{"id":"https://openalex.org/W2120396959","doi":"https://doi.org/10.1145/2330784.2330962","title":"A dynamical model of cancer chemotherapy with disturbance","display_name":"A dynamical model of cancer chemotherapy with disturbance","publication_year":2012,"publication_date":"2012-07-07","ids":{"openalex":"https://openalex.org/W2120396959","doi":"https://doi.org/10.1145/2330784.2330962","mag":"2120396959"},"language":"en","primary_location":{"id":"doi:10.1145/2330784.2330962","is_oa":false,"landing_page_url":"https://doi.org/10.1145/2330784.2330962","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 14th annual conference companion on Genetic and evolutionary computation","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Henri C. Jimbo","orcid":null},"institutions":[{"id":"https://openalex.org/I2803079837","display_name":"American University of the Middle East","ror":"https://ror.org/02gqgne03","country_code":"KW","type":"education","lineage":["https://openalex.org/I2803079837"]}],"countries":["KW"],"is_corresponding":false,"raw_author_name":"Henri C. Jimbo","raw_affiliation_strings":["American University of the Middle East, Dasman, Kuwait"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"American University of the Middle East, Dasman, Kuwait","institution_ids":["https://openalex.org/I2803079837"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5070682430","display_name":"Matthew J. Craven","orcid":"https://orcid.org/0000-0001-9522-6173"},"institutions":[{"id":"https://openalex.org/I877506347","display_name":"Abertay University","ror":"https://ror.org/04mwwnx67","country_code":"GB","type":"education","lineage":["https://openalex.org/I877506347"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Matthew J. Craven","raw_affiliation_strings":["University of Abertay Dundee, Dundee, United Kingdom","University of Abertay Dundee, Dundee, United Kingdom#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Abertay Dundee, Dundee, United Kingdom","institution_ids":["https://openalex.org/I877506347"]},{"raw_affiliation_string":"University of Abertay Dundee, Dundee, United Kingdom#TAB#","institution_ids":["https://openalex.org/I877506347"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.12454526,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":null,"issue":null,"first_page":"1417","last_page":"1418"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11829","display_name":"Mathematical Biology Tumor Growth","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11829","display_name":"Mathematical Biology Tumor Growth","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9779000282287598,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11215","display_name":"Chronic Myeloid Leukemia Treatments","score":0.9668999910354614,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/schedule","display_name":"Schedule","score":0.6585399508476257},{"id":"https://openalex.org/keywords/quadratic-equation","display_name":"Quadratic equation","score":0.5994455218315125},{"id":"https://openalex.org/keywords/mathematical-optimization","display_name":"Mathematical optimization","score":0.5954158306121826},{"id":"https://openalex.org/keywords/scheduling","display_name":"Scheduling (production processes)","score":0.5724713802337646},{"id":"https://openalex.org/keywords/cancer-chemotherapy","display_name":"Cancer chemotherapy","score":0.5508813261985779},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5175973176956177},{"id":"https://openalex.org/keywords/work-schedule","display_name":"Work schedule","score":0.5105444192886353},{"id":"https://openalex.org/keywords/work","display_name":"Work (physics)","score":0.4189002513885498},{"id":"https://openalex.org/keywords/quadratic-model","display_name":"Quadratic model","score":0.418887734413147},{"id":"https://openalex.org/keywords/chemotherapy","display_name":"Chemotherapy","score":0.413967102766037},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.303274005651474},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.13379627466201782},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.10596540570259094},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.09397634863853455}],"concepts":[{"id":"https://openalex.org/C68387754","wikidata":"https://www.wikidata.org/wiki/Q7271585","display_name":"Schedule","level":2,"score":0.6585399508476257},{"id":"https://openalex.org/C129844170","wikidata":"https://www.wikidata.org/wiki/Q41299","display_name":"Quadratic equation","level":2,"score":0.5994455218315125},{"id":"https://openalex.org/C126255220","wikidata":"https://www.wikidata.org/wiki/Q141495","display_name":"Mathematical optimization","level":1,"score":0.5954158306121826},{"id":"https://openalex.org/C206729178","wikidata":"https://www.wikidata.org/wiki/Q2271896","display_name":"Scheduling (production processes)","level":2,"score":0.5724713802337646},{"id":"https://openalex.org/C2983288658","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Cancer chemotherapy","level":3,"score":0.5508813261985779},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5175973176956177},{"id":"https://openalex.org/C2993145049","wikidata":"https://www.wikidata.org/wiki/Q7271585","display_name":"Work schedule","level":3,"score":0.5105444192886353},{"id":"https://openalex.org/C18762648","wikidata":"https://www.wikidata.org/wiki/Q42213","display_name":"Work (physics)","level":2,"score":0.4189002513885498},{"id":"https://openalex.org/C2983524802","wikidata":"https://www.wikidata.org/wiki/Q41299","display_name":"Quadratic model","level":3,"score":0.418887734413147},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.413967102766037},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.303274005651474},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.13379627466201782},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.10596540570259094},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.09397634863853455},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.0},{"id":"https://openalex.org/C150077022","wikidata":"https://www.wikidata.org/wiki/Q3136137","display_name":"Response surface methodology","level":2,"score":0.0},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.0},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1145/2330784.2330962","is_oa":false,"landing_page_url":"https://doi.org/10.1145/2330784.2330962","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 14th annual conference companion on Genetic and evolutionary computation","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":3,"referenced_works":["https://openalex.org/W2060994634","https://openalex.org/W2075763799","https://openalex.org/W2087600569"],"related_works":["https://openalex.org/W4249495319","https://openalex.org/W2174746710","https://openalex.org/W2028264618","https://openalex.org/W2004938008","https://openalex.org/W2327151097","https://openalex.org/W2358049220","https://openalex.org/W2110178607","https://openalex.org/W4241933130","https://openalex.org/W2360375312","https://openalex.org/W2769601682"],"abstract_inverted_index":{"This":[0],"work":[1],"proposes":[2],"a":[3,28],"controlled":[4],"stochastic":[5],"difference":[6],"equation":[7],"model":[8,55,80],"of":[9,61,72],"scheduling,":[10],"with":[11],"quadratic":[12,23],"cost":[13],"criteria,":[14],"for":[15,83],"cancer":[16,62,84],"chemotherapy.":[17,85],"By":[18],"reducing":[19],"the":[20,58,66,70,78],"problem":[21],"to":[22,42,64],"control":[24],"optimization":[25],"and":[26,90],"introducing":[27],"random":[29],"search":[30],"algorithm,":[31],"we":[32],"seek":[33],"an":[34],"optimal":[35],"chemotherapy":[36],"schedule.":[37],"Our":[38,75,86],"ultimate":[39],"goal":[40],"is":[41,88],"provide":[43],"more":[44],"realistic":[45],"solutions":[46],"than":[47],"previous":[48],"models.":[49],"To":[50],"reach":[51],"this":[52],"goal,":[53],"our":[54],"ideally":[56],"kills":[57],"maximum":[59],"number":[60,71],"cells":[63],"eradicate":[65],"disease":[67],"while":[68],"preserving":[69],"normal":[73],"cells.":[74],"results":[76],"show":[77],"proposed":[79],"works":[81],"well":[82],"algorithm":[87],"fast":[89],"helps":[91],"produce":[92],"practical":[93],"schedules.":[94]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}
