{"id":"https://openalex.org/W2039776767","doi":"https://doi.org/10.1145/1854776.1854898","title":"Application of systems biology for understanding of disease and selection of molecular targets for therapy","display_name":"Application of systems biology for understanding of disease and selection of molecular targets for therapy","publication_year":2010,"publication_date":"2010-08-02","ids":{"openalex":"https://openalex.org/W2039776767","doi":"https://doi.org/10.1145/1854776.1854898","mag":"2039776767"},"language":"en","primary_location":{"id":"doi:10.1145/1854776.1854898","is_oa":false,"landing_page_url":"https://doi.org/10.1145/1854776.1854898","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the First ACM International Conference on Bioinformatics and Computational Biology","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5051084819","display_name":"Andreas Heinzel","orcid":"https://orcid.org/0000-0002-8447-1795"},"institutions":[{"id":"https://openalex.org/I4210136249","display_name":"University of Applied Sciences Upper Austria","ror":"https://ror.org/03jqp6d56","country_code":"AT","type":"education","lineage":["https://openalex.org/I4210136249"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Andreas Heinzel","raw_affiliation_strings":["Upper Austria University of Applied Sciences, Hagenberg, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Upper Austria University of Applied Sciences, Hagenberg, Austria","institution_ids":["https://openalex.org/I4210136249"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077719225","display_name":"Johannes S\u00f6llner","orcid":null},"institutions":[{"id":"https://openalex.org/I4210145989","display_name":"EmergenTec (Austria)","ror":"https://ror.org/04f8y1a51","country_code":"AT","type":"company","lineage":["https://openalex.org/I4210145989"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Johannes S\u00f6llner","raw_affiliation_strings":["emergentec biodevelopment GmbH, Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"emergentec biodevelopment GmbH, Vienna, Austria","institution_ids":["https://openalex.org/I4210145989"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001308864","display_name":"Suszan Szathmary","orcid":null},"institutions":[{"id":"https://openalex.org/I68214267","display_name":"Regional Environmental Center for Central and Eastern Europe","ror":"https://ror.org/05b45bk66","country_code":"HU","type":"other","lineage":["https://openalex.org/I68214267"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"Suszan Szathmary","raw_affiliation_strings":["RT-Europe Research Center, Hungary"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"RT-Europe Research Center, Hungary","institution_ids":["https://openalex.org/I68214267"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.15420928,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"647","last_page":"647"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10981","display_name":"Cytomegalovirus and herpesvirus research","score":0.9890000224113464,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10981","display_name":"Cytomegalovirus and herpesvirus research","score":0.9890000224113464,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9800000190734863,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":0.9733999967575073,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/context","display_name":"Context (archaeology)","score":0.6664933562278748},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.6561792492866516},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.6022194623947144},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.5478687882423401},{"id":"https://openalex.org/keywords/drug-discovery","display_name":"Drug discovery","score":0.4738379418849945},{"id":"https://openalex.org/keywords/systems-biology","display_name":"Systems biology","score":0.4401888847351074},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.353732705116272},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.3495652675628662},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.13579925894737244}],"concepts":[{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.6664933562278748},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6561792492866516},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6022194623947144},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5478687882423401},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.4738379418849945},{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.4401888847351074},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.353732705116272},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3495652675628662},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.13579925894737244},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1145/1854776.1854898","is_oa":false,"landing_page_url":"https://doi.org/10.1145/1854776.1854898","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the First ACM International Conference on Bioinformatics and Computational Biology","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.7400000095367432}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2013003323","https://openalex.org/W1981076832","https://openalex.org/W2024773645","https://openalex.org/W5284979","https://openalex.org/W2001717001","https://openalex.org/W2043147644","https://openalex.org/W4245853730","https://openalex.org/W2111650087","https://openalex.org/W1143447605","https://openalex.org/W1995085194"],"abstract_inverted_index":{"The":[0],"Herpesviridae":[1],"are":[2,14,26,61],"a":[3,177,181,195,228,242],"large":[4],"family":[5,13],"of":[6,11,29,42,58,86,92,96,117,130,136,155,176,201,227,234,237,247,252,257,260,269,280,285,291],"DNA":[7],"viruses.":[8],"Several":[9],"members":[10],"this":[12,40,93,258],"known":[15],"to":[16,71,80,126,159,207,210,296],"cause":[17],"disease":[18,121],"in":[19,33,55,83,112,133,173,220,254,289],"animals":[20],"and":[21,36,53,67,99,191],"human.":[22],"In":[23],"particular":[24,274],"there":[25],"several":[27,49],"lines":[28],"evidence":[30],"for":[31,48,149,231,245,267,283],"involvement":[32],"human":[34,110,183,198],"cancer":[35],"autoimmune":[37],"conditions.":[38],"Although":[39],"group":[41],"viruses":[43],"has":[44],"been":[45],"investigated":[46],"intensively":[47],"decades":[50],"molecular":[51,87],"mechanisms":[52],"roles":[54],"the":[56,84,90,128,134,174,255,277],"development":[57,268],"associated":[59,163],"diseases":[60],"not":[62,294],"yet":[63],"fully":[64],"understood.":[65],"Bioinformatics":[66],"Systems":[68,229,281],"Biology":[69,282],"allow":[70],"incorporate":[72],"current":[73],"knowledge":[74],"with":[75,120,142],"high":[76,202],"throughput":[77],"Omics":[78],"data":[79,124,172],"analyze":[81,127],"them":[82],"context":[85,135,175],"networks.":[88,193],"Among":[89],"applications":[91],"development,":[94],"effects":[95],"pathogen":[97,131,235],"proteins":[98,132],"non-coding":[100],"RNAs":[101],"can":[102],"be":[103,251],"more":[104],"readily":[105],"understood":[106],"by":[107,215],"viewing":[108],"their":[109,113],"targets":[111,288],"functional-dependency":[114],"network.":[115],"Combination":[116],"generated":[118],"networks":[119,190],"specific":[122],"transcriptomics":[123],"allows":[125,145],"effect":[129],"medically":[137],"relevant":[138,197],"phenomena.":[139],"Additional":[140],"enrichment":[141],"drug-target":[143,187],"information":[144],"generating":[146],"new":[147],"hypotheses":[148],"drug":[150,153],"re-use":[151],"or":[152],"repositioning":[154],"currently":[156],"available":[157,169],"drugs":[158,248],"treat":[160],"herpes":[161],"virus":[162,171],"diseases.":[164],"Here":[165],"we":[166,272],"show":[167],"publicly":[168],"Epstein-Barr":[170],"meta-network":[178],"which":[179,249],"combines":[180],"proprietary":[182],"interaction":[184],"network":[185],"(omicsNET),":[186],"networks,":[188],"host-pathogen":[189],"orthology":[192],"EBV,":[194],"clinically":[196],"Lymphocryptovirus,":[199],"is":[200,262],"immunological":[203],"interest":[204,253],"also":[205],"due":[206],"its":[208],"potential":[209],"bias":[211],"natural":[212],"immune":[213],"responses":[214],"establishing":[216],"(life-long)":[217],"latent":[218],"infection":[219],"memory":[221],"B-cells.":[222],"We":[223],"thereby":[224],"exemplify":[225],"implications":[226],"view":[230],"better":[232],"understanding":[233],"mode":[236],"action.":[238],"Our":[239],"work":[240],"towards":[241],"methodological":[243],"basis":[244],"selection":[246,284],"could":[250],"treatment":[256],"class":[259],"pathogens":[261],"presented.":[263],"While":[264],"investigating":[265],"options":[266],"novel":[270],"therapies":[271],"place":[273],"focus":[275],"on":[276],"application":[278],"potentials":[279],"candidate":[286],"vaccine":[287],"light":[290],"chronic":[292],"infections":[293],"amenable":[295],"classical":[297],"vaccination":[298],"strategies.":[299]},"counts_by_year":[],"updated_date":"2026-07-29T14:22:42.915294","created_date":"2025-10-10T00:00:00"}
