{"id":"https://openalex.org/W1983242649","doi":"https://doi.org/10.1145/1141277.1141319","title":"Innovative computational methods for transcriptomic data analysis","display_name":"Innovative computational methods for transcriptomic data analysis","publication_year":2006,"publication_date":"2006-04-23","ids":{"openalex":"https://openalex.org/W1983242649","doi":"https://doi.org/10.1145/1141277.1141319","mag":"1983242649"},"language":"en","primary_location":{"id":"doi:10.1145/1141277.1141319","is_oa":false,"landing_page_url":"https://doi.org/10.1145/1141277.1141319","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 2006 ACM symposium on Applied computing","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011863644","display_name":"Michael A. Langston","orcid":"https://orcid.org/0000-0001-5945-5796"},"institutions":[{"id":"https://openalex.org/I75027704","display_name":"University of Tennessee at Knoxville","ror":"https://ror.org/020f3ap87","country_code":"US","type":"education","lineage":["https://openalex.org/I75027704"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Michael A. Langston","raw_affiliation_strings":["University of Tennessee, Knoxville, TN","University of Tennessee, Knoxville, TN;"],"affiliations":[{"raw_affiliation_string":"University of Tennessee, Knoxville, TN","institution_ids":["https://openalex.org/I75027704"]},{"raw_affiliation_string":"University of Tennessee, Knoxville, TN;","institution_ids":["https://openalex.org/I75027704"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005914571","display_name":"Andy Perkins","orcid":"https://orcid.org/0000-0002-3583-1010"},"institutions":[{"id":"https://openalex.org/I75027704","display_name":"University of Tennessee at Knoxville","ror":"https://ror.org/020f3ap87","country_code":"US","type":"education","lineage":["https://openalex.org/I75027704"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andy D. Perkins","raw_affiliation_strings":["University of Tennessee, Knoxville, TN","University of Tennessee, Knoxville, TN;"],"affiliations":[{"raw_affiliation_string":"University of Tennessee, Knoxville, TN","institution_ids":["https://openalex.org/I75027704"]},{"raw_affiliation_string":"University of Tennessee, Knoxville, TN;","institution_ids":["https://openalex.org/I75027704"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041646784","display_name":"Arnold M. Saxton","orcid":"https://orcid.org/0000-0003-3345-5127"},"institutions":[{"id":"https://openalex.org/I75027704","display_name":"University of Tennessee at Knoxville","ror":"https://ror.org/020f3ap87","country_code":"US","type":"education","lineage":["https://openalex.org/I75027704"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Arnold M. Saxton","raw_affiliation_strings":["University of Tennessee, Knoxville, TN","University of Tennessee, Knoxville, TN;"],"affiliations":[{"raw_affiliation_string":"University of Tennessee, Knoxville, TN","institution_ids":["https://openalex.org/I75027704"]},{"raw_affiliation_string":"University of Tennessee, Knoxville, TN;","institution_ids":["https://openalex.org/I75027704"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004037069","display_name":"Jon A. Scharff","orcid":null},"institutions":[{"id":"https://openalex.org/I75027704","display_name":"University of Tennessee at Knoxville","ror":"https://ror.org/020f3ap87","country_code":"US","type":"education","lineage":["https://openalex.org/I75027704"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jon A. Scharff","raw_affiliation_strings":["University of Tennessee, Knoxville, TN","University of Tennessee, Knoxville, TN;"],"affiliations":[{"raw_affiliation_string":"University of Tennessee, Knoxville, TN","institution_ids":["https://openalex.org/I75027704"]},{"raw_affiliation_string":"University of Tennessee, Knoxville, TN;","institution_ids":["https://openalex.org/I75027704"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5007918640","display_name":"Brynn H. Voy","orcid":"https://orcid.org/0000-0003-1923-9110"},"institutions":[{"id":"https://openalex.org/I1289243028","display_name":"Oak Ridge National Laboratory","ror":"https://ror.org/01qz5mb56","country_code":"US","type":"facility","lineage":["https://openalex.org/I1289243028","https://openalex.org/I1330989302","https://openalex.org/I39565521","https://openalex.org/I4210159294"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brynn H. Voy","raw_affiliation_strings":["Mammalian Genetics and Genomics, Oak Ridge National Laboratory, Oak Ridge, TN"],"affiliations":[{"raw_affiliation_string":"Mammalian Genetics and Genomics, Oak Ridge National Laboratory, Oak Ridge, TN","institution_ids":["https://openalex.org/I1289243028"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5011863644"],"corresponding_institution_ids":["https://openalex.org/I75027704"],"apc_list":null,"apc_paid":null,"fwci":0.4086,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.60326342,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":96},"biblio":{"volume":null,"issue":null,"first_page":"190","last_page":"194"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9939000010490417,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9925000071525574,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5977067351341248},{"id":"https://openalex.org/keywords/genomics","display_name":"Genomics","score":0.5088889598846436},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.49543488025665283},{"id":"https://openalex.org/keywords/functional-genomics","display_name":"Functional genomics","score":0.48905858397483826},{"id":"https://openalex.org/keywords/implementation","display_name":"Implementation","score":0.4847428500652313},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.4180413484573364},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3684448003768921},{"id":"https://openalex.org/keywords/genome","display_name":"Genome","score":0.3560956120491028},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.19484958052635193}],"concepts":[{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5977067351341248},{"id":"https://openalex.org/C189206191","wikidata":"https://www.wikidata.org/wiki/Q222046","display_name":"Genomics","level":4,"score":0.5088889598846436},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.49543488025665283},{"id":"https://openalex.org/C161078062","wikidata":"https://www.wikidata.org/wiki/Q1068690","display_name":"Functional genomics","level":5,"score":0.48905858397483826},{"id":"https://openalex.org/C26713055","wikidata":"https://www.wikidata.org/wiki/Q245962","display_name":"Implementation","level":2,"score":0.4847428500652313},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4180413484573364},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3684448003768921},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.3560956120491028},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.19484958052635193},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1145/1141277.1141319","is_oa":false,"landing_page_url":"https://doi.org/10.1145/1141277.1141319","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 2006 ACM symposium on Applied computing","raw_type":"proceedings-article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.122.3157","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.122.3157","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://comjnl.oxfordjournals.org/cgi/reprint/bxm003v1.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.4099999964237213,"display_name":"Partnerships for the goals","id":"https://metadata.un.org/sdg/17"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":42,"referenced_works":["https://openalex.org/W75155422","https://openalex.org/W161038807","https://openalex.org/W1528914253","https://openalex.org/W1530803355","https://openalex.org/W1584846756","https://openalex.org/W1588911128","https://openalex.org/W1589993665","https://openalex.org/W1637197683","https://openalex.org/W1976149501","https://openalex.org/W1987092466","https://openalex.org/W1989787830","https://openalex.org/W1992452843","https://openalex.org/W1993031800","https://openalex.org/W2010656511","https://openalex.org/W2013444425","https://openalex.org/W2018468690","https://openalex.org/W2020681752","https://openalex.org/W2026781850","https://openalex.org/W2036836182","https://openalex.org/W2043004358","https://openalex.org/W2043344835","https://openalex.org/W2061439657","https://openalex.org/W2062664462","https://openalex.org/W2065183358","https://openalex.org/W2074615853","https://openalex.org/W2077542647","https://openalex.org/W2093017030","https://openalex.org/W2096768449","https://openalex.org/W2108334325","https://openalex.org/W2112090702","https://openalex.org/W2133747068","https://openalex.org/W2141815340","https://openalex.org/W2151326548","https://openalex.org/W2154437541","https://openalex.org/W2163480486","https://openalex.org/W2611104316","https://openalex.org/W2913688336","https://openalex.org/W2944782266","https://openalex.org/W3021663328","https://openalex.org/W4244850198","https://openalex.org/W4292230561","https://openalex.org/W6671166549"],"related_works":["https://openalex.org/W2360935227","https://openalex.org/W2364993072","https://openalex.org/W2115576822","https://openalex.org/W2356429006","https://openalex.org/W2380568150","https://openalex.org/W2385787406","https://openalex.org/W2155595079","https://openalex.org/W4362472570","https://openalex.org/W2411510900","https://openalex.org/W2263355832"],"abstract_inverted_index":{"The":[0,43],"tools":[1,8],"of":[2,9,29,46,86,163,180],"molecular":[3],"biology":[4],"and":[5,36,40,88,92,99,169],"the":[6,17,101,147,159],"evolving":[7],"genomics":[10],"can":[11],"now":[12],"be":[13],"exploited":[14],"to":[15,25,50,81,96,128,145,158,173,188],"study":[16],"genetic":[18,121],"regulatory":[19,122],"mechanisms":[20,123],"that":[21,66,124,149],"control":[22,125],"cellular":[23,126],"responses":[24,32,60,127,172],"a":[26,52,111,155],"wide":[27],"variety":[28],"stimuli.":[30],"These":[31],"are":[33,49,150],"highly":[34],"complex,":[35],"involve":[37],"many":[38],"genes":[39],"gene":[41,69,83,104,137],"products.":[42],"main":[44],"objectives":[45],"this":[47],"paper":[48],"describe":[51,115],"novel":[53],"research":[54],"program":[55],"centered":[56],"on":[57],"understanding":[58,179],"these":[59,79,164],"by":[61],"developing":[62],"powerful":[63],"graph":[64],"algorithms":[65],"generate":[67],"distilled":[68],"sets,":[70],"producing":[71],"high":[72],"performance":[73],"implementations":[74,80],"utilizing":[75],"cutting-edge":[76],"platforms,":[77],"employing":[78],"identify":[82,146],"sets":[84,105],"suggestive":[85],"coregulation,":[87],"performing":[89],"sequence":[90],"analysis":[91],"genomic":[93],"data":[94,139],"mining":[95],"examine,":[97],"winnow":[98],"highlight":[100],"most":[102],"promising":[103],"for":[106],"more":[107],"detailed":[108],"investigation.":[109],"As":[110],"case":[112],"study,":[113],"we":[114],"our":[116,178],"work":[117],"aimed":[118],"at":[119],"elucidating":[120],"low":[129],"dose":[130],"ionizing":[131],"radiation":[132,160],"(IR).":[133],"We":[134],"use":[135],"genome-scale":[136],"expression":[138],"after":[140],"IR":[141,182],"exposure":[142],"in":[143],"vivo":[144],"pathways":[148,165],"activated":[151],"or":[152],"repressed":[153],"as":[154],"tissue":[156],"responds":[157],"insult.":[161],"Knowledge":[162],"should":[166],"help":[167],"clarify":[168],"interpret":[170],"physiological":[171],"IR,":[174],"which":[175],"will":[176],"advance":[177],"how":[181],"exposures":[183],"pose":[184],"an":[185],"increased":[186],"risk":[187],"human":[189],"health.":[190]},"counts_by_year":[{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-04-04T16:13:02.066488","created_date":"2025-10-10T00:00:00"}