{"id":"https://openalex.org/W2004881888","doi":"https://doi.org/10.1145/2390068.2390083","title":"Rule-based whole body modeling for analyzing multi-compound effects","display_name":"Rule-based whole body modeling for analyzing multi-compound effects","publication_year":2012,"publication_date":"2012-10-29","ids":{"openalex":"https://openalex.org/W2004881888","doi":"https://doi.org/10.1145/2390068.2390083","mag":"2004881888"},"language":"en","primary_location":{"id":"doi:10.1145/2390068.2390083","is_oa":false,"landing_page_url":"https://doi.org/10.1145/2390068.2390083","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the ACM sixth international workshop on Data and text mining in biomedical informatics","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033201097","display_name":"Woochang Hwang","orcid":"https://orcid.org/0000-0003-0876-7305"},"institutions":[{"id":"https://openalex.org/I157485424","display_name":"Korea Advanced Institute of Science and Technology","ror":"https://ror.org/05apxxy63","country_code":"KR","type":"education","lineage":["https://openalex.org/I157485424"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Woochang Hwang","raw_affiliation_strings":["KAIST, Daejeon, South Korea","KAIST, Daejeon , South Korea#TAB#"],"affiliations":[{"raw_affiliation_string":"KAIST, Daejeon, South Korea","institution_ids":["https://openalex.org/I157485424"]},{"raw_affiliation_string":"KAIST, Daejeon , South Korea#TAB#","institution_ids":["https://openalex.org/I157485424"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037983389","display_name":"Youngdeuk Hwang","orcid":null},"institutions":[{"id":"https://openalex.org/I157485424","display_name":"Korea Advanced Institute of Science and Technology","ror":"https://ror.org/05apxxy63","country_code":"KR","type":"education","lineage":["https://openalex.org/I157485424"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Youngdeuk Hwang","raw_affiliation_strings":["KAIST, Daejeon, South Korea","KAIST, Daejeon , South Korea#TAB#"],"affiliations":[{"raw_affiliation_string":"KAIST, Daejeon, South Korea","institution_ids":["https://openalex.org/I157485424"]},{"raw_affiliation_string":"KAIST, Daejeon , South Korea#TAB#","institution_ids":["https://openalex.org/I157485424"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081247408","display_name":"Sunjae Lee","orcid":"https://orcid.org/0000-0002-6428-5936"},"institutions":[{"id":"https://openalex.org/I157485424","display_name":"Korea Advanced Institute of Science and Technology","ror":"https://ror.org/05apxxy63","country_code":"KR","type":"education","lineage":["https://openalex.org/I157485424"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Sunjae Lee","raw_affiliation_strings":["KAIST, Daejeon, South Korea","KAIST, Daejeon , South Korea#TAB#"],"affiliations":[{"raw_affiliation_string":"KAIST, Daejeon, South Korea","institution_ids":["https://openalex.org/I157485424"]},{"raw_affiliation_string":"KAIST, Daejeon , South Korea#TAB#","institution_ids":["https://openalex.org/I157485424"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5037879375","display_name":"Doheon Lee","orcid":"https://orcid.org/0000-0001-9070-4316"},"institutions":[{"id":"https://openalex.org/I157485424","display_name":"Korea Advanced Institute of Science and Technology","ror":"https://ror.org/05apxxy63","country_code":"KR","type":"education","lineage":["https://openalex.org/I157485424"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Doheon Lee","raw_affiliation_strings":["KAIST, Daejeon, South Korea","KAIST, Daejeon , South Korea#TAB#"],"affiliations":[{"raw_affiliation_string":"KAIST, Daejeon, South Korea","institution_ids":["https://openalex.org/I157485424"]},{"raw_affiliation_string":"KAIST, Daejeon , South Korea#TAB#","institution_ids":["https://openalex.org/I157485424"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5033201097"],"corresponding_institution_ids":["https://openalex.org/I157485424"],"apc_list":null,"apc_paid":null,"fwci":0.7039,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.69915001,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":null,"issue":null,"first_page":"77","last_page":"84"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9966999888420105,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rotation-formalisms-in-three-dimensions","display_name":"Rotation formalisms in three dimensions","score":0.8433802127838135},{"id":"https://openalex.org/keywords/robustness","display_name":"Robustness (evolution)","score":0.7144834995269775},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6482143402099609},{"id":"https://openalex.org/keywords/redundancy","display_name":"Redundancy (engineering)","score":0.5652961730957031},{"id":"https://openalex.org/keywords/crosstalk","display_name":"Crosstalk","score":0.5456070303916931},{"id":"https://openalex.org/keywords/reliability-engineering","display_name":"Reliability engineering","score":0.3830547332763672},{"id":"https://openalex.org/keywords/risk-analysis","display_name":"Risk analysis (engineering)","score":0.37277454137802124},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.3367782235145569},{"id":"https://openalex.org/keywords/biochemical-engineering","display_name":"Biochemical engineering","score":0.3207758069038391},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.19601893424987793},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.18318673968315125},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.1464805006980896},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.12811121344566345},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.12727904319763184}],"concepts":[{"id":"https://openalex.org/C171018156","wikidata":"https://www.wikidata.org/wiki/Q7370306","display_name":"Rotation formalisms in three dimensions","level":2,"score":0.8433802127838135},{"id":"https://openalex.org/C63479239","wikidata":"https://www.wikidata.org/wiki/Q7353546","display_name":"Robustness (evolution)","level":3,"score":0.7144834995269775},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6482143402099609},{"id":"https://openalex.org/C152124472","wikidata":"https://www.wikidata.org/wiki/Q1204361","display_name":"Redundancy (engineering)","level":2,"score":0.5652961730957031},{"id":"https://openalex.org/C169822122","wikidata":"https://www.wikidata.org/wiki/Q230187","display_name":"Crosstalk","level":2,"score":0.5456070303916931},{"id":"https://openalex.org/C200601418","wikidata":"https://www.wikidata.org/wiki/Q2193887","display_name":"Reliability engineering","level":1,"score":0.3830547332763672},{"id":"https://openalex.org/C112930515","wikidata":"https://www.wikidata.org/wiki/Q4389547","display_name":"Risk analysis (engineering)","level":1,"score":0.37277454137802124},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3367782235145569},{"id":"https://openalex.org/C183696295","wikidata":"https://www.wikidata.org/wiki/Q2487696","display_name":"Biochemical engineering","level":1,"score":0.3207758069038391},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.19601893424987793},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.18318673968315125},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.1464805006980896},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.12811121344566345},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.12727904319763184},{"id":"https://openalex.org/C24326235","wikidata":"https://www.wikidata.org/wiki/Q126095","display_name":"Electronic engineering","level":1,"score":0.0},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1145/2390068.2390083","is_oa":false,"landing_page_url":"https://doi.org/10.1145/2390068.2390083","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the ACM sixth international workshop on Data and text mining in biomedical informatics","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.4699999988079071,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W323766208","https://openalex.org/W605068603","https://openalex.org/W1504533062","https://openalex.org/W1554646488","https://openalex.org/W1608828583","https://openalex.org/W1703438007","https://openalex.org/W1988327939","https://openalex.org/W1999892605","https://openalex.org/W2002062638","https://openalex.org/W2002915579","https://openalex.org/W2019020805","https://openalex.org/W2033591223","https://openalex.org/W2065332736","https://openalex.org/W2074192927","https://openalex.org/W2087312216","https://openalex.org/W2102382908","https://openalex.org/W2104067072","https://openalex.org/W2105536900","https://openalex.org/W2116566535","https://openalex.org/W2144063122","https://openalex.org/W2151251638","https://openalex.org/W2155142785","https://openalex.org/W2165958420","https://openalex.org/W2166199281","https://openalex.org/W2168258971","https://openalex.org/W2611943439","https://openalex.org/W4237095724"],"related_works":["https://openalex.org/W57206970","https://openalex.org/W4235091896","https://openalex.org/W2185981755","https://openalex.org/W2023896637","https://openalex.org/W2498253392","https://openalex.org/W2996527951","https://openalex.org/W2121924470","https://openalex.org/W3196191855","https://openalex.org/W4244481131","https://openalex.org/W1532035848"],"abstract_inverted_index":{"Essential":[0],"reasons":[1],"including":[2],"robustness,":[3],"redundancy,":[4],"and":[5,18,36,60,72,116],"crosstalk":[6],"of":[7,21,38,47,69,77,80,93],"biological":[8],"systems,":[9],"have":[10,26,40,88,105],"been":[11,89,106],"reported":[12],"to":[13,28,32,98,109],"explain":[14],"the":[15,75,94],"limited":[16],"efficacy":[17,52],"unexpected":[19,122],"side-effects":[20,57],"drugs.":[22],"Many":[23],"pharmaceutical":[24],"laboratories":[25],"begun":[27],"develop":[29],"multi-compound":[30],"drugs":[31],"remedy":[33],"this":[34],"situation,":[35],"some":[37],"them":[39],"shown":[41],"successful":[42],"clinical":[43],"results.":[44],"Simultaneous":[45],"application":[46],"multiple":[48],"compounds":[49],"could":[50],"increase":[51],"as":[53,55,74,91],"well":[54],"reduce":[56],"through":[58],"pharmacodynamics":[59],"pharmacokinetic":[61],"interactions.":[62],"However,":[63],"such":[64,101],"approach":[65],"requires":[66],"overwhelming":[67],"cost":[68],"preclinical":[70],"experiments":[71,87],"tests":[73],"number":[76],"possible":[78],"combinations":[79],"compound":[81],"dosages":[82],"increases":[83],"exponentially.":[84],"Computer":[85],"model-based":[86],"emerging":[90],"one":[92],"most":[95],"promising":[96],"solutions":[97],"cope":[99],"with":[100],"complexity.":[102],"Though":[103],"there":[104],"many":[107],"efforts":[108],"model":[110],"specific":[111],"molecular":[112],"pathways":[113],"using":[114],"qualitative":[115],"quantitative":[117],"formalisms,":[118],"they":[119],"suffer":[120],"from":[121],"results":[123],"caused":[124],"by":[125],"distant":[126],"interactions":[127],"beyond":[128],"their":[129],"localized":[130],"models.":[131]},"counts_by_year":[{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}