{"id":"https://openalex.org/W1989099983","doi":"https://doi.org/10.1145/1389095.1389156","title":"Protein-protein functional association prediction using genetic programming","display_name":"Protein-protein functional association prediction using genetic programming","publication_year":2008,"publication_date":"2008-07-12","ids":{"openalex":"https://openalex.org/W1989099983","doi":"https://doi.org/10.1145/1389095.1389156","mag":"1989099983"},"language":"en","primary_location":{"id":"doi:10.1145/1389095.1389156","is_oa":false,"landing_page_url":"https://doi.org/10.1145/1389095.1389156","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 10th annual conference on Genetic and evolutionary computation","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10016/9781","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034245473","display_name":"Beatriz Garc\u00eda-Jim\u00e9nez","orcid":"https://orcid.org/0000-0002-8129-6506"},"institutions":[{"id":"https://openalex.org/I50357001","display_name":"Universidad Carlos III de Madrid","ror":"https://ror.org/03ths8210","country_code":"ES","type":"education","lineage":["https://openalex.org/I50357001"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Beatriz Garcia","raw_affiliation_strings":["Universidad Carlos III de Madrid, Leganes - Madrid, Spain","Universidad Carlos III de Madrid, Leganes, Madrid, Spain#TAB#"],"affiliations":[{"raw_affiliation_string":"Universidad Carlos III de Madrid, Leganes - Madrid, Spain","institution_ids":["https://openalex.org/I50357001"]},{"raw_affiliation_string":"Universidad Carlos III de Madrid, Leganes, Madrid, Spain#TAB#","institution_ids":["https://openalex.org/I50357001"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005335460","display_name":"Ricardo Aler","orcid":"https://orcid.org/0000-0002-7472-4840"},"institutions":[{"id":"https://openalex.org/I50357001","display_name":"Universidad Carlos III de Madrid","ror":"https://ror.org/03ths8210","country_code":"ES","type":"education","lineage":["https://openalex.org/I50357001"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Ricardo Aler","raw_affiliation_strings":["Universidad Carlos III de Madrid, Leganes - Madrid, Spain","Universidad Carlos III de Madrid, Leganes, Madrid, Spain#TAB#"],"affiliations":[{"raw_affiliation_string":"Universidad Carlos III de Madrid, Leganes - Madrid, Spain","institution_ids":["https://openalex.org/I50357001"]},{"raw_affiliation_string":"Universidad Carlos III de Madrid, Leganes, Madrid, Spain#TAB#","institution_ids":["https://openalex.org/I50357001"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059348719","display_name":"Agapito Ledezma","orcid":"https://orcid.org/0000-0002-0041-6829"},"institutions":[{"id":"https://openalex.org/I50357001","display_name":"Universidad Carlos III de Madrid","ror":"https://ror.org/03ths8210","country_code":"ES","type":"education","lineage":["https://openalex.org/I50357001"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Agapito Ledezma","raw_affiliation_strings":["Universidad Carlos III de Madrid, Leganes - Madrid, Spain","Universidad Carlos III de Madrid, Leganes, Madrid, Spain#TAB#"],"affiliations":[{"raw_affiliation_string":"Universidad Carlos III de Madrid, Leganes - Madrid, Spain","institution_ids":["https://openalex.org/I50357001"]},{"raw_affiliation_string":"Universidad Carlos III de Madrid, Leganes, Madrid, Spain#TAB#","institution_ids":["https://openalex.org/I50357001"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5075840120","display_name":"Araceli Sanchis","orcid":"https://orcid.org/0000-0002-1429-4092"},"institutions":[{"id":"https://openalex.org/I50357001","display_name":"Universidad Carlos III de Madrid","ror":"https://ror.org/03ths8210","country_code":"ES","type":"education","lineage":["https://openalex.org/I50357001"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Araceli Sanchis","raw_affiliation_strings":["Universidad Carlos III de Madrid, Leganes - Madrid, Spain","Universidad Carlos III de Madrid, Leganes, Madrid, Spain#TAB#"],"affiliations":[{"raw_affiliation_string":"Universidad Carlos III de Madrid, Leganes - Madrid, Spain","institution_ids":["https://openalex.org/I50357001"]},{"raw_affiliation_string":"Universidad Carlos III de Madrid, Leganes, Madrid, Spain#TAB#","institution_ids":["https://openalex.org/I50357001"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5034245473"],"corresponding_institution_ids":["https://openalex.org/I50357001"],"apc_list":null,"apc_paid":null,"fwci":2.9329,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.91178426,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":null,"issue":null,"first_page":"347","last_page":"348"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11975","display_name":"Evolutionary Algorithms and Applications","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11975","display_name":"Evolutionary Algorithms and Applications","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10100","display_name":"Metaheuristic Optimization Algorithms Research","score":0.9947999715805054,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11663","display_name":"Viral Infectious Diseases and Gene Expression in Insects","score":0.9591000080108643,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/genetic-programming","display_name":"Genetic programming","score":0.8703985214233398},{"id":"https://openalex.org/keywords/interpretability","display_name":"Interpretability","score":0.8545082807540894},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.7022659182548523},{"id":"https://openalex.org/keywords/flexibility","display_name":"Flexibility (engineering)","score":0.6954739689826965},{"id":"https://openalex.org/keywords/domain","display_name":"Domain (mathematical analysis)","score":0.6646848320960999},{"id":"https://openalex.org/keywords/association","display_name":"Association (psychology)","score":0.47501835227012634},{"id":"https://openalex.org/keywords/genetic-algorithm","display_name":"Genetic algorithm","score":0.4490523934364319},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.3838932514190674},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.3788849711418152},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.323081374168396},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.17998021841049194},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.08889397978782654}],"concepts":[{"id":"https://openalex.org/C110332635","wikidata":"https://www.wikidata.org/wiki/Q629498","display_name":"Genetic programming","level":2,"score":0.8703985214233398},{"id":"https://openalex.org/C2781067378","wikidata":"https://www.wikidata.org/wiki/Q17027399","display_name":"Interpretability","level":2,"score":0.8545082807540894},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.7022659182548523},{"id":"https://openalex.org/C2780598303","wikidata":"https://www.wikidata.org/wiki/Q65921492","display_name":"Flexibility (engineering)","level":2,"score":0.6954739689826965},{"id":"https://openalex.org/C36503486","wikidata":"https://www.wikidata.org/wiki/Q11235244","display_name":"Domain (mathematical analysis)","level":2,"score":0.6646848320960999},{"id":"https://openalex.org/C142853389","wikidata":"https://www.wikidata.org/wiki/Q744778","display_name":"Association (psychology)","level":2,"score":0.47501835227012634},{"id":"https://openalex.org/C8880873","wikidata":"https://www.wikidata.org/wiki/Q187787","display_name":"Genetic algorithm","level":2,"score":0.4490523934364319},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3838932514190674},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.3788849711418152},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.323081374168396},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.17998021841049194},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.08889397978782654},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1145/1389095.1389156","is_oa":false,"landing_page_url":"https://doi.org/10.1145/1389095.1389156","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 10th annual conference on Genetic and evolutionary computation","raw_type":"proceedings-article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.152.9295","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.152.9295","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.cs.bham.ac.uk/~wbl/biblio/gecco2008/docs/p347.pdf","raw_type":"text"},{"id":"pmh:oai:e-archivo.uc3m.es:10016/9781","is_oa":true,"landing_page_url":"http://hdl.handle.net/10016/9781","pdf_url":null,"source":{"id":"https://openalex.org/S4306400817","display_name":"e-Archivo (Carlos III University of Madrid)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I50357001","host_organization_name":"Universidad Carlos III de Madrid","host_organization_lineage":["https://openalex.org/I50357001"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/other"}],"best_oa_location":{"id":"pmh:oai:e-archivo.uc3m.es:10016/9781","is_oa":true,"landing_page_url":"http://hdl.handle.net/10016/9781","pdf_url":null,"source":{"id":"https://openalex.org/S4306400817","display_name":"e-Archivo (Carlos III University of Madrid)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I50357001","host_organization_name":"Universidad Carlos III de Madrid","host_organization_lineage":["https://openalex.org/I50357001"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/other"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":5,"referenced_works":["https://openalex.org/W1488666798","https://openalex.org/W1570448133","https://openalex.org/W2147068690","https://openalex.org/W2418011578","https://openalex.org/W2966207845"],"related_works":["https://openalex.org/W2905433371","https://openalex.org/W2888392564","https://openalex.org/W4310278675","https://openalex.org/W4388422664","https://openalex.org/W4390569940","https://openalex.org/W4361193272","https://openalex.org/W2963326959","https://openalex.org/W4388685194","https://openalex.org/W4312407344","https://openalex.org/W2894289927"],"abstract_inverted_index":{"Determining":[0],"if":[1,40],"a":[2,41],"group":[3],"of":[4,23,36,44,52,63,128],"proteins":[5,45],"are":[6],"functionally":[7],"associated":[8],"among":[9],"themselves":[10],"is":[11,71,75,109],"an":[12],"open":[13],"problem":[14],"in":[15,56,79,123],"molecular":[16],"biology.":[17],"Within":[18],"our":[19],"long":[20],"term":[21],"goal":[22],"applying":[24],"Genetic":[25],"Programming":[26],"(GP)":[27],"to":[28,38,95],"this":[29,31,66,80,112],"domain,":[30],"paper":[32],"evaluates":[33],"the":[34,61,68,76,90,97,101,116],"feasibility":[35],"GP":[37,47,108],"predict":[39],"given":[42],"pair":[43],"interacts.":[46],"has":[48],"been":[49],"chosen":[50],"because":[51],"its":[53],"potential":[54],"flexibility":[55],"many":[57],"aspects,":[58],"such":[59],"as":[60],"definition":[62],"operations.":[64],"In":[65],"paper,":[67],"if-unknown":[69],"operation":[70],"defined,":[72],"which":[73],"semantically":[74],"most":[77],"appropriate":[78],"domain":[81,113],"for":[82,111],"handling":[83],"missing":[84],"values.":[85],"We":[86],"have":[87],"also":[88],"used":[89],"Tarpeian":[91,117],"bloat":[92],"control":[93],"method":[94,118],"decrease":[96],"computational":[98],"time":[99],"and":[100,114,126],"solution":[102],"size.":[103],"Our":[104],"results":[105],"show":[106],"that":[107,115],"feasible":[110],"can":[119],"obtain":[120],"large":[121],"improvements":[122],"search":[124],"efficiency":[125],"interpretability":[127],"solutions.":[129]},"counts_by_year":[{"year":2016,"cited_by_count":1}],"updated_date":"2026-04-05T17:49:38.594831","created_date":"2025-10-10T00:00:00"}