{"id":"https://openalex.org/W1986801820","doi":"https://doi.org/10.1145/1854776.1854901","title":"Structural landscape of immunoglobulin lambda light chains","display_name":"Structural landscape of immunoglobulin lambda light chains","publication_year":2010,"publication_date":"2010-08-02","ids":{"openalex":"https://openalex.org/W1986801820","doi":"https://doi.org/10.1145/1854776.1854901","mag":"1986801820"},"language":"en","primary_location":{"id":"doi:10.1145/1854776.1854901","is_oa":false,"landing_page_url":"https://doi.org/10.1145/1854776.1854901","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the First ACM International Conference on Bioinformatics and Computational Biology","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044974282","display_name":"Anna Chailyan","orcid":"https://orcid.org/0000-0002-1661-3288"},"institutions":[{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Anna Chailyan","raw_affiliation_strings":["Sapienza University of Rome","Sapienza, university of Rome"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sapienza University of Rome","institution_ids":["https://openalex.org/I861853513"]},{"raw_affiliation_string":"Sapienza, university of Rome","institution_ids":["https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044037386","display_name":"Davide Cirillo","orcid":"https://orcid.org/0000-0003-4982-4716"},"institutions":[{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Davide Cirillo","raw_affiliation_strings":["Sapienza University of Rome","Sapienza, university of Rome"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sapienza University of Rome","institution_ids":["https://openalex.org/I861853513"]},{"raw_affiliation_string":"Sapienza, university of Rome","institution_ids":["https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043947069","display_name":"Paolo Marcatili","orcid":"https://orcid.org/0000-0003-2615-5695"},"institutions":[{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Paolo Marcatili","raw_affiliation_strings":["Sapienza University of Rome","Sapienza, university of Rome"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sapienza University of Rome","institution_ids":["https://openalex.org/I861853513"]},{"raw_affiliation_string":"Sapienza, university of Rome","institution_ids":["https://openalex.org/I861853513"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112661316","display_name":"Anna Tramontano","orcid":null},"institutions":[{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Anna Tramontano","raw_affiliation_strings":["Sapienza University of Rome","Sapienza, university of Rome"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sapienza University of Rome","institution_ids":["https://openalex.org/I861853513"]},{"raw_affiliation_string":"Sapienza, university of Rome","institution_ids":["https://openalex.org/I861853513"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I861853513"],"apc_list":null,"apc_paid":null,"fwci":0.9236,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.74538799,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"651","last_page":"652"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10602","display_name":"Glycosylation and Glycoproteins Research","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10602","display_name":"Glycosylation and Glycoproteins Research","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13326","display_name":"Biochemical and Structural Characterization","score":0.9965000152587891,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/immunoglobulin-light-chain","display_name":"Immunoglobulin light chain","score":0.7902365922927856},{"id":"https://openalex.org/keywords/lambda","display_name":"Lambda","score":0.7791082262992859},{"id":"https://openalex.org/keywords/isotype","display_name":"Isotype","score":0.6739234924316406},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5838332772254944},{"id":"https://openalex.org/keywords/cluster-analysis","display_name":"Cluster analysis","score":0.5657214522361755},{"id":"https://openalex.org/keywords/antibody","display_name":"Antibody","score":0.5588036179542542},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.49442195892333984},{"id":"https://openalex.org/keywords/sequence","display_name":"Sequence (biology)","score":0.4929502010345459},{"id":"https://openalex.org/keywords/set","display_name":"Set (abstract data type)","score":0.45997902750968933},{"id":"https://openalex.org/keywords/immune-system","display_name":"Immune system","score":0.4486536681652069},{"id":"https://openalex.org/keywords/sequence-motif","display_name":"Sequence motif","score":0.42404186725616455},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3360480070114136},{"id":"https://openalex.org/keywords/evolutionary-biology","display_name":"Evolutionary biology","score":0.3296512961387634},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.2567138671875},{"id":"https://openalex.org/keywords/immunology","display_name":"Immunology","score":0.24482080340385437},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.23608458042144775},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.15063804388046265},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.12740060687065125},{"id":"https://openalex.org/keywords/programming-language","display_name":"Programming language","score":0.0874553918838501}],"concepts":[{"id":"https://openalex.org/C36394416","wikidata":"https://www.wikidata.org/wiki/Q949267","display_name":"Immunoglobulin light chain","level":3,"score":0.7902365922927856},{"id":"https://openalex.org/C2778113609","wikidata":"https://www.wikidata.org/wiki/Q10897","display_name":"Lambda","level":2,"score":0.7791082262992859},{"id":"https://openalex.org/C2777991845","wikidata":"https://www.wikidata.org/wiki/Q2396793","display_name":"Isotype","level":4,"score":0.6739234924316406},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5838332772254944},{"id":"https://openalex.org/C73555534","wikidata":"https://www.wikidata.org/wiki/Q622825","display_name":"Cluster analysis","level":2,"score":0.5657214522361755},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.5588036179542542},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.49442195892333984},{"id":"https://openalex.org/C2778112365","wikidata":"https://www.wikidata.org/wiki/Q3511065","display_name":"Sequence (biology)","level":2,"score":0.4929502010345459},{"id":"https://openalex.org/C177264268","wikidata":"https://www.wikidata.org/wiki/Q1514741","display_name":"Set (abstract data type)","level":2,"score":0.45997902750968933},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4486536681652069},{"id":"https://openalex.org/C117745874","wikidata":"https://www.wikidata.org/wiki/Q901612","display_name":"Sequence motif","level":3,"score":0.42404186725616455},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3360480070114136},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.3296512961387634},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.2567138671875},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.24482080340385437},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.23608458042144775},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.15063804388046265},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.12740060687065125},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0874553918838501},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1145/1854776.1854901","is_oa":false,"landing_page_url":"https://doi.org/10.1145/1854776.1854901","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the First ACM International Conference on Bioinformatics and Computational Biology","raw_type":"proceedings-article"},{"id":"pmh:oai:iris.uniroma1.it:11573/997835","is_oa":false,"landing_page_url":"http://hdl.handle.net/11573/997835","pdf_url":null,"source":{"id":"https://openalex.org/S4377196107","display_name":"IRIS Research product catalog (Sapienza University of Rome)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.7300000190734863,"id":"https://metadata.un.org/sdg/15","display_name":"Life in Land"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":4,"referenced_works":["https://openalex.org/W1982679430","https://openalex.org/W1986801820","https://openalex.org/W2143467722","https://openalex.org/W2162561057"],"related_works":["https://openalex.org/W73431230","https://openalex.org/W2053595623","https://openalex.org/W2385969805","https://openalex.org/W2140892108","https://openalex.org/W2402872663","https://openalex.org/W2419301406","https://openalex.org/W2325138686","https://openalex.org/W1973358897","https://openalex.org/W4225337096","https://openalex.org/W2080955824"],"abstract_inverted_index":{"The":[0,60],"immunoglobulin":[1],"lambda":[2,77],"isotype":[3],"family":[4],"is":[5,65],"present":[6],"in":[7,16],"nearly":[8],"all":[9],"vertebrates":[10],"and":[11,42,89,97],"plays":[12],"a":[13,45],"primary":[14],"role":[15],"the":[17,38,52,71],"human":[18],"immune":[19],"system.":[20],"Despite":[21],"its":[22,55],"importance,":[23],"few":[24],"if":[25],"any":[26],"systematic":[27],"studies":[28],"have":[29],"been":[30,37],"performed":[31],"to":[32,66],"identify,":[33],"as":[34],"it":[35],"has":[36],"case":[39],"for":[40],"kappa":[41],"heavy":[43],"chains,":[44],"set":[46],"of":[47,62,74,81,85],"structural":[48],"conformations":[49],"adopted":[50],"by":[51,79],"loops":[53],"forming":[54],"Antigen":[56],"Binding":[57],"Site":[58],"(ABSs).":[59],"aim":[61],"this":[63],"work":[64],"perform":[67],"such":[68],"analysis":[69],"on":[70],"vast":[72],"majority":[73],"known":[75],"antibody":[76],"chains":[78],"means":[80],"an":[82],"integrative":[83],"approach":[84],"bioinformatics":[86],"(structural":[87],"superpositions":[88],"sequence":[90],"alignments),":[91],"machine":[92],"learning":[93],"(clustering,":[94],"random":[95],"forest)":[96],"statistical":[98],"techniques.":[99]},"counts_by_year":[],"updated_date":"2026-07-29T14:22:42.915294","created_date":"2025-10-10T00:00:00"}