{"id":"https://openalex.org/W2062274727","doi":"https://doi.org/10.1145/2330784.2330966","title":"Checkpoint oriented cell-cycle simulation","display_name":"Checkpoint oriented cell-cycle simulation","publication_year":2012,"publication_date":"2012-07-07","ids":{"openalex":"https://openalex.org/W2062274727","doi":"https://doi.org/10.1145/2330784.2330966","mag":"2062274727"},"language":"en","primary_location":{"id":"doi:10.1145/2330784.2330966","is_oa":false,"landing_page_url":"https://doi.org/10.1145/2330784.2330966","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 14th annual conference companion on Genetic and evolutionary computation","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049425627","display_name":"Jonathan Pascalie","orcid":null},"institutions":[{"id":"https://openalex.org/I4210119061","display_name":"Institut de Recherche en Informatique de Toulouse","ror":"https://ror.org/01rx4qw44","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I205747304","https://openalex.org/I205747304","https://openalex.org/I4210119061","https://openalex.org/I4387153255","https://openalex.org/I4405258862","https://openalex.org/I4405258862"]},{"id":"https://openalex.org/I134560555","display_name":"Universit\u00e9 Toulouse III - Paul Sabatier","ror":"https://ror.org/02v6kpv12","country_code":"FR","type":"education","lineage":["https://openalex.org/I134560555","https://openalex.org/I4405258862"]},{"id":"https://openalex.org/I4210160189","display_name":"Institut Polytechnique de Bordeaux","ror":"https://ror.org/054qv7y42","country_code":"FR","type":"education","lineage":["https://openalex.org/I4210160189"]},{"id":"https://openalex.org/I4210152422","display_name":"Universit\u00e9 Toulouse - Jean Jaur\u00e8s","ror":"https://ror.org/04ezk3x31","country_code":"FR","type":"education","lineage":["https://openalex.org/I4210152422","https://openalex.org/I4405258862"]},{"id":"https://openalex.org/I3131550300","display_name":"Universit\u00e9 Toulouse-I-Capitole","ror":"https://ror.org/0443n9e75","country_code":"FR","type":"education","lineage":["https://openalex.org/I3131550300"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Jonathan Pascalie","raw_affiliation_strings":["IRIT - University of Toulouse, toulouse, France"],"affiliations":[{"raw_affiliation_string":"IRIT - University of Toulouse, toulouse, France","institution_ids":["https://openalex.org/I4210119061","https://openalex.org/I134560555","https://openalex.org/I3131550300","https://openalex.org/I4210160189","https://openalex.org/I4210152422"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011253451","display_name":"Val\u00e9rie Lobjois","orcid":"https://orcid.org/0000-0003-2428-2084"},"institutions":[{"id":"https://openalex.org/I4210126285","display_name":"Institut des Technologies Avanc\u00e9es en sciences du Vivant","ror":"https://ror.org/028pmgd25","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I134560555","https://openalex.org/I4210126285","https://openalex.org/I4210133643","https://openalex.org/I4210139971","https://openalex.org/I4405258862"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Val\u00e9rie Lobjois","raw_affiliation_strings":["CNRS - ITAV - UMS3039, Toulouse, France"],"affiliations":[{"raw_affiliation_string":"CNRS - ITAV - UMS3039, Toulouse, France","institution_ids":["https://openalex.org/I4210126285","https://openalex.org/I1294671590"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070431284","display_name":"Herv\u00e9 Luga","orcid":"https://orcid.org/0000-0001-8675-197X"},"institutions":[{"id":"https://openalex.org/I4210152422","display_name":"Universit\u00e9 Toulouse - Jean Jaur\u00e8s","ror":"https://ror.org/04ezk3x31","country_code":"FR","type":"education","lineage":["https://openalex.org/I4210152422","https://openalex.org/I4405258862"]},{"id":"https://openalex.org/I4210160189","display_name":"Institut Polytechnique de Bordeaux","ror":"https://ror.org/054qv7y42","country_code":"FR","type":"education","lineage":["https://openalex.org/I4210160189"]},{"id":"https://openalex.org/I4210119061","display_name":"Institut de Recherche en Informatique de Toulouse","ror":"https://ror.org/01rx4qw44","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I205747304","https://openalex.org/I205747304","https://openalex.org/I4210119061","https://openalex.org/I4387153255","https://openalex.org/I4405258862","https://openalex.org/I4405258862"]},{"id":"https://openalex.org/I3131550300","display_name":"Universit\u00e9 Toulouse-I-Capitole","ror":"https://ror.org/0443n9e75","country_code":"FR","type":"education","lineage":["https://openalex.org/I3131550300"]},{"id":"https://openalex.org/I134560555","display_name":"Universit\u00e9 Toulouse III - Paul Sabatier","ror":"https://ror.org/02v6kpv12","country_code":"FR","type":"education","lineage":["https://openalex.org/I134560555","https://openalex.org/I4405258862"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Herv\u00e9 Luga","raw_affiliation_strings":["IRIT - University of Toulouse, Toulouse, France"],"affiliations":[{"raw_affiliation_string":"IRIT - University of Toulouse, Toulouse, France","institution_ids":["https://openalex.org/I4210119061","https://openalex.org/I134560555","https://openalex.org/I3131550300","https://openalex.org/I4210160189","https://openalex.org/I4210152422"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079627411","display_name":"Bernard Ducommun","orcid":"https://orcid.org/0000-0002-7126-8368"},"institutions":[{"id":"https://openalex.org/I4210126285","display_name":"Institut des Technologies Avanc\u00e9es en sciences du Vivant","ror":"https://ror.org/028pmgd25","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I134560555","https://openalex.org/I4210126285","https://openalex.org/I4210133643","https://openalex.org/I4210139971","https://openalex.org/I4405258862"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Bernard Ducommun","raw_affiliation_strings":["CNRS - ITAV - UMS3039, Toulouse, France"],"affiliations":[{"raw_affiliation_string":"CNRS - ITAV - UMS3039, Toulouse, France","institution_ids":["https://openalex.org/I4210126285","https://openalex.org/I1294671590"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102990952","display_name":"Yves Duthen","orcid":"https://orcid.org/0000-0003-3877-9489"},"institutions":[{"id":"https://openalex.org/I3131550300","display_name":"Universit\u00e9 Toulouse-I-Capitole","ror":"https://ror.org/0443n9e75","country_code":"FR","type":"education","lineage":["https://openalex.org/I3131550300"]},{"id":"https://openalex.org/I134560555","display_name":"Universit\u00e9 Toulouse III - Paul Sabatier","ror":"https://ror.org/02v6kpv12","country_code":"FR","type":"education","lineage":["https://openalex.org/I134560555","https://openalex.org/I4405258862"]},{"id":"https://openalex.org/I4210119061","display_name":"Institut de Recherche en Informatique de Toulouse","ror":"https://ror.org/01rx4qw44","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I205747304","https://openalex.org/I205747304","https://openalex.org/I4210119061","https://openalex.org/I4387153255","https://openalex.org/I4405258862","https://openalex.org/I4405258862"]},{"id":"https://openalex.org/I4210160189","display_name":"Institut Polytechnique de Bordeaux","ror":"https://ror.org/054qv7y42","country_code":"FR","type":"education","lineage":["https://openalex.org/I4210160189"]},{"id":"https://openalex.org/I4210152422","display_name":"Universit\u00e9 Toulouse - Jean Jaur\u00e8s","ror":"https://ror.org/04ezk3x31","country_code":"FR","type":"education","lineage":["https://openalex.org/I4210152422","https://openalex.org/I4405258862"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Yves Duthen","raw_affiliation_strings":["IRIT - University of Toulouse, Toulouse, France"],"affiliations":[{"raw_affiliation_string":"IRIT - University of Toulouse, Toulouse, France","institution_ids":["https://openalex.org/I4210119061","https://openalex.org/I134560555","https://openalex.org/I3131550300","https://openalex.org/I4210160189","https://openalex.org/I4210152422"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5049425627"],"corresponding_institution_ids":["https://openalex.org/I134560555","https://openalex.org/I3131550300","https://openalex.org/I4210119061","https://openalex.org/I4210152422","https://openalex.org/I4210160189"],"apc_list":null,"apc_paid":null,"fwci":0.2521,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.55691333,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":null,"issue":null,"first_page":"1425","last_page":"1426"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11829","display_name":"Mathematical Biology Tumor Growth","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11829","display_name":"Mathematical Biology Tumor Growth","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.984000027179718,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11190","display_name":"3D Printing in Biomedical Research","score":0.9797000288963318,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/initialization","display_name":"Initialization","score":0.901021420955658},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.7447795867919922},{"id":"https://openalex.org/keywords/convergence","display_name":"Convergence (economics)","score":0.6139429211616516},{"id":"https://openalex.org/keywords/constraint","display_name":"Constraint (computer-aided design)","score":0.5758111476898193},{"id":"https://openalex.org/keywords/relevance","display_name":"Relevance (law)","score":0.5087373852729797},{"id":"https://openalex.org/keywords/orientation","display_name":"Orientation (vector space)","score":0.5055930614471436},{"id":"https://openalex.org/keywords/in-silico","display_name":"In silico","score":0.497254878282547},{"id":"https://openalex.org/keywords/state","display_name":"State (computer science)","score":0.4363708198070526},{"id":"https://openalex.org/keywords/theoretical-computer-science","display_name":"Theoretical computer science","score":0.42797982692718506},{"id":"https://openalex.org/keywords/distributed-computing","display_name":"Distributed computing","score":0.3312200903892517},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.2543032765388489},{"id":"https://openalex.org/keywords/programming-language","display_name":"Programming language","score":0.1595551073551178},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.10307121276855469},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.08300843834877014},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.0704512894153595}],"concepts":[{"id":"https://openalex.org/C114466953","wikidata":"https://www.wikidata.org/wiki/Q6034165","display_name":"Initialization","level":2,"score":0.901021420955658},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.7447795867919922},{"id":"https://openalex.org/C2777303404","wikidata":"https://www.wikidata.org/wiki/Q759757","display_name":"Convergence (economics)","level":2,"score":0.6139429211616516},{"id":"https://openalex.org/C2776036281","wikidata":"https://www.wikidata.org/wiki/Q48769818","display_name":"Constraint (computer-aided design)","level":2,"score":0.5758111476898193},{"id":"https://openalex.org/C158154518","wikidata":"https://www.wikidata.org/wiki/Q7310970","display_name":"Relevance (law)","level":2,"score":0.5087373852729797},{"id":"https://openalex.org/C16345878","wikidata":"https://www.wikidata.org/wiki/Q107472979","display_name":"Orientation (vector space)","level":2,"score":0.5055930614471436},{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.497254878282547},{"id":"https://openalex.org/C48103436","wikidata":"https://www.wikidata.org/wiki/Q599031","display_name":"State (computer science)","level":2,"score":0.4363708198070526},{"id":"https://openalex.org/C80444323","wikidata":"https://www.wikidata.org/wiki/Q2878974","display_name":"Theoretical computer science","level":1,"score":0.42797982692718506},{"id":"https://openalex.org/C120314980","wikidata":"https://www.wikidata.org/wiki/Q180634","display_name":"Distributed computing","level":1,"score":0.3312200903892517},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.2543032765388489},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.1595551073551178},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.10307121276855469},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.08300843834877014},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0704512894153595},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C199539241","wikidata":"https://www.wikidata.org/wiki/Q7748","display_name":"Law","level":1,"score":0.0},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.0},{"id":"https://openalex.org/C50522688","wikidata":"https://www.wikidata.org/wiki/Q189833","display_name":"Economic growth","level":1,"score":0.0},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1145/2330784.2330966","is_oa":false,"landing_page_url":"https://doi.org/10.1145/2330784.2330966","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 14th annual conference companion on Genetic and evolutionary computation","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":4,"referenced_works":["https://openalex.org/W2022414551","https://openalex.org/W2136977672","https://openalex.org/W2171531225","https://openalex.org/W2406314600"],"related_works":["https://openalex.org/W3204184292","https://openalex.org/W3176564347","https://openalex.org/W1985458517","https://openalex.org/W2355833770","https://openalex.org/W3031039437","https://openalex.org/W3095877357","https://openalex.org/W183202219","https://openalex.org/W2072565696","https://openalex.org/W10861731","https://openalex.org/W2050451745"],"abstract_inverted_index":{"In":[0],"this":[1,63],"paper":[2],"we":[3,65],"start":[4],"to":[5,50],"validate":[6],"a":[7,14,39,55,73,77],"computational":[8,91],"cell":[9],"cycle":[10],"model,":[11],"developed":[12],"in":[13,80],"collaborative":[15],"work":[16],"between":[17,25],"computer":[18],"scientists":[19],"and":[20,27,43],"biologists,":[21],"evaluating":[22],"the":[23,52,59,69,81,84],"convergence":[24],"in-vitro":[26],"in-silico":[28],"results.":[29,85],"Whereas":[30],"most":[31],"models":[32],"are":[33],"phase-orientated":[34],"our":[35],"model":[36],"deals":[37],"with":[38,54],"checkpoint":[40],"orientated":[41],"paradigm":[42],"uses":[44],"phase":[45],"orientation":[46],"as":[47,93],"an":[48],"output":[49],"provide":[51],"biologists":[53],"relevant":[56],"view":[57],"of":[58,72,83],"simulation":[60],"result.":[61],"Throughout":[62],"paper,":[64],"will":[66],"show":[67],"that":[68],"initialization":[70,87],"state":[71,88],"multi-cellular":[74],"culture":[75],"is":[76],"high":[78],"constraint":[79],"relevance":[82],"This":[86],"lets":[89],"emerge":[90],"artifacts":[92],"phasing.":[94]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}