viral Diseases","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":0.9979000091552734,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/epitope","display_name":"Epitope","score":0.8415855169296265},{"id":"https://openalex.org/keywords/virology","display_name":"Virology","score":0.7626813650131226},{"id":"https://openalex.org/keywords/antibody","display_name":"Antibody","score":0.7398653626441956},{"id":"https://openalex.org/keywords/antigen","display_name":"Antigen","score":0.7034947276115417},{"id":"https://openalex.org/keywords/dengue-virus","display_name":"Dengue virus","score":0.6476391553878784},{"id":"https://openalex.org/keywords/monoclonal-antibody","display_name":"Monoclonal antibody","score":0.5944574475288391},{"id":"https://openalex.org/keywords/dengue-fever","display_name":"Dengue fever","score":0.5273020267486572},{"id":"https://openalex.org/keywords/neutralizing-antibody","display_name":"Neutralizing antibody","score":0.5091564059257507},{"id":"https://openalex.org/keywords/cross-reactivity","display_name":"Cross-reactivity","score":0.5024399757385254},{"id":"https://openalex.org/keywords/original-antigenic-sin","display_name":"Original antigenic sin","score":0.48432862758636475},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.4286201298236847},{"id":"https://openalex.org/keywords/virus","display_name":"Virus","score":0.410248339176178},{"id":"https://openalex.org/keywords/immunology","display_name":"Immunology","score":0.23972946405410767},{"id":"https://openalex.org/keywords/antigenic-drift","display_name":"Antigenic drift","score":0.14316287636756897},{"id":"https://openalex.org/keywords/cross-reactions","display_name":"Cross reactions","score":0.06285500526428223},{"id":"https://openalex.org/keywords/influenza-a-virus","display_name":"Influenza A virus","score":0.06061786413192749}],"concepts":[{"id":"https://openalex.org/C195616568","wikidata":"https://www.wikidata.org/wiki/Q128711","display_name":"Epitope","level":3,"score":0.8415855169296265},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.7626813650131226},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.7398653626441956},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.7034947276115417},{"id":"https://openalex.org/C2779635636","wikidata":"https://www.wikidata.org/wiki/Q476209","display_name":"Dengue virus","level":3,"score":0.6476391553878784},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.5944574475288391},{"id":"https://openalex.org/C533803919","wikidata":"https://www.wikidata.org/wiki/Q30953","display_name":"Dengue fever","level":2,"score":0.5273020267486572},{"id":"https://openalex.org/C2779261636","wikidata":"https://www.wikidata.org/wiki/Q7003054","display_name":"Neutralizing antibody","level":3,"score":0.5091564059257507},{"id":"https://openalex.org/C2779142602","wikidata":"https://www.wikidata.org/wiki/Q1760689","display_name":"Cross-reactivity","level":4,"score":0.5024399757385254},{"id":"https://openalex.org/C180915046","wikidata":"https://www.wikidata.org/wiki/Q575264","display_name":"Original antigenic sin","level":5,"score":0.48432862758636475},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4286201298236847},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.410248339176178},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.23972946405410767},{"id":"https://openalex.org/C7842527","wikidata":"https://www.wikidata.org/wiki/Q575258","display_name":"Antigenic drift","level":4,"score":0.14316287636756897},{"id":"https://openalex.org/C3020064264","wikidata":"https://www.wikidata.org/wiki/Q1760689","display_name":"Cross reactions","level":3,"score":0.06285500526428223},{"id":"https://openalex.org/C2777546802","wikidata":"https://www.wikidata.org/wiki/Q834390","display_name":"Influenza A virus","level":3,"score":0.06061786413192749}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1145/2506583.2512359","is_oa":false,"landing_page_url":"https://doi.org/10.1145/2506583.2512359","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the International Conference on Bioinformatics, Computational Biology and Biomedical Informatics","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.7799999713897705}],"awards":[],"funders":[{"id":"https://openalex.org/F4320325957","display_name":"Novo Nordisk Fonden","ror":"https://ror.org/04txyc737"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W1535117461","https://openalex.org/W1649650194","https://openalex.org/W1801288333","https://openalex.org/W1974880874","https://openalex.org/W2018750823","https://openalex.org/W2031578199","https://openalex.org/W2069331412","https://openalex.org/W2110575808","https://openalex.org/W2123637444","https://openalex.org/W2124657746","https://openalex.org/W2136358972","https://openalex.org/W2137995709","https://openalex.org/W2151240643","https://openalex.org/W2158714788","https://openalex.org/W2160354505","https://openalex.org/W2161337380","https://openalex.org/W2274083554","https://openalex.org/W6632003565"],"related_works":["https://openalex.org/W2399399246","https://openalex.org/W1585158025","https://openalex.org/W2775372485","https://openalex.org/W2149961808","https://openalex.org/W2549485495","https://openalex.org/W2021776701","https://openalex.org/W3004711645","https://openalex.org/W3156758060","https://openalex.org/W951912817","https://openalex.org/W2034848905"],"abstract_inverted_index":{"The":[0,12,62,83],"majority":[1],"of":[2,45,48,56,65,85,89,97,115,117,127,143],"antibody":[3,17,25,50,98,104],"binding":[4,13,51],"sites":[5,52,67],"(B-cell":[6],"epitopes)":[7],"on":[8,68],"antigens":[9],"are":[10],"discontinuous.":[11],"between":[14],"antigen":[15,29],"and":[16,53,95,140],"is":[18,121],"specific,":[19],"but":[20],"in":[21,103],"some":[22],"cases,":[23],"the":[24,43,54,69,113,125,134,138,141],"elicited":[26],"by":[27,58],"one":[28],"will":[30],"show":[31],"cross-reactivity":[32,116],"against":[33],"other":[34,128],"antigens.":[35],"We":[36,106],"have":[37,107],"developed":[38],"a":[39,80,109],"bioinformatics-based":[40],"approach":[41],"for":[42,112,137],"analysis":[44,64,114,126],"sequence":[46],"variability":[47],"neutralizing":[49,60,99,118,145],"assessment":[55],"coverage":[57,100],"individual":[59],"antibodies.":[61],"antigenic":[63],"functional":[66],"envelope":[70],"(E)":[71],"protein":[72],"from":[73],"dengue":[74],"virus":[75],"has":[76],"been":[77],"used":[78],"as":[79],"case":[81],"study.":[82],"description":[84],"B-cell":[86],"epitopes,":[87],"measurement":[88],"epitope":[90],"similarity":[91],"among":[92],"different":[93],"strains,":[94],"estimation":[96],"provide":[101],"insights":[102],"cross-reactivity.":[105],"defined":[108],"generalized":[110],"method":[111,131],"antibodies":[119],"that":[120],"also":[122],"applicable":[123],"to":[124,133],"pathogens.":[129],"This":[130],"adds":[132],"toolset":[135],"available":[136],"characterization":[139],"design":[142],"broadly":[144],"vaccines.":[146]},"counts_by_year":[{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}