{"id":"https://openalex.org/W2015948115","doi":"https://doi.org/10.1145/2147805.2147890","title":"A molecular systems analysis of HOX PPI networks in hematopoiesis and leukemogenesis","display_name":"A molecular systems analysis of HOX PPI networks in hematopoiesis and leukemogenesis","publication_year":2011,"publication_date":"2011-08-01","ids":{"openalex":"https://openalex.org/W2015948115","doi":"https://doi.org/10.1145/2147805.2147890","mag":"2015948115"},"language":"en","primary_location":{"id":"doi:10.1145/2147805.2147890","is_oa":false,"landing_page_url":"https://doi.org/10.1145/2147805.2147890","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 2nd ACM Conference on Bioinformatics, Computational Biology and Biomedicine","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000329045","display_name":"Maragaille R. Capiroso","orcid":null},"institutions":[{"id":"https://openalex.org/I5791819","display_name":"University of the Philippines Manila","ror":"https://ror.org/01rrczv41","country_code":"PH","type":"education","lineage":["https://openalex.org/I103911934","https://openalex.org/I5791819"]}],"countries":["PH"],"is_corresponding":true,"raw_author_name":"Maragaille R. Capiroso","raw_affiliation_strings":["University of the Philippines, Manila, Philippines"],"affiliations":[{"raw_affiliation_string":"University of the Philippines, Manila, Philippines","institution_ids":["https://openalex.org/I5791819"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046491778","display_name":"Marla A. Endriga","orcid":"https://orcid.org/0000-0002-5594-6480"},"institutions":[{"id":"https://openalex.org/I5791819","display_name":"University of the Philippines Manila","ror":"https://ror.org/01rrczv41","country_code":"PH","type":"education","lineage":["https://openalex.org/I103911934","https://openalex.org/I5791819"]}],"countries":["PH"],"is_corresponding":false,"raw_author_name":"Marla A. Endriga","raw_affiliation_strings":["University of the Philippines, Manila, Philippines"],"affiliations":[{"raw_affiliation_string":"University of the Philippines, Manila, Philippines","institution_ids":["https://openalex.org/I5791819"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078855605","display_name":"Valerie Diane Valeriano","orcid":"https://orcid.org/0000-0002-4396-346X"},"institutions":[{"id":"https://openalex.org/I5791819","display_name":"University of the Philippines Manila","ror":"https://ror.org/01rrczv41","country_code":"PH","type":"education","lineage":["https://openalex.org/I103911934","https://openalex.org/I5791819"]}],"countries":["PH"],"is_corresponding":false,"raw_author_name":"Valerie Diane V. Valeriano","raw_affiliation_strings":["University of the Philippines, Manila, Philippines"],"affiliations":[{"raw_affiliation_string":"University of the Philippines, Manila, Philippines","institution_ids":["https://openalex.org/I5791819"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5070969494","display_name":"Custer C. Deocaris","orcid":"https://orcid.org/0000-0003-3530-1228"},"institutions":[{"id":"https://openalex.org/I87074743","display_name":"University of the Philippines Diliman","ror":"https://ror.org/03tbh6y23","country_code":"PH","type":"education","lineage":["https://openalex.org/I103911934","https://openalex.org/I87074743"]}],"countries":["PH"],"is_corresponding":false,"raw_author_name":"Custer C. Deocaris","raw_affiliation_strings":["University of the Philippines, Diliman, Philippines"],"affiliations":[{"raw_affiliation_string":"University of the Philippines, Diliman, Philippines","institution_ids":["https://openalex.org/I87074743"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5000329045"],"corresponding_institution_ids":["https://openalex.org/I5791819"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.07805906,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"273","issue":null,"first_page":"525","last_page":"527"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.995199978351593,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.995199978351593,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.9764999747276306,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9746000170707703,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hox-gene","display_name":"Hox gene","score":0.9126031398773193},{"id":"https://openalex.org/keywords/haematopoiesis","display_name":"Haematopoiesis","score":0.6329557299613953},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5419638156890869},{"id":"https://openalex.org/keywords/phenotype","display_name":"Phenotype","score":0.5261784791946411},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.49706152081489563},{"id":"https://openalex.org/keywords/fusion-protein","display_name":"Fusion protein","score":0.4500735402107239},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.4235613942146301},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.32728058099746704},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.295738160610199},{"id":"https://openalex.org/keywords/transcription-factor","display_name":"Transcription factor","score":0.2443585991859436},{"id":"https://openalex.org/keywords/stem-cell","display_name":"Stem cell","score":0.17125722765922546}],"concepts":[{"id":"https://openalex.org/C111039654","wikidata":"https://www.wikidata.org/wiki/Q253149","display_name":"Hox gene","level":4,"score":0.9126031398773193},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.6329557299613953},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5419638156890869},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.5261784791946411},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.49706152081489563},{"id":"https://openalex.org/C123894998","wikidata":"https://www.wikidata.org/wiki/Q425158","display_name":"Fusion protein","level":4,"score":0.4500735402107239},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4235613942146301},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.32728058099746704},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.295738160610199},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.2443585991859436},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.17125722765922546},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1145/2147805.2147890","is_oa":false,"landing_page_url":"https://doi.org/10.1145/2147805.2147890","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 2nd ACM Conference on Bioinformatics, Computational Biology and Biomedicine","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.6399999856948853}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W193161790","https://openalex.org/W1522139704","https://openalex.org/W1964743451","https://openalex.org/W1965510999","https://openalex.org/W1972237730","https://openalex.org/W1973323553","https://openalex.org/W1984384005","https://openalex.org/W1991419585","https://openalex.org/W1995703120","https://openalex.org/W2003173822","https://openalex.org/W2023785759","https://openalex.org/W2027216468","https://openalex.org/W2028425461","https://openalex.org/W2043059629","https://openalex.org/W2077530603","https://openalex.org/W2093769888","https://openalex.org/W2125067529","https://openalex.org/W2136850043","https://openalex.org/W2149111956","https://openalex.org/W2171030481","https://openalex.org/W2323491695"],"related_works":["https://openalex.org/W2624356479","https://openalex.org/W2101306722","https://openalex.org/W4401780492","https://openalex.org/W3146170303","https://openalex.org/W2131918846","https://openalex.org/W1558557497","https://openalex.org/W1972522546","https://openalex.org/W2285867737","https://openalex.org/W1560744534","https://openalex.org/W2084756959"],"abstract_inverted_index":{"Hox":[0,28,61],"proteins":[1,26,29,88,108],"are":[2,105],"important":[3],"regulators":[4],"in":[5,14,35,55,67,95],"hematopoiesis":[6,36],"and":[7,42,59,89,103,112],"their":[8],"dysregulation":[9],"by":[10,72],"other":[11,24,64],"factors":[12],"results":[13],"different":[15],"phenotypes":[16],"during":[17],"leukemia.":[18],"To":[19],"determine":[20],"the":[21,79,84,91],"interaction":[22,51],"of":[23,86,90],"developmental":[25],"with":[27],"implicated":[30],"to":[31,47],"have":[32],"specific":[33,73],"roles":[34],"(HOXA7,":[37],"HOXA9,":[38],"HOXA10,":[39],"HOXB3,":[40],"HOXB4":[41],"HOXC8),":[43],"Cytoscape":[44],"was":[45],"used":[46],"create":[48],"a":[49],"protein-protein":[50],"network":[52],"utilizing":[53],"information":[54],"publicly":[56],"available":[57],"databases":[58],"literature.":[60],"genes":[62,65],"regulate":[63],"but":[66],"turn":[68],"can":[69],"be":[70],"dysregulated":[71],"fusion":[74],"protein":[75],"partners.":[76],"HOXB3":[77],"provides":[78],"most":[80],"significant":[81],"complexes,":[82],"indicating":[83],"importance":[85],"TALE":[87],"MLL":[92],"PHD":[93],"finger":[94],"hematopoietic":[96],"regulation.":[97],"The":[98],"ID3":[99],"complex,":[100],"NUP98,":[101],"MLL,":[102],"Notch1":[104],"also":[106],"key":[107],"for":[109],"leukemia":[110],"prevention":[111],"treatment.":[113]},"counts_by_year":[],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}
