{"id":"https://openalex.org/W2055821568","doi":"https://doi.org/10.1145/1389095.1389153","title":"Structure and parameter estimation for cell systems biology models","display_name":"Structure and parameter estimation for cell systems biology models","publication_year":2008,"publication_date":"2008-07-12","ids":{"openalex":"https://openalex.org/W2055821568","doi":"https://doi.org/10.1145/1389095.1389153","mag":"2055821568"},"language":"en","primary_location":{"id":"doi:10.1145/1389095.1389153","is_oa":false,"landing_page_url":"https://doi.org/10.1145/1389095.1389153","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 10th annual conference on Genetic and evolutionary computation","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://idus.us.es/handle//11441/86733","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021627857","display_name":"Francisco J. Romero\u2013Campero","orcid":"https://orcid.org/0000-0001-9834-030X"},"institutions":[{"id":"https://openalex.org/I142263535","display_name":"University of Nottingham","ror":"https://ror.org/01ee9ar58","country_code":"GB","type":"education","lineage":["https://openalex.org/I142263535"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Francisco J. Romero-Campero","raw_affiliation_strings":["Univeristy of Nottingham, Nottingham, United Kingdom"],"affiliations":[{"raw_affiliation_string":"Univeristy of Nottingham, Nottingham, United Kingdom","institution_ids":["https://openalex.org/I142263535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100920722","display_name":"Hongqing Cao","orcid":null},"institutions":[{"id":"https://openalex.org/I142263535","display_name":"University of Nottingham","ror":"https://ror.org/01ee9ar58","country_code":"GB","type":"education","lineage":["https://openalex.org/I142263535"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Hongqing Cao","raw_affiliation_strings":["University of Nottingham, Nottingham, United Kingdom"],"affiliations":[{"raw_affiliation_string":"University of Nottingham, Nottingham, United Kingdom","institution_ids":["https://openalex.org/I142263535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020331709","display_name":"Miguel C\u00e1mara","orcid":"https://orcid.org/0000-0003-4585-7385"},"institutions":[{"id":"https://openalex.org/I142263535","display_name":"University of Nottingham","ror":"https://ror.org/01ee9ar58","country_code":"GB","type":"education","lineage":["https://openalex.org/I142263535"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Miguel Camara","raw_affiliation_strings":["University of Nottingham, Nottingham, United Kingdom"],"affiliations":[{"raw_affiliation_string":"University of Nottingham, Nottingham, United Kingdom","institution_ids":["https://openalex.org/I142263535"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043620976","display_name":"Natalio Krasnogor","orcid":"https://orcid.org/0000-0002-2651-4320"},"institutions":[{"id":"https://openalex.org/I142263535","display_name":"University of Nottingham","ror":"https://ror.org/01ee9ar58","country_code":"GB","type":"education","lineage":["https://openalex.org/I142263535"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Natalio Krasnogor","raw_affiliation_strings":["University of Nottingham, Nottingham, United Kingdom"],"affiliations":[{"raw_affiliation_string":"University of Nottingham, Nottingham, United Kingdom","institution_ids":["https://openalex.org/I142263535"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5021627857"],"corresponding_institution_ids":["https://openalex.org/I142263535"],"apc_list":null,"apc_paid":null,"fwci":2.2129,"has_fulltext":false,"cited_by_count":25,"citation_normalized_percentile":{"value":0.87397465,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":null,"issue":null,"first_page":"331","last_page":"338"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12029","display_name":"DNA and Biological Computing","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12029","display_name":"DNA and Biological Computing","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":0.989799976348877,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9883999824523926,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/modular-design","display_name":"Modular design","score":0.6488277912139893},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6177347302436829},{"id":"https://openalex.org/keywords/systems-biology","display_name":"Systems biology","score":0.6154810786247253},{"id":"https://openalex.org/keywords/memetic-algorithm","display_name":"Memetic algorithm","score":0.5460415482521057},{"id":"https://openalex.org/keywords/genetic-algorithm","display_name":"Genetic algorithm","score":0.5222861766815186},{"id":"https://openalex.org/keywords/process","display_name":"Process (computing)","score":0.48133763670921326},{"id":"https://openalex.org/keywords/evolutionary-algorithm","display_name":"Evolutionary algorithm","score":0.4585849940776825},{"id":"https://openalex.org/keywords/simple","display_name":"Simple (philosophy)","score":0.43769371509552},{"id":"https://openalex.org/keywords/estimation-theory","display_name":"Estimation theory","score":0.4220121204853058},{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.3791559040546417},{"id":"https://openalex.org/keywords/theoretical-computer-science","display_name":"Theoretical computer science","score":0.37882280349731445},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.32831740379333496},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.23886489868164062},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.20714783668518066},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.17655760049819946},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.11669006943702698}],"concepts":[{"id":"https://openalex.org/C101468663","wikidata":"https://www.wikidata.org/wiki/Q1620158","display_name":"Modular design","level":2,"score":0.6488277912139893},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6177347302436829},{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.6154810786247253},{"id":"https://openalex.org/C35129592","wikidata":"https://www.wikidata.org/wiki/Q324793","display_name":"Memetic algorithm","level":3,"score":0.5460415482521057},{"id":"https://openalex.org/C8880873","wikidata":"https://www.wikidata.org/wiki/Q187787","display_name":"Genetic algorithm","level":2,"score":0.5222861766815186},{"id":"https://openalex.org/C98045186","wikidata":"https://www.wikidata.org/wiki/Q205663","display_name":"Process (computing)","level":2,"score":0.48133763670921326},{"id":"https://openalex.org/C159149176","wikidata":"https://www.wikidata.org/wiki/Q14489129","display_name":"Evolutionary algorithm","level":2,"score":0.4585849940776825},{"id":"https://openalex.org/C2780586882","wikidata":"https://www.wikidata.org/wiki/Q7520643","display_name":"Simple (philosophy)","level":2,"score":0.43769371509552},{"id":"https://openalex.org/C167928553","wikidata":"https://www.wikidata.org/wiki/Q1376021","display_name":"Estimation theory","level":2,"score":0.4220121204853058},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.3791559040546417},{"id":"https://openalex.org/C80444323","wikidata":"https://www.wikidata.org/wiki/Q2878974","display_name":"Theoretical computer science","level":1,"score":0.37882280349731445},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.32831740379333496},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.23886489868164062},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.20714783668518066},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.17655760049819946},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.11669006943702698},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1145/1389095.1389153","is_oa":false,"landing_page_url":"https://doi.org/10.1145/1389095.1389153","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 10th annual conference on Genetic and evolutionary computation","raw_type":"proceedings-article"},{"id":"pmh:oai:idus.us.es:11441/86733","is_oa":true,"landing_page_url":"https://idus.us.es/handle//11441/86733","pdf_url":null,"source":{"id":"https://openalex.org/S4306400333","display_name":"idUS (Universidad de Sevilla)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I79238269","host_organization_name":"Universidad de Sevilla","host_organization_lineage":["https://openalex.org/I79238269"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/conferenceObject"}],"best_oa_location":{"id":"pmh:oai:idus.us.es:11441/86733","is_oa":true,"landing_page_url":"https://idus.us.es/handle//11441/86733","pdf_url":null,"source":{"id":"https://openalex.org/S4306400333","display_name":"idUS (Universidad de Sevilla)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I79238269","host_organization_name":"Universidad de Sevilla","host_organization_lineage":["https://openalex.org/I79238269"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/conferenceObject"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G7447450248","display_name":null,"funder_award_id":"EP/E017215/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G7712439438","display_name":null,"funder_award_id":"BB/F01855X/1","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"}],"funders":[{"id":"https://openalex.org/F4320334627","display_name":"Engineering and Physical Sciences Research Council","ror":"https://ror.org/0439y7842"},{"id":"https://openalex.org/F4320334629","display_name":"Biotechnology and Biological Sciences Research Council","ror":"https://ror.org/00cwqg982"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W1529898704","https://openalex.org/W1543741893","https://openalex.org/W1599969036","https://openalex.org/W1601977376","https://openalex.org/W1639032689","https://openalex.org/W1644749979","https://openalex.org/W1765898577","https://openalex.org/W1984719832","https://openalex.org/W2049646146","https://openalex.org/W2057225682","https://openalex.org/W2097571405","https://openalex.org/W2105217850","https://openalex.org/W2113997157","https://openalex.org/W2164211912","https://openalex.org/W2167154952","https://openalex.org/W2170186790","https://openalex.org/W2170704198","https://openalex.org/W2528271650","https://openalex.org/W3023540311","https://openalex.org/W4205597578","https://openalex.org/W4256259619","https://openalex.org/W4322738676"],"related_works":["https://openalex.org/W2010336970","https://openalex.org/W4205193211","https://openalex.org/W3034364924","https://openalex.org/W3196925172","https://openalex.org/W3091613133","https://openalex.org/W2147204676","https://openalex.org/W2787833928","https://openalex.org/W4307002224","https://openalex.org/W4297400681","https://openalex.org/W4223471723"],"abstract_inverted_index":{"In":[0],"this":[1],"work":[2],"we":[3,68],"present":[4],"a":[5,64,70,88],"new":[6],"methodology":[7],"for":[8],"structure":[9,34,54],"and":[10,35,55,154,174],"parameter":[11],"estimation":[12],"in":[13,133,176],"cell":[14],"systems":[15,142],"biology":[16],"modelling.":[17],"Our":[18,99],"modelling":[19],"framework":[20],"is":[21,61],"based":[22],"on":[23,165],"P":[24,110,141],"systems,":[25],"an":[26,103],"unconventional":[27],"computational":[28],"paradigm":[29],"that":[30],"abstracts":[31],"from":[32,107],"the":[33,38,49,52,57,75,82,94,97,137,161],"functioning":[36],"of":[37,43,47,51,56,96,102,139,160],"living":[39],"cell.":[40],"The":[41,158],"process":[42],"designing":[44],"models,":[45],"consisting":[46],"both":[48],"optimisation":[50],"modular":[53],"stochastic":[58],"kinetic":[59],"parameters,":[60],"performed":[62],"using":[63],"memetic":[65],"algorithm.":[66],"Specically,":[67],"use":[69],"nested":[71],"evolutionary":[72],"algorithm":[73,90,162],"where":[74],"first":[76],"layer":[77],"evolves":[78],"rule":[79],"structures":[80],"while":[81],"inner":[83],"layer,":[84],"implemented":[85],"also":[86],"as":[87,145],"genetic":[89],"(GA),":[91],"fine":[92],"tunes":[93],"parameters":[95],"model.":[98],"approach":[100],"consists":[101],"incremental":[104],"methodology.":[105],"Starting":[106],"very":[108],"simple":[109],"system":[111],"modules":[112,119,131,143],"specifying":[113],"basic":[114],"molecular":[115,126,170],"interactions,":[116],"more":[117,124,152],"complicated":[118],"are":[120,132],"produced":[121],"to":[122,136,146,150],"model":[123],"complex":[125],"systems.":[127],"These":[128],"newly":[129],"found":[130],"turn":[134],"added":[135],"library":[138],"available":[140],"so":[144],"be":[147],"used":[148],"subsequently":[149],"develop":[151],"intricate":[153],"circuitous":[155],"cellular":[156],"models.":[157],"effectiveness":[159],"was":[163],"tested":[164],"three":[166],"case":[167],"studies,":[168],"namely,":[169],"complexation,":[171],"enzymatic":[172],"reactions":[173],"autoregulation":[175],"transcriptional":[177],"networks.":[178]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-04-05T17:49:38.594831","created_date":"2025-10-10T00:00:00"}
