{"id":"https://openalex.org/W2118556950","doi":"https://doi.org/10.1145/1401890.1401988","title":"Fastanova","display_name":"Fastanova","publication_year":2008,"publication_date":"2008-08-24","ids":{"openalex":"https://openalex.org/W2118556950","doi":"https://doi.org/10.1145/1401890.1401988","mag":"2118556950","pmid":"https://pubmed.ncbi.nlm.nih.gov/20945829"},"language":"en","primary_location":{"id":"doi:10.1145/1401890.1401988","is_oa":false,"landing_page_url":"https://doi.org/10.1145/1401890.1401988","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 14th ACM SIGKDD international conference on Knowledge discovery and data mining","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2951741","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100368855","display_name":"Xiang Zhang","orcid":"https://orcid.org/0000-0002-3466-4193"},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Xiang Zhang","raw_affiliation_strings":["University of North Carolina at Chapel Hill, Chapel Hill, NC, USA","University of North Carolina at Chapel Hill , Chapel Hill, NC, USA"],"affiliations":[{"raw_affiliation_string":"University of North Carolina at Chapel Hill, Chapel Hill, NC, USA","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"University of North Carolina at Chapel Hill , Chapel Hill, NC, USA","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100782494","display_name":"Fei Zou","orcid":"https://orcid.org/0000-0002-6637-3593"},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fei Zou","raw_affiliation_strings":["University of North Carolina at Chapel Hill, Chapel Hill, NC, USA","University of North Carolina at Chapel Hill , Chapel Hill, NC, USA"],"affiliations":[{"raw_affiliation_string":"University of North Carolina at Chapel Hill, Chapel Hill, NC, USA","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"University of North Carolina at Chapel Hill , Chapel Hill, NC, USA","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100392089","display_name":"Wei Wang","orcid":"https://orcid.org/0000-0002-8180-2886"},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wei Wang","raw_affiliation_strings":["University of North Carolina at Chapel Hill, Chapel Hill, NC, USA","University of North Carolina at Chapel Hill , Chapel Hill, NC, USA"],"affiliations":[{"raw_affiliation_string":"University of North Carolina at Chapel Hill, Chapel Hill, NC, USA","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"University of North Carolina at Chapel Hill , Chapel Hill, NC, USA","institution_ids":["https://openalex.org/I114027177"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5100368855"],"corresponding_institution_ids":["https://openalex.org/I114027177"],"apc_list":null,"apc_paid":null,"fwci":1.9103,"has_fulltext":false,"cited_by_count":45,"citation_normalized_percentile":{"value":0.86773101,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":null,"issue":null,"first_page":"821","last_page":"829"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11468","display_name":"Genetic Mapping and Diversity in Plants and Animals","score":0.9979000091552734,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9954000115394592,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bonferroni-correction","display_name":"Bonferroni correction","score":0.8303259611129761},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphism","display_name":"Single-nucleotide polymorphism","score":0.8122864961624146},{"id":"https://openalex.org/keywords/snp","display_name":"SNP","score":0.6045535206794739},{"id":"https://openalex.org/keywords/genetic-association","display_name":"Genetic association","score":0.5620447993278503},{"id":"https://openalex.org/keywords/multiple-comparisons-problem","display_name":"Multiple comparisons problem","score":0.5332659482955933},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.46460598707199097},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.4439982771873474},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.42397546768188477},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.4017517566680908},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.271132230758667},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.26172342896461487},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.2563517391681671},{"id":"https://openalex.org/keywords/genotype","display_name":"Genotype","score":0.17054498195648193}],"concepts":[{"id":"https://openalex.org/C127808970","wikidata":"https://www.wikidata.org/wiki/Q385989","display_name":"Bonferroni correction","level":2,"score":0.8303259611129761},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.8122864961624146},{"id":"https://openalex.org/C139275648","wikidata":"https://www.wikidata.org/wiki/Q17134011","display_name":"SNP","level":5,"score":0.6045535206794739},{"id":"https://openalex.org/C186413461","wikidata":"https://www.wikidata.org/wiki/Q744727","display_name":"Genetic association","level":5,"score":0.5620447993278503},{"id":"https://openalex.org/C183905921","wikidata":"https://www.wikidata.org/wiki/Q1038757","display_name":"Multiple comparisons problem","level":2,"score":0.5332659482955933},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.46460598707199097},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4439982771873474},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.42397546768188477},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4017517566680908},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.271132230758667},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.26172342896461487},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.2563517391681671},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.17054498195648193}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1145/1401890.1401988","is_oa":false,"landing_page_url":"https://doi.org/10.1145/1401890.1401988","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 14th ACM SIGKDD international conference on Knowledge discovery and data mining","raw_type":"proceedings-article"},{"id":"pmid:20945829","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20945829","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"KDD : proceedings. International Conference on Knowledge Discovery & Data Mining","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:2951741","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2951741","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"KDD","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2951741","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2951741","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"KDD","raw_type":"Text"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W1570713908","https://openalex.org/W1820420379","https://openalex.org/W1918345025","https://openalex.org/W1939987176","https://openalex.org/W1981723690","https://openalex.org/W1987851328","https://openalex.org/W2004199685","https://openalex.org/W2040516688","https://openalex.org/W2048755332","https://openalex.org/W2065121811","https://openalex.org/W2069107889","https://openalex.org/W2073881372","https://openalex.org/W2090713084","https://openalex.org/W2098979053","https://openalex.org/W2099629766","https://openalex.org/W2110678911","https://openalex.org/W2113042365","https://openalex.org/W2118428126","https://openalex.org/W2126843316","https://openalex.org/W2148467175","https://openalex.org/W2149796867","https://openalex.org/W2154572047","https://openalex.org/W2169294950","https://openalex.org/W2171963306","https://openalex.org/W2914367856"],"related_works":["https://openalex.org/W2333750400","https://openalex.org/W2034495139","https://openalex.org/W2164855536","https://openalex.org/W2104806243","https://openalex.org/W2467227750","https://openalex.org/W4250330777","https://openalex.org/W4293336298","https://openalex.org/W1997352593","https://openalex.org/W4235821062","https://openalex.org/W1970047903"],"abstract_inverted_index":{"Studying":[0],"the":[1,62,65,114,124,174,194,239,250,268],"association":[2,50,118],"between":[3],"quantitative":[4,136],"phenotype":[5,200],"(such":[6],"as":[7,173],"height":[8],"or":[9],"weight)":[10],"and":[11,107,196,229],"single":[12],"nucleotide":[13],"polymorphisms":[14],"(SNPs)":[15],"is":[16,30,46,79,95,182,191,262],"an":[17,140,162],"important":[18],"problem":[19,125],"in":[20,49,61,150],"biology.":[21],"To":[22],"understand":[23],"underlying":[24],"mechanisms":[25],"of":[26,43,67,77,90,117,126,165,176,198,210,222,246,252,264,271],"complex":[27],"phenotypes,":[28],"it":[29],"often":[31],"necessary":[32],"to":[33,72,237],"consider":[34],"joint":[35,75],"genetic":[36],"effects":[37,76],"across":[38],"multiple":[39],"SNPs.":[40],"ANOVA":[41,146,167,186,240,272],"(analysis":[42],"variance)":[44],"test":[45,241],"routinely":[47],"used":[48],"study.":[51],"Important":[52],"findings":[53],"from":[54],"studying":[55],"gene-gene":[56],"(SNP-pair)":[57],"interactions":[58],"are":[59],"appearing":[60],"literature.":[63],"However,":[64],"number":[66,89,245],"SNPs":[68,78,91,195],"can":[69,170,204],"be":[70,171,205],"up":[71],"millions.":[73],"Evaluating":[74],"a":[80,134,151,213,243],"challenging":[81],"task":[82],"even":[83],"for":[84,101,144,219],"SNP-pairs.":[85],"Moreover,":[86],"with":[87,133],"large":[88,157],"correlated,":[92],"permutation":[93,158],"procedure":[94],"preferred":[96],"over":[97],"simple":[98],"Bonferroni":[99],"correction":[100],"properly":[102],"controlling":[103],"family-wise":[104],"error":[105],"rate":[106],"retaining":[108],"mapping":[109],"power,":[110],"which":[111,154,169,211],"dramatically":[112],"increases":[113],"computational":[115],"cost":[116],"study.In":[119],"this":[120],"paper,":[121],"we":[122],"study":[123],"finding":[127],"SNP-pairs":[128,149,203,248],"that":[129,260],"have":[130],"significant":[131,255],"associations":[132],"given":[135],"phenotype.":[137],"We":[138,160],"propose":[139],"efficient":[141,225],"algorithm,":[142],"FastANOVA,":[143],"performing":[145],"tests":[147,273],"on":[148,184,193,242,274],"batch":[152],"mode,":[153],"also":[155],"supports":[156],"test.":[159,187],"derive":[161],"upper":[163,215,226],"bound":[164,227],"SNP-pair":[166,231],"test,":[168],"expressed":[172],"sum":[175],"two":[177],"terms.":[178],"The":[179,188],"first":[180],"term":[181,190],"based":[183,192],"single-SNP":[185],"second":[189],"independent":[197],"any":[199,254],"permutation.":[201],"Furthermore,":[202],"organized":[206],"into":[207],"groups,":[208],"each":[209],"shares":[212],"common":[214],"bound.":[216],"This":[217],"allows":[218],"maximum":[220],"reuse":[221],"intermediate":[223],"computation,":[224],"estimation,":[228],"effective":[230],"pruning.":[232],"Consequently,":[233],"FastANOVA":[234,261],"only":[235],"needs":[236],"perform":[238],"small":[244],"candidate":[247],"without":[249],"risk":[251],"missing":[253],"ones.":[256],"Extensive":[257],"experiments":[258],"demonstrate":[259],"orders":[263],"magnitude":[265],"faster":[266],"than":[267],"brute-force":[269],"implementation":[270],"all":[275],"SNP":[276],"pairs.":[277]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":5}],"updated_date":"2026-04-21T08:09:41.155169","created_date":"2016-06-24T00:00:00"}