{"id":"https://openalex.org/W2032166497","doi":"https://doi.org/10.1145/1854776.1854839","title":"An intelligent data-centric approach toward identification of conserved motifs in protein sequences","display_name":"An intelligent data-centric approach toward identification of conserved motifs in protein sequences","publication_year":2010,"publication_date":"2010-08-02","ids":{"openalex":"https://openalex.org/W2032166497","doi":"https://doi.org/10.1145/1854776.1854839","mag":"2032166497"},"language":"en","primary_location":{"id":"doi:10.1145/1854776.1854839","is_oa":false,"landing_page_url":"https://doi.org/10.1145/1854776.1854839","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the First ACM International Conference on Bioinformatics and Computational Biology","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005196882","display_name":"Kathryn Dempsey","orcid":null},"institutions":[{"id":"https://openalex.org/I122266389","display_name":"University of Nebraska at Omaha","ror":"https://ror.org/04yrkc140","country_code":"US","type":"education","lineage":["https://openalex.org/I122266389"]},{"id":"https://openalex.org/I59130452","display_name":"University of Nebraska Medical Center","ror":"https://ror.org/00thqtb16","country_code":"US","type":"funder","lineage":["https://openalex.org/I59130452"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Kathryn Dempsey","raw_affiliation_strings":["University of Nebraska at Omaha and University of Nebraska Medical Center"],"affiliations":[{"raw_affiliation_string":"University of Nebraska at Omaha and University of Nebraska Medical Center","institution_ids":["https://openalex.org/I59130452","https://openalex.org/I122266389"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088196138","display_name":"Benjamin Currall","orcid":"https://orcid.org/0000-0001-6023-6400"},"institutions":[{"id":"https://openalex.org/I114493937","display_name":"Creighton University","ror":"https://ror.org/05wf30g94","country_code":"US","type":"education","lineage":["https://openalex.org/I114493937"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Benjamin Currall","raw_affiliation_strings":["Creighton University","Creighton University;"],"affiliations":[{"raw_affiliation_string":"Creighton University","institution_ids":["https://openalex.org/I114493937"]},{"raw_affiliation_string":"Creighton University;","institution_ids":["https://openalex.org/I114493937"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055499336","display_name":"Richard Hallworth","orcid":null},"institutions":[{"id":"https://openalex.org/I114493937","display_name":"Creighton University","ror":"https://ror.org/05wf30g94","country_code":"US","type":"education","lineage":["https://openalex.org/I114493937"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard Hallworth","raw_affiliation_strings":["Creighton University","Creighton University;"],"affiliations":[{"raw_affiliation_string":"Creighton University","institution_ids":["https://openalex.org/I114493937"]},{"raw_affiliation_string":"Creighton University;","institution_ids":["https://openalex.org/I114493937"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5047703641","display_name":"Hesham Ali","orcid":"https://orcid.org/0000-0001-6675-7987"},"institutions":[{"id":"https://openalex.org/I59130452","display_name":"University of Nebraska Medical Center","ror":"https://ror.org/00thqtb16","country_code":"US","type":"funder","lineage":["https://openalex.org/I59130452"]},{"id":"https://openalex.org/I122266389","display_name":"University of Nebraska at Omaha","ror":"https://ror.org/04yrkc140","country_code":"US","type":"education","lineage":["https://openalex.org/I122266389"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hesham Ali","raw_affiliation_strings":["University of Nebraska at Omaha and University of Nebraska Medical Center"],"affiliations":[{"raw_affiliation_string":"University of Nebraska at Omaha and University of Nebraska Medical Center","institution_ids":["https://openalex.org/I59130452","https://openalex.org/I122266389"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5005196882"],"corresponding_institution_ids":["https://openalex.org/I122266389","https://openalex.org/I59130452"],"apc_list":null,"apc_paid":null,"fwci":0.5287,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.64974754,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":null,"issue":null,"first_page":"398","last_page":"401"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":0.9987999796867371,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":0.9987999796867371,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.9876000285148621,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.736264169216156},{"id":"https://openalex.org/keywords/sophistication","display_name":"Sophistication","score":0.7214003801345825},{"id":"https://openalex.org/keywords/software","display_name":"Software","score":0.5982425212860107},{"id":"https://openalex.org/keywords/identification","display_name":"Identification (biology)","score":0.5553042888641357},{"id":"https://openalex.org/keywords/biological-data","display_name":"Biological data","score":0.4800040125846863},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.4769136607646942},{"id":"https://openalex.org/keywords/domain","display_name":"Domain (mathematical analysis)","score":0.47579774260520935},{"id":"https://openalex.org/keywords/motif","display_name":"Motif (music)","score":0.43575823307037354},{"id":"https://openalex.org/keywords/function","display_name":"Function (biology)","score":0.41570496559143066},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.3997519016265869},{"id":"https://openalex.org/keywords/theoretical-computer-science","display_name":"Theoretical computer science","score":0.38027966022491455},{"id":"https://openalex.org/keywords/data-science","display_name":"Data science","score":0.37054964900016785},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.3385148048400879},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.32424861192703247},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.23683100938796997},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.22508206963539124},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.11852076649665833},{"id":"https://openalex.org/keywords/ecology","display_name":"Ecology","score":0.0858968198299408},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.08513334393501282}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.736264169216156},{"id":"https://openalex.org/C168725872","wikidata":"https://www.wikidata.org/wiki/Q991663","display_name":"Sophistication","level":2,"score":0.7214003801345825},{"id":"https://openalex.org/C2777904410","wikidata":"https://www.wikidata.org/wiki/Q7397","display_name":"Software","level":2,"score":0.5982425212860107},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.5553042888641357},{"id":"https://openalex.org/C201797286","wikidata":"https://www.wikidata.org/wiki/Q4914986","display_name":"Biological data","level":2,"score":0.4800040125846863},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.4769136607646942},{"id":"https://openalex.org/C36503486","wikidata":"https://www.wikidata.org/wiki/Q11235244","display_name":"Domain (mathematical analysis)","level":2,"score":0.47579774260520935},{"id":"https://openalex.org/C32276052","wikidata":"https://www.wikidata.org/wiki/Q908349","display_name":"Motif (music)","level":2,"score":0.43575823307037354},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.41570496559143066},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3997519016265869},{"id":"https://openalex.org/C80444323","wikidata":"https://www.wikidata.org/wiki/Q2878974","display_name":"Theoretical computer science","level":1,"score":0.38027966022491455},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.37054964900016785},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3385148048400879},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.32424861192703247},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.23683100938796997},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.22508206963539124},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.11852076649665833},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0858968198299408},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.08513334393501282},{"id":"https://openalex.org/C36289849","wikidata":"https://www.wikidata.org/wiki/Q34749","display_name":"Social science","level":1,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C24890656","wikidata":"https://www.wikidata.org/wiki/Q82811","display_name":"Acoustics","level":1,"score":0.0},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1145/1854776.1854839","is_oa":false,"landing_page_url":"https://doi.org/10.1145/1854776.1854839","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the First ACM International Conference on Bioinformatics and Computational Biology","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/17","score":0.44999998807907104,"display_name":"Partnerships for the goals"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332167","display_name":"Directorate for Biological Sciences","ror":"https://ror.org/001xhss06"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":9,"referenced_works":["https://openalex.org/W1999108741","https://openalex.org/W2038717281","https://openalex.org/W2041187152","https://openalex.org/W2042728738","https://openalex.org/W2094349878","https://openalex.org/W2140880010","https://openalex.org/W2141408320","https://openalex.org/W2158266834","https://openalex.org/W2166647921"],"related_works":["https://openalex.org/W2317823609","https://openalex.org/W4241263575","https://openalex.org/W3130462184","https://openalex.org/W2902287117","https://openalex.org/W4318256508","https://openalex.org/W2401463593","https://openalex.org/W2349808627","https://openalex.org/W2391671934","https://openalex.org/W3023500690","https://openalex.org/W3124280623"],"abstract_inverted_index":{"The":[0],"continued":[1],"integration":[2],"of":[3,24,40,48,54,89,116],"the":[4,22,38,41,49,113],"computational":[5],"and":[6,12,82,92,106,111],"biological":[7,32],"sciences":[8],"has":[9],"revolutionized":[10],"genomic":[11],"proteomic":[13],"studies.":[14,99],"However,":[15],"efficient":[16],"collaboration":[17],"between":[18],"these":[19],"fields":[20],"requires":[21],"creation":[23],"shared":[25],"standards.":[26],"A":[27],"common":[28],"problem":[29],"arises":[30],"when":[31,60],"input":[33,75,102],"does":[34],"not":[35],"properly":[36],"fit":[37],"expectations":[39],"algorithm,":[42],"which":[43],"can":[44,108],"result":[45],"in":[46,95],"misinterpretation":[47],"output.":[50],"This":[51,85],"potential":[52],"confounding":[53],"input/output":[55],"is":[56],"a":[57,68],"drawback":[58],"especially":[59],"regarding":[61],"motif":[62],"finding":[63],"software.":[64,118],"Here":[65],"we":[66],"propose":[67],"method":[69,86],"for":[70],"improving":[71],"output":[72],"by":[73],"selecting":[74],"based":[76],"upon":[77],"evolutionary":[78],"distance,":[79],"domain":[80],"architecture,":[81],"known":[83,91],"function.":[84],"improved":[87],"detection":[88],"both":[90,104],"unknown":[93],"motifs":[94],"two":[96],"separate":[97],"case":[98],"By":[100],"standardizing":[101],"considerations,":[103],"biologists":[105],"bioinformaticians":[107],"better":[109],"interpret":[110],"design":[112],"evolving":[114],"sophistication":[115],"bioinformatic":[117]},"counts_by_year":[{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}