{"id":"https://openalex.org/W2125091804","doi":"https://doi.org/10.1145/1854776.1854825","title":"A novel network model for molecular prognosis","display_name":"A novel network model for molecular prognosis","publication_year":2010,"publication_date":"2010-08-02","ids":{"openalex":"https://openalex.org/W2125091804","doi":"https://doi.org/10.1145/1854776.1854825","mag":"2125091804","pmid":"https://pubmed.ncbi.nlm.nih.gov/26005718"},"language":"en","primary_location":{"id":"doi:10.1145/1854776.1854825","is_oa":false,"landing_page_url":"https://doi.org/10.1145/1854776.1854825","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the First ACM International Conference on Bioinformatics and Computational Biology","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":null,"any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016453515","display_name":"Ying\u2010Wooi Wan","orcid":"https://orcid.org/0000-0002-4354-7482"},"institutions":[{"id":"https://openalex.org/I12097938","display_name":"West Virginia University","ror":"https://ror.org/011vxgd24","country_code":"US","type":"education","lineage":["https://openalex.org/I12097938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ying-Wooi Wan","raw_affiliation_strings":["West Virginia University, Morgantown, WV"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"West Virginia University, Morgantown, WV","institution_ids":["https://openalex.org/I12097938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082907376","display_name":"Swetha Bose","orcid":null},"institutions":[{"id":"https://openalex.org/I12097938","display_name":"West Virginia University","ror":"https://ror.org/011vxgd24","country_code":"US","type":"education","lineage":["https://openalex.org/I12097938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Swetha Bose","raw_affiliation_strings":["West Virginia University, Morgantown, WV"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"West Virginia University, Morgantown, WV","institution_ids":["https://openalex.org/I12097938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016924282","display_name":"James Denvir","orcid":"https://orcid.org/0000-0001-8836-6653"},"institutions":[{"id":"https://openalex.org/I12097938","display_name":"West Virginia University","ror":"https://ror.org/011vxgd24","country_code":"US","type":"education","lineage":["https://openalex.org/I12097938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James Denvir","raw_affiliation_strings":["West Virginia University, Morgantown, WV"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"West Virginia University, Morgantown, WV","institution_ids":["https://openalex.org/I12097938"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072867312","display_name":"Nancy Lan Guo","orcid":"https://orcid.org/0000-0002-8050-6268"},"institutions":[{"id":"https://openalex.org/I12097938","display_name":"West Virginia University","ror":"https://ror.org/011vxgd24","country_code":"US","type":"education","lineage":["https://openalex.org/I12097938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nancy Lan Guo","raw_affiliation_strings":["West Virginia University, Morgantown, WV"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"West Virginia University, Morgantown, WV","institution_ids":["https://openalex.org/I12097938"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I12097938"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"2010","issue":null,"first_page":"342","last_page":"345"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9973000288009644,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.9695000052452087,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.6343072652816772},{"id":"https://openalex.org/keywords/gene-regulatory-network","display_name":"Gene regulatory network","score":0.5767834186553955},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.5533506870269775},{"id":"https://openalex.org/keywords/genome","display_name":"Genome","score":0.5277700424194336},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.4705902636051178},{"id":"https://openalex.org/keywords/identification","display_name":"Identification (biology)","score":0.44700175523757935},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.42842185497283936},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.42049640417099},{"id":"https://openalex.org/keywords/biological-network","display_name":"Biological network","score":0.41383498907089233},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.20222660899162292},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.17452675104141235},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.13727664947509766}],"concepts":[{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6343072652816772},{"id":"https://openalex.org/C67339327","wikidata":"https://www.wikidata.org/wiki/Q1502576","display_name":"Gene regulatory network","level":4,"score":0.5767834186553955},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5533506870269775},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.5277700424194336},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4705902636051178},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.44700175523757935},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.42842185497283936},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.42049640417099},{"id":"https://openalex.org/C28225019","wikidata":"https://www.wikidata.org/wiki/Q4915005","display_name":"Biological network","level":2,"score":0.41383498907089233},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.20222660899162292},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.17452675104141235},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.13727664947509766},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1145/1854776.1854825","is_oa":false,"landing_page_url":"https://doi.org/10.1145/1854776.1854825","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the First ACM International Conference on Bioinformatics and Computational Biology","raw_type":"proceedings-article"},{"id":"pmid:26005718","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26005718","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The 2010 ACM International Conference on Bioinformatics and Computational Biology : ACM-BCB 2010 : Niagara Falls, New York, U.S.A., August 2-4, 2010. ACM International Conference on Bioinformatics and Computational Biology (1st : 2010 :...","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:4440690","is_oa":true,"landing_page_url":null,"pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4440690","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4440690","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ACM Int Conf Bioinform Comput Biol (2010)","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4440690","is_oa":true,"landing_page_url":null,"pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.7699999809265137,"id":"https://metadata.un.org/sdg/3"}],"awards":[{"id":"https://openalex.org/G6128679305","display_name":null,"funder_award_id":"P20RR16440","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G8125862152","display_name":null,"funder_award_id":"R01 LM009500","funder_id":"https://openalex.org/F4320337372","funder_display_name":"U.S. National Library of Medicine"},{"id":"https://openalex.org/G8491518428","display_name":null,"funder_award_id":"R01LM009500","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8911382810","display_name":null,"funder_award_id":"P20 RR016440","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337372","display_name":"U.S. National Library of Medicine","ror":"https://ror.org/0060t0j89"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W1570448133","https://openalex.org/W1585691819","https://openalex.org/W1644749979","https://openalex.org/W1968455934","https://openalex.org/W1995907191","https://openalex.org/W1996215128","https://openalex.org/W1997823739","https://openalex.org/W2050303144","https://openalex.org/W2054541484","https://openalex.org/W2062029454","https://openalex.org/W2066235893","https://openalex.org/W2070404462","https://openalex.org/W2073307618","https://openalex.org/W2084001490","https://openalex.org/W2088683127","https://openalex.org/W2090808827","https://openalex.org/W2099768941","https://openalex.org/W2100025044","https://openalex.org/W2100603120","https://openalex.org/W2108579152","https://openalex.org/W2112573366","https://openalex.org/W2114518254","https://openalex.org/W2121277505","https://openalex.org/W2125631472","https://openalex.org/W2132165198","https://openalex.org/W2137082708","https://openalex.org/W2143174846","https://openalex.org/W2152227081","https://openalex.org/W2153624566","https://openalex.org/W2154947819","https://openalex.org/W2966207845","https://openalex.org/W3015826635","https://openalex.org/W4232719563"],"related_works":["https://openalex.org/W2130939068","https://openalex.org/W3163717165","https://openalex.org/W2114466827","https://openalex.org/W249159571","https://openalex.org/W2791736663","https://openalex.org/W2806770614","https://openalex.org/W2129949791","https://openalex.org/W2131550814","https://openalex.org/W1710460698","https://openalex.org/W3199739261"],"abstract_inverted_index":{"Network-based":[0],"genome-wide":[1,41,84],"association":[2],"studies":[3],"(NWAS)":[4],"utilize":[5],"the":[6,36,83,101,116],"molecular":[7],"interactions":[8],"between":[9,60],"genes":[10],"and":[11],"functional":[12],"pathways":[13],"in":[14,67,134],"biomarker":[15],"identification.":[16],"This":[17],"study":[18],"presents":[19],"a":[20,124],"novel":[21],"network-based":[22],"methodology":[23,34],"for":[24,44,130],"identifying":[25],"prognostic":[26,126],"gene":[27,64],"signatures":[28],"to":[29,55],"predict":[30],"cancer":[31],"recurrence.":[32],"The":[33],"contains":[35],"following":[37],"steps:":[38],"1)":[39],"Constructing":[40],"coexpression":[42,85],"networks":[43],"different":[45],"disease":[46,80,97,102],"states":[47,81],"(metastatic":[48],"vs.":[49],"non-metastatic).":[50],"Prediction":[51],"logic":[52,71],"is":[53],"used":[54],"induct":[56],"valid":[57],"implication":[58],"relations":[59],"each":[61],"pair":[62],"of":[63,69],"expression":[65],"profiles":[66],"terms":[68],"formal":[70],"rules.":[72],"2)":[73],"Identifying":[74,107],"differential":[75,104],"components":[76],"associated":[77,111],"with":[78,95,112],"specific":[79,103],"from":[82,100,115],"networks.":[86],"3)":[87],"Dissecting":[88],"network":[89,119],"modules":[90],"that":[91],"are":[92],"tightly":[93],"connected":[94,118],"major":[96],"signal":[98],"hallmarks":[99],"components.":[105],"4)":[106],"most":[108],"significant":[109],"genes/probes":[110],"clinical":[113],"outcome":[114],"pathway":[117],"modules.":[120],"Using":[121],"this":[122],"methodology,":[123],"14-gene":[125],"signature":[127],"was":[128],"identified":[129],"accurate":[131],"patient":[132],"stratification":[133],"early":[135],"stage":[136],"lung":[137],"cancer.":[138]},"counts_by_year":[{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-07-14T23:27:15.235271","created_date":"2025-10-10T00:00:00"}
