{"id":"https://openalex.org/W2076574677","doi":"https://doi.org/10.1145/2001576.2001618","title":"The power of quantitative grammatical evolution neural networks to detect gene-gene interactions","display_name":"The power of quantitative grammatical evolution neural networks to detect gene-gene interactions","publication_year":2011,"publication_date":"2011-07-12","ids":{"openalex":"https://openalex.org/W2076574677","doi":"https://doi.org/10.1145/2001576.2001618","mag":"2076574677"},"language":"en","primary_location":{"id":"doi:10.1145/2001576.2001618","is_oa":false,"landing_page_url":"https://doi.org/10.1145/2001576.2001618","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 13th annual conference on Genetic and evolutionary computation","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067859954","display_name":"Nicholas E. Hardison","orcid":null},"institutions":[{"id":"https://openalex.org/I137902535","display_name":"North Carolina State University","ror":"https://ror.org/04tj63d06","country_code":"US","type":"education","lineage":["https://openalex.org/I137902535"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nicholas E. Hardison","raw_affiliation_strings":["North Carolina State University, Raleigh, NC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"North Carolina State University, Raleigh, NC, USA","institution_ids":["https://openalex.org/I137902535"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5055785853","display_name":"Alison A. Motsinger\u2010Reif","orcid":"https://orcid.org/0000-0003-1346-2493"},"institutions":[{"id":"https://openalex.org/I137902535","display_name":"North Carolina State University","ror":"https://ror.org/04tj63d06","country_code":"US","type":"education","lineage":["https://openalex.org/I137902535"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alison A. Motsinger-Reif","raw_affiliation_strings":["North Carolina State University, Raleigh, NC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"North Carolina State University, Raleigh, NC, USA","institution_ids":["https://openalex.org/I137902535"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I137902535"],"apc_list":null,"apc_paid":null,"fwci":1.93,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.88287753,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":null,"issue":null,"first_page":"299","last_page":"306"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10594","display_name":"Genetic and phenotypic traits in livestock","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10594","display_name":"Genetic and phenotypic traits in livestock","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11468","display_name":"Genetic Mapping and Diversity in Plants and Animals","score":0.996399998664856,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.993399977684021,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/grammatical-evolution","display_name":"Grammatical evolution","score":0.7729791402816772},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.626239538192749},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5347928404808044},{"id":"https://openalex.org/keywords/artificial-neural-network","display_name":"Artificial neural network","score":0.5148864984512329},{"id":"https://openalex.org/keywords/power","display_name":"Power (physics)","score":0.4770638048648834},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.42535415291786194},{"id":"https://openalex.org/keywords/evolutionary-biology","display_name":"Evolutionary biology","score":0.39324644207954407},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.39253944158554077},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.35385048389434814},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.33115649223327637},{"id":"https://openalex.org/keywords/genetic-programming","display_name":"Genetic programming","score":0.11915472149848938},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.10616850852966309}],"concepts":[{"id":"https://openalex.org/C10906938","wikidata":"https://www.wikidata.org/wiki/Q5593687","display_name":"Grammatical evolution","level":3,"score":0.7729791402816772},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.626239538192749},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5347928404808044},{"id":"https://openalex.org/C50644808","wikidata":"https://www.wikidata.org/wiki/Q192776","display_name":"Artificial neural network","level":2,"score":0.5148864984512329},{"id":"https://openalex.org/C163258240","wikidata":"https://www.wikidata.org/wiki/Q25342","display_name":"Power (physics)","level":2,"score":0.4770638048648834},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.42535415291786194},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.39324644207954407},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.39253944158554077},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.35385048389434814},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.33115649223327637},{"id":"https://openalex.org/C110332635","wikidata":"https://www.wikidata.org/wiki/Q629498","display_name":"Genetic programming","level":2,"score":0.11915472149848938},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.10616850852966309},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1145/2001576.2001618","is_oa":false,"landing_page_url":"https://doi.org/10.1145/2001576.2001618","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 13th annual conference on Genetic and evolutionary computation","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.800000011920929,"display_name":"Good health and well-being"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320337361","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W1503370304","https://openalex.org/W1560801430","https://openalex.org/W1565095998","https://openalex.org/W1588537248","https://openalex.org/W1802825888","https://openalex.org/W1966315117","https://openalex.org/W1966360257","https://openalex.org/W1969196411","https://openalex.org/W2019024533","https://openalex.org/W2028393082","https://openalex.org/W2033383209","https://openalex.org/W2055913343","https://openalex.org/W2072685350","https://openalex.org/W2102150960","https://openalex.org/W2111762864","https://openalex.org/W2123491203","https://openalex.org/W2124509331","https://openalex.org/W2125858955","https://openalex.org/W2134579531","https://openalex.org/W2137669384","https://openalex.org/W2150531171","https://openalex.org/W2167638767","https://openalex.org/W2168175751","https://openalex.org/W2296218809","https://openalex.org/W2489292218","https://openalex.org/W3104824402","https://openalex.org/W4235721129"],"related_works":["https://openalex.org/W2002128513","https://openalex.org/W2092874662","https://openalex.org/W1828691184","https://openalex.org/W2171277769","https://openalex.org/W2120393042","https://openalex.org/W1991523530","https://openalex.org/W1903732681","https://openalex.org/W2020824267","https://openalex.org/W2057739827","https://openalex.org/W2075354549"],"abstract_inverted_index":{"Applying":[0],"grammatical":[1],"evolution":[2],"to":[3,15,35,53,69,73,91,108,124],"evolve":[4],"neural":[5],"networks":[6],"(GENN)":[7],"has":[8,49,104],"been":[9,33,51],"increasing":[10],"used":[11],"in":[12,25,39],"genetic":[13,78],"epidemiology":[14],"detect":[16,109],"gene-gene":[17],"or":[18],"gene-environment":[19],"interactions,":[20],"also":[21],"known":[22],"as":[23,113,115],"epistasis,":[24],"high":[26,106],"dimensional":[27],"data.":[28],"GENN":[29,68],"approaches":[30],"have":[31],"previously":[32],"shown":[34],"be":[36],"highly":[37],"successful":[38],"a":[40,74],"range":[41,75],"of":[42,64,67,76,84],"simulated":[43,77],"and":[44,48,87,121],"real":[45],"case-control":[46],"studies,":[47],"recently":[50],"applied":[52],"quantitative":[54,70],"traits.":[55],"In":[56],"the":[57,62,82,85,101,125],"current":[58],"study,":[59],"we":[60],"evaluate":[61],"potential":[63],"an":[65],"application":[66],"traits":[71],"(QTGENN)":[72],"models.":[79],"We":[80,98],"demonstrate":[81],"power":[83,90,107],"approach,":[86],"compare":[88],"this":[89],"more":[92],"traditional":[93],"linear":[94],"regression":[95,126],"analysis":[96],"approaches.":[97],"find":[99],"that":[100],"QTGENN":[102],"approach":[103],"relatively":[105],"both":[110],"single-locus":[111],"models":[112],"well":[114],"several":[116],"completely":[117],"epistatic":[118],"two-locus":[119],"models,":[120],"favorably":[122],"compares":[123],"methods.":[127]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2013,"cited_by_count":1}],"updated_date":"2026-07-29T14:22:42.915294","created_date":"2025-10-10T00:00:00"}
