{"id":"https://openalex.org/W2047167692","doi":"https://doi.org/10.1145/2506583.2506657","title":"In silico analysis of autoimmune diseases and genetic relationships to vaccination against infectious diseases","display_name":"In silico analysis of autoimmune diseases and genetic relationships to vaccination against infectious diseases","publication_year":2013,"publication_date":"2013-09-22","ids":{"openalex":"https://openalex.org/W2047167692","doi":"https://doi.org/10.1145/2506583.2506657","mag":"2047167692"},"language":"en","primary_location":{"id":"doi:10.1145/2506583.2506657","is_oa":false,"landing_page_url":"https://doi.org/10.1145/2506583.2506657","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the International Conference on Bioinformatics, Computational Biology and Biomedical Informatics","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082558927","display_name":"Peter B. McGarvey","orcid":"https://orcid.org/0000-0002-8312-6017"},"institutions":[{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]},{"id":"https://openalex.org/I2799903593","display_name":"Georgetown University Medical Center","ror":"https://ror.org/00hjz7x27","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799903593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter McGarvey","raw_affiliation_strings":["Innovation Center for Biomedical Informatics, Georgetown University, Medical Center 2115 Wisconsin Ave, NW, Suite 110 Washington, DC 20007"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Innovation Center for Biomedical Informatics, Georgetown University, Medical Center 2115 Wisconsin Ave, NW, Suite 110 Washington, DC 20007","institution_ids":["https://openalex.org/I184565670","https://openalex.org/I2799903593"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042134761","display_name":"Bar\u0131\u015f Ethem S\u00fczek","orcid":"https://orcid.org/0000-0002-1521-4306"},"institutions":[{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]},{"id":"https://openalex.org/I2799903593","display_name":"Georgetown University Medical Center","ror":"https://ror.org/00hjz7x27","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799903593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Baris E. Suzek","raw_affiliation_strings":["Innovation Center for Biomedical Informatics, Georgetown University, Medical Center 2115 Wisconsin Ave, NW, Suite 110 Washington, DC 20007"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Innovation Center for Biomedical Informatics, Georgetown University, Medical Center 2115 Wisconsin Ave, NW, Suite 110 Washington, DC 20007","institution_ids":["https://openalex.org/I184565670","https://openalex.org/I2799903593"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076408461","display_name":"Shruti Rao","orcid":"https://orcid.org/0000-0002-7235-0777"},"institutions":[{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]},{"id":"https://openalex.org/I2799903593","display_name":"Georgetown University Medical Center","ror":"https://ror.org/00hjz7x27","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799903593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shruti Rao","raw_affiliation_strings":["Innovation Center for Biomedical Informatics, Georgetown University, Medical Center 2115 Wisconsin Ave, NW, Suite 110 Washington, DC 20007"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Innovation Center for Biomedical Informatics, Georgetown University, Medical Center 2115 Wisconsin Ave, NW, Suite 110 Washington, DC 20007","institution_ids":["https://openalex.org/I184565670","https://openalex.org/I2799903593"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037218810","display_name":"Subha Madhavan","orcid":"https://orcid.org/0000-0001-7617-3547"},"institutions":[{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]},{"id":"https://openalex.org/I2799903593","display_name":"Georgetown University Medical Center","ror":"https://ror.org/00hjz7x27","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799903593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Subha Madhavan","raw_affiliation_strings":["Innovation Center for Biomedical Informatics, Georgetown University, Medical Center 2115 Wisconsin Ave, NW, Suite 110 Washington, DC 20007"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Innovation Center for Biomedical Informatics, Georgetown University, Medical Center 2115 Wisconsin Ave, NW, Suite 110 Washington, DC 20007","institution_ids":["https://openalex.org/I184565670","https://openalex.org/I2799903593"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032707806","display_name":"James N. Baraniuk","orcid":"https://orcid.org/0000-0002-1866-4177"},"institutions":[{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]},{"id":"https://openalex.org/I2799903593","display_name":"Georgetown University Medical Center","ror":"https://ror.org/00hjz7x27","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799903593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James N. Baraniuk","raw_affiliation_strings":["Division of Rheumatology, Immunology and Allergy, Department of Medicine, Georgetown University, Medical Center, 3800 Reservoir Road, NW, Washington, D.C. 20007"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Rheumatology, Immunology and Allergy, Department of Medicine, Georgetown University, Medical Center, 3800 Reservoir Road, NW, Washington, D.C. 20007","institution_ids":["https://openalex.org/I184565670","https://openalex.org/I2799903593"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075745134","display_name":"Samir Lababidi","orcid":"https://orcid.org/0000-0002-1406-0448"},"institutions":[{"id":"https://openalex.org/I1318287680","display_name":"Center for Biologics Evaluation and Research","ror":"https://ror.org/02nr3fr97","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1318287680","https://openalex.org/I1320320070"]},{"id":"https://openalex.org/I1320320070","display_name":"United States Food and Drug Administration","ror":"https://ror.org/034xvzb47","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1320320070"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Samir Lababidi","raw_affiliation_strings":["Office of Biostatistics and Epidemiology, Center for Biologics Evaluation and Research, US Food and Drug Administration, 1401 Rockville Pike, Rockville, Maryland 20852"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Office of Biostatistics and Epidemiology, Center for Biologics Evaluation and Research, US Food and Drug Administration, 1401 Rockville Pike, Rockville, Maryland 20852","institution_ids":["https://openalex.org/I1318287680","https://openalex.org/I1320320070"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086298024","display_name":"Andrea Sutherland","orcid":null},"institutions":[{"id":"https://openalex.org/I1318287680","display_name":"Center for Biologics Evaluation and Research","ror":"https://ror.org/02nr3fr97","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1318287680","https://openalex.org/I1320320070"]},{"id":"https://openalex.org/I1320320070","display_name":"United States Food and Drug Administration","ror":"https://ror.org/034xvzb47","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1320320070"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrea Sutherland","raw_affiliation_strings":["Office of Biostatistics and Epidemiology, Center for Biologics Evaluation and Research, US Food and Drug Administration, 1401 Rockville Pike, Rockville, Maryland 20852"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Office of Biostatistics and Epidemiology, Center for Biologics Evaluation and Research, US Food and Drug Administration, 1401 Rockville Pike, Rockville, Maryland 20852","institution_ids":["https://openalex.org/I1318287680","https://openalex.org/I1320320070"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5087332112","display_name":"Richard A. Forshee","orcid":"https://orcid.org/0000-0002-5805-2837"},"institutions":[{"id":"https://openalex.org/I1318287680","display_name":"Center for Biologics Evaluation and Research","ror":"https://ror.org/02nr3fr97","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1318287680","https://openalex.org/I1320320070"]},{"id":"https://openalex.org/I1320320070","display_name":"United States Food and Drug Administration","ror":"https://ror.org/034xvzb47","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1320320070"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard Forshee","raw_affiliation_strings":["Office of Biostatistics and Epidemiology, Center for Biologics Evaluation and Research, US Food and Drug Administration, 1401 Rockville Pike, Rockville, Maryland 20852"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Office of Biostatistics and Epidemiology, Center for Biologics Evaluation and Research, US Food and Drug Administration, 1401 Rockville Pike, Rockville, Maryland 20852","institution_ids":["https://openalex.org/I1318287680","https://openalex.org/I1320320070"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"650","last_page":"651"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.9975000023841858,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.9975000023841858,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11735","display_name":"Peripheral Neuropathies and Disorders","score":0.9968000054359436,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":0.9955000281333923,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vaccination","display_name":"Vaccination","score":0.8013961911201477},{"id":"https://openalex.org/keywords/immunology","display_name":"Immunology","score":0.7601145505905151},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.6519713997840881},{"id":"https://openalex.org/keywords/immune-system","display_name":"Immune system","score":0.5918647050857544},{"id":"https://openalex.org/keywords/rheumatoid-arthritis","display_name":"Rheumatoid arthritis","score":0.546939492225647},{"id":"https://openalex.org/keywords/autoimmunity","display_name":"Autoimmunity","score":0.516045093536377},{"id":"https://openalex.org/keywords/adverse-effect","display_name":"Adverse effect","score":0.4464065730571747}],"concepts":[{"id":"https://openalex.org/C22070199","wikidata":"https://www.wikidata.org/wiki/Q192995","display_name":"Vaccination","level":2,"score":0.8013961911201477},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.7601145505905151},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6519713997840881},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5918647050857544},{"id":"https://openalex.org/C2777575956","wikidata":"https://www.wikidata.org/wiki/Q187255","display_name":"Rheumatoid arthritis","level":2,"score":0.546939492225647},{"id":"https://openalex.org/C2780130043","wikidata":"https://www.wikidata.org/wiki/Q192360","display_name":"Autoimmunity","level":3,"score":0.516045093536377},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.4464065730571747},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1145/2506583.2506657","is_oa":false,"landing_page_url":"https://doi.org/10.1145/2506583.2506657","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the International Conference on Bioinformatics, Computational Biology and Biomedical Informatics","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.6499999761581421}],"awards":[],"funders":[{"id":"https://openalex.org/F4320332744","display_name":"Center of Excellence in Regulatory Science and Innovation","ror":"https://ror.org/05vzafd60"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":67,"referenced_works":["https://openalex.org/W156897084","https://openalex.org/W184793361","https://openalex.org/W241934223","https://openalex.org/W1507694053","https://openalex.org/W1851971391","https://openalex.org/W1900120061","https://openalex.org/W1911591859","https://openalex.org/W1963639770","https://openalex.org/W1969552240","https://openalex.org/W1972285445","https://openalex.org/W1975545468","https://openalex.org/W1985063313","https://openalex.org/W1990502407","https://openalex.org/W1999542797","https://openalex.org/W2001182200","https://openalex.org/W2006759162","https://openalex.org/W2009780311","https://openalex.org/W2010324323","https://openalex.org/W2028133290","https://openalex.org/W2028339001","https://openalex.org/W2029465014","https://openalex.org/W2040022355","https://openalex.org/W2040835300","https://openalex.org/W2045278877","https://openalex.org/W2048296798","https://openalex.org/W2056679815","https://openalex.org/W2058539819","https://openalex.org/W2058990908","https://openalex.org/W2059980695","https://openalex.org/W2060415427","https://openalex.org/W2065899554","https://openalex.org/W2078956734","https://openalex.org/W2083950392","https://openalex.org/W2085328891","https://openalex.org/W2085752173","https://openalex.org/W2091029408","https://openalex.org/W2092602103","https://openalex.org/W2093211495","https://openalex.org/W2095217266","https://openalex.org/W2096766502","https://openalex.org/W2097029995","https://openalex.org/W2103017472","https://openalex.org/W2108491719","https://openalex.org/W2110065044","https://openalex.org/W2113186177","https://openalex.org/W2115813002","https://openalex.org/W2118156146","https://openalex.org/W2124001239","https://openalex.org/W2125072615","https://openalex.org/W2125353047","https://openalex.org/W2127553917","https://openalex.org/W2130443006","https://openalex.org/W2131660156","https://openalex.org/W2131924932","https://openalex.org/W2134845483","https://openalex.org/W2137518425","https://openalex.org/W2138165257","https://openalex.org/W2147168728","https://openalex.org/W2149671003","https://openalex.org/W2150658610","https://openalex.org/W2150842873","https://openalex.org/W2151936673","https://openalex.org/W2155142785","https://openalex.org/W2160894282","https://openalex.org/W2184417913","https://openalex.org/W2605068739","https://openalex.org/W4233888847"],"related_works":["https://openalex.org/W2185550546","https://openalex.org/W2416097977","https://openalex.org/W2028766184","https://openalex.org/W2993678931","https://openalex.org/W2384738060","https://openalex.org/W3045583548","https://openalex.org/W812086887","https://openalex.org/W2101475263","https://openalex.org/W4312109267","https://openalex.org/W4386016105"],"abstract_inverted_index":{"Vaccines":[0],"are":[1,16,38],"profoundly":[2],"important":[3],"to":[4,51,120,134,143],"global":[5],"health":[6],"in":[7],"preventing":[8],"infectious":[9],"diseases.":[10],"Reported":[11],"adverse":[12,94],"events":[13],"following":[14],"vaccination":[15],"diverse,":[17],"rare":[18,39],"and":[19,23,40,43,60,68,98,116,125,140,156],"require":[20],"thorough":[21],"investigation":[22],"evaluation":[24,71],"[1].":[25],"Autoimmune":[26],"diseases":[27,37,59],"(AD)":[28],"have":[29,41],"been":[30],"reported":[31,104],"after":[32],"some":[33],"vaccinations.":[34],"Because":[35],"autoimmune":[36,58],"variable":[42],"prolonged":[44],"onset":[45],"times,":[46],"it":[47,49],"makes":[48],"difficult":[50],"fully":[52],"assess":[53],"the":[54,57,64,93,99,102,111,138],"association":[55],"between":[56],"vaccination.":[61],"One":[62],"of":[63,66,74,78,87,101,114],"components":[65],"pharmacovigilance":[67],"vaccine":[69,121],"safety":[70],"is":[72,108],"consideration":[73],"biologic":[75,79],"plausibility.":[76],"Knowledge":[77],"plausibility":[80],"may":[81],"be":[82],"enhanced":[83],"by":[84,110],"an":[85],"understanding":[86],"molecular":[88],"immune":[89,118],"mechanisms":[90],"responsible":[91],"for":[92],"events,":[95],"natural":[96],"infections":[97],"pathogenesis":[100],"associated,":[103],"AD.":[105],"The":[106],"situation":[107],"complicated":[109],"complex":[112],"matrix":[113],"innate":[115],"adaptive":[117],"responses":[119],"antigens,":[122],"adjuvants,":[123],"preservatives":[124],"stabilizers.":[126],"A":[127],"bioinformatics,":[128],"systems":[129],"biology":[130],"approach":[131],"was":[132],"used":[133],"collect":[135],"data":[136],"from":[137],"literature":[139],"curated":[141],"databases":[142],"understand":[144],"post-vaccination":[145],"Guillain-Barr\u00e9":[146],"Syndrome":[147],"(GBS),":[148],"Rheumatoid":[149],"Arthritis":[150],"(RA),":[151],"Systemic":[152],"Lupus":[153],"Erythematosus":[154],"(SLE),":[155],"Idiopathic":[157],"(or":[158],"Immune)":[159],"Thrombocytopenic":[160],"Purpura":[161],"(ITP).":[162]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2017,"cited_by_count":1}],"updated_date":"2026-07-22T07:51:19.307946","created_date":"2025-10-10T00:00:00"}
