{"id":"https://openalex.org/W1997823018","doi":"https://doi.org/10.1145/1543834.1543940","title":"A proposed modularized DNA computer, based on biochips","display_name":"A proposed modularized DNA computer, based on biochips","publication_year":2009,"publication_date":"2009-06-12","ids":{"openalex":"https://openalex.org/W1997823018","doi":"https://doi.org/10.1145/1543834.1543940","mag":"1997823018"},"language":"en","primary_location":{"id":"doi:10.1145/1543834.1543940","is_oa":false,"landing_page_url":"https://doi.org/10.1145/1543834.1543940","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the first ACM/SIGEVO Summit on Genetic and Evolutionary Computation","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004053740","display_name":"Ying Zhu","orcid":"https://orcid.org/0000-0003-3738-598X"},"institutions":[{"id":"https://openalex.org/I181326427","display_name":"Donghua University","ror":"https://ror.org/035psfh38","country_code":"CN","type":"education","lineage":["https://openalex.org/I181326427"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Ying Zhu","raw_affiliation_strings":["Donghua University, Shanghai, China","Donghua University, Shanghai, China#TAB#"],"affiliations":[{"raw_affiliation_string":"Donghua University, Shanghai, China","institution_ids":["https://openalex.org/I181326427"]},{"raw_affiliation_string":"Donghua University, Shanghai, China#TAB#","institution_ids":["https://openalex.org/I181326427"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100688228","display_name":"Yongsheng Ding","orcid":"https://orcid.org/0000-0001-5631-3581"},"institutions":[{"id":"https://openalex.org/I181326427","display_name":"Donghua University","ror":"https://ror.org/035psfh38","country_code":"CN","type":"education","lineage":["https://openalex.org/I181326427"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yongsheng Ding","raw_affiliation_strings":["Donghua University, Shanghai, China","Donghua University, Shanghai, China#TAB#"],"affiliations":[{"raw_affiliation_string":"Donghua University, Shanghai, China","institution_ids":["https://openalex.org/I181326427"]},{"raw_affiliation_string":"Donghua University, Shanghai, China#TAB#","institution_ids":["https://openalex.org/I181326427"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056147012","display_name":"Wanggen Li","orcid":null},"institutions":[{"id":"https://openalex.org/I181326427","display_name":"Donghua University","ror":"https://ror.org/035psfh38","country_code":"CN","type":"education","lineage":["https://openalex.org/I181326427"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wanggen Li","raw_affiliation_strings":["Donghua University, Shanghai, China","Donghua University, Shanghai, China#TAB#"],"affiliations":[{"raw_affiliation_string":"Donghua University, Shanghai, China","institution_ids":["https://openalex.org/I181326427"]},{"raw_affiliation_string":"Donghua University, Shanghai, China#TAB#","institution_ids":["https://openalex.org/I181326427"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5002162896","display_name":"Gregory W. Kemp","orcid":null},"institutions":[{"id":"https://openalex.org/I1292875679","display_name":"Commonwealth Scientific and Industrial Research Organisation","ror":"https://ror.org/03qn8fb07","country_code":"AU","type":"funder","lineage":["https://openalex.org/I1292875679","https://openalex.org/I2801453606","https://openalex.org/I4387156119"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Gregory Kemp","raw_affiliation_strings":["CSIRO Livestock Industries, Brisbane, Australia"],"affiliations":[{"raw_affiliation_string":"CSIRO Livestock Industries, Brisbane, Australia","institution_ids":["https://openalex.org/I1292875679"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5004053740"],"corresponding_institution_ids":["https://openalex.org/I181326427"],"apc_list":null,"apc_paid":null,"fwci":0.1312,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.52037898,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"773","last_page":"780"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12029","display_name":"DNA and Biological Computing","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12029","display_name":"DNA and Biological Computing","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12784","display_name":"Modular Robots and Swarm Intelligence","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/2210","display_name":"Mechanical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":0.9987000226974487,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biochip","display_name":"Biochip","score":0.9503528475761414},{"id":"https://openalex.org/keywords/dna-computing","display_name":"DNA computing","score":0.850399374961853},{"id":"https://openalex.org/keywords/microfluidics","display_name":"Microfluidics","score":0.7918822169303894},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6336482763290405},{"id":"https://openalex.org/keywords/digital-microfluidics","display_name":"Digital microfluidics","score":0.5118269324302673},{"id":"https://openalex.org/keywords/scripting-language","display_name":"Scripting language","score":0.5039541125297546},{"id":"https://openalex.org/keywords/computer-hardware","display_name":"Computer hardware","score":0.49154695868492126},{"id":"https://openalex.org/keywords/lab-on-a-chip","display_name":"Lab-on-a-chip","score":0.48926231265068054},{"id":"https://openalex.org/keywords/von-neumann-architecture","display_name":"Von Neumann architecture","score":0.47073662281036377},{"id":"https://openalex.org/keywords/computation","display_name":"Computation","score":0.4688630700111389},{"id":"https://openalex.org/keywords/fluidics","display_name":"Fluidics","score":0.4559323489665985},{"id":"https://openalex.org/keywords/python","display_name":"Python (programming language)","score":0.43633025884628296},{"id":"https://openalex.org/keywords/embedded-system","display_name":"Embedded system","score":0.4066884517669678},{"id":"https://openalex.org/keywords/nanotechnology","display_name":"Nanotechnology","score":0.24425682425498962},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.2033793032169342},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.19683250784873962},{"id":"https://openalex.org/keywords/programming-language","display_name":"Programming language","score":0.11916160583496094},{"id":"https://openalex.org/keywords/electrical-engineering","display_name":"Electrical engineering","score":0.1029839813709259}],"concepts":[{"id":"https://openalex.org/C87892846","wikidata":"https://www.wikidata.org/wiki/Q864256","display_name":"Biochip","level":2,"score":0.9503528475761414},{"id":"https://openalex.org/C82047324","wikidata":"https://www.wikidata.org/wiki/Q177126","display_name":"DNA computing","level":3,"score":0.850399374961853},{"id":"https://openalex.org/C8673954","wikidata":"https://www.wikidata.org/wiki/Q138845","display_name":"Microfluidics","level":2,"score":0.7918822169303894},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6336482763290405},{"id":"https://openalex.org/C92444450","wikidata":"https://www.wikidata.org/wiki/Q5276112","display_name":"Digital microfluidics","level":4,"score":0.5118269324302673},{"id":"https://openalex.org/C61423126","wikidata":"https://www.wikidata.org/wiki/Q187432","display_name":"Scripting language","level":2,"score":0.5039541125297546},{"id":"https://openalex.org/C9390403","wikidata":"https://www.wikidata.org/wiki/Q3966","display_name":"Computer hardware","level":1,"score":0.49154695868492126},{"id":"https://openalex.org/C138942068","wikidata":"https://www.wikidata.org/wiki/Q633261","display_name":"Lab-on-a-chip","level":3,"score":0.48926231265068054},{"id":"https://openalex.org/C80469333","wikidata":"https://www.wikidata.org/wiki/Q189088","display_name":"Von Neumann architecture","level":2,"score":0.47073662281036377},{"id":"https://openalex.org/C45374587","wikidata":"https://www.wikidata.org/wiki/Q12525525","display_name":"Computation","level":2,"score":0.4688630700111389},{"id":"https://openalex.org/C132651336","wikidata":"https://www.wikidata.org/wiki/Q185571","display_name":"Fluidics","level":2,"score":0.4559323489665985},{"id":"https://openalex.org/C519991488","wikidata":"https://www.wikidata.org/wiki/Q28865","display_name":"Python (programming language)","level":2,"score":0.43633025884628296},{"id":"https://openalex.org/C149635348","wikidata":"https://www.wikidata.org/wiki/Q193040","display_name":"Embedded system","level":1,"score":0.4066884517669678},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.24425682425498962},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.2033793032169342},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.19683250784873962},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.11916160583496094},{"id":"https://openalex.org/C119599485","wikidata":"https://www.wikidata.org/wiki/Q43035","display_name":"Electrical engineering","level":1,"score":0.1029839813709259},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.0},{"id":"https://openalex.org/C2779673822","wikidata":"https://www.wikidata.org/wiki/Q907239","display_name":"Electrowetting","level":3,"score":0.0},{"id":"https://openalex.org/C165801399","wikidata":"https://www.wikidata.org/wiki/Q25428","display_name":"Voltage","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1145/1543834.1543940","is_oa":false,"landing_page_url":"https://doi.org/10.1145/1543834.1543940","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the first ACM/SIGEVO Summit on Genetic and Evolutionary Computation","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321435","display_name":"Anhui University","ror":"https://ror.org/05th6yx34"},{"id":"https://openalex.org/F4320328006","display_name":"Anhui Normal University","ror":"https://ror.org/05fsfvw79"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":26,"referenced_works":["https://openalex.org/W176347961","https://openalex.org/W1552212403","https://openalex.org/W1839356836","https://openalex.org/W1867949460","https://openalex.org/W1919237828","https://openalex.org/W1971211688","https://openalex.org/W1977312644","https://openalex.org/W2003091620","https://openalex.org/W2018047108","https://openalex.org/W2027603534","https://openalex.org/W2045533724","https://openalex.org/W2072606541","https://openalex.org/W2082335540","https://openalex.org/W2103207402","https://openalex.org/W2111990121","https://openalex.org/W2115654286","https://openalex.org/W2124918094","https://openalex.org/W2128427912","https://openalex.org/W2141030767","https://openalex.org/W2162575652","https://openalex.org/W2362843315","https://openalex.org/W2368445312","https://openalex.org/W2988753298","https://openalex.org/W3011891279","https://openalex.org/W4210493499","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2593620286","https://openalex.org/W2029481052","https://openalex.org/W2074654211","https://openalex.org/W2332939083","https://openalex.org/W1995422305","https://openalex.org/W2071803082","https://openalex.org/W2182486668","https://openalex.org/W2020086507","https://openalex.org/W2903853891","https://openalex.org/W2588455182"],"abstract_inverted_index":{"There":[0],"are":[1,157],"limits":[2],"to":[3,22,67],"miniaturization":[4],"with":[5,54,90,150],"current":[6],"computer":[7,145],"technologies.":[8],"Information-processing":[9],"capabilities":[10],"of":[11,31,60,76],"organic":[12],"molecules":[13],"such":[14,95],"as":[15,96],"DNA":[16,55,118,143,199],"can":[17,84,121,169],"be":[18,39,68,170,194],"used":[19],"in":[20,36,148,172,196],"computers":[21],"replace":[23],"digital":[24],"switching":[25],"modality.":[26],"However,":[27],"without":[28],"the":[29,58,61,64,74,125,183,188,197],"emergence":[30],"microfluidic":[32],"devices,":[33],"all":[34],"operations":[35,62,94,168],"vitro":[37],"would":[38,193],"user":[40],"regulated.":[41],"A":[42],"more":[43],"advanced":[44],"model":[45],"is":[46,52],"where":[47],"robotic":[48],"and":[49,104,128,185],"electronic":[50],"regulation":[51],"combined":[53],"computing":[56],"allowing":[57],"majority":[59],"within":[63,182],"test":[65],"environment":[66],"carried":[69],"out":[70],"automatically.":[71],"Microfluidics":[72],"offers":[73],"promise":[75],"a":[77,80,112,116,140,173],"\"lab":[78],"on":[79],"chip\"":[81],"system.":[82],"This":[83,137],"control":[85,126],"pico":[86],"liter":[87],"scale":[88],"volumes,":[89],"integrated":[91],"support":[92],"for":[93,114,124,131],"mixing,":[97],"storage,":[98],"PCR,":[99],"heating/cooling,":[100],"cell":[101],"lysis,":[102],"electrophoresis,":[103],"others":[105],"[1],":[106],"[2]],":[107],"[3].":[108],"Thus":[109],"has":[110],"emerged":[111],"vision":[113],"creating":[115],"hybrid":[117],"computer:":[119],"that":[120,146],"use":[122],"microfluidics":[123],"paths":[127],"biological":[129],"primitives":[130],"computation":[132],"(the":[133],"Arithmetic":[134],"Logical":[135],"Units).":[136],"paper":[138],"presents":[139],"proposed":[141,198],"modularized":[142],"biochip":[144,184],"works":[147],"accordance":[149],"Von":[151],"Neumann's":[152],"principles":[153],"[4].":[154],"The":[155],"biochips":[156],"divided":[158],"into":[159],"several":[160],"modules,":[161],"which":[162],"have":[163],"different":[164],"functions.":[165],"Thus,":[166],"biochemical":[167],"regulated":[171],"step":[174],"wise":[175],"fusion.":[176],"We":[177],"then":[178],"describe":[179],"each":[180],"module":[181],"simulate":[186],"how":[187],"classic":[189],"Hamiltonian":[190],"Path":[191],"Problem":[192],"solved":[195],"computer.":[200]},"counts_by_year":[],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}