{"id":"https://openalex.org/W2171658501","doi":"https://doi.org/10.1145/1854776.1854866","title":"<i>In silico</i> predicted essential genes required for zebrafish ( <i>Danio rerio</i> ) steroid hormone production","display_name":"<i>In silico</i> predicted essential genes required for zebrafish ( <i>Danio rerio</i> ) steroid hormone production","publication_year":2010,"publication_date":"2010-08-02","ids":{"openalex":"https://openalex.org/W2171658501","doi":"https://doi.org/10.1145/1854776.1854866","mag":"2171658501"},"language":"en","primary_location":{"id":"doi:10.1145/1854776.1854866","is_oa":false,"landing_page_url":"https://doi.org/10.1145/1854776.1854866","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the First ACM International Conference on Bioinformatics and Computational Biology","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064812182","display_name":"David Hala","orcid":"https://orcid.org/0000-0003-4820-6078"},"institutions":[{"id":"https://openalex.org/I123534392","display_name":"University of North Texas","ror":"https://ror.org/00v97ad02","country_code":"US","type":"education","lineage":["https://openalex.org/I123534392"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Hala","raw_affiliation_strings":["University of North Texas, Denton, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of North Texas, Denton, Texas","institution_ids":["https://openalex.org/I123534392"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063844302","display_name":"Duane B. Huggett","orcid":null},"institutions":[{"id":"https://openalex.org/I123534392","display_name":"University of North Texas","ror":"https://ror.org/00v97ad02","country_code":"US","type":"education","lineage":["https://openalex.org/I123534392"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Duane B. Huggett","raw_affiliation_strings":["University of North Texas, Denton, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of North Texas, Denton, Texas","institution_ids":["https://openalex.org/I123534392"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026223461","display_name":"Dalma Martinovi\u0107\u2010Weigelt","orcid":"https://orcid.org/0000-0002-9973-4965"},"institutions":[{"id":"https://openalex.org/I161515732","display_name":"University of St. Thomas - Minnesota","ror":"https://ror.org/05vfxvp80","country_code":"US","type":"education","lineage":["https://openalex.org/I161515732"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dalma Martinovi\u0107","raw_affiliation_strings":["University of St. Thomas, St. Paul, Minnesota"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of St. Thomas, St. Paul, Minnesota","institution_ids":["https://openalex.org/I161515732"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.23718887,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"487","last_page":"489"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9894999861717224,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9894999861717224,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11056","display_name":"Physiological and biochemical adaptations","score":0.9480000138282776,"subfield":{"id":"https://openalex.org/subfields/2303","display_name":"Ecology"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9437999725341797,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/zebrafish","display_name":"Zebrafish","score":0.8711233139038086},{"id":"https://openalex.org/keywords/danio","display_name":"Danio","score":0.8203017711639404},{"id":"https://openalex.org/keywords/in-silico","display_name":"In silico","score":0.7893551588058472},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.7099317908287048},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.595761775970459},{"id":"https://openalex.org/keywords/steroid-hormone","display_name":"Steroid hormone","score":0.44783899188041687},{"id":"https://openalex.org/keywords/hormone","display_name":"Hormone","score":0.40928006172180176},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.3654235005378723},{"id":"https://openalex.org/keywords/endocrinology","display_name":"Endocrinology","score":0.2084577977657318}],"concepts":[{"id":"https://openalex.org/C2776878037","wikidata":"https://www.wikidata.org/wiki/Q169444","display_name":"Zebrafish","level":3,"score":0.8711233139038086},{"id":"https://openalex.org/C2780384893","wikidata":"https://www.wikidata.org/wiki/Q901804","display_name":"Danio","level":4,"score":0.8203017711639404},{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.7893551588058472},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7099317908287048},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.595761775970459},{"id":"https://openalex.org/C2776888042","wikidata":"https://www.wikidata.org/wiki/Q422137","display_name":"Steroid hormone","level":3,"score":0.44783899188041687},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.40928006172180176},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3654235005378723},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.2084577977657318}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1145/1854776.1854866","is_oa":false,"landing_page_url":"https://doi.org/10.1145/1854776.1854866","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the First ACM International Conference on Bioinformatics and Computational Biology","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Life below water","score":0.4099999964237213,"id":"https://metadata.un.org/sdg/14"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":12,"referenced_works":["https://openalex.org/W609187031","https://openalex.org/W632974725","https://openalex.org/W1969728400","https://openalex.org/W1998117009","https://openalex.org/W2014766558","https://openalex.org/W2030676023","https://openalex.org/W2032631468","https://openalex.org/W2084239839","https://openalex.org/W2147472054","https://openalex.org/W2165649971","https://openalex.org/W2494386767","https://openalex.org/W4238101851"],"related_works":["https://openalex.org/W4237600267","https://openalex.org/W4245153001","https://openalex.org/W24064635","https://openalex.org/W1992684640","https://openalex.org/W4253352342","https://openalex.org/W3109425268","https://openalex.org/W4388158194","https://openalex.org/W2947128474","https://openalex.org/W2938575486","https://openalex.org/W2922730069"],"abstract_inverted_index":{"Genome-scale":[0],"metabolic":[1],"models":[2],"associate":[3],"genes":[4,59,69,85,127,155,173],"and":[5,25,38,81,105],"transcript":[6],"enzymes":[7],"involved":[8,91],"in":[9,66,76,129,131,153,169,183],"biochemical":[10],"reactions.":[11],"We":[12],"present":[13],"a":[14],"genome-scale":[15],"stoichiometric":[16],"reconstruction":[17],"of":[18,45,51,96,101,122,138],"the":[19,32,43,46,65,93,99,135,168],"zebrafish":[20,132],"(Danio":[21],"rerio)":[22],"steroidogenic":[23,35,110,125,172],"network":[24,39,117],"apply":[26],"linear":[27],"programming":[28],"methods":[29],"to":[30,88,115,134],"investigate":[31],"association":[33],"between":[34],"gene":[36,54],"expression":[37],"redundancy":[40],"required":[41,60,75],"for":[42,61,160],"productions":[44,100],"key":[47],"reproductive":[48,79],"steroid":[49,180],"hormone":[50,181],"17\u03b2-estradiol.":[52],"Network-wide":[53],"deletions":[55],"helped":[56],"identify":[57],"essential":[58,84,159],"its":[62],"production":[63],"with":[64,73,92,152,177],"silico":[67,154],"identified":[68,156],"giving":[70],"good":[71],"agreement":[72,151,164],"those":[74],"vivo":[77,130,170],"during":[78],"development":[80],"maturation.":[82],"The":[83],"were":[86,112,174],"shown":[87,114],"be":[89],"mainly":[90],"initial":[94],"reactions":[95,111],"steroidogenesis.":[97],"Furthermore,":[98],"intermediate":[102],"metabolites":[103],"(17\u03b1-hydroxyprogesterone":[104],"androstenedione),":[106],"highly":[107],"participant":[108],"within":[109],"also":[113,175],"allow":[116],"redundancy.":[118],"This":[119,163],"analysis":[120],"is":[121,165],"importance":[123],"as":[124,157,167],"enzyme":[126],"down-regulated":[128,171],"exposed":[133],"environmental":[136],"stressor":[137],"hypoxia":[139],"or":[140],"low":[141],"oxygen":[142],"stress":[143],"(\u2264":[144],"2":[145],"mg/L":[146],"dissolved":[147],"oxygen)":[148],"showed":[149],"71%":[150],"being":[158],"17\u03b2-estradiol":[161],"production.":[162],"relevant,":[166],"correlated":[176],"lowered":[178],"sex":[179],"concentrations":[182],"zebrafish.":[184]},"counts_by_year":[],"updated_date":"2026-07-29T14:22:42.915294","created_date":"2025-10-10T00:00:00"}
