{"id":"https://openalex.org/W2089489502","doi":"https://doi.org/10.1145/1854776.1854870","title":"Alzheimer's disease target selection","display_name":"Alzheimer's disease target selection","publication_year":2010,"publication_date":"2010-08-02","ids":{"openalex":"https://openalex.org/W2089489502","doi":"https://doi.org/10.1145/1854776.1854870","mag":"2089489502"},"language":"en","primary_location":{"id":"doi:10.1145/1854776.1854870","is_oa":false,"landing_page_url":"https://doi.org/10.1145/1854776.1854870","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the First ACM International Conference on Bioinformatics and Computational Biology","raw_type":"proceedings-article"},"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043817060","display_name":"Bradley W. Poland","orcid":null},"institutions":[{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bradley W. Poland","raw_affiliation_strings":["Pfizer Neuroscience, Groton CT","Pfizer Neuroscience, Groton CT#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pfizer Neuroscience, Groton CT","institution_ids":["https://openalex.org/I180857899"]},{"raw_affiliation_string":"Pfizer Neuroscience, Groton CT#TAB#","institution_ids":["https://openalex.org/I180857899"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033925691","display_name":"Panayiotis Zagouras","orcid":null},"institutions":[{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Panayiotis Zagouras","raw_affiliation_strings":["Pfizer Neuroscience, Groton CT","Pfizer Neuroscience, Groton CT#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pfizer Neuroscience, Groton CT","institution_ids":["https://openalex.org/I180857899"]},{"raw_affiliation_string":"Pfizer Neuroscience, Groton CT#TAB#","institution_ids":["https://openalex.org/I180857899"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036843116","display_name":"Snehal Naik","orcid":null},"institutions":[{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Snehal Naik","raw_affiliation_strings":["Pfizer Neuroscience, Groton CT","Pfizer Neuroscience, Groton CT#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pfizer Neuroscience, Groton CT","institution_ids":["https://openalex.org/I180857899"]},{"raw_affiliation_string":"Pfizer Neuroscience, Groton CT#TAB#","institution_ids":["https://openalex.org/I180857899"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090475181","display_name":"Eric B. Fauman","orcid":"https://orcid.org/0000-0002-9739-0249"},"institutions":[{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eric Fauman","raw_affiliation_strings":["Pfizer Computational Center of Excellence, Cambridge MA","Pfizer Computational Center of Excellence, Cambridge MA#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pfizer Computational Center of Excellence, Cambridge MA","institution_ids":["https://openalex.org/I180857899"]},{"raw_affiliation_string":"Pfizer Computational Center of Excellence, Cambridge MA#TAB#","institution_ids":["https://openalex.org/I180857899"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082893696","display_name":"K. Richter","orcid":"https://orcid.org/0000-0001-8470-3157"},"institutions":[{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Karl Richter","raw_affiliation_strings":["Pfizer Neuroscience, Groton CT","Pfizer Neuroscience, Groton CT#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pfizer Neuroscience, Groton CT","institution_ids":["https://openalex.org/I180857899"]},{"raw_affiliation_string":"Pfizer Neuroscience, Groton CT#TAB#","institution_ids":["https://openalex.org/I180857899"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5042643395","display_name":"Robert M. Peitzsch","orcid":null},"institutions":[{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert M. Peitzsch","raw_affiliation_strings":["Pfizer Neuroscience, Groton CT","Pfizer Neuroscience, Groton CT#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pfizer Neuroscience, Groton CT","institution_ids":["https://openalex.org/I180857899"]},{"raw_affiliation_string":"Pfizer Neuroscience, Groton CT#TAB#","institution_ids":["https://openalex.org/I180857899"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I180857899"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"498","last_page":"498"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9987000226974487,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9987000226974487,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9950000047683716,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.6651229858398438},{"id":"https://openalex.org/keywords/mechanism","display_name":"Mechanism (biology)","score":0.6486667394638062},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.5521067380905151},{"id":"https://openalex.org/keywords/context","display_name":"Context (archaeology)","score":0.5475417971611023},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5316513180732727},{"id":"https://openalex.org/keywords/human-disease","display_name":"Human disease","score":0.4810069501399994},{"id":"https://openalex.org/keywords/selection","display_name":"Selection (genetic algorithm)","score":0.4579665958881378},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.43439286947250366},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.3931005895137787},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3695005774497986},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.26503512263298035},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.21792665123939514},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.14633938670158386}],"concepts":[{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.6651229858398438},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.6486667394638062},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5521067380905151},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.5475417971611023},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5316513180732727},{"id":"https://openalex.org/C2988867146","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Human disease","level":3,"score":0.4810069501399994},{"id":"https://openalex.org/C81917197","wikidata":"https://www.wikidata.org/wiki/Q628760","display_name":"Selection (genetic algorithm)","level":2,"score":0.4579665958881378},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.43439286947250366},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3931005895137787},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3695005774497986},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.26503512263298035},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.21792665123939514},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.14633938670158386},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1145/1854776.1854870","is_oa":false,"landing_page_url":"https://doi.org/10.1145/1854776.1854870","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the First ACM International Conference on Bioinformatics and Computational Biology","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/15","score":0.7099999785423279,"display_name":"Life in Land"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2382997850","https://openalex.org/W2390968135","https://openalex.org/W2382213751","https://openalex.org/W2351750670","https://openalex.org/W1597848696","https://openalex.org/W2354715126","https://openalex.org/W2388563748","https://openalex.org/W2375179084","https://openalex.org/W2366646518","https://openalex.org/W2370906336"],"abstract_inverted_index":{"The":[0],"integration":[1],"of":[2,31,37,60,67,80,125,174],"information":[3],"across":[4],"carefully":[5],"selected":[6],"species":[7],"and":[8,35,55,150,159,170],"experimental":[9,33,179],"platforms":[10],"is":[11,50,137,162],"emerging":[12],"as":[13,118,120],"a":[14,28,74,86,130],"powerful":[15],"technique":[16],"for":[17,22,132],"selecting":[18],"potential":[19,153],"therapeutic":[20],"targets":[21,142,176],"human":[23,116],"diseases:":[24],"this":[25],"method":[26,87],"enables":[27],"holistic":[29],"view":[30],"the":[32,38,68,78,81,141,172,175],"landscape":[34],"hence":[36],"disease.":[39,82],"Alzheimer's":[40],"disease":[41],"(AD),":[42],"which":[43],"affects":[44],"an":[45,95],"estimated":[46],"5.3":[47],"million":[48],"patients,":[49],"characterized":[51],"by":[52],"Amyloid-\u03b2":[53],"plaques":[54],"neurofibril":[56],"tangles":[57],"made":[58],"up":[59],"Tau":[61],"aggregated":[62],"protein":[63],"in":[64,101,166],"different":[65,110,123],"regions":[66,112],"brain.":[69],"Current":[70],"therapies":[71],"produce":[72],"only":[73],"minimal":[75],"impact":[76],"on":[77],"progression":[79],"Here":[83],"we":[84],"present":[85],"that":[88],"integrates":[89],"gene":[90,106],"expression":[91,107],"profiling":[92],"data":[93,108],"from":[94,109,113],"AD":[96,126],"mouse":[97],"model":[98],"(Tg4510)":[99],"with":[100],"vitro":[102],"cell":[103],"assays":[104],"plus":[105],"brain":[111],"several":[114,178],"normal":[115],"brains":[117],"well":[119],"those":[121],"displaying":[122],"degrees":[124],"pathology":[127],"to":[128,139,164],"provide":[129],"mechanism":[131,161],"target":[133,157,168],"selection.":[134],"Pathway":[135],"analysis":[136],"used":[138,163],"put":[140],"into":[143],"biological":[144],"context,":[145],"including":[146],"established":[147],"signaling":[148],"cascades,":[149],"explore":[151],"other":[152],"novel":[154],"targets.":[155],"A":[156],"scoring":[158],"tracking":[160],"assist":[165],"new":[167],"selection":[169],"monitor":[171],"progress":[173],"through":[177],"validation":[180],"assays.":[181]},"counts_by_year":[{"year":2024,"cited_by_count":1}],"updated_date":"2026-07-14T23:27:15.235271","created_date":"2025-10-10T00:00:00"}
