{"id":"https://openalex.org/W2164983637","doi":"https://doi.org/10.1145/2147805.2147907","title":"Using HLA binding prediction algorithms for epitope mapping in HIV vaccine clinical trials","display_name":"Using HLA binding prediction algorithms for epitope mapping in HIV vaccine clinical trials","publication_year":2011,"publication_date":"2011-08-01","ids":{"openalex":"https://openalex.org/W2164983637","doi":"https://doi.org/10.1145/2147805.2147907","mag":"2164983637"},"language":"en","primary_location":{"id":"doi:10.1145/2147805.2147907","is_oa":false,"landing_page_url":"https://doi.org/10.1145/2147805.2147907","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 2nd ACM Conference on Bioinformatics, Computational Biology and Biomedicine","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023085024","display_name":"Dan He","orcid":"https://orcid.org/0000-0001-9064-566X"},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Dan He","raw_affiliation_strings":["University of California Los Angeles, Los Angeles, CA"],"affiliations":[{"raw_affiliation_string":"University of California Los Angeles, Los Angeles, CA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031185057","display_name":"Pratima Kunwar","orcid":null},"institutions":[{"id":"https://openalex.org/I1294824412","display_name":"Center for Infectious Disease Research","ror":"https://ror.org/04jkbnw46","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1294824412"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pratima Kunwar","raw_affiliation_strings":["Seattle BioMed, Seattle, WA"],"affiliations":[{"raw_affiliation_string":"Seattle BioMed, Seattle, WA","institution_ids":["https://openalex.org/I1294824412"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009368988","display_name":"Eleazar Eskin","orcid":"https://orcid.org/0000-0003-1149-4758"},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eleazar Eskin","raw_affiliation_strings":["University of California Los Angeles, Los Angeles, CA"],"affiliations":[{"raw_affiliation_string":"University of California Los Angeles, Los Angeles, CA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108483206","display_name":"Helen Horton","orcid":null},"institutions":[{"id":"https://openalex.org/I1294824412","display_name":"Center for Infectious Disease Research","ror":"https://ror.org/04jkbnw46","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1294824412"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Helen Horton","raw_affiliation_strings":["Seattle BioMed, Seattle, WA"],"affiliations":[{"raw_affiliation_string":"Seattle BioMed, Seattle, WA","institution_ids":["https://openalex.org/I1294824412"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085731242","display_name":"Peter B. Gilbert","orcid":"https://orcid.org/0000-0002-2662-9427"},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter Gilbert","raw_affiliation_strings":["Fred Hutchinson Cancer Research Center, Seattle, WA"],"affiliations":[{"raw_affiliation_string":"Fred Hutchinson Cancer Research Center, Seattle, WA","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5004268970","display_name":"Tomer Hertz","orcid":"https://orcid.org/0000-0002-0561-1578"},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tomer Hertz","raw_affiliation_strings":["Fred Hutchinson Cancer Research Center, Seattle, WA"],"affiliations":[{"raw_affiliation_string":"Fred Hutchinson Cancer Research Center, Seattle, WA","institution_ids":["https://openalex.org/I4210089486"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5023085024"],"corresponding_institution_ids":["https://openalex.org/I161318765"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.1315257,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":null,"issue":null,"first_page":"594","last_page":"601"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.996999979019165,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/immunogen","display_name":"Immunogen","score":0.847595751285553},{"id":"https://openalex.org/keywords/epitope","display_name":"Epitope","score":0.7240996956825256},{"id":"https://openalex.org/keywords/peripheral-blood-mononuclear-cell","display_name":"Peripheral blood mononuclear cell","score":0.7130387425422668},{"id":"https://openalex.org/keywords/peptide-vaccine","display_name":"Peptide vaccine","score":0.5619555711746216},{"id":"https://openalex.org/keywords/immunology","display_name":"Immunology","score":0.5430459976196289},{"id":"https://openalex.org/keywords/hiv-vaccine","display_name":"HIV vaccine","score":0.5257939696311951},{"id":"https://openalex.org/keywords/human-leukocyte-antigen","display_name":"Human leukocyte antigen","score":0.49471017718315125},{"id":"https://openalex.org/keywords/t-cell","display_name":"T cell","score":0.4180009663105011},{"id":"https://openalex.org/keywords/human-immunodeficiency-virus","display_name":"Human immunodeficiency virus (HIV)","score":0.36002153158187866},{"id":"https://openalex.org/keywords/antigen","display_name":"Antigen","score":0.3585028648376465},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3579404950141907},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.35253584384918213},{"id":"https://openalex.org/keywords/immune-system","display_name":"Immune system","score":0.3428667187690735},{"id":"https://openalex.org/keywords/vaccine-trial","display_name":"Vaccine trial","score":0.34284114837646484},{"id":"https://openalex.org/keywords/antibody","display_name":"Antibody","score":0.18919479846954346},{"id":"https://openalex.org/keywords/in-vitro","display_name":"In vitro","score":0.16089347004890442},{"id":"https://openalex.org/keywords/monoclonal-antibody","display_name":"Monoclonal antibody","score":0.0846855640411377}],"concepts":[{"id":"https://openalex.org/C2779909307","wikidata":"https://www.wikidata.org/wiki/Q1660181","display_name":"Immunogen","level":4,"score":0.847595751285553},{"id":"https://openalex.org/C195616568","wikidata":"https://www.wikidata.org/wiki/Q128711","display_name":"Epitope","level":3,"score":0.7240996956825256},{"id":"https://openalex.org/C137061746","wikidata":"https://www.wikidata.org/wiki/Q736033","display_name":"Peripheral blood mononuclear cell","level":3,"score":0.7130387425422668},{"id":"https://openalex.org/C2776789287","wikidata":"https://www.wikidata.org/wiki/Q7166532","display_name":"Peptide vaccine","level":4,"score":0.5619555711746216},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5430459976196289},{"id":"https://openalex.org/C2780195530","wikidata":"https://www.wikidata.org/wiki/Q1479804","display_name":"HIV vaccine","level":4,"score":0.5257939696311951},{"id":"https://openalex.org/C188280979","wikidata":"https://www.wikidata.org/wiki/Q911125","display_name":"Human leukocyte antigen","level":3,"score":0.49471017718315125},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.4180009663105011},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.36002153158187866},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.3585028648376465},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3579404950141907},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.35253584384918213},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.3428667187690735},{"id":"https://openalex.org/C2778190748","wikidata":"https://www.wikidata.org/wiki/Q7907956","display_name":"Vaccine trial","level":3,"score":0.34284114837646484},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.18919479846954346},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.16089347004890442},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.0846855640411377},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1145/2147805.2147907","is_oa":false,"landing_page_url":"https://doi.org/10.1145/2147805.2147907","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 2nd ACM Conference on Bioinformatics, Computational Biology and Biomedicine","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8100000023841858}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":38,"referenced_works":["https://openalex.org/W1549641435","https://openalex.org/W1929921649","https://openalex.org/W1966755343","https://openalex.org/W1967972465","https://openalex.org/W1980139884","https://openalex.org/W2009791743","https://openalex.org/W2012385803","https://openalex.org/W2019711015","https://openalex.org/W2020564539","https://openalex.org/W2041553413","https://openalex.org/W2043071727","https://openalex.org/W2046060933","https://openalex.org/W2048848017","https://openalex.org/W2053843590","https://openalex.org/W2056384440","https://openalex.org/W2067058184","https://openalex.org/W2067504188","https://openalex.org/W2073374251","https://openalex.org/W2076639605","https://openalex.org/W2077480262","https://openalex.org/W2081400647","https://openalex.org/W2082296437","https://openalex.org/W2083900229","https://openalex.org/W2094706980","https://openalex.org/W2099485004","https://openalex.org/W2110574412","https://openalex.org/W2110802771","https://openalex.org/W2111066113","https://openalex.org/W2124106036","https://openalex.org/W2125014261","https://openalex.org/W2125732073","https://openalex.org/W2136234423","https://openalex.org/W2146667458","https://openalex.org/W2157371332","https://openalex.org/W2162891851","https://openalex.org/W2168688111","https://openalex.org/W2439454780","https://openalex.org/W2917847056"],"related_works":["https://openalex.org/W2804815996","https://openalex.org/W2755142048","https://openalex.org/W2754478331","https://openalex.org/W2071327612","https://openalex.org/W2966479367","https://openalex.org/W2330692954","https://openalex.org/W2944090095","https://openalex.org/W3142450751","https://openalex.org/W1679190250","https://openalex.org/W2313041244"],"abstract_inverted_index":{"Current":[0,46],"HIV":[1],"vaccines":[2],"are":[3,21,41,53,78,117,129],"designed":[4],"to":[5,35,114],"elicit":[6],"both":[7],"T-cell":[8,17,25,51],"and":[9,30,68,128,137],"B-cell":[10],"responses.":[11],"A":[12],"common":[13],"endpoint":[14],"in":[15,56,84,111],"any":[16],"based":[18],"vaccine":[19],"trial":[20],"measurements":[22],"of":[23,72,93,99,135],"vaccine-induced":[24],"responses":[26,52,113],"such":[27,37,75],"as":[28,76,91],"breadth":[29],"magnitude":[31],"[7].":[32],"In":[33],"order":[34,98],"measure":[36],"endpoints":[38],"blood":[39,59],"samples":[40],"collected":[42],"at":[43],"multiple":[44],"timepoints.":[45],"immunological":[47],"assays":[48,55],"for":[49],"measuring":[50],"functional":[54],"which":[57,112],"peripheral":[58],"mononuclear":[60],"cells":[61],"(PBMC)":[62],"is":[63,88],"incubated":[64],"with":[65],"target":[66],"peptide(s)":[67],"then":[69,130],"the":[70,115],"release":[71],"various":[73],"cytokines":[74],"IFN-\u03b3":[77],"measured.":[79],"The":[80],"major":[81],"limiting":[82],"factor":[83],"these":[85,94],"mappping":[86],"studies":[87],"sample":[89],"availability,":[90],"each":[92],"tests":[95],"requires":[96],"an":[97],"100K":[100],"live":[101],"cells.":[102],"Therefore":[103],"current":[104],"mapping":[105],"strategies":[106],"use":[107],"a":[108,125,139],"group-testing":[109],"approach":[110],"immunogen":[116],"first":[118],"measured":[119],"using":[120,133],"peptide":[121,140],"pools":[122],"that":[123],"span":[124],"full":[126],"protein,":[127],"further":[131],"refined":[132],"sets":[134],"mini-pool":[136],"finally":[138],"matrix":[141],"[23].":[142]},"counts_by_year":[{"year":2019,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}