{"id":"https://openalex.org/W2026264169","doi":"https://doi.org/10.1145/2147805.2147857","title":"Changes in gene expression near evolutionary breakpoints","display_name":"Changes in gene expression near evolutionary breakpoints","publication_year":2011,"publication_date":"2011-08-01","ids":{"openalex":"https://openalex.org/W2026264169","doi":"https://doi.org/10.1145/2147805.2147857","mag":"2026264169"},"language":"en","primary_location":{"id":"doi:10.1145/2147805.2147857","is_oa":false,"landing_page_url":"https://doi.org/10.1145/2147805.2147857","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 2nd ACM Conference on Bioinformatics, Computational Biology and Biomedicine","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040413626","display_name":"Adriana Mu\u00f1oz","orcid":null},"institutions":[{"id":"https://openalex.org/I153718931","display_name":"University of Ottawa","ror":"https://ror.org/03c4mmv16","country_code":"CA","type":"education","lineage":["https://openalex.org/I153718931"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Adriana Mu\u00f1oz","raw_affiliation_strings":["University of Ottawa, Ottawa, Canada"],"affiliations":[{"raw_affiliation_string":"University of Ottawa, Ottawa, Canada","institution_ids":["https://openalex.org/I153718931"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5089707881","display_name":"David Sankoff","orcid":"https://orcid.org/0000-0001-8415-5189"},"institutions":[{"id":"https://openalex.org/I153718931","display_name":"University of Ottawa","ror":"https://ror.org/03c4mmv16","country_code":"CA","type":"education","lineage":["https://openalex.org/I153718931"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"David Sankoff","raw_affiliation_strings":["University of Ottawa, Ottawa, Canada"],"affiliations":[{"raw_affiliation_string":"University of Ottawa, Ottawa, Canada","institution_ids":["https://openalex.org/I153718931"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5040413626"],"corresponding_institution_ids":["https://openalex.org/I153718931"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.08978073,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"393","last_page":"398"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9987000226974487,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9987000226974487,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11213","display_name":"Genomic variations and chromosomal abnormalities","score":0.9987000226974487,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13664","display_name":"Genome Rearrangement Algorithms","score":0.9980999827384949,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/breakpoint","display_name":"Breakpoint","score":0.9413868188858032},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.6742540597915649},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.6475808024406433},{"id":"https://openalex.org/keywords/genome","display_name":"Genome","score":0.6328879594802856},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.5797320008277893},{"id":"https://openalex.org/keywords/gene-duplication","display_name":"Gene duplication","score":0.47104811668395996},{"id":"https://openalex.org/keywords/chromosome","display_name":"Chromosome","score":0.39970433712005615}],"concepts":[{"id":"https://openalex.org/C206936463","wikidata":"https://www.wikidata.org/wiki/Q634179","display_name":"Breakpoint","level":4,"score":0.9413868188858032},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6742540597915649},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.6475808024406433},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.6328879594802856},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5797320008277893},{"id":"https://openalex.org/C7602840","wikidata":"https://www.wikidata.org/wiki/Q746284","display_name":"Gene duplication","level":3,"score":0.47104811668395996},{"id":"https://openalex.org/C30481170","wikidata":"https://www.wikidata.org/wiki/Q37748","display_name":"Chromosome","level":3,"score":0.39970433712005615}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1145/2147805.2147857","is_oa":false,"landing_page_url":"https://doi.org/10.1145/2147805.2147857","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 2nd ACM Conference on Bioinformatics, Computational Biology and Biomedicine","raw_type":"proceedings-article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.667.9417","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.667.9417","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://recombcg.uottawa.ca/Papers/RefConference/2011_Munoz_Sankoff.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W36405680","https://openalex.org/W1969131231","https://openalex.org/W1973352264","https://openalex.org/W1976722506","https://openalex.org/W1996962402","https://openalex.org/W2027660956","https://openalex.org/W2029747645","https://openalex.org/W2051896853","https://openalex.org/W2073028958","https://openalex.org/W2085275533","https://openalex.org/W2095893411","https://openalex.org/W2096254048","https://openalex.org/W2099821697","https://openalex.org/W2105510846","https://openalex.org/W2115879886","https://openalex.org/W2120965285","https://openalex.org/W2137780942","https://openalex.org/W2146158248","https://openalex.org/W2161080683","https://openalex.org/W2163809592","https://openalex.org/W2168783124","https://openalex.org/W4230565756","https://openalex.org/W4362221370"],"related_works":["https://openalex.org/W1554401503","https://openalex.org/W2093773491","https://openalex.org/W2161263170","https://openalex.org/W2304205445","https://openalex.org/W2050456981","https://openalex.org/W1912284124","https://openalex.org/W2039614575","https://openalex.org/W3025364102","https://openalex.org/W2987420353","https://openalex.org/W3127109662"],"abstract_inverted_index":{"We":[0,88,119,141],"study":[1,120],"the":[2,18,26,29,57,76,83,93,98,108,111,115,148,153,167,170,176,182,196,202],"relation":[3],"between":[4],"genome":[5],"rearrangements,":[6],"breakpoints":[7,21,34,46],"and":[8,22,38,132],"gene":[9,117,171],"expression.":[10],"Genome":[11],"rearrangement":[12],"research":[13],"has":[14],"been":[15,193],"concerned":[16],"with":[17,107],"creation":[19,62],"of":[20,32,45,50,55,60,78,85,95,101,110,150,156,169,189,205],"their":[23,67],"position":[24],"in":[25,122,128,133,137,143,195],"chromosome,":[27],"but":[28],"functional":[30],"consequences":[31,59],"individual":[33],"remain":[35],"virtually":[36],"unknown,":[37],"there":[39],"are":[40,104],"no":[41],"direct":[42],"genome-wide":[43],"studies":[44],"from":[47,162,207],"this":[48,90,121,163],"point":[49],"view.":[51],"A":[52],"question":[53,71],"arises":[54],"what":[56],"biological":[58],"breakpoint":[61,80,100,155],"are,":[63],"rather":[64],"than":[65],"just":[66],"structural":[68],"aspects.":[69],"The":[70],"is":[72],"whether":[73],"proximity":[74],"to":[75,97,152,181,201],"site":[77],"a":[79,86],"event":[81],"changes":[82],"activity":[84],"gene.":[87],"investigate":[89],"by":[91],"comparing":[92],"distribution":[94,109,149],"distances":[96,113,151],"nearest":[99,154],"genes":[102,179],"that":[103,147,187],"differentially":[105],"expressed":[106],"same":[112],"for":[114,166],"entire":[116],"complement.":[118,172],"data":[123,145],"on":[124,175],"whole":[125],"blood":[126],"tissue":[127,136],"human":[129,138],"versus":[130,139],"macaque,":[131],"cerebral":[134],"cortex":[135],"chimpanzee.":[140],"find":[142],"both":[144],"sets":[146],"\"changed":[157],"expression":[158,178],"genes\"":[159],"differs":[160],"little":[161],"distance":[164],"calculated":[165],"rest":[168],"In":[173],"focusing":[174],"changed":[177],"closest":[180],"breakpoints,":[183],"however,":[184],"we":[185],"discover":[186],"several":[188],"these":[190],"have":[191],"previously":[192],"implicated":[194],"literature":[197],"as":[198],"being":[199],"connected":[200],"evolutionary":[203],"divergence":[204],"humans":[206],"other":[208],"primates.":[209]},"counts_by_year":[],"updated_date":"2026-04-05T17:49:38.594831","created_date":"2025-10-10T00:00:00"}
